Article
Food Science & Technology
Barbara Reynes, Mariona Palou, Andreu Palou, Francisca Serra
Summary: The co-administration of MET with beta-sitosterol seems to neutralise part of the beneficial effects of MET in WDIO rats.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Myrtille C. R. Gumbs, Leslie Eggels, Anna H. Vuuregge, Unga A. Unmehopa, Joram D. Mul, Susanne E. la Fleur
Summary: This study found that the effects of intra-LHA NPY on caloric intake vary depending on the consumption of a fat or sugar component in a free-choice diet. The study also revealed that baseline preference for the fat diet component modulates the effects of intra-LHA NPY in rats fed with a free-choice high-fat and high-sugar diet.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Psychology, Biological
Katherine A. Kern, Adrianne M. DiBrog, Johnathan T. Przybysz, Elizabeth G. Mietlicki-Baase
Summary: Pramlintide reduces food intake in rats largely by reducing intake of high-fat diet, also suppressing intake of standard chow, which may contribute to weight loss.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Kento Ohbayashi, Yukiko Oyama, Chiharu Yamaguchi, Toshiki Asano, Toshihiko Yada, Yusaku Iwasaki
Summary: This study found that gastrointestinal distension stimulates GLP-1 secretion and vagal afferent signaling, regulating feeding behavior and glucose tolerance, and has a positive effect on obesity induced by high-fat diet.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Physiology
Clinton T. Elfers, James E. Blevins, Elizabeth A. Lawson, Richard Pittner, David Silva, Alex Kiselyov, Christian L. Roth
Summary: The study demonstrated the efficacy of oxytocin analog ASK1476 in reducing food intake and body weight in experimental animals, showing a stronger dose response and similar reduction in food intake compared to native oxytocin.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Courtney Clyburn, R. Alberto Travagli, Amy C. Arnold, Kirsteen N. Browning
Summary: Acute exposure to a high-fat diet induces a brief period of hyperphagia, which is associated with activation of synaptic NMDA receptors on dorsal motor nucleus of the vagus neurons, increasing vagal control of gastric functions.
Review
Biochemistry & Molecular Biology
Juliette Salvi, Pierre Andreoletti, Etienne Audinat, Eglantine Balland, Selma Ben Fradj, Mustapha Cherkaoui-Malki, Tony Heurtaux, Fabienne Lienard, Emmanuelle Nedelec, Carole Rovere, Stephane Savary, Anne Vejux, Doriane Trompier, Alexandre Benani
Summary: Maintaining energy balance is crucial for survival and health. The brain receives various signals to regulate food intake based on energy needs. Microglial cell activation in the hypothalamus may affect energy balance, and nutritional lipids can play a role in this process.
Review
Biochemistry & Molecular Biology
Jose Luis Marcos, Rossy Olivares-Barraza, Karina Ceballo, Melisa Wastavino, Victor Ortiz, Julio Riquelme, Jonathan Martinez-Pinto, Pablo Munoz, Gonzalo Cruz, Ramon Sotomayor-Zarate
Summary: Obesity-induced neuroinflammation is a chronic inflammation in the central nervous system characterized by increased pro-inflammatory cytokines and the activation of the NLRP3 inflammasome. It is caused by lifestyle changes such as excessive intake of obesogenic foods and decreased physical activity. Chronic lipid intake triggers neuroinflammation in multiple brain regions, affecting feeding control and leading to metabolic and neurological alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Abigail L. Horn, Brooke M. Bell, Bernardo Garcia Bulle Bueno, Mohsen Bahrami, Burcin Bozkaya, Yan Cui, John P. Wilson, Alex Pentland, Esteban Moro, Kayla de la Haye
Summary: This study investigates the use of mobility data in studying the relationship between dynamic food environments and diet-related health. The findings suggest that visits to fast food outlets can be a better predictor of individuals' obesity and diabetes risks than self-reported fast food intake.
