Article
Neurosciences
Julian Day-Cooney, Jackson J. Cone, John H. R. Maunsell
Summary: This study examines how spikes occurring at different times contribute to visual perception and action. The researchers used optogenetic stimulation to excite inhibitory interneurons in the visual cortex of mice and found that spikes occurring early in response to a visual stimulus play a crucial role in guiding behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Steffen Gonda, Ina Koehler, Andre Haase, Katrin Czubay, Andrea Raek, Christian Riedel, Petra Wahle
Summary: Spontaneous or experimentally evoked activity can lead to changes in neocortical pyramidal cell dendrites. In this study, optogenetic stimulation at 0.5 Hz frequency caused shorter and less branched dendrites in rat visual cortex organotypic cultures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Vinod Menon, Domenic Cerri, Byeongwook Lee, Rui Yuan, Sung-Ho Lee, Yen-Yu Ian Shih
Summary: This study demonstrates that optogenetic stimulation of AI neurons in the rat brain can suppress DMN activity and decrease connectivity between AI and DMN nodes. These findings reveal new insights into the network organization of the rodent brain and advance our understanding of the causal mechanisms underlying dynamic interactions and network switching.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Wei-wei Deng, Guang-yan Wu, Ling-xia Min, Zhou Feng, Hui Chen, Ming-liang Tan, Jian-feng Sui, Hong-liang Liu, Jing-ming Hou
Summary: Activation of glutamate neurons in the primary motor cortex can significantly improve motor function scores in rats, shorten the incubation period of motor evoked potentials, and increase motor potentials' amplitude. Accurate activation of the primary motor cortex can effectively promote tissue recovery and neurofilament growth, while also increasing the content of some growth-related proteins at the injured site. These findings suggest that selective activation of glutamate neurons in the primary motor cortex may play a significant role in promoting functional recovery after SCI and understanding the neural cell mechanism involved in recovery induced by motor cortex stimulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Brendan Ryu, Shivathmihai Nagappan, Fernando Santos-Valencia, Psyche Lee, Erica Rodriguez, Meredith Lackie, Jun Takatoh, Kevin M. Franks
Summary: Using optogenetics, researchers found that brief activation of targeted populations of mouse PCx principal neurons can trigger massive, generalized seizures. Optokindling disrupts the balance of recurrent excitation and feedback inhibition mainly by causing a significant decrease in feedback inhibition.
Article
Multidisciplinary Sciences
Heiko Pohl, Peter S. Sandor, Marius Moisa, Christian C. Ruff, Jean Schoenen, Roger Luechinger, Ruth O'Gorman, Franz Riederer, Andreas R. Gantenbein, Lars Michels
Summary: Cerebral blood flow differs between migraine patients and healthy controls, and anodal transcranial direct current stimulation (tDCS) can modulate brain perfusion in migraine patients. tDCS can increase blood flow in regions processing visual stimuli in the short term, but the effect is not sustained.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Motoki Nakao, Masaya Watanabe, Lucile Miquerol, Hiroyuki Natsui, Takuya Koizumi, Takahide Kadosaka, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Antoine A. F. de Vries, Toshihisa Anzai
Summary: Recent studies have shown that optogenetic therapy using light-gated ion channels can effectively terminate atrial fibrillation without causing pain. This study investigated the mechanism of optogenetic termination of atrial tachyarrhythmia by examining the changes in action potential duration and refractory period induced by brief pulsed light stimulation in transgenic mice.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanpeng Lv, Zhikui Feng, Shuo Chen, Xian Cheng, Jianhua Zhang, Chenguo Yao
Summary: This study investigated the electroporation effect on endothelial cells in normal and tumor blood vessels using a multilayer dielectric model. It found that vascular smooth muscle cells in normal blood vessels may provide protection against electroporation, while the lack of these cells in tumor blood vessels led to a stronger electroporation effect on endothelial cells. This study may help explain why the structure of endothelial cells in normal blood vessels is preserved during electroporation treatment and how ECT or IRE may selectively damage tumor blood vessels and cells while preserving normal blood vessels.
BIOELECTROCHEMISTRY
(2022)
Article
Psychiatry
Ying Hao Yu, Arthur C. Tsai, Chen Yin Ou, Cai-N Cheng, Fang Chih Chang, Bai Chuang Shyu, Andrew Chih Wei Huang
Summary: This study found that optogenetic stimulation in the medial prefrontal cortex can modulate the valence of stimuli, including rewarding, aversive, and neutral states. This finding is important for the development of new treatments for drug addiction.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Ivan V. Smirnov, Alexey Y. Malyshev
Summary: In this study, the researchers used the Hebbian paradigm to demonstrate the role of associative plasticity in the dynamic organization of the receptive fields of neurons in the mouse visual cortex. They showed that optogenetic stimulation paired with visual stimulus induced long-term changes in the properties of the receptive field, specifically altering the orientation selectivity of the cell.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Fereshteh Arab, Sareh Rostami, Mohammad Dehghani-Habibabadi, Diego M. Mateos, Roisin Braddell, Felix Scholkmann, Mohammad Ismail Zibaii, Serafim Rodrigues, Vahid Salari, Mir-Shahram Safari
Summary: The present study investigates the effects of visual stimulation on the primary visual cortex under gamma oscillations. The results show that optogenetic stimulation enhances low gamma power in both layers of the visual cortex, while simultaneous visual stimulation has differing effects on the two layers, reducing gamma power in layer II and increasing it in layer IV.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Alexa Brown, Nadia Chaudhri
Summary: This study reveals that fear extinction retrieval and reinstatement of drug seeking are mediated by the influence of prelimbic (PL) and infralimbic (IL) cortices on the paraventricular nucleus of the thalamus (PVT). These findings are crucial for understanding the role of conditioning and contextual processing in behavioral responses.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
M. Provansal, G. Labernede, C. Joffrois, A. Rizkallah, R. Goulet, M. Valet, W. Deschamps, U. Ferrari, A. Chaffiol, D. Dalkara, J. A. Sahel, M. Tanter, S. Picaud, G. Gauvain, F. Arcizet
Summary: This study demonstrates the detection of deep optogenetic activations in anesthetized rats' V1 using fUS imaging. The optogenetic specificity of these activations and their neuronal origin were confirmed through electrophysiological recordings. Furthermore, it was shown that the optogenetic response initiated in V1 spreads to downstream (LGN) and upstream (V2) visual areas.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Daniela Laricchiuta, Giuseppe Sciamanna, Juliette Gimenez, Andrea Termine, Carlo Fabrizio, Silvia Caioli, Francesca Balsamo, Anna Panuccio, Marco De Bardi, Luana Saba, Noemi Passarello, Debora Cutuli, Anna Mattioni, Cristina Zona, Valerio Orlando, Laura Petrosini
Summary: This study investigated the coordinated neural activity within the amygdala and medial prefrontal cortex during fear extinction. The optogenetic activation of prelimbic pyramidal neurons in fear-conditioned mice led to deficits in fear extinction and significant modifications in the transcriptome of amygdala pyramidal neurons, highlighting the importance of understanding the electrophysiological, morphological, and transcriptomic architecture of fear extinction in fear-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Christian Stald Skoven, Leo Tomasevic, Duda Kvitsiani, Bente Pakkenberg, Tim Bjorn Dyrby, Hartwig Roman Siebner
Summary: This study utilizes optogenetic stimulation to investigate the interaction between the left and right primary motor cortex in rats. Stimulation of the right motor cortex consistently triggers a response in the left motor cortex. Increasing the intensity and duration of stimulation results in larger and more consistent responses.
FRONTIERS IN NEUROSCIENCE
(2022)
