Article
Immunology
Derek T. Larson, John H. Sherner, Kia M. Gallagher, Cynthia L. Judy, Madison B. Paul, Alexandra M. Mahoney, Peter J. Weina
Summary: This retrospective study of an institutional cohort shows positive outcomes for patients with confirmed COVID-19 when evidence-based supportive therapies are included in the organizational standards of care.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Oncology
Robert S. Phillips, Bas Vaarwerk, Jessica E. Morgan
Summary: Evidence-based medicine uses healthcare professional experience, research evidence, and patient preferences to inform clinical decision-making. In the field of rhabdomyosarcoma, collaborative groups like EpSSG have played a crucial role in developing evidence to support this process. This review explores key research developments in areas such as patient and public involvement, decision-making research, core outcome sets, evidence synthesis, and supporting research in rhabdomyosarcoma.
Article
Clinical Neurology
Johann de Jong, Ioana Cutcutache, Matthew Page, Sami Elmoufti, Cynthia Dilley, Holger Froehlich, Martin Armstrong
Summary: This study successfully established a machine learning model that integrates clinical and genetic data to predict drug response in epilepsy patients, achieving significant results and providing a blueprint for the goals of precision medicine.
Article
Education, Scientific Disciplines
Fereshte Goshtasbpour, Bronwen J. Swinnerton, James D. Pickering
Summary: Educators play a critical role in shaping learners' experiences and achievements in online medical education. The 12 tips provided in the article aim to guide medical educators in creating engaging online discussions that both support and challenge learners' understanding.
Article
Computer Science, Artificial Intelligence
Chuang Han, Shihao Pan, Wenge Que, Zhizhong Wang, Yunkai Zhai, Li Shi
Summary: This paper proposes an interpretable method for myocardial infarction (MI) localization and severity period prediction using deep learning and knowledge graph. The method extracts attribute values based on ontology structure and diagnostic rules, and employs production rules for diagnosis reasoning. Experimental results demonstrate the superior performance of the proposed method in accuracy and F1 value.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rosa Autorino, Benedetta Gui, Giulia Panza, Luca Boldrini, Davide Cusumano, Luca Russo, Alessia Nardangeli, Salvatore Persiani, Maura Campitelli, Gabriella Ferrandina, Gabriella Macchia, Vincenzo Valentini, Maria Antonietta Gambacorta, Riccardo Manfredi
Summary: This study aims to investigate whether radiomics features extracted from magnetic resonance images can predict long-term clinical outcomes in patients with locally advanced cervical cancer after neoadjuvant chemoradiotherapy. The results show that the proposed radiomics model has promising performance in predicting patient survival rates.
Article
Computer Science, Artificial Intelligence
Fakhare Alam, Hamed Babaei Giglou, Khalid Mahmood Malik
Summary: To support evidence-based medicine, this paper proposes a topic-specific and fully automated framework that utilizes knowledge graphs (KGs) to curate information and create KGs for different clinical domains. By employing concept extraction, semantic enrichment, optimized clustering, and state-of-the-art RNNs, the framework categorizes PICO elements and predicts relationships using a large corpus of literature on COVID-19 and cerebral aneurysm. The evaluation results show a significant improvement over baseline models in PICO classification accuracy, achieving 93% and 82% accuracy on the aneurysm and COVID datasets, respectively. The relationship extraction module also achieves high accuracy, with precision and recall of 92% and 90%, respectively.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Health Care Sciences & Services
Daniele Piovani, Rozeta Sokou, Andreas G. Tsantes, Alfonso Stefano Vitello, Stefanos Bonovas
Summary: A large number of prediction models are published to support personalized decision making in diagnosis or prognosis. Conventional statistical measures are not suitable for assessing the clinical value of scores or biomarkers. Decision curve analysis is a popular technique used to assess the clinical utility of a prognostic or diagnostic score/rule, or a biomarker. It is a powerful tool for judging whether newly published or existing scores may truly benefit patients, representing a significant advancement in improving transparent clinical decision making.
