Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Immunology
Tatsuaki Watanabe, Christina Lam, Jillian Oliver, Hisashi Oishi, Grace Teskey, Samuel Beber, Kristen Boonstra, Juan Mauricio Umana, Hifza Buhari, Betty Joe, Zehong Guan, Miho Horie, Shaf Keshavjee, Tereza Martinu, Stephen C. Juvet
Summary: Chronic lung allograft dysfunction (CLAD) is a major obstacle in the survival of lung transplant patients. This study investigated the role of a specific type of dendritic cells (cDC1) in CLAD using a mouse lung transplant model. The results showed that cDC1s accumulated in the transplanted lungs and their activation was enhanced by airway inflammation. Furthermore, the absence of BATF3, a transcription factor essential for cDC1 development, had differential effects on acute rejection and T-cell expansion depending on the presence of airway inflammation.
MUCOSAL IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Immunology
Guangyang Weng, Zhiping Fan, Huiwen Xue, Fen Huang, Na Xu, Hua Jin, Sijian Yu, Zhixin Ye, Jingchao Fan, Li Xuan, Qifa Liu
Summary: The study found that haploidentical donor stem cell transplantation had a lower incidence of bronchiolitis obliterans syndrome (BOS) compared to HLA-matched sibling donor stem cell transplantation. Additionally, the use of antithymocyte globulin (ATG) and mixed grafts may be protective factors in reducing the incidence of BOS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Martin Reichert, Srebrena Atanasova, Kathrin Petri, Marian Kampschulte, Baktybek Kojonazarov, Gabriele Fuchs-Moll, Gabriele A. Krombach, Winfried Padberg, Veronika Grau
Summary: Alloreactive and autoreactive antibodies have been associated with chronic lung allograft dysfunction, with lipopolysaccharide-induced infiltration of B cells and accumulation of immunoglobulins potentially contributing to the pathogenesis of this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rebeca Bailen, Jose Luis Vicario, Laura Solan, Irene Sanchez-Vadillo, Pilar Herrera, Maria Calbacho, Raquel Alenda, Jose Luis Lopez-Lorenzo, Karem Humala, Anabelle Chinea, Jose Sanchez-Pina, Antonio Balas, Miguel Angel Moreno, Javier Arzuaga, Virginia Pradillo, Nieves Dorado, Gillen Oarbeascoa, Javier Anguita, Jose Luis Diez-Martin, Mi Kwon
Summary: This study reports the experience of using desensitization treatments for patients with DSAs undergoing haplo-HSCT. The results show that utilizing desensitization strategies guided by DSAs intensity kinetics can effectively decrease DSA intensity and improve engraftment rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Ei Miyamoto, Akihiro Takahagi, Akihiro Ohsumi, Tereza Martinu, David Hwang, Kristen M. Boonstra, Betty Joe, Juan Mauricio Umana, Ke F. Bei, Daniel Vosoughi, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Stephen C. Juvet
Summary: Pre-transplant administration of recipient-derived Tregs through EVLP can maintain their immunomodulatory function within the donor lungs.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Maria S. S. Hadjiagapiou, George Krashias, Elie Deeba, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Antibodies against coagulation components contribute to thrombotic and inflammatory signaling pathways in diseases similar to multiple sclerosis. A preclinical study examined the effects of IgG antibodies from MS patients on astrocytic activation and found an upregulation of pro-inflammatory factors. However, serum samples from patients and controls did not show significant differences, possibly due to medication.
Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Review
Medicine, General & Internal
Trieu-Nghi Hoang-Thi, Guillaume Chassagnon, Thong Hua-Huy, Veronique Boussaud, Anh-Tuan Dinh-Xuan, Marie-Pierre Revel
Summary: Quantitative imaging methods play a key role in early identification and prognostic estimation of CLAD, with the need for novel approaches to predict, understand, and identify CLAD in its early stages. However, there are limitations to be addressed in quantitative imaging for evaluating CLAD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Aparna C. Swaminathan, Jamie L. Todd, Scott M. Palmer
Summary: Lung transplantation has substantially increased in volume in recent decades, with advances being made in understanding and treating post-transplant complications like CLAD. Ongoing studies are exploring novel approaches to improve long-term outcomes for lung transplant recipients.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Respiratory System
Sara Assadiasl, Mohammad Hossein Nicknam
Summary: Post-transplant care and patients' survival in lung transplantation need improvement, and cytokine monitoring pre- and post-transplant could be used for prevention and early diagnosis of inflammatory events, providing new therapeutic options to enhance lung allograft survival.
