Article
Biochemistry & Molecular Biology
Pablo Delgado-Bonet, Beatriz Davinia Tomeo-Martin, Blanca Delgado-Bonet, David Sardon-Ruiz, Angel Torrado-Carvajal, Isidro Mateo, Ana Judith Perise-Barrios
Summary: This study investigates the use of oncolytic virus ICOCAV15 as an adjuvant treatment for incomplete tumor resection in canine intracranial hemangioma. The results show that the treatment has no side effects and leads to a decrease in tumor volume as measured by magnetic resonance imaging. The patient has a longer survival time and an increased number of infiltrated immune cells in the tumor, suggesting that ICOCAV15 could be a safe and effective treatment for canine hemangiomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Sauson Soldozy, Daniel G. Eichberg, Alexis A. Morell, Evan Luther, Victor M. Lu, Dominique M. O. Higgins, Nitesh V. Patel, Ashish H. Shah, Simon J. Hanft, Ricardo J. Komotar, Michael E. Ivan
Summary: The incidence of brain tumors, particularly glioblastoma, is increasing. Current treatments have limited success, highlighting the need for new strategies. Oncolytic virotherapy shows promise as a robust and effective treatment for brain tumors, with ongoing clinical trials for high-grade glioma. The unique properties of the nervous system and heterogeneity of brain tumors make oncolytic viruses a potential solution, with the ability for genetic modification and direct inoculation.
Review
Pharmacology & Pharmacy
Gelare Ghajar-Rahimi, Kyung-Don Kang, Stacie K. Totsch, Sam Gary, Abbey Rocco, Sarah Blitz, Kara Kachurak, M. R. Chambers, Rong Li, Elizabeth A. Beierle, Asim Bag, James M. Johnston, James M. Markert, Joshua D. Bernstock, Gregory K. Friedman
Summary: Malignant brain tumors are a significant health issue in children and current treatment options have poor outcomes and long-term morbidity. Oncolytic virotherapy has emerged as a promising immunotherapy for pediatric brain tumors. This review focuses on past and current clinical trials using oncolytic virotherapy in pediatric brain tumors and discusses future research directions.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul P. Tak, Ghazaleh Tabatabai, James A. Lederer, E. Antonio Chiocca, Sean Lawler
Summary: This study found that concurrent high-dose dexamethasone treatment with CAN-2409 led to significantly reduced median survival in GBM patients and inhibited the activity of immune cells. This suggests that the use of dexamethasone should be balanced between symptom control and treatment outcome when using CAN-2409 for oncolytic viral immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Quan Cheng, Anliu Tang, Zeyu Wang, Ning Fang, Zhuojing Zhang, Liyang Zhang, Chuntao Li, Yu Zeng
Summary: Caldesmon (CALD1) may play a crucial role in monitoring glioma patient prognosis and angiogenesis, with higher CALD1 expression associated with worse clinical outcomes and potential modulation of tumor angiogenesis. High CALD1 expression was also linked to abnormal microvessels in anaplastic astrocytoma and GBM, making CALD1 a possible key marker for monitoring glioma progress.
Article
Pharmacology & Pharmacy
Laura Lucia Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andres Golombek, Juan Jose Chiesa, Luciano Marpegan
Summary: The study revealed circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Article
Oncology
Jawad Fares, Atique U. Ahmed, Ilya Ulasov, Adam M. Sonabend, Jason Miska, Catalina Lee-Chang, Irina Balyasnikova, James P. Chandler, Jana Portnow, Matthew C. Tate, Priya Kumthekar, Rimas Lukas, Sean A. Grimm, Ann K. Adams, Charles D. Hebert, Theresa Strong, Christina Amidei, Victor A. Arrieta, Markella Zannikou, Craig Horbinski, Hui Zhang, Kirsten Bell Burdett, David T. Curiel, Sean Sachdev, Karen S. Aboody, Roger Stupp, Maciej S. Lesniak
Summary: The study investigated the safety and activity of NSC-CRAd-S-pk7, an engineered oncolytic adenovirus delivered by neural stem cells (NSCs), in patients with newly diagnosed high-grade glioma. The treatment was found to be feasible and safe, supporting further investigation in a phase 2/3 clinical trial.
