Article
Materials Science, Multidisciplinary
Zhou Ye, Irawan Pramuyda, Yuanhui Xiang, Sihan Yu, Teng Chi, Dongping Liu, Bo Su, Christopher J. Addonizio, Sijie Xian, Lei Zou, Matthew J. Webber
Summary: Point-of-use devices are needed to conveniently deliver protein therapeutics. Microneedles offer a method to deliver biopharmaceuticals across the skin and avoid injection or oral administration. A microneedle platform combining a PEG-based supramolecular polymer network with a mechanical biopolymer network can penetrate the skin and deliver sustained release of insulin. This approach simplifies the fabrication of detachable microneedles using polymer formulations with supramolecular bonding.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Bingbing Shi, Yun-Fei Zhang, Zheng-Hua Zhang, Hong Yao, Wen-Juan Qu, You-Ming Zhang, Tai-Bao Wei, Qi Lin
Summary: A PbS QD-based supramolecular polymer network is formed through host-guest complexation involving pillar[5]arene, allowing for living cell imaging applications.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Anna Kataki-Anastasakou, Selena Hernandez, Ellen M. Sletten
Summary: The widespread adoption of the bioorthogonal chemical reporter strategy has revolutionized chemical biology, but its translation to living mammals has been challenging. This study introduces a novel bioorthogonal complexation approach, leveraging intermolecular interactions instead of new bioorthogonal reactions, to efficiently label cell surfaces and implement in the chemical reporter strategy.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Applied
Meng-Qi Wang, Qian Wang, Meng Chen, Da-Hui Qu
Summary: The study successfully fabricated a supramolecular luminescence system with tunable fluorescence emissions ranging from yellow to green by assembling a simple fluorescent molecule, 4-(pyren-1-yl)-1-(4-vinylbenzyl)pyridin-1-ium chloride (PPD), and cucurbit[n]uril (CB[n], n = 7, 8) via host-guest interactions. This system exhibited enhanced emission efficiency and longer fluorescence lifetime, making it suitable for applications in fluorescent ink and potential for information encryption materials.
Review
Chemistry, Multidisciplinary
Takehiro Hirao, Takeharu Haino
Summary: This review introduces the research directions for the synthesis of supramolecular fullerene polymers, including the linear, networked, helical arrays directed by the use of calix[5]arene-fullerene interactions, and the investigation of the calix[5]arene-fullerene interaction for control over the chain structures of covalent polymers.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Arka Som, Meenakshi Pahwa, Sumit Bawari, Nilanjana Das Saha, Ranjan Sasmal, Monica Swetha Bosco, Jagannath Mondal, Sarit S. Agasti
Summary: Modern chemical and biological studies are focusing more on understanding the fate of individual cells within apparently homogeneous populations. This has led to a need for strategies that label individual cells with unique fluorescent signatures, and one promising approach involves using optically controlled host-guest recognition to generate distinct barcodes in cells. Multiple spectrally distinct CB[7]-conjugated fluorophores can be used to perform 10-color barcoding in fixed cells and 7-color barcoding in live cells, demonstrating the potential for multiplexed applications in cellular studies.
