Breast cancer organoids and their applications for precision cancer immunotherapy

Using patient-derived tumor organoids from common epithelial cancers to analyze personalized T-cell responses to neoantigens

(2023) Anup Y. Parikh et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Mesothelin-targeted CAR-NK Cells Derived From Induced Pluripotent Stem Cells Have a High Efficacy in Killing Triple-negative Breast Cancer Cells as Shown in Several Preclinical Models

(2023) Mei Yang et al.   JOURNAL OF IMMUNOTHERAPY

Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer

(2022) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Three-Dimensional Organoid Model of Primary Breast Cancer to Investigate the Effects of Oncolytic Virotherapy

(2022) Mary E. Carter et al.   Frontiers in Molecular Biosciences

Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

(2022) Jie Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent progress in antibody-based therapeutics for triple-negative breast cancer

(2022) Wen-Jing Ning et al.   Expert Opinion on Drug Delivery

KEYNOTE-355 — OS benefit now reported

(2022) Diana Romero   Nature Reviews Clinical Oncology

Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy

(2022) Ethan Shelkey et al.   Scientific Reports

IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

(2022) Olga S. Blomberg et al.   CANCER CELL

Oncolytic Urabe mumps virus: A promising virotherapy for triple-negative breast cancer

(2022) Marshall D. Behrens et al.   Molecular Therapy-Oncolytics

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Engineered in vitro tumor models for cell-based immunotherapy

(2021) Yuta Ando et al.   Acta Biomaterialia

Landscape of Immune Microenvironment Under Immune Cell Infiltration Pattern in Breast Cancer

(2021) Qianhui Xu et al.   Frontiers in Immunology

Breast cancer immune microenvironment: from pre-clinical models to clinical therapies

(2021) Brooke E. Wilson et al.   BREAST CANCER RESEARCH AND TREATMENT

The Incidence of Breast Cancer Recurrence 10-32 Years After Primary Diagnosis

(2021) Rikke Nørgaard Pedersen et al.   JNCI-Journal of the National Cancer Institute

An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity

(2021) Zhuolong Zhou et al.   Nature Biomedical Engineering

Tumor Immunology and Tumor Evolution: Intertwined Histories

(2020) Jérôme Galon et al.   IMMUNITY

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Organoid Models of Tumor Immunology

(2020) Kanako Yuki et al.   TRENDS IN IMMUNOLOGY

Screening Cancer Immunotherapy: When Engineering Approaches Meet Artificial Intelligence

(2020) Xingwu Zhou et al.   Advanced Science

Anti-tumor and immune modulating activity of T cell induced tumor-targeting effectors (TITE)

(2020) Archana Thakur et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pleiotropic mechanisms drive endocrine resistance in the three-dimensional bone microenvironment

(2020) Eugen Dhimolea et al.   CANCER RESEARCH

Tumor resident stromal cells promote breast cancer invasion through regulation of the basal phenotype

(2020) Christopher J Hanley et al.   MOLECULAR CANCER RESEARCH

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

(2020) Javier Cortes et al.   LANCET

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Engineering Microfluidic Organoid-on-a-Chip Platforms

(2019) Fang Yu et al.   Micromachines

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

(2019) Danh D Truong et al.   CANCER RESEARCH

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

The Janus Face of Tumor Microenvironment Targeted by Immunotherapy

(2019) Buoncervello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

(2018) Elham Azizi et al.   CELL

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening

(2018) Michael L. Beshiri et al.   CLINICAL CANCER RESEARCH

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy

(2018) Yue Zhao et al.   GUT

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

(2018) Kosaku Nanki et al.   CELL

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

(2018) Jose M. Ayuso et al.   OncoImmunology

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

(2017) Henrik Jespersen et al.   Nature Communications

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

(2017) Jiehui Deng et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2 + T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate

(2016) Nicholas A. Zumwalde et al.   Cancer Prevention Research

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Recapitulating Cell–Cell Interactions for Organoid Construction – Are Biomaterials Dispensable?

(2016) Andrew C.A. Wan   TRENDS IN BIOTECHNOLOGY

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

The Clinical Relevance of Cancer Cell Lines

(2013) J.-P. Gillet et al.   JNCI-Journal of the National Cancer Institute

The role of tumour–stromal interactions in modifying drug response: challenges and opportunities

(2013) Douglas W. McMillin et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody-Based Immunotherapy of Cancer

(2012) Louis M. Weiner et al.   CELL

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE