期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603884
关键词
gas; hyperpolarization; MRI; NMR; propane; Xe-129
资金
- UK's Medical Research Council (MRC)
- Engineering and Physical Sciences Research Council (EPSRC)
- Burroughs Wellcome Fund Career Award at the Scientific Interface, Human Frontiers Science Program [RGP0050]
- Heritage Medical Research Institute
- NIH [1F32EB021840, 1R21EB018014, 1R21EB020323]
- NSF [CHE-1416268, CHE-1416432]
- DOD CDMRP BRP [W81XWH-12-1-0159/BC112431]
- PRMRP [W81XWH-15-1-0271, W81XWH-15-1-0272]
- ExxonMobil Research and Engineering Company Knowledge Build
- Russian Science Foundation [14-35-00020]
- President's of Russian Federation Funding [MK-4498.2016.3]
- Academy of Finland [289649, 294027]
- European Research Council under the European Community's Seventh Framework Programme (FP7)/ERC [242710]
- Leibniz Association [SAW-2011-FMP-2]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416432] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416268] Funding Source: National Science Foundation
Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4-8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can often be readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.
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