Article
Multidisciplinary Sciences
Jeffrey A. Kline, Carlos A. Camargo, D. Mark Courtney, Christopher Kabrhel, Kristen E. Nordenholz, Thomas Aufderheide, Joshua J. Baugh, David G. Beiser, Christopher L. Bennett, Joseph Bledsoe, Edward Castillo, Makini Chisolm-Straker, Elizabeth M. Goldberg, Hans House, Stacey House, Timothy Jang, Stephen C. Lim, Troy E. Madsen, Danielle M. McCarthy, Andrew Meltzer, Stephen Moore, Craig Newgard, Justine Pagenhardt, Katherine L. Pettit, Michael S. Pulia, Michael A. Puskarich, Lauren T. Southerland, Scott Sparks, Danielle Turner-Lawrence, Marie Vrablik, Alfred Wang, Anthony J. Weekes, Lauren Westafer, John Wilburn
Summary: A clinical prediction score has been derived and validated to estimate the probability of SARS-CoV-2 infection using widely available criteria at the point of care. The score accurately predicts the probability of infection and can assist with decisions about isolation and testing at high throughput checkpoints.
Article
Immunology
Nobuhiro Asai, Daisuke Sakanashi, Hiroyuki Suematsu, Hideo Kato, Mao Hagihara, Arufumi Shiota, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Summary: This study reviewed all candidemia patients in the institute from 2014 to 2018 and found that only 24% of the patients were eligible for clinical trials. Compared to those who were not eligible, the eligible patients had better performance status, fewer comorbidities and longer overall survival times. This suggests that clinical trials may not accurately reflect the real world among candidemia patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Gastroenterology & Hepatology
Jordi Bruix
Summary: Clinical trials rely on strict definitions and criteria, but real-world clinical practice may not follow the same guidelines, leading to discrepancies in patient selection, disease assessment, and treatment decisions. Understanding these differences is crucial in refining criteria for drug activity, toxicity, and treatment failure in order to achieve evidence-based clinical practice and precision oncology.
JOURNAL OF HEPATOLOGY
(2021)
Article
Health Care Sciences & Services
Bo Li, Yumeng Yan, Meng Lv, Guozhen Zhao, Zeyu Li, Shuo Feng, Jing Hu, Yuqing Zhang, Xuan Yu, Jingyi Zhang, Bin Ma, Kehu Yang, Yaolong Chen
Summary: The evolution of EBM in China was described and recorded through oral history interviews with international and Chinese experts. More than 20 EBM centers have been established in China since the mid-1990s. China has contributed to EBM internationally by conducting systematic reviews, developing reporting checklists, and integrating EBM principles into Traditional Medicine, but still faces challenges such as funding shortages and limited local high-quality evidence.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Gregor Lichtner, Brian S. Alper, Carlo Jurth, Claudia Spies, Martin Boeker, Joerg J. Meerpohl, Falk von Dincklage
Summary: This study proposes a FHIR-based format that uses computer-interpretable representations of knowledge artifacts to directly generate evidence-based recommendations. An information model and corresponding representation based on FHIR resources were developed, allowing for the transparent evaluation of evidence and the facilitation of computer-interpretable guideline recommendations.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Review
Integrative & Complementary Medicine
Seungwon Shin, Wonkyung Moon, Suran Kim, Seok Hee Chung, Jongwoo Kim, Namkwen Kim, Yoon Jae Lee, Minjung Park
Summary: This study reviewed the development, dissemination, and implementation of clinical practice guidelines (CPGs) in Korean Medicine (KM). KM-CPGs are developed and evaluated using standardized methods, with quality controlled through a tri-step appraisal process. The Steering Committee of the KoMIT project reviews and confirms the CPGs for public disclosure and dissemination.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Hiroto Miwa, Akihito Nagahara, Akihiro Asakawa, Makoto Arai, Tadayuki Oshima, Kunio Kasugai, Kazuhiro Kamada, Hidekazu Suzuki, Fumio Tanaka, Kazunari Tominaga, Seiji Futagami, Mariko Hojo, Hiroshi Mihara, Kazuhide Higuchi, Motoyasu Kusano, Tomiyasu Arisawa, Mototsugu Kato, Takashi Joh, Satoshi Mochida, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike
Summary: Functional dyspepsia is a common disorder that significantly affects the quality of life of patients. The revised guidelines in Japan specify the use of endoscopy and update the drug treatment options based on the latest evidence.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Emergency Medicine
Alan Garner, Elwyn Poynter, Ruth Parsell, Andrew Weatherall, Mary Morgan, Anna Lee
Summary: This study compared the complication rates of different thoracic decompression techniques and found that finger thoracostomy did not reduce overall complication rates compared to tube thoracostomy. However, the rate of recurrent tension physiology was higher with finger thoracostomy.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Respiratory System
Christina So, Lowell Ling, Wai Tat Wong, Jack Zhenhe Zhang, Chun Ming Ho, Pauline Yeung Ng, Hoi Ping Shum, Alwin Wai Tak Yeung, Kai Cheuk Sin, Jacky Chan, Ka Fai Au, Ting Liong, Eunise Ho, Fu Loi Chow, Laptin Ho, Kai Man Chan, Gavin Matthew Joynt
Summary: Survival of ICU patients with tuberculosis has not improved over the last decade and mortality remains high. Delay in tuberculosis treatment was associated with higher hospital mortality. Use of MTB PCR may improve diagnostic yield and facilitate early treatment.