NPJ DIGITAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Shigenobu Matsumura, Fuka Ishikawa, Tsutomu Sasaki, Mike Krogh Terkelsen, Kim Ravnskjaer, Tomoki Jinno, Jin Tanaka, Tsuyoshi Goto, Kazuo Inoue
Summary: CRTC1 in SF1 cells is a sensitive factor for high-fat diet-induced obesity, necessary for normal appetite regulation. It is primarily expressed in the brain, playing an important role in the ventromedial hypothalamus. RNA sequencing analysis of microdissected ventromedial hypothalamus samples revealed that the loss of CRTC1 significantly altered the expression levels of certain genes.
Article
Nutrition & Dietetics
Natasha Kapoor, Werd al Najim, Camilo Menezes, Ruth K. Price, Colm O'Boyle, Zsolt Bodnar, Alan C. Spector, Neil G. Docherty, Carel W. le Roux
Summary: Long-term reductions in food intake, especially energy dense foods, have been found in individuals who underwent Roux-en-Y gastric bypass surgery. At 24 months post-surgery, overall energy intake decreased by 60%, with reductions seen across all food categories. The study also suggests a possible increase in the proportional intake of protein after surgery.
Article
Neurosciences
Courtney Clyburn, Kaitlin E. Carson, Caleb R. Smith, R. Alberto Travagli, Kirsteen N. Browning
Summary: Prolonged exposure to a high-fat diet leads to hyperphagia and weight gain, but within a short period of time, caloric intake is regulated and energy balance is restored. Acute high-fat diet exposure activates brainstem astrocytes, increasing glutamatergic transmission to gastric-projecting neurons and restoring caloric balance. Inhibiting brainstem astrocytes reduces glutamatergic signaling, disrupts gastric tone and motility, delays gastric emptying, and prevents the decrease in food intake during energy regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Endocrinology & Metabolism
Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron, Natalie Jane Michael
Summary: Histamine, a neuromodulator in the brain, contributes to the regulation of various physiological processes, including energy balance, through histaminergic signaling in the hypothalamus. Two histamine receptors, H1R and H3R, play important roles in key hypothalamic nuclei involved in energy homeostasis. Activation of H1R suppresses food intake, while activation of H3R stimulates appetite. The central histaminergic system is implicated in weight gain induced by atypical antipsychotics and has potential as a therapeutic target for obesity treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Psychology, Biological
Khulood Almehmadi, Sarah Fourman, Dana Buesing, Yvonne M. Ulrich-Lai
Summary: Limited intermittent consumption of palatable food reduces stress responses in chow-fed rats, but this effect is diminished in rats with diet-induced obesity. Adult male rats were given unlimited access to high-fat, high-sugar diet or normal chow, followed by limited sucrose intake for 2 weeks. The results showed that sucrose reduced stress responses in lean rats, but not in obese rats. This suggests that obesity attenuates the stress-relieving effects of palatable foods.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Endocrinology & Metabolism
Anna Aulinas, Maged Muhammed, Kendra R. Becker, Elisa Asanza, Kristine Hauser, Casey Stern, Julia Gydus, Tara Holmes, Helen Burton Murray, Lauren Breithaupt, Nadia Micali, Madhusmita Misra, Kamryn T. Eddy, Jennifer J. Thomas, Elizabeth A. Lawson
Summary: This study examined the response of anorexigenic oxytocin to food intake in adolescents and young adults with avoidant/restrictive food intake disorder (ARFID). It was found that individuals with ARFID had higher levels of oxytocin compared to healthy controls at all time points.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Hui Zou, Wen-Quan Liang, Qi-Liang Wu, Li Zhou, Xiao-Hua Hou, Na Liu, Zong-Quan Wu
Summary: This work presents the design and synthesis of two types of star-shaped hybrid helical polymers, one with enantioselective crystallization properties and the other with self-assembling ability to form micelles in aqueous solutions.
Article
Cell Biology
Liuying Chen, Huikuan Chu, Lilin Hu, Zhonglin Li, Ling Yang, Xiaohua Hou
Summary: This study reveals that alcohol consumption can lead to intestinal barrier injury. NOX1, a protein, plays a role in accumulating reactive oxygen species (ROS) and causing cell apoptosis in intestinal epithelial cells. Propionate, an endogenous inhibitor of HDAC2, can alleviate oxidative stress injury and reduce cell apoptosis in the intestines.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Dong Jiang, Ying Liu, Jian-Di Wu, Gang-Ping Li, Jun Liu, Xiao-Hua Hou, Jun Song
Summary: This case report highlights a rare but severe complication of massive bleeding following ERBL therapy for internal hemorrhoids. Despite the successful management of bleeding with hemoclipping, it emphasizes the importance of close monitoring and follow-up for all patients undergoing RBL procedures, even those without coagulation disorders.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Otorhinolaryngology
Xiaoyun Yu, Jiaqi Wang, Tian Jin, Lizhi Xiang, Xiaoli Pan, Xiaohua Hou
Summary: This study investigated the relationship between HGMUE and laryngopharyngeal symptoms. The results showed that HGMUE is an important cause of laryngopharyngeal symptoms, especially in patients without evidence of GERD. The study also revealed the mechanism of HGMUE-induced laryngopharyngeal symptoms.
CLINICAL OTOLARYNGOLOGY
(2023)
Review
Gastroenterology & Hepatology
Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh
Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gaichao Hong, Ying Li, Min Yang, Gangping Li, Yu Jin, Hanhua Xiong, Wei Qian, Xiaohua Hou
Summary: This study investigated the relationship between gut microbiota and the efficacy of probiotics in the treatment of IBS-D. The results showed that BE improved symptoms and altered gut microbiota composition. Additionally, the study found that baseline gut microbiota was associated with the efficacy of probiotics.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Microbiology
Shengyan Zhang, Gaichao Hong, Gangping Li, Wei Qian, Yu Jin, Xiaohua Hou
Summary: Rifaximin can alleviate visceral hypersensitivity in PI-IBS mice, and this effect is associated with the change in the relative abundance of ileal mucosal microbiota. Rifaximin mainly affects the microbiota of ileal mucosa, and its effect on colonic mucosal and fecal microbiota is not obvious.
Article
Medicine, Research & Experimental
Weijun Wang, Xuelian Tang, Caihan Duan, Shuxin Tian, Chaoqun Han, Wei Qian, Xin Jiang, Xiaohua Hou, Rong Lin
Summary: This study aimed to investigate the effect and underlying mechanism of action of Fut2 in colorectal cancer (CRC). The results showed that Fut2 deficiency is closely related to the development of CRC and downregulates the fucosylation of MCAM. Therefore, regulating fucosylation may be a potential therapy for CRC, especially in patients with Fut2 gene defects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yan Xu, Yilin Xiong, Ying Liu, Gangping Li, Tao Bai, Gen Zheng, Xiaohua Hou, Jun Song
Summary: Recent studies have shown that intestinal mechanical signals can regulate mucus synthesis and secretion through Piezo1. This study aimed to investigate the molecular mechanisms by which Piezo1 on goblet cells regulates mucus barrier function through methylation modification. The results revealed that Piezo1 mediates mechanical stimulation to inhibit H3K9me3, thereby promoting mucin2 expression in goblet cells and regulating mucus barrier function.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Liuying Chen, Pengcheng Yang, Lilin Hu, Ling Yang, Huikuan Chu, Xiaohua Hou
Summary: Impaired phenylalanine metabolism and its relationship with gut microbiota in alcohol-related liver disease (ALD) were investigated. Elevated levels of phenylalanine and its metabolites were found in the intestines of alcohol-fed mice, negatively correlated with the abundance of Lactobacillus. Phenylalanine levels were correlated with colon inflammation and intestinal barrier dysfunction, while oral supplementation of L. acidophilus improved phenylalanine metabolism and protected mice from ALD.