Article
Engineering, Biomedical
B. Sarala, G. Sumathy, A. V. Kalpana, J. Jasmine Hephzipah
Summary: In this study, Glioma brain tumor images are detected using Edge preserving image fusion and dual-deep learning Convolutional Neural Network. The first CNN module extracts internal features from the brain image, while the second module is used for feature classification. The training process involves fusing brain tumor and healthy brain images, augmenting the fused images, and classifying them with a proposed CNN classifier. In the testing process, the source brain images are fused, augmented, and classified into Glioma or healthy brain image, followed by tumor region segmentation using Histogram-Density Segmentation Algorithm.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Engineering, Environmental
Meng-Yi Xie, Guang-Long Huang, Zhi-Ying Lin, Xiang-Fei Sun, Chen-Chou Wu, Ya-Wei Liu, Liang-Ying Liu, Eddy Y. Zeng
Summary: Information on potential association between heavy metal concentrations and glioma incidences is limited, especially in human brain tissue. This study measured 13 heavy metals in glioma and non-glioma samples and found that all target heavy metals were present, indicating their ability to cross the blood-brain barrier. Concentrations of Mn, Cu, and Zn were higher in glioma samples, while Ni and Se were higher in non-glioma samples, suggesting their susceptibility to pathological changes. Furthermore, certain concentration ratios of heavy metals were statistically different between glioma and non-glioma samples, which may serve as chemical markers for differentiating tumor from healthy tissues. However, no direct link between heavy metal concentrations or concentration ratios and biomarkers of glioma was observed due to limited sample size, indicating that heavy metals may be a consequence rather than a cause of pathological changes in brain tumors.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Oncology
Colin Thorbinson, John-Paul Kilday
Summary: Brain tumors are the leading cause of childhood cancer deaths in developed countries, representing the most common solid tumor in this age group, accounting for approximately one-quarter of all pediatric cancers. Developments in neuro-imaging, neurosurgical techniques, adjuvant therapy, and supportive care have improved survival rates for certain tumors, allowing a focus on optimizing cure while minimizing long-term adverse effects. Recent advancements in the molecular characterization of common pediatric brain tumors have identified unique clinical and biological patient subgroups, but achieving a paradigm shift in translational therapy and subsequent survival for many tumors remains challenging, with recurrence presenting a significant clinical challenge. This review provides insight into key molecular developments and global cooperative trial results for the most common malignant pediatric brain tumors, highlighting potential future directions for management, including novel therapeutic options and unresolved critical challenges.
Article
Oncology
Teresa T. Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K. Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F. Lang, Christopher Alvarez-Breckenridge, Filipa Godoy-Vitorino, Lisha Zhu, W. Jim Zheng, Lijie Zhai, Erik Ladomersky, Kristen L. Lauing, Marta M. Alonso, Derek A. Wainwright, Candelaria Gomez-Manzano, Juan Fueyo
Summary: This study evaluates the optimization of viroimmunotherapy by targeting specific mechanisms underlying the immunosuppressive tumor microenvironment. The results suggest that targeting these mechanisms can enhance the immune response against solid tumors and improve the outcomes of virotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Safwan Alomari, Irma Zhang, Adrian Hernandez, Caitlin Y. Kraft, Divyaansh Raj, Jayanidhi Kedda, Betty Tyler
Summary: Glioblastoma is a common malignant brain tumor with poor prognosis, and there is a need for effective therapeutics. Drug repurposing is a potential strategy, with some drugs showing efficacy against GBM cell lines. However, the blood-brain barrier may limit their effectiveness.
Article
Oncology
Giulia Raimondi, Sabrina Gea-Sorli, Marc Otero-Mateo, Cristina Fillat
Summary: Oncolytic adenoviruses are replication-competent viruses designed for cancer treatment, with miR-222 playing a crucial role as a limiting factor. Through genetic engineering of adenovirus with miR-222 sponges, the viral activity has been significantly improved.