Article
Chemistry, Multidisciplinary
Jieyu Zheng, Larissa K. S. von Krbek, Tanya K. Ronson, Jonathan R. Nitschke
Summary: Spin-crossover (SCO) metal-organic cages have the potential to be used as magnetic sensors and switches. Variations in the donor strength of heterocyclic aldehyde subcomponents in imine-based ligands can tune the ligand field for a Fe-II center, resulting in diverse SCO behaviors in the cages. The tetrahedral SCO cage built from 1-methyl-1H-imidazole-2-carbaldehyde can encapsulate various guests and stabilize different cage spin states depending on guest size. The SCO tetrahedron also exhibits different affinities for guests in different spin states, which is attributed to subtle structural differences caused by the change in the metal center spin state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Hyoju Choi, Young-Ho Oh, Soojin Park, Sung-Sik Lee, Han Bin Oh, Sungyul Lee
Summary: We propose a novel method to examine host-guest-solvent interactions in solution from their gas phase structures. By conducting experiments and quantum chemical calculations, we establish the corresponding relationship between the structure of the complex in the gas phase and the stable conformer in solution.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Inorganic & Nuclear
Shunsuke Ohtani, Kenichi Kato, Shixin Fa, Tomoki Ogoshi
Summary: Pillar[n]arenes, a new type of pillar-shaped host molecule, exhibit versatile and unique host-guest behaviors in host-guest chemistry. Solid-state host-guest complexation offers advantages such as cavity-size dependency, efficient complexation, and easy isolation and reuse. This review discusses recent developments in solid-state host-guest complexation using crystalline pillar[n]arenes, networks containing pillar[n]arenes, pillar[n]arene-assembled surfaces, and solid-state organic polymers.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Polymer Science
Amy C. Madl, David Myung
Summary: Over 6.2 million people worldwide suffer from moderate to severe vision loss due to corneal disease. While transplantation with allogenic donor tissue is sight-restoring for many patients with corneal blindness, this treatment modality is limited by long waiting lists and high rejection rates. Host-guest interactions have emerged as an important crosslinking strategy for cytocompatible, minimally invasive, injectable tissue substitutes.
Article
Chemistry, Multidisciplinary
Sharafudheen Pottanam Chali, Suna Azhdari, Anzhela Galstyan, Andre H. Groschel, Bart Jan Ravoo
Summary: Biodegradable supramolecular micelles were prepared by utilizing the host-guest interaction of cyclodextrin and adamantane, with cyclodextrin-initiated polypeptides acting as the hydrophilic corona and adamantane-terminated polycaprolactones serving as the hydrophobic core.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Chenghao Hou, Lijing Liu, Siyang Meng, Yue Wu, Meiran Xie, Yongkui Shan, Pingang He, Pengfei Sun, Xiaojuan Liao
Summary: By constructing pillar[5]arene/silica hybrid vesicles, which combine the high strength of silica and the unique molecular recognition of pillar[5]arene, the pH-triggered release behavior can be tuned and more RhB-C6 can be loaded and released slowly.
CHINESE CHEMICAL LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Weng-I Katherine Chio, Jia Liu, Tabitha Jones, Jayakumar Perumal, U. S. Dinish, Ivan P. Parkin, Malini Olivo, Tung-Chun Lee
Summary: Multiplexed detection and quantification of structurally similar drug molecules can be achieved via solution-based surface-enhanced Raman spectroscopy (SERS), with highly reproducible SERS signals and detection limits down to 50 nM for some molecules. Machine learning algorithms can extend the dynamic range and robustness of the sensing scheme, showing potential for applications in therapeutic drug monitoring, food processing, forensics, and veterinary science.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Multidisciplinary
Guotai Li, Fanny Trausel, Michelle P. van Der Helm, Benjamin Klemm, Tobias G. Breve, Susan A. P. van Rossum, Muhamad Hartono, Harm H. P. J. Gerlings, Matija Lovrak, Jan H. van Esch, Rienk Eelkema
Summary: The study explores the use of cucurbit[7]uril molecular container to modulate the activity of synthetic organocatalysts, successfully changing the activity of four different organocatalysts and one initiator, with the potential to regulate chemical reaction rates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Gang Wu, Sheng-Yi Zhuang, Yusran Yusran, Zhan-Ting Li, Dan-Wei Zhang
Summary: Paracyclophane has been understudied compared to other macrocyclic compounds, but through modification of pillar[5]arene, new pentagonal macrocycles (pseudo[n]-pillar[5]arenes) were obtained. These macrocycles showed the ability to form complexes with various guests in a 1:1 ratio. The binding constants decreased with the decrease of substituted phenylene segments. Notably, the conformation of P[n]P[5]s could adjust effectively when binding with succinonitrile in the solid state.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Xiaotao Shen, Si Wu, Liang Liang, Songjie Chen, Kevin Contrepois, Zheng-Jiang Zhu, Michael Snyder
Summary: Accurate and efficient compound annotation has been a challenge for LC-MS-based data, but efforts to overcome this obstacle have been limited by the sources of spectral information used. The metID R package aims to address this issue by combining information from major databases for streamlined compound annotation, making the process automatic and reproducible across platforms.
