Review
Medicine, General & Internal
Maciej Majsterek, Magdalena Wierzchowska-Opoka, Inga Makosz, Lena Kreczynska, Zaneta Kimber-Trojnar, Bozena Leszczynska-Gorzelak
Summary: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by elevated levels of bile acids (BAs) in blood serum and an increased risk of adverse perinatal outcomes. Early diagnosis and prompt management based on BA levels are crucial in reducing fetal complications.
Article
Medicine, General & Internal
Inbar Lifshitz, Geffen Kleinstern, Ori Rottenstreich, Shay Porat, Joshua Rosenbloom, Doron Kabiri, Moshe Rottenstreich, Yosef Ezra, Oren Shibolet, Rifaat Safadi, Amihai Rottenstreich
Summary: The combination of laboratory values (TB, ALK, GGT, AST) was shown to reliably exclude the diagnosis of ICP, particularly useful in settings with limited access to BA levels testing.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade
Summary: ICP is associated with poor perinatal outcomes in some women, but recent evidence shows that UDCA may not have a significant impact on most perinatal outcomes, therefore a comprehensive approach is needed to manage ICP effectively.
REPRODUCTIVE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen
Summary: This study revealed that 4-PBA could alleviate RFP-induced cholestatic liver injury by inhibiting ER stress and ubiquitination degradation of MRP2, leading to a decrease in serum total bilirubin concentration. These findings provide important insights into the treatment mechanism of 4-PBA in RFP-induced cholestasis and liver damage.
Article
Biochemistry & Molecular Biology
Edgar Ontsouka, Alessandra Epstein, Sampada Kallol, Jonas Zaugg, Marc Baumann, Henning Schneider, Christiane Albrecht
Summary: The study found significant alterations in placental SLCO3A1 (OATP3A1) gene expression in patients with intrahepatic cholestasis of pregnancy (ICP), while the expression levels of the other 20 genes were comparable between healthy and ICP placentae. Additionally, certain genes in ICP placentae showed positive correlations with BA concentrations and maternal body mass index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Roberta Granese, Gloria Calagna, Angela Alibrandi, Canio Martinelli, Paola Romeo, Roberto Filomia, Maria Immacolata Ferraro, Eleonora Piccione, Alfredo Ercoli, Carlo Saitta
Summary: The study aimed to evaluate the outcomes of intrahepatic cholestasis of pregnancy (ICP) on both maternal and fetal health. A retrospective case-control study was conducted, including pregnant women diagnosed with ICP between January 2010 and December 2020 at a university hospital. The results showed a higher incidence of hypothyroidism, thrombophilia, gestational diabetes, gestational hypertension, postpartum hemorrhage, and preterm delivery in ICP patients compared to the control group. However, there were no recorded neonatal adverse events and no signs of chronic liver disease in ICP patients during the 24-month follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Przemyslaw Kosinski, Malgorzata Kedzia, Adrianna Mostowska, Pawel Gutaj, Michal Lipa, Ewa Wender-Ozegowska, Adriana Rozy, Joanna Chorostowska-Wynimko, Miroslaw Wielgos, Aleksandra Jezela-Stanek
Summary: The study revealed an increased prevalence of the SERPINA1 PI*Z variant in women with intrahepatic cholestasis, suggesting a possible genetic origin of a higher risk of intrahepatic cholestasis in pregnancy.
