Article
Multidisciplinary Sciences
Adil Farooq Wali, Shafat Ali, Summya Rashid, Rana M. Alsaffar, Azher Arafah, Wajhul Qamar, Ajaz Ahmad, Bilal Ahmad Paray, Sheikh Bilal Ahmad, Bashayr M. Alsuwayni, Muneeb U. Rehman
Summary: The study showed that piperine can effectively reduce carbon tetrachloride-induced hepatic fibrosis and has a significant hepatoprotective effect.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Yu Sun, Hadrien Demagny, Adrien Faure, Francesca Pontanari, Antoine Jalil, Nadia Bresciani, Ece Yildiz, Melanie Korbelius, Alessia Perino, Kristina Schoonjans
Summary: The enzyme asparagine synthetase (ASNS) is responsible for the de novo synthesis of the nonessential amino acid asparagine. The expression of ASNS in pericentral hepatocytes, specialized liver cells in xenobiotic detoxification, is significantly increased in models of acute liver injury. Mice with hepatocyte-specific Asns deletion are more susceptible to pericentral liver damage, which can be reversed by intravenous administration of asparagine. The upregulation of ASNS in response to stress is mediated by the nuclear receptor, liver receptor homolog 1 (LRH-1; NR5A2) through an ATF4-independent, noncanonical pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Atsushi Miura, Takashi Hosono, Taiichiro Seki
Summary: Depleting macrophages can suppress tissue remodeling and partially delay cell proliferation during regeneration after acute liver injury. Inhibiting tissue remodeling caused by depleted macrophages can delay the recovery of metabolic functions, indicating that liver injury affects liver metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Nathaly Enciso, Jose Amiel, Fredy Fabian-Dominguez, Jhon Pando, Nancy Rojas, Carlos Cisneros-Huamani, Ernesto Nava, Javier Enciso
Summary: This study established an advanced liver fibrosis model in rats using thioacetamide (TAA) induction. Transplanted cells were detected in the fibrous liver, indicating the success of the model.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Juan-Li Duan, Zi-Yi Zhou, Bai Ruan, Zhi-Qiang Fang, Jian Ding, Jing-Jing Liu, Ping Song, Hao Xu, Chen Xu, Zhen-Sheng Yue, Hua Han, Guo-Rui Dou, Lin Wang
Summary: c-Kit-positive liver sinusoidal endothelial cells play a role in promoting hepatocyte proliferation and reducing liver injuries. Mutation in the Notch pathway affects the distribution of these cells and liver zonation. Activation of Notch signaling impedes liver regeneration and weakens the positive regulatory effects of c-Kit-positive liver sinusoidal endothelial cells on hepatocytes.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, Research & Experimental
Vicenc Ruiz de Porras, Mariona Figols, Albert Font, Eva Pardina
Summary: Chemotherapy-induced hepatotoxicity is a significant concern in cancer treatment, but curcumin has emerged as a potential strategy to mitigate this adverse effect. By targeting specific molecular mechanisms, curcumin exhibits anti-inflammatory, antioxidant, antifibrotic, and hypolipidemic properties that can help prevent and reduce chemotherapy-induced liver injury. Further clinical investigation is needed to demonstrate the efficacy of bioavailable curcumin formulations as hepatoprotective agents in cancer patients.
Article
Pharmacology & Pharmacy
Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rulicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Summary: The study revealed the crucial role of p62 in APAP-induced liver injury (AILI), showing that it inhibits the late injury phase by enhancing autophagic selective removal of APAP adducts and mitochondria while impairing the recovery phase likely by enhancing hepatic blood coagulation.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Junmei Zhou, Chunbao Sun, Lu Yang, Jinhui Wang, Natacha Jn-Simon, Chen Zhou, Andrew Bryant, Qi Cao, Chenglong Li, Bryon Petersen, Liya Pi
Summary: YAP activation is involved in alcohol-related liver injury, and knocking out the Yap1 gene exacerbates liver damage. The regulation of ALDH1A1 by YAP plays an important role in liver regeneration and detoxification.
Article
Engineering, Environmental
Fan Li, Guili Song, Xiaochen Wang, Yumiao Sun, Shanqi Zhou, Yindan Zhang, Jianghuan Hua, Biran Zhu, Lihua Yang, Wei Zhang, Bingsheng Zhou
Summary: This study reveals the adverse effects of DBDPE on liver development and regeneration in zebrafish. The underlying mechanisms involving disturbed signaling pathways and cell cycle arrest were identified. These findings have implications for ecological and health risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhe Qing, Hanfei Huang, Qun Luo, Jie Lin, Shikun Yang, Tao Liu, Zhong Zeng, Tingfeng Ming
Summary: This study identified a specific miRNA-mRNA network associated with hypoxia-induced proliferation of LSECs through whole transcriptome sequencing and bioinformatics analysis, which helps elucidate the potential mechanisms involved in hypoxia-promoting liver regeneration during LR.