Article
Cardiac & Cardiovascular Systems
Siddhartha G. Kapnadak, Eric D. Morrell, Travis Hee Wai, Christopher H. Goss, Pali D. Shah, Christian A. Merlo, Ramsey R. Hachem, Kathleen J. Ramos
Summary: This study investigated the practices of azithromycin use among lung transplant providers internationally. The results showed significant variations in indications, timing, and dosing of azithromycin, with even inconsistencies within the same center. Most providers initiated azithromycin after the occurrence of risk factors and/or events related to chronic lung allograft dysfunction (CLAD).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Chemistry, Multidisciplinary
Danila A. Barskiy, Aaron M. Coffey, Panayiotis Nikolaou, Dmitry M. Mikhaylov, Boyd M. Goodson, Rosa T. Branca, George J. Lu, Mikhail G. Shapiro, Ville-Veikko Telkki, Vladimir V. Zhivonitko, Igor V. Koptyug, Oleg G. Salnikov, Kirill V. Kovtunov, Valerii I. Bukhtiyarov, Matthew S. Rosen, Michael J. Barlow, Shahideh Safavi, Ian P. Hall, Leif Schroeder, Eduard Y. Chekmenev
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
Article
Allergy
Krzysztof Kowalik, Ruixue Dai, Shahideh Safavi, Myrtha E. Reyna, Wendy Lou, Claire Lepine, Erica McDonald, Mirjam J. Schaap, May G. Brydges, Aimee Dubeau, Kathy Boutis, Indra Narang, Thomas Eiwegger, Theo J. Moraes, Felix Ratjen, Padmaja Subbarao
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahideh Safavi, Christoph Arthofer, Andrew Cooper, James W. Harkin, Andrew P. Prayle, Milind P. Sovani, Charlotte E. Bolton, Penny A. Gowland, Ian P. Hall
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Shahideh Safavi, Samal Munidasa, Brandon Zanette, Ruixue Dai, Elaine Stirrat, Daniel Li, Theo J. Moraes, Padmaja Subbarao, Giles Santyr
Summary: The study found that 129Xe-MRI is a sensitive marker for assessing ventilation inhomogeneity in pediatric severe asthma. It has the potential to be used as a biomarker for disease progression and therapeutic response assessment.
RESPIRATORY MEDICINE
(2021)
Article
Microbiology
Vadsala Baskaran, Hannah Lawrence, Louise E. Lansbury, Karmel Webb, Shahideh Safavi, Nurul Zainuddin, Tausif Huq, Charlotte Eggleston, Jayne Ellis, Clare Thakker, Bethan Charles, Sara Boyd, Tom Williams, Claire Phillips, Ethan Redmore, Sarah Platt, Eve Hamilton, Andrew Barr, Lucy Venyo, Peter Wilson, Tom Bewick, Priya Daniel, Paul Dark, Adam R. Jeans, Jamie McCanny, Jonathan D. Edgeworth, Martin J. Llewelyn, Matthias L. Schmid, Tricia M. McKeever, Martin Beed, Wei Shen Lim
Summary: A study in England found limited evidence for community-acquired bacterial co-infection in hospitalized adults with COVID-19, but a higher rate of Gram-negative infection acquired during ICU stay.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Allergy
Shahideh Safavi, Ruixue Dai, Vanessa L. Breton, Melanie N. Emmerson, Krzysztof Kowalik, Zihang Lu, Wendy Lou, Aimee Dubeau, Stephanie DeLorenzo, Meghan B. Azad, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Per Gustafsson, Diana L. Lefebvre, Malcolm R. Sears, Theo J. Moraes, Padmaja Subbarao
Summary: The study demonstrates a strong association between lung clearance index (LCI) at age 3 and recurrent wheeze, as well as its predictive value for the persistence of symptoms until age 5.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mehrossadat Alavi, Shahide Safavi
IRANIAN JOURNAL OF NUCLEAR MEDICINE
(2007)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Mehrossadat Alavi, Shahideh Safavi
HELLENIC JOURNAL OF NUCLEAR MEDICINE
(2010)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mehrossadat Alavi, Shahideh Safavi
HELLENIC JOURNAL OF NUCLEAR MEDICINE
(2008)