Article
Chemistry, Analytical
Xi Chen, Yandong Yin, Mingdu Luo, Zhiwei Zhou, Yuping Cai, Zheng-Jiang Zhu
Summary: Lipids play important roles in physiological and pathological processes in living organisms. However, high-coverage and high-accuracy lipidomic analysis of complex biological samples remains challenging due to the structural diversity and isomer and isobaric features of lipids. In this study, a four-dimensional untargeted lipidomics approach based on trapped ion mobility spectrometry-mass spectrometry (TIMS-MS) was developed to improve lipid identification and quantification. The results showed that TIMS-based multi-dimensional separation improved the differentiation of isomeric and isobaric lipids and increased the quality of MS/MS spectra.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Jingshu Li, Ye Cao, Kongyan Niu, Jiaqian Qiu, Han Wang, Yingnag You, Dean Li, Yu Luo, Zhengjiang Zhu, Yaoyang Zhang, Nan Liu
Summary: Lysine acetylation is an important post-translational modification involved in regulating various cellular processes, including aging. However, the acetylome-wide analysis in mammalian tissues during aging is limited. This study combines antibody enrichment and label-free quantitative acetylomic analysis to investigate the changes in protein acetylation during natural aging and upon the treatment of NMN. The results identify previously unknown acetylation sites and highlight the potential of protein acetylation events as aging biomarkers. Furthermore, the study demonstrates the beneficial effects of NMN on age-related protein acetylation. These findings lay a critical foundation for understanding the functional role of protein post-translational modifications in healthy aging and disease conditions.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Chemistry, Multidisciplinary
Yuri Park, Soyeon Shin, Nutan Shukla, Kibeom Kim, Myoung-Hwan Park
Summary: Dermal delivery is a non-invasive and simple method that has attracted attention. However, overcoming the skin barrier remains a challenge, and green chemistry is crucial in the cosmetic industry. This study provides a new method using nanobubbles to enhance dermal delivery effects.
Article
Chemistry, Medicinal
Jingyao Wang, Shaoqing Zhou, Yan Cheng, Lin Cheng, Ying Qin, Zhenfeng Zhang, Aiwei Bi, Huaijiang Xiang, Xinheng He, Xiaoxu Tian, Wenbin Liu, Jian Zhang, Chao Peng, Zhengjiang Zhu, Min Huang, Ying Li, Guanglei Zhuang, Li Tan
Summary: There is increasing interest in covalent targeted inhibitors for drug discovery against previously undruggable sites and targets. Novel arsenous warheads are characterized for their unique features in reacting with thiol species in a reversible manner. The development of selective and potent inhibitors using organoarsenic probes proves effective in targeting pyruvate kinase M2 (PKM2) and inhibiting tumor growth.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Benjamin Barclay, Bradley Duncan, Maxwell Plaut, John Russo, Theodore Fedynyshyn
Summary: 3D printed nanocomposites have the potential to create high-performance radio frequency devices. However, little is known about how the diameter of the nanoparticles used in these composites affect their performance. This study develops a range of 3D printable nanocomposite inks with nanoparticles ranging from 30 to 300 nm in diameter. The relative permittivity of the printed nanocomposites is unaffected by nanoparticle diameter, but the loss tangent, glass transition temperature, and elastic modulus are altered. This research provides a framework for designing 3D printable nanocomposites and emphasizes the importance of nanoparticle diameter in formulation strategy.
