Article
Biology
Vivien Horvath, Sara Guirao-Rico, Judit Salces-Ortiz, Gabriel E. Rech, Llewellyn Green, Eugenio Aprea, Mirco Rodeghiero, Gianfranco Anfora, Josefa Gonzalez
Summary: Climate change significantly impacts the distribution and biodiversity of organisms, particularly by altering water availability and exposing species to desiccation stress. Most previous studies have focused on the effects of temperature, but integrating transcriptomics and physiology is essential for understanding how species cope with desiccation stress. European D. melanogaster populations from arid regions were found to be more tolerant to desiccation compared to those from temperate regions, and their gene expression and physiological responses were correlated.
Article
Multidisciplinary Sciences
Melissa A. White, Alessandro Bonfini, Mariana F. Wolfner, Nicolas Buchon
Summary: After mating, Drosophila melanogaster females experience significant changes in their digestive system, triggered by the seminal fluid protein Sex Peptide (SP), to support egg production by altering gene expression and metabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Entomology
Melissa A. White, Mariana F. Wolfner
Summary: This article summarizes the studies on post-mating signaling events in the reproductive tract and digestive system of fruit flies, highlighting the role of male seminal fluid proteins. It also identifies incomplete parts of these pathways and proposes questions for future research.
Article
Multidisciplinary Sciences
Hsiao-Ching Yang, Yung-Chi Ge, Kuan-Hsuan Su, Chia-Cheng Chang, King-Chuen Lin, Vincenzo Aquilanti, Toshio Kasai
Summary: This study investigates the role of water in cellular respiration and its correlation with temperature. Through experiments and modeling, the effects of temperature on enzymes like Phosphofructokinase (PFK-1) in the respiration process are examined. The research reveals the water channel network structure of the PFK-1 tetramer and how temperature regulates respiration rates.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
John R. Speakman, Yosuke Yamada, Hiroyuki Sagayama, Elena S. F. Berman, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Seth A. Creasy, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Cara B. Ebbeling, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle Lambert, William R. Leonard, Nader Lessan, David S. Ludwig, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Edward L. Melanson, Amy H. Luke, Herman Pontzer, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong
Summary: The study showed that the use of different equations may introduce considerable variability in estimating total energy expenditure. Based on validation studies, the authors proposed a new equation for estimating rCO(2) sensitive to dilution space ratio and found DSR decreases at body masses below 10 kg.
CELL REPORTS MEDICINE
(2021)
Article
Zoology
Gonzalo Barcelo, Jonathan N. Pauli, Mathew Alldredge, William H. Karasov
Summary: Estimating energy expenditure is crucial for addressing ecological issues and conservation strategies. This study validates a movement model estimation of puma energy expenditure using doubly labeled water. The results show that this estimation method is consistent with other approaches, and that decreasing air temperature and increasing movement distance are correlated with higher energy expenditure in monitored pumas.
CANADIAN JOURNAL OF ZOOLOGY
(2022)
Article
Biophysics
Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Pablo Tomas-Carus, Rafael Timon, Guillermo Olcina, Martin Burtscher
Summary: This study aimed to explore the differences in cardiorespiratory responses to normobaric hypoxia between men and women. The results showed that men had a more pronounced ventilatory response to hypoxia compared to women, while women experienced a faster decrease in peripheral oxygen saturation during the first few hours in hypoxia.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2022)
Article
Entomology
Amador Rodriguez-Gomez, Virginia Balanza, Alberto Donate, Ana Belen Abelaira, Maria del Carmen Reche, Isabel Sanchez-Martinez, Pablo Bielza
Summary: This study found that male Orius laevigatus have a high capacity for consecutive mating in mass-rearing, and fecundity changes with male and female age. While fecundity is influenced by female age and mating status, little is known about the impact of parental status at mating on female reproductive outcomes in BCAs for efficient mass-rearing and field performance.