FRONTIERS IN GENETICS
(2021)
Review
Obstetrics & Gynecology
Rebecca Horgan, Christiana Bitas, Alfred Abuhamad
Summary: This study compared the guidelines for the diagnosis, antepartum surveillance, and timing of delivery of pregnancies complicated by intrahepatic cholestasis of pregnancy published by the Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists. The two organizations have several key differences in their clinical guidelines, including the criteria for diagnosing intrahepatic cholestasis of pregnancy and the recommended treatments. The Society for Maternal-Fetal Medicine recommends fetal surveillance and specific delivery timing based on bile acid levels, while the Royal College of Obstetricians and Gynaecologists does not recommend additional fetal testing beyond kick count assessment and stratifies delivery timing based on bile acid levels.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Medicine, Research & Experimental
Zhuoqiao Yang, Mengxin Yao, Chunhua Zhang, Xuan Hu, Yi Zhong, Xiangxiang Xu, Jieyun Yin
Summary: This study reviewed metabolomics studies related to intrahepatic cholestasis of pregnancy (ICP), revealing dysregulation of bile acid metabolism and lipid metabolism. Metabolomics shows potential for the diagnosis of ICP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Sai Wang, Rilu Feng, Shan Shan Wang, Hui Liu, Chen Shao, Yujia Li, Frederik Link, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Summary: This study investigates the transcriptional regulation of multidrug resistance protein 2 (MRP2) under different pathophysiological conditions and identifies FOXA2 as a potential replacement for FXR in maintaining MRP2 expression in patients with acute liver failure (ALF). The findings suggest that by regulating the expression of FOXA2, it may be possible to prevent hyperbilirubinemia in ALF patients with sepsis.
Article
Medicine, General & Internal
Gal Hershkovitz, Yael Raz, Ilana Goldinger, Ariel Many, Liran Hiersch, Rimon Eli
Summary: Intrahepatic cholestasis of pregnancy (ICP) is characterized by elevated total bile acids (TBA). It is unclear why some fetuses are more prone to the hazardous effect of bile acids (BA) over the others. We aimed to compare TBA levels in umbilical vein and artery to maternal TBA in women with ICP. The study included 18 women and 23 fetuses, and we found that the TBA level in umbilical vein was significantly lower compared to maternal TBA level.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Wenhu Liu, Qiang Wang, Jinxia Chang, Anup Bhetuwal, Nisha Bhattarai, Xin Ni
Summary: This study revealed the metabolomic profiles in circulation and the correlation of the metabolites with clinical features in intrahepatic cholestasis of pregnancy (ICP) patients. The data suggest that disturbances in metabolic pathways might be associated with adverse pregnancy outcomes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang
Summary: This study aims to systematically elucidate the mechanism by which Gardenia extract ameliorates ANIT-induced cholestatic liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Gastroenterology & Hepatology
Tharni Vasavan, Sahil Deepak, Indu Asanka Jayawardane, Maristella Lucchini, Catherine Martin, Victoria Geenes, Joel Yang, Anita Lovgren-Sandblom, Paul Townsend Seed, Jenny Chambers, Sophia Stone, Lesia Kurlak, Peter Hendy Dixon, Hanns-Ulrich Marschall, Julia Gorelik, Lucy Chappell, Pam Loughna, Jim Thornton, Fiona Broughton Pipkin, Barrie Hayes-Gill, William Paul Fifer, Catherine Williamson
Summary: Elevated fetal and maternal serum bile acid concentrations in untreated ICP are associated with an abnormal fetal cardiac phenotype characterized by increased NT-proBNP concentration, PR interval length and HRV. UDCA treatment partially attenuates this phenotype.