Article
Biochemistry & Molecular Biology
Kongyan Niu, Jinyang Zhang, Shuwen Ge, Dean Li, Kunfeng Sun, Yingnan You, Jiaqian Qiu, Kun Wang, Xueting Wang, Rui Liu, Yandong Liu, Bing Li, Zheng-Jiang Zhu, Lefeng Qu, Hong Jiang, Nan Liu
Summary: The researchers introduced the ONE-seq method to identify RNA transcripts containing NAD cap. They discovered over a thousand previously unknown NAD-RNAs and revealed the overall dynamics of NAD-RNAs with age. This method facilitates the functional investigation of NAD-capped RNAs.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Chemistry, Analytical
Yuping Cai, Zhiwei Zhou, Zheng-Jiang Zhu
Summary: Liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics faces challenges in annotating large-scale and unambiguous metabolites in complex biological matrices due to the diversity of metabolome. Recent advancements in metabolite annotation strategies include spectral match algorithms, in-silico MS/MS spectral prediction, and network-based approaches. Analytical dimensions such as retention time and collision cross-section have been expanded to support multidimensional metabolite annotation. Stable-isotope labeling is also highlighted for aiding structural verification of metabolites. This review summarizes the state-of-the-art approaches in annotating metabolites for LC-MS-based untargeted metabolomics, with the aim of discovering novel functional metabolites.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Bradley Duncan, Robert D. Weeks, Benjamin Barclay, Devon Beck, Patrick Bluem, Roberto Rojas, Maxwell Plaut, John Russo, Sebastien G. M. Uzel, Jennifer A. Lewis, Theodore Fedynyshyn
Summary: In this study, low-loss graded dielectric materials were successfully designed and printed using active mixing of nanocomposite inks. This method enables the rapid fabrication of high-performance RF devices with locally tunable dielectric properties.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Analytical
Hongmiao Wang, Yandong Yin, Zheng-Jiang Zhu
Summary: In this study, a method called MetImage was developed to encode LC-MS-based untargeted metabolomics data into multi-channel digital images, which were then used for developing deep learning-based AI models for clinical diagnosis. MetImage was successfully applied in the clinical screening of ESCC, achieving superior performances. This method encoding raw data into images improved the interpretability of the AI models.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Mingdu Luo, Yandong Yin, Zhiwei Zhou, Haosong Zhang, Xi Chen, Hongmiao Wang, Zheng-Jiang Zhu
Summary: The study develops a mass spectrum-oriented bottom-up assembly algorithm and a computational framework called Met4DX for ion mobility (IM)-resolved metabolomics, which addresses the challenge of high dimensionality in data processing. Met4DX outperforms existing tools in terms of coverage, sensitivity, peak fidelity, and quantification precision, and successfully detects and differentiates co-eluted metabolite isomers.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Kibeom Kim, Jungmin Lee, Myoung-Hwan Park
Summary: The blood-brain barrier is an important barrier that protects the brain and maintains homeostasis. Traditional drug delivery methods face limitations such as low diversity and efficiency. Microbubble-based drug delivery systems, which utilize ultrasound-induced physical changes, have gained attention in recent years for their ability to enhance drug delivery by disrupting the blood-brain barrier.
Article
Water Resources
Chan-Hyun Cho, Hye-Ji Shin, Baljinder Singh, Kibeom Kim, Myoung-Hwan Park
Summary: Bubble technology has been proven to be an efficient method for reducing environmental pollution, strengthening water treatment processes, and increasing production in industrial and agricultural applications. Nanobubbles, particularly those smaller than 200 nm, possess unique properties such as low buoyancy, high mass transfer efficiency, and unexpected stability. This study investigates the number and stability of high-concentration nanobubbles under various conditions, and the results demonstrate their potential for mass production and distribution in bubble technologies.
APPLIED WATER SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Baljinder Singh, Junkee Kim, Nutan Shukla, Jungmin Lee, Kibeom Kim, Myoung-Hwan Park
Summary: An effective method for accelerating wound healing is through a smart delivery platform that releases drugs based on the different stages of healing. Electrospun nanofibers have gained attention due to their simple manufacturing process, unique structure, and biological functions similar to the extracellular matrix. In this study, a core-shell nanofiber platform loaded with two drugs was investigated, with the shell releasing the drug into an aqueous solution and the core generating localized heat for programmable drug release. This versatile platform can provide controlled and safe drug delivery to wound sites and potentially be used for treating other topical diseases.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Analytical
Haosong Zhang, Mingdu Luo, Hongmiao Wang, Fandong Ren, Yandong Yin, Zheng-Jiang Zhu
Summary: The development of IM-MS has revolutionized the analysis of small molecules. The curation of comprehensive CCS databases plays a pivotal role in the successful application of IM-MS. AllCCS2, an enhanced version, achieved exceptional prediction accuracy and compatibility with different instrument platforms.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