Article
Nutrition & Dietetics
Ross L. Prentice, Aaron K. Aragaki, JoAnn E. Manson, Dale A. Schoeller, Lesley F. Tinker, Yasmin Mossavar-Rahmani, Robert B. Wallace, Michael J. LaMonte, Janet A. Tooze, Karen C. Johnson, Johanna W. Lampe, Marian L. Neuhouser
Summary: High energy expenditure is associated with higher all-cause mortality in younger postmenopausal women, but not in older postmenopausal women.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Daiki Watanabe, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Hiroyuki Sagayama, Naoyuki Ebine, Hisamine Kobayashi, Misaka Kimura, Yosuke Yamada
Summary: The study highlights the importance of appropriate energy intake in preventing frailty among older adults, and the use of DLW-calibrated energy intake for accurate assessment of frailty prevalence. Additionally, it suggests that uncalibrated self-reported energy intake may lead to underestimation, emphasizing the need for biomarker calibration.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Plant Sciences
Abiodun Samuel Afolabi, In-Lee Choi, Joo Hwan Lee, Yong Beom Kwon, Hyuk Sung Yoon, Ho-Min Kang
Summary: The effect of 10% CO2 pre-storage treatment for different durations alongside modified atmosphere packaging (MAP) on chilling injury in sweet peppers was studied. Significant interactions were found between chilling injuries and cell membrane damage indicators. The results showed that CO2 treatment could partially reduce chilling injuries. Immediate increase in respiration rate was observed with longer treatment durations, but it did not affect ethylene production rate, electrolyte leakage, or malondialdehyde. MAP treatment appeared to be the most effective, with 24 h treatment being the preferred option. Weight loss, firmness, calyx browning, and chilling injury were best maintained in MAP due to the presence of CO2 and high humidity.
Article
Agronomy
Maria Pineda, Emanuel Lucas de Andrade Alves, Julia Almeida Antunes, Vinicius de Castro Carvalho, Khalid Haddi
Summary: Plant-extracted essential oils are considered as potential alternatives to synthetic insecticides for insect pest control. Although they are generally perceived as safe for the environment and non-target organisms, their unintended effects on insect biological and reproductive traits have been overlooked. This study examined the toxicity of Eucalyptus globulus essential oil to Drosophila suzukii and found that low concentrations of the oil enhanced the fecundity and lifespan of the flies in a sex- and mating status-dependent manner. These findings highlight the need for further investigation and consideration of the age, sex, and mating status-dependent responses to low concentration exposures of essential oils.
Article
Sport Sciences
Bas Van Hooren, Jasper Most, Eline Collombon, Henrietta Nieminen, Guy Plasqui
Summary: This study assessed the accuracy of a new method for estimating total body water and energy expenditure during high-energy turnover and compared it with other methods. The results showed that the new method provided a more accurate estimation of energy expenditure during high physical activity conditions and was more accurate than traditional methods for day-to-day energy expenditure determination.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Multidisciplinary Sciences
Natalia El-Merhie, Arne Krueger, Karin Uliczka, Stephanie Papenmeier, Thomas Roeder, Klaus F. Rabe, Christina Wagner, Hanna Angstmann, Susanne Krauss-Etschmann
Summary: This study investigated the impact of maternal e-nicotine exposure on offspring development, revealing that maternal exposure not only reduces fertility, but also affects offspring size, weight, and tracheal development from embryonic stage to adulthood. These findings underscore the need for further research on the effects of maternal vaping on offspring health and suggest a potential model for analyzing the molecular mechanisms involved in these intergenerational changes.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Tatiane Lopes De Pontes, F. Pinheiro Amador Dos Santos Pessanha, R. C. Freire Junior, K. Pfrimer, N. M. Da Cruz Alves, P. G. Fassini, O. L. S. Almeida, J. C. Moriguti, N. K. Da Costa Lima, J. L. Ferreira Santos, E. Ferriolli
Summary: This study found that higher total energy expenditure in older adults was associated with better performance in gait speed tests, 6-minute walk tests, and handgrip strength. Multivariate analysis adjusted for sex and fat-free mass showed an association between total energy expenditure and the 6-minute walk test, as well as the number of sedentary events. Therefore, in clinical practice, older individuals with lower gait speed, worse performance in the 6-minute walk test, and lower handgrip strength may benefit from increasing their total energy expenditure to prevent potential issues related to low energy expenditure.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Biochemistry & Molecular Biology
Matthew D. W. Piper, Brooke Zanco, Carla M. Sgro, Margo Adler, Christen K. Mirth, Russell Bonduriansky
Summary: Reducing overall food intake or altering the proportion of protein relative to other macronutrients can extend lifespan in various organisms. A recent study using Drosophila melanogaster females has identified a single micronutrient that can explain the impact of dietary restriction on lifespan. This finding suggests a potential mechanism involving a trade-off between lifespan and reproduction, depending on the availability of an essential micronutrient - a sterol.