Article
Biochemistry & Molecular Biology
Timothy J. Humpton, Andreas K. Hock, Christos Kiourtis, Marco De Donatis, Frederic Fercoq, Colin Nixon, Sheila Bryson, Douglas Strathdee, Leo M. Carlin, Thomas G. Bird, Karen Blyth, Karen H. Vousden
Summary: Genetically encoded probes are commonly used to visualize cellular processes, but traditional fluorescent protein tags are suboptimal for in vivo studies due to poor tissue penetration and high background signal. A new knock-in reporter mouse model linking near-infrared fluorescent protein expression to a synthetic p53-responsive promoter enables noninvasive, longitudinal analysis of p53 activity in vivo. This model has provided insights into the timing and localization of p53 activation in response to various stimuli, potentially advancing our understanding of physiological and pathophysiological p53 responses.
Article
Multidisciplinary Sciences
Alyaa Farid, Valina Michael, Gehan Safwat
Summary: This study aimed to create Melatonin-loaded nanoparticles to alleviate liver damage caused by a chemical substance, CCL4. The nanoparticles exhibited good antioxidant, anti-inflammatory, and anticoagulant effects in vitro. Treatment with the nanoparticles improved histopathological changes in liver tissues, restored the levels of liver function enzymes, inflammatory cytokines, and matrix metalloproteinases to normal levels. These nanoparticles significantly protected the liver from the toxicity of CCL4.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Meng Wang, Haoyu Liu, Xu Zhang, Wenbo Zhao, Danyang Li, Chengpeng Xu, Zhen Wu, Fei Xie, Xiangzhi Li
Summary: The study revealed that MOF is significantly overexpressed during ALI and can impact liver cell proliferation, fibrosis, and activation of certain signaling pathways. Knockdown of Mof attenuated ALI and promoted liver regeneration by activating the Insulin-like growth factor 1 signaling pathway. These findings suggest a potential therapeutic target for ALI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Lorenzo Cinelli, Edoardo Maria Muttillo, Emanuele Felli, Andrea Baiocchini, Fabio Giannone, Jacques Marescaux, Didier Mutter, Michel De Mathelin, Sylvain Gioux, Eric Felli, Michele Diana
Summary: This study reviewed surgical experiments on liver regeneration in pigs to standardize experimental methodologies. A total of 41 articles involving 689 pigs were included in the study. Most studies focused on partial hepatectomy, and some also examined the effects of other liver procedures. However, the mechanisms of liver regeneration and the chronic pathological aspects of the liver are still poorly understood.
Article
Biochemistry & Molecular Biology
Noura M. Mesalam, Sami Ali Aldhumri, Salah A. Gabr, Marwa A. Ibrahim, Asmaa K. Al-Mokaddem, Abdel-Moneim Eid Abdel-Moneim
Summary: The study demonstrates that Ajwa seeds aqueous extract (ASE) protects the liver from CCl4-induced damage by inhibiting oxidative stress, regulating hepatic lipid metabolism, and reducing apoptosis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Anatomy & Morphology
Geert Peeters, Charlotte Debbaut, Adrian Friebel, Pieter Cornillie, Winnok H. De Vos, Kasper Favere, Ingrid Vander Elst, Tim Vandecasteele, Tim Johann, Luc Van Hoorebeke, Diethard Monbaliu, Dirk Drasdo, Stefan Hoehme, Wim Laleman, Patrick Segers
JOURNAL OF ANATOMY
(2018)
Article
Biophysics
Mikheil Gogiashvili, Salome Horsch, Rosemarie Marchan, Kathrin Gianmoena, Cristina Cadenas, Berno Tanner, Sabrina Naumann, Diana Ersova, Frank Lippek, Joerg Rahnenfuehrer, Jan T. Andersson, Roland Hergenroeder, Joerg Lambert, Jan G. Hengstler, Karolina Edlund
NMR IN BIOMEDICINE
(2018)
Article
Toxicology
Harshal Nemade, Umesh Chaudhari, Aviseka Acharya, Juergen Hescheler, Jan Georg Hengstler, Symeon Papadopoulos, Agapios Sachinidis
ARCHIVES OF TOXICOLOGY
(2018)
Article
Biology
Stefan Hoehme, Francois Bertaux, William Weens, Bettina Grasl-Kraupp, Jan G. Hengstler, Dirk Drasdo
BULLETIN OF MATHEMATICAL BIOLOGY
(2018)
Article
Immunology
Daniel Moyo, Lynette Beattie, Paul S. Andrews, John W. J. Moore, Jon Timmis, Amy Sawtell, Stefan Hoehme, Adam T. Sampson, Paul M. Kaye
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biophysics
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzalez-Valverde, Stefan Hoehme, Steffen Grosser, Josef Kaes, Dirk Drasdo
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2020)
Article
Cell Biology
Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stoepel, Stefan Hoehme, Michael Kuecken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja
Article
Gastroenterology & Hepatology
Nachiket Vartak, Georgia Guenther, Florian Joly, Amruta Damle-Vartak, Gudrun Wibbelt, Joerns Fickel, Simone Joers, Brigitte Begher-Tibbe, Adrian Friebel, Kasimir Wansing, Ahmed Ghallab, Marie Rosselin, Noemie Boissier, Irene Vignon-Clementel, Christian Hedberg, Fabian Geisler, Heribert Hofer, Peter Jansen, Stefan Hoehme, Dirk Drasdo, Jan G. Hengstler
Summary: The study challenges the current theory of bile flow in the liver by showing that diffusion mainly drives the flux in the canalicular domain, while regulated advection enhances diffusion flux only in the interlobular ducts.