JOURNAL OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yifan He, Xiaoqing Zhang, Yong Shao, Biao Xu, Yue Cui, Xiao Chen, Hong Chen, Can Luo, Min Ding
Summary: The risk of adverse fetal outcomes was significantly higher in the AHP group compared to normal pregnancies but lower than the ICP group. Multivariate statistics analysis revealed distinct serum BAs metabolic profiling among the three groups, with elevated levels of deoxycholic acid species in the AHP group. Overall, AHP had unique clinical features and serum BAs metabolism compared to ICP and normal pregnancies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Gastroenterology & Hepatology
Silvia Sookoian, Gustavo O. Castano, Romina Scian, Pablo Mallardi, Tomas Fernandez Gianotti, Adriana L. Burgueno, Julio San Martino, Carlos J. Pirola
Article
Medicine, General & Internal
Carlos J. Pirola, Romina Scian, Tomas Fernandez Gianotti, Hernan Dopazo, Cristian Rohr, Julio San Martino, Gustavo O. Castano, Silvia Sookoian
Article
Nutrition & Dietetics
Silvia Sookoian, Gustavo O. Castano, Romina Scian, Tomas Fernandez Gianotti, Hernan Dopazo, Cristian Rohr, Graciela Gaj, Julio San Martino, Ina Sevic, Diego Flichman, Carlos J. Pirola
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Oncology
Silvia Sookoian, Diego Flichman, Romina Scian, Cristian Rohr, Hernan Dopazo, Tomas Fernandez Gianotti, Julio San Martino, Gustavo O. Castano, Carlos J. Pirola
JOURNAL OF PATHOLOGY
(2016)
Article
Oncology
Silvia Sookoian, Cristian Rohr, Adrian Salatino, Hernan Dopazo, Tomas Fernandez Gianotti, Gustavo O. Castano, Carlos J. Pirola
Review
Endocrinology & Metabolism
Adriana L. Burgueno, Yamila R. Juarez, Ana M. Genaro, Mariana L. Tellechea
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Pharmacology & Pharmacy
Melisa F. Mensegue, Adriana L. Burgueno, Mariana L. Tellechea
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Review
Endocrinology & Metabolism
Adriana L. Burgueno, Yamila R. Juarez, Ana M. Genaro, Mariana L. Tellechea
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Behavioral Sciences
Sofia Quiroga, Yamila Raquel Juarez, Maria Paula Marcone, Maria Agustina Vidal, Ana Maria Genaro, Adriana Laura Burgueno
Summary: Exposure to prenatal stress can lead to metabolic alterations and changes in gene expression, resulting in insulin resistance without inflammation or obesity markers.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Review
Pharmacology & Pharmacy
Maria Laura Palumbo, Alejandro David Moroni, Sofia Quiroga, Maria Micaela Castro, Adriana Laura Burgueno, Ana Maria Genaro
Summary: Neurodegenerative diseases are characterized by the progressive loss of neurons and the interaction between the immune system and the central nervous system plays a key role in neuronal damage. Protective autoimmunity concept and CNS-related peptides with immunomodulatory neuroprotective effects have been proposed as potential therapeutic options for NDD.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Andres Prochnik, Adriana L. Burgueno, Mara R. Rubinstein, Maria P. Marcone, Maria S. Bianchi, Maria R. Gonzalez Murano, Ana M. Genaro, Miriam R. Wald
Summary: The study found that there is a sexual dimorphism in modulating metabolic and cognitive functions under high-fat diet and chronic mild stress, with males being more susceptible than females. In addition, poorer cognitive performance was related to a decrease in hippocampal BDNF mRNA expression.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Editorial Material
Physiology
Adriana L. Burgueno, Mariana Astiz, Alexies Dagnino-Subiabre
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Ignacio Lagger, Eliana Garino, Oscar Martinez, Eduardo Knorre, Glenda Ernst, Adriana Laura Burgueno
Summary: This study aimed to identify risk factors for drug-resistant epilepsy by comparing the characteristics of patients with drug-sensitive epilepsy and drug-resistant epilepsy. The results showed that risk factors for drug-resistant epilepsy included febrile seizures, focal epilepsy, focal seizures with loss of consciousness, structural etiology, and abnormal MRI.
Article
Public, Environmental & Occupational Health
Yamila Raquel Juarez, Sofia Quiroga, Andres Prochnik, Miriam Wald, Mariana Lorena Tellechea, Ana Maria Genaro, Adriana Laura Burgueno
Summary: The study found that prenatal stress may lead to metabolic disturbances in males, while females are more resilient but also show significant metabolic impairments when exposed to a high-fat diet.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Gastroenterology & Hepatology
Carlos J. Pirola, Diego Flichman, Hernin Dopazo, Tomas Fernandez Gianotti, Julio San Martino, Cristian Rohr, Martin Garaycoechea, Carla Gazzi, Gustavo O. Castano, Silvia Sookoian
HEPATOLOGY COMMUNICATIONS
(2018)