Article
Behavioral Sciences
Helen J. Rushby, Zane B. Andrews, Matthew D. W. Piper, Christen K. Mirth
Summary: Modifying the proportions of macronutrients in the diet has significant effects on the reproduction and health of animals. In this study, using capillary feeding assays, we explored how adult fruit flies compromise their nutrient intake when limited to single diets. We found that young male and female flies compromised by consuming more food on diets with low protein to carbohydrate ratios. Additionally, female flies showed greater variations in carbohydrate intake compared to males, and mated females consumed more food than virgin females.
Article
Physiology
Elzbieta Krol, Frances Turner, Davina Derous, Sharon E. Mitchell, Samuel A. M. Martin, Alex Douglas, John R. Speakman
Summary: Peak lactation is limited by the capacity of lactating females to dissipate body heat, and manipulations that enhance heat dissipation, such as shaving, can increase peak milk production. Shaving-induced increases in milk production were paradoxically linked to reduced expression of some milk synthesis-related genes. Shaved mice were also more likely to wean their young faster and experience earlier involution of the mammary gland compared to unshaved mice.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Sarah Mele, Felipe Martelli, Jiayi Lin, Oguz Kanca, John Christodoulou, Hugo J. Bellen, Matthew D. W. Piper, Travis K. Johnson
Summary: Amino acid disorders (AADs) are rare inherited conditions that affect one in 6500 live births, often leading to neurological decline and death in infants. Dietary modification can be an effective treatment for some AADs like phenylketonuria, but the potential for dietary therapy remains largely unexplored for most AADs. Drosophila is a suitable animal model for nutrigenomic disease modeling due to its conserved amino acid pathways, genetic tractability, and the availability of a customizable synthetic diet.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Katherine A. Kentistou, Jian'an Luan, Laura B. L. Wittemans, Catherine Hambly, Lucija Klaric, Zoltan Kutalik, John R. Speakman, Nicholas J. Wareham, Timothy J. Kendall, Claudia Langenberg, James F. Wilson, Peter K. Joshi, Nicholas M. Morton
Summary: Our understanding of the genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. In this study, the authors used whole-body imaging adiposity phenotypes in large biobanks to enhance their ability to discover genes driving human adiposity, and investigated one such gene using a mouse model.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Anja Biltoft-Jensen, Karin Hess Ygil, Lenette Knudsen, Jeppe Matthiessen, Sisse Fagt, Ellen Trolle, Trine Holmgaard Nielsen, Diane McIntosh Hansen, Cecilie Loe Licht, Maurice Martens, Catherine Hambly, John R. Speakman, Tue Christensen
Summary: The European Food Safety Authority recommends the use of the 2 x 24 h diet recall and physical activity measurements for national dietary surveys. Denmark has been using 7 d food diaries with PA questionnaires and measurements. The study shows that the 2 x 24 h diet recall performs better than the 7 d food diaries method.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Physiology
Daniel G. Ellis, John Speakman, Catherine Hambly, James P. Morton, Graeme L. Close, Tim F. Donovan
Summary: This study examined the total daily energy expenditure (TEE) of elite tennis players during high-level competition. Results showed that tennis is a highly energetically demanding sport with variability in TEE between individuals. Therefore, individual differences in energy requirements should be considered when developing nutritional strategies.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Geriatrics & Gerontology
Lu Wang, Davina Derous, Xiahe Huang, Sharon E. Mitchell, Alex Douglas, David Lusseau, Yingchun Wang, John R. Speakman
Summary: Calorie restriction extends life span by modulating aging-related mechanisms. Metabolic pathways such as glycolysis/gluconeogenesis and fatty acid degradation are significantly stimulated, while main signaling pathways and pathways in cancer are not significantly affected. Moreover, the metabolism of xenobiotics is altered by calorie restriction.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Gronke, Linda Partridge
Summary: Reduced insulin/insulin-like growth factor signaling (IIS) extends health and lifespan, but the exact tissues involved are unknown. This study found that lack of IRS1 in liver, muscle, or fat does not increase lifespan or improve health, but neuronal loss of IRS1 specifically in old males leads to improved health and metabolic adaptations consistent with activated stress response.