Article
Toxicology
Ahmed Ghallab, Reham Hassan, Maiju Myllys, Wiebke Albrecht, Adrian Friebel, Stefan Hoehme, Ute Hofmann, Abdel-Latif Seddek, Albert Braeuning, Lars Kuepfer, Benedikt Cramer, Hans-Ulrich Humpf, Peter Boor, Gisela H. Degen, Jan G. Hengstler
Summary: The study reveals significant differences in the distribution of mycotoxins in the kidneys and livers of mice, with distinct clearance rates and enrichment locations possibly influenced by specific cell types and expression. These local discrepancies may impact the metabolism and potential toxic effects of the toxins.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Cell Biology
Ahmed Ghallab, Maiju Myllys, Adrian Friebel, Julia Duda, Karolina Edlund, Emina Halilbasic, Mihael Vucur, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Reham Hassan, Michael Burke, Erhan Genc, Lynn Johann Frohwein, Ute Hofmann, Christian H. Holland, Daniela Gonzalez, Magdalena Keller, Abdel-latif Seddek, Tahany Abbas, Elsayed S. I. Mohammed, Andreas Teufel, Timo Itzel, Sarah Metzler, Rosemarie Marchan, Cristina Cadenas, Carsten Watzl, Michael A. Nitsche, Franziska Kappenberg, Tom Luedde, Thomas Longerich, Joerg Rahnenfuehrer, Stefan Hoehme, Michael Trauner, Jan G. Hengstler
Summary: In this study, time-resolved characterization of a mouse model of NAFLD identified a sequence of eight key events in the development of the disease, along with functional changes and transcriptomic landscape similarities to human NAFLD and HCC. The findings provide a basis for identifying therapeutic targets in NAFLD.
Article
Biochemical Research Methods
Adrian Friebel, Tim Johann, Dirk Drasdo, Stefan Hoehme
Summary: In this paper, a novel approach combining machine learning and clustering methods is presented for interactive segmentation and quantification of large image sets. The approach addresses the issue of decreased accuracy when reusing classifiers in biological and medical images due to color variability and improves the applicability and efficiency of interactive segmentation.
Article
Multidisciplinary Sciences
Stefan Hoehme, Seddik Hammad, Jan Boettger, Brigitte Begher-Tibbe, Petru Bucur, Eric Vibert, Rolf Gebhardt, Jan G. Hengstler, Dirk Drasdo
Summary: Partial liver removal is a significant treatment option for liver cancer, but the regeneration process can fail in some cases. To better understand liver regeneration, researchers created a 3D model using experiments in mice and found that a biomechanical growth control mechanism plays a crucial role in controlling cell proliferation. The model's predictions were confirmed in pigs and mice. These findings highlight the importance of biomechanics in liver growth control.
Article
Toxicology
Dandan Han, Jian Gao, Xiaolong Gu, Jan Georg Hengstler, Limei Zhang, Muhammad Shahid, Tariq Ali, Bo Han
ARCHIVES OF TOXICOLOGY
(2018)
Article
Toxicology
Umesh Chaudhari, Harshal Nemade, Poornima Sureshkumar, Mathieu Vinken, Gamze Ates, Vera Rogiers, Juergen Hescheler, Jan Georg Hengstler, Agapios Sachinidis
ARCHIVES OF TOXICOLOGY
(2018)
Article
Surgery
Petru O. Bucur, Mohamed Bekheit, Chloe Audebert, Amnah Othman, Seddik Hammad, Mylene Sebagh, Marc-Antoine Allard, Benoit Decante, Adrian Friebel, Elodie Miquelestorena-Standley, Dirk Drasdo, Jan G. Hengstler, Irene E. Vignon-Clementel, Eric Vibert