Article
Medicine, Research & Experimental
Kittikun Viwatpinyo, Sujira Mukda, Sakan Warinhomhoun
Summary: This study demonstrates that MG induces cell death and cell cycle arrest, disrupts cell migration, and reduces the clonogenicity of brain tumor cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Zhaoqing Cong, Songsong Tang, Leiming Xie, Ming Yang, Yangyang Li, Dongdong Lu, Jiahong Li, Qingxin Yang, Qiwei Chen, Zhiqiang Zhang, Xueji Zhang, Song Wu
Summary: A unique robotic medical platform is designed using cell robots as carriers to selectively bind and kill tumors with oncolytic adenovirus. The cell robots are modified and coated to enable specific targeting and movement within the body, resulting in enhanced efficacy in tumor treatment.
ADVANCED MATERIALS
(2022)
Review
Cell Biology
Elizaveta Belyaeva, Rajesh Kumar Kharwar, Ilya Ulasov, Irina Karlina, Petr Timashev, Reza Mohammadinejad, Arbind Acharya
Summary: Autophagy is a crucial self-regulating mechanism in cells, allowing them to maintain homeostasis under conditions of stress or nutrient deprivation, and is also considered a form of cell death. Recent studies have identified autophagy as a potential mechanism in the treatment of malignant glioma, however, the molecular mechanisms involving autophagy-related proteins require further investigation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Oncology
Daria Fayzullina, Rajesh Kumar Kharwar, Arbind Acharya, Anton Buzdin, Nicolas Borisov, Peter Timashev, Ilya Ulasov, Byron Kapomba
Summary: Azvudine (FNC) is a novel drug with both antiviral and anticancer properties. It inhibits the RNA-dependent polymerase enzymes of positive-stand RNA viruses, retroviruses, and human retrotransposons, thereby suppressing viral life cycle and cancer cell growth. It also inhibits adhesion, migration, invasion, and proliferation of malignant cells and has the potential to enhance the efficacy of multiple anticancer therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Daria Fayzullina, Sergey Tsibulnikov, Mikhail Stempen, Brett A. Schroeder, Naveen Kumar, Rajesh Kumar Kharwar, Arbind Acharya, Peter Timashev, Ilya Ulasov
Summary: Ewing sarcoma is a rare malignant bone tumor with a high recurrence rate. This study identifies new therapeutic targets, particularly the EWSR1/FLI1 fusion protein, and proposes experimental therapy targeting multiple signaling pathways for improved patient survival.
Review
Oncology
Irina Karlina, Brett A. Schroeder, Kirill Kirgizov, Olga Romantsova, Andrey L. Istranov, Andrey Nedorubov, Peter Timashev, Ilya Ulasov
Summary: Ewing's sarcoma is a common aggressive tumor that mainly affects adolescents. Current standard treatment includes surgery and systemic therapy, but patients often develop drug resistance. Recent research has identified unique characteristics in the tumorigenesis of Ewing's sarcoma, offering potential for targeted therapy.
JOURNAL OF BONE ONCOLOGY
(2022)
Review
Oncology
Elena Popova, Sergey Tkachev, Igor Reshetov, Peter Timashev, Ilya Ulasov
Summary: Sarcomas are the largest group of rare solid tumors and are a leading cause of cancer death in individuals younger than 20 years old. There are over 100 morphological subtypes of sarcomas with various epidemiology, clinical features, management, and prognosis. Therefore, the development of an algorithm for early and accurate diagnosis of sarcomas is crucial.
Article
Oncology
Munendra Singh Tomar, Rishi Kant Singh, Ilya Ulasov, Kaushalendra, Arbind Acharya
Summary: Natural killer (NK) cells play a crucial role in anti-tumor activities, and their function is regulated by CD4(+)CD25(+) regulatory T (Treg) cells through the NKG2D receptor. It is unclear whether Treg cells also affect other receptors of NK cells, and the effect of CYP treatment on the expression and functions of AR and IR receptors of NK cells is not well understood.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Semyon Yakushov, Maxim Menyailo, Evgeny Denisov, Irina Karlina, Viktoria Zainullina, Kirill Kirgizov, Olga Romantsova, Peter Timashev, Ilya Ulasov
Summary: This study identified potential biomarkers of doxorubicin resistance in Ewing sarcoma cells using single-cell transcriptomic and proteomic analyses. The identified biomarkers, MGST1 and COL6A2, were found to have clinical significance for the survