Review
Immunology
Jin Yuan, Xiaoyang Li, Shengji Yu
Summary: Three-dimensional cancer organoids derived from self-organizing cancer stems faithfully mimic the structure, features, and genetic signatures of tumors. Co-culture models involving immune cells or fibroblasts provide a means to investigate the tumor microenvironment and molecular interactions, potentially benefiting cancer research and precision medicine. However, the lack of a complete tumor microenvironment remains a major limitation that needs to be addressed for further improvements.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Dongguo Lin, Xiao Chen, Zhun Lin, Jinqiong Lin, Yang Liu, Dayu Liu
Summary: The study developed a paper-supported co-culture system to dynamically investigate the lung-tropic migration of breast cancer cells. Experimental results demonstrated that breast cancer cells induced lung cells to convert into cancer-associated fibroblasts (CAFs) and reciprocally recruited each other for migration.
BIOMEDICAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Liqun Chen, Zhuo Mao, Yang Wang, Yong Kang, Ying Wang, Lin Mei, Xiaoyuan Ji
Summary: By constructing a two-dimensional interplanar heterojunction, the lifetime of excited electrons and holes is prolonged, and the selectivity of substrates is extended, resulting in high-performance cancer therapy.
Article
Multidisciplinary Sciences
Yong Kang, Zhuo Mao, Ying Wang, Chao Pan, Meitong Ou, Hanjie Zhang, Weiwei Zeng, Xiaoyuan Ji
Summary: This study presents a two-dimensional interplanar heterojunction that generates hydroxyl radicals in the tumor region under ultrasound irradiation, showing promising anti-cancer activity. The integration of interplanar heterojunction synthesis and exfoliation in one step, facilitates efficient center dot OH generation via the Fenton-like reaction, leading to excellent anti-tumor performance.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Brett, Michael Rosemann, Omid Azimzadeh, Andrea Pagani, Cosima Prahm, Adrien Daigeler, Dominik Duscher, Jonas Kolbenschlag
Summary: This study analyzed the proteomic changes in the tumor microenvironment of irradiated breast cancer cells, revealing that radiation may not only ablate cancer cells but also create a less oncogenic microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yejiao Ruan, Lingyun He, Jiamin Chen, Jinfeng Wang, Shujing Zhao, Xiaoling Guo, Yao Xie, Zhenzhai Cai, Xian Shen, Chao Li
Summary: There is still a lack of convenient ways to simulate the in vivo hypoxic tumor microenvironment (TME) under normoxia in vitro. In this study, a three-dimensional culture system with a core-shell structure (3d-ACS) was established to simulate the hypoxic TME. The gastric cancer cells formed organoid-like structures in the 3d-ACS and showed more aggressive growth and decreased drug responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Fariza Juliana Nordin, Lishantini Pearanpan, Kok Meng Chan, Endang Kumolosasi, Yoke Keong Yong, Khozirah Shaari, Nor Fadilah Rajab
Summary: Clinacanthus nutans (CN) extracts did not show cytotoxic effects on MDA-MB-231 and THP-1 cells, but exhibited potential in ameliorating chronic inflammation in the tumor microenvironment of breast cancer. Further studies are needed to fully understand the underlying mechanisms of CN in cooling the inflamed TME in breast cancer.
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tatsuya Kometani, Koki Kamo, Taketomo Kido, Nobuyoshi Hiraoka, Taku Chibazakura, Kenji Unno, Keisuke Sekine
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a serious and chemotherapy-resistant disease. We established a co-culture system using PDAC patient-derived cancer cells and stellate cells from human induced pluripotent stem cells to mimic the tumor microenvironment (TME) of PDAC. This system successfully demonstrated the interaction between cancer cells and stellate cells and replicated some features of PDAC in vitro. Furthermore, the co-culture system showed potential for drug treatment testing in vitro.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jiaojiao Tai, Linbang Wang, Hao Guo, Ziqiang Yan, Jingkun Liu
Summary: The study investigates the potential role of m6A regulators in breast cancer using bioinformatics methods and experiments. The findings reveal that YTHDF1 is a key regulator with potential as a prognostic biomarker and molecular marker for immunotherapy in breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Jiazhou Liu, Yuxian Wei, Yushen Wu, Jie Li, Jiazheng Sun, Guosheng Ren, Hongzhong Li
Summary: This study comprehensively analyzed the tumor microenvironment and identified 7 immune-specific genes related to BRCA survival, with ATPase Secretory Pathway Ca2+ Transporting 2 (ATP2C2) standing out for significantly predicting prognosis. Further analysis revealed ATP2C2's close relationship with clinicopathological features and its impact on BRCA patients' survival. ATP2C2 may play a role in maintaining immune-dominant status in the TME, as evidenced by its correlation with specific immune cell types.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Xiaocong Jiang, Haixing Shen, Xi Shang, Jianwen Fang, Yuexin Lu, Yue Lu, Jingyan Zheng, Peifen Fu
Summary: The incidence of breast cancer has been rapidly increasing in recent years, and aging is one of the risk factors for advanced breast cancer. This review summarizes the effects of the aging microenvironment on breast cancer initiation and progression and discusses potential therapeutic targets in the aging microenvironment. These findings are of great importance for future research on breast cancer.
Review
Oncology
Dandan Guan, Xiaozhen Liu, Qingyang Shi, Bangjie He, Chaopeng Zheng, Xuli Meng
Summary: Immunotherapy is gaining attention as a treatment strategy for breast cancer. However, precise application of immunotherapy in breast cancer has not been fully studied. This study investigates different organoid culture methods and their applications in modeling the breast cancer tumor microenvironment and precision immunotherapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Norlaily Mohd Ali, Swee Keong Yeap, Wan Yong Ho, Lily Boo, Huynh Ky, Dilan Amila Satharasinghe, Sheau Wei Tan, Soon Keng Cheong, Hsien Da Huang, Kuan Chun Lan, Men Yee Chiew, Han Kiat Ong
Summary: Breast cancer is the most frequently diagnosed cancer in women globally, and TME and MSCs play crucial roles in inducing dormancy of breast cancer cells, with exosomal miRNAs potentially serving as important therapeutic targets.
Review
Immunology
Raquel Castillo-Gonzalez, Ana Valle-Noguera, Maria Jose Gomez-Sanchez, Pu Xia, Aranzazu Cruz-Adalia
Summary: Cancer is a complex disease caused by genetic and environmental factors. Innate lymphoid cells (ILCs), which lack antigen-specific receptors, have been found in tumors and play a role in early immune response. Among ILCs, ILC3s are controversial in tumor immunity, as they can enhance anti-tumor immunity but also promote tumor growth.
FRONTIERS IN IMMUNOLOGY
(2022)