Article
Biology
Javier Moron-Oset, Lilly K. S. Fischer, Mireia Carcole, Ashling Giblin, Pingze Zhang, Adrian M. Isaacs, Sebastian Groenke, Linda Partridge
Summary: Hexanucleotide repeat expansions in the C9orf72 gene are the most prevalent genetic cause of amyotrophic lateral sclerosis frontotemporal dementia. Transcripts of the expansions translated into toxic dipeptide repeat (DPR) proteins. This study investigated the effects of protein tags on DPR toxicity using Drosophila.
LIFE SCIENCE ALLIANCE
(2023)
Article
Endocrinology & Metabolism
John R. Speakman, Jasper M. A. de Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S. W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma, Daniel Hoffman, Sumei Hu, Annemiek M. Joosen, Jennifer L. Kaplan, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Marie Loef, Corby K. Martin, Eric Matsiko, Anine C. Medin, Erwin P. Meijer, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilaeinen, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne M. Redman, Susan B. Roberts, Michael C. Rudolph, Luis B. Sardinha, Albertine J. Schuit, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Brian M. Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Anura Kurpad, Amy H. Luke, Herman Pontzer, Matthew S. Rodeheffer, Jennifer Rood, Dale A. Schoeller, William W. Wong
Summary: Obesity is caused by prolonged positive energy balance, and the contribution of reduced activity levels to energy expenditure is still debated. Our study shows that total energy expenditure (TEE) adjusted for body composition and age has declined since the late 1980s, while adjusted activity energy expenditure has increased over time in both sexes. The decline in adjusted basal energy expenditure (BEE) is identified as a previously unrecognized factor. These findings suggest that the increasing obesity in the United States/Europe is not likely fueled by reduced physical activity leading to lowered TEE.
Editorial Material
Biology
David B. Allison, Thorkild I. A. Sorensen, Kevin D. Hall, John R. Speakman
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biology
John R. Speakman, Kevin D. Hall
Summary: Body weight and fatness are regulated phenomena, and several theoretical models, such as the set-point, dynamic equilibrium, adiposity force, and control theory, have been proposed to explain this. Further experiments are needed to test the differences between these models.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Carolina Monzo, Lisonia Gkioni, Andreas Beyer, Dario Riccardo Valenzano, Sebastian Gronke, Linda Partridge
Summary: Aging impairs immune function, but dietary restriction (DR) can attenuate this decline. In this study, it was shown that DR preserves B cell receptor (BCR) repertoire diversity and reduces clonal expansions during aging in mice. Remarkably, mice starting DR in mid-life have similar BCR diversity and clonal expansion rates as mice on chronic DR. These findings suggest a potential role of B cell repertoire dynamics in age-related health.
Article
Endocrinology & Metabolism
Deng Bao Yang, Lin Gao, Xin Yu Liu, Yan Chao Xu, C. Hambly, De Hua Wang, John R. Speakman
Summary: The objective of this study was to assess the impact of diet and obesity on glucose homeostasis. Laboratory voles exposed to long photoperiod were resistant to high-fat diet-induced obesity but exhibited impaired glucose tolerance. This model provides insights into the relationship between diet, obesity, and metabolic health.
MOLECULAR METABOLISM
(2023)