CELL AND BIOSCIENCE
(2023)
Article
Microbiology
Bangzhou Zhang, Luxi Yang, Hanbing Ning, Man Cao, Zhangran Chen, Qiongyun Chen, Guanghui Lian, Hailing Tang, Qizhi Wang, Junping Wang, Zhihui Lin, Jianbo Wen, Yuedong Liu, Ji Xuan, Xuejun Li, Aiqiang Lin, Jianquan He, Lei Zhang, Xiaohua Hou, Qiang Zeng, Chuanxing Xiao
Summary: FMT, a treatment method for UC targeting gut microbiota, has shown varying effectiveness in clinical trials. Donor selection might be a contributing factor to this variability, as a patient's response to FMT could depend on the ability of the used donor's microbiota to restore the specific gut disturbances of the patient. This study developed a donor-recipient matching model to guide donor selection for UC in FMT, based on analysis of fecal bacterial diversity and composition.
MICROBIOLOGY SPECTRUM
(2023)
Article
Green & Sustainable Science & Technology
Xiaohua Hou, Bo Cheng, Zhiliang Xia, Haijun Zhou, Qi Shen, Yanjie Lu, Ehsan Nazemi, Guodao Zhang
Summary: In order to promote ecological sustainability, researchers are increasingly interested in the issue of sulphur dioxide emissions. However, current research mainly focuses on the relationship between sulphur dioxide (SO2) emissions, foreign direct investment (FDI), and trade, and the effects of trade on SO2 emissions, without giving sufficient consideration to the impact of the institutional environment and economic growth on SO2 emissions. This paper empirically tests the institutional environment and economic growth of sulphur dioxide (SO2) emissions using provincial panel data from 2008 to 2017, employing a fixed effects model. The results indicate an inverted U-shaped relationship between GDP growth and SO2 emissions. The institutional environment and higher government intervention in the region lead to a significant decrease in SO2 emissions, and the institutional environment and level of government intervention have a negative regulatory role on economic growth and SO2 emissions. The paper provides empirical evidence based on environmental governance research, particularly in the context of regional environmental governance and government environmental performance audit policy, thus promoting sustainable ecological and environmental development.
Article
Biochemistry & Molecular Biology
Zhe Wang, Chen Tan, Caihan Duan, Junhao Wu, Dan Zhou, Lingzhi Hou, Wei Qian, Chaoqun Han, Xiaohua Hou
Summary: The repair of intestinal epithelial after injury is coordinated by intestinal stem cells (ISCs), which can be influenced by fucosylation catalyzed by FUT2. This study explores the role of FUT2 in ISCs using a DSS and LPS model, and demonstrates that fucosylation of ISCs alleviates epithelial damage and maintains their function and stemness. Furthermore, FUT2 depletion in ISCs aggravates epithelial damage and disrupts the growth and proliferation capacity of ISCs by inducing ER stress and the unfolded protein response. The study also identifies HYOU1 as a fucosylated protein that facilitates ISC survival and self-renewal, and improves their resistance to ER stress and inflammatory injury.
Article
Gastroenterology & Hepatology
Hai Tao Shang, Zhen Ouyang, Can Chen, Chao Fan Duan, Tao Bai, Xiao Hua Hou
Summary: The aim of this study was to determine the prevalence and risk factors, particularly lifestyle factors, of belching disorders among freshman college students in central China. The study found that coffee consumption and stress were independent risk factors for belching disorders, while intake of whole grains was a protective factor. Therefore, dietary intervention may be a potential management for belching disorders.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ao Liu, Yongqiang Zheng, Pengcheng Yang, Huikuan Chu, Xiaohua Hou
Summary: The average age of first primary colorectal cancer (CRC) diagnosis in the USA has decreased significantly from 1992 to 2017, with a more pronounced decline after 2000. Proximal CRC cases have a higher age at diagnosis compared to distal CRC cases. Advanced stage CRC patients have a lower age at diagnosis than early stage patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