Correction
Emergency Medicine
Alan Garner, Elwyn Poynter, Ruth Parsell, Andrew Weatherall, Mary Morgan, Anna Lee
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Health Care Sciences & Services
Victor M. Montori, Merel M. Ruissen, Megan E. Branda, Ian G. Hargraves, Marleen Kunneman
Summary: This study aims to evaluate the implementation of shared decision making (SDM) in clinical encounters and across different SDM forms. The findings suggest that the prescribed steps of SDM are rarely followed in order, regardless of whether an SDM intervention was used. There is no clear pattern of steps that distinguishes among different SDM forms.
HEALTH EXPECTATIONS
(2023)
Editorial Material
Medicine, General & Internal
Victor Montori, Marleen Kunneman
BMJ EVIDENCE-BASED MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Victor M. Montori, Merel M. Ruissen, Ian G. Hargraves, Juan P. Brito, Marleen Kunneman
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
David Conen, Ekaterine Popova, Michael Ke Wang, Matthew T. V. Chan, Giovanni Landoni, Cara Reimer, Sadeesh K. Srinathan, Juan P. Cata, Sean R. McLean, Juan Carlos Trujillo Reyes, Ascension Martin Grande, Anna Gonzalez Tallada, Daniel I. Sessler, Edith Fleischmann, Donna E. Maziak, Barbara Kabon, Luca Voltolini, Laura Gutierrez-Soriano, Vikas Tandon, Deborah DuMerton, Biniam Kidane, Ravi Rajaram, Yaron Shargall, John D. Neary, Jennifer R. Wells, William F. McIntyre, Steffen Blum, Sandra N. Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, Jeff S. Healey, Amit X. Garg, P. J. Devereaux
Summary: The COP-AF trial aims to test whether colchicine reduces the incidence of perioperative atrial fibrillation and myocardial injury after noncardiac surgery.
AMERICAN HEART JOURNAL
(2023)
Editorial Material
Anesthesiology
A. Lee, S. R. Moonesinghe
Article
Medicine, General & Internal
Maura Marcucci, Thomas W. Painter, David Conen, Vladimir Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Kate Leslie, Emmanuelle Duceppe, Maria Jose Martinez-Zapata, Chew Yin Wang, Denis Xavier, Sandra N. Ofori, Michael Ke Wang, Sergey Efremov, Giovanni Landoni, Ydo Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Kurt Ruetzler, Joel L. Parlow, Vikas Tandon, Edith Fleischmann, Carisi A. Polanczyk, Andre Lamy, Raja Jayaram, Sergey V. Astrakov, William Ka Kei Wu, Chao Chia Cheong, Sabry Ayad, Mikhail Kirov, Miriam de Nadal, Valery V. Likhvantsev, Pilar Paniagua, Hector J. Aguado, Kamal Maheshwari, Richard P. Whitlock, Michael H. McGillion, Jessica Vincent, Ingrid Copland, Kumar Balasubramanian, Bruce M. Biccard, Sadeesh Srinathan, Samandar Ismoilov, Shirley Pettit, David Stillo, Andrea Kurz, Emilie P. Belley-Cote, Jessica Spence, William F. McIntyre, Shrikant Bangdiwala, Gordon Guyatt, Salim Yusuf, P. J. Devereaux
Summary: This study compared the effects of two different blood pressure management strategies, hypotension-avoidance and hypertension-avoidance, on major vascular complications after noncardiac surgery. The results showed that both strategies had similar incidence of major vascular complications.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Marleen Kunneman, Derek Gravholt, Sandra A. Hartasanchez, Michael R. Gionfriddo, Zoe Paskins, Larry J. Prokop, Anne M. Stiggelbout, Victor M. Montori
Summary: This study aimed to summarize instruments capable of measuring dimensions of patient-clinician collaboration to make care fit. The researchers systematically searched several databases and included 189 relevant papers. The results showed that existing measures of making care fit focus heavily on the content and manner of patient-clinician collaboration, while neglecting other crucial dimensions and actions.
HEALTH EXPECTATIONS
(2023)
Letter
Medicine, General & Internal
Loai Albarqouni, Victor Montori, Karsten Juhl Jorgensen, Martin Ringsten, Helen Bulbeck, Minna Johannson
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Medicine, General & Internal
Merel M. Ruissen, Victor M. Montori, Ian G. Hargraves, Megan E. Branda, Montserrat Leon Garcia, Eelco J. P. de Koning, Marleen Kunneman
Summary: This study aimed to describe the collaborative approaches to shared decision-making (SDM) in clinical encounters of patients with diabetes and their clinicians. The findings showed that at least one instance of SDM was observed in 86 out of 100 encounters, with varying forms of SDM present. Weighing alternatives, negotiating conflicting desires, and problemsolving were the most common forms of SDM observed. The study also found a correlation between the form of SDM focused on weighing alternatives and higher patient involvement. Overall, recognizing the different forms of SDM used by clinicians and patients opens new possibilities for research and practice in patient-centered care.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Medicine, General & Internal
David Conen, Michael Ke Wang, Ekaterine Popova, Matthew T. Chan, Giovanni Landoni, Juan P. Cata, Cara Reimer, Sean R. McLean, Sadeesh K. Srinathan, Juan Carlos Trujillo Reyes, Ascension Martin Grande, Anna Gonzalez Tallada, Daniel Sessler, Edith Fleischmann, Barbara Kabon, Luca Voltolini, Patricia Cruz, Donna E. Maziak, Laura Gutierrez-Soriano, William F. Mcintyre, Vikas Tandon, Elisabeth Martinez-Tellez, Juan Jose Guerra-Londono, Deborah DuMerton, Randolph H. L. Wong, Anna L. McGuire, Biniam Kidane, Diego Parise Roux, Yaron Shargall, Jennifer R. Wells, Sandra N. Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, John W. Eikelboom, Sanjit S. Jolly, Jeff S. Healey, P. J. Devereaux
Summary: In patients undergoing major non-cardiac thoracic surgery, the use of colchicine did not significantly lower the incidence of clinically important atrial fibrillation or MINS, but increased the risk of non-infectious diarrhea.
Review
Endocrinology & Metabolism
Alejandra Meza-Contreras, Camila Wenczenovicz, Kim Ruiz-Arellanos, Elissa A. Kinzelman Vesely, Renzo Mogollon, Victor M. Montori
Summary: This systematic review examined 26 articles on expert recommendations for statin intolerance, revealing substantial variability in the definition and management approaches. Most experts provided management suggestions, but lacked supporting evidence. Few experts focused on reducing atherosclerotic cardiovascular disease (ASCVD) risk, and none promoted shared decision making with patients.
Article
Critical Care Medicine
Chi Yeung Yeung, Kit Ying So, Helen Hoi Ting Cheung, Pik Yi Hou, Hiu Fai Ko, Anna Lee
Summary: There are many barriers to implementing BLS training in secondary schools. Trained teachers were found to be as effective as healthcare instructors in teaching BLS skills to secondary school students. Students had positive attitudes towards learning and performing BLS.
RESUSCITATION PLUS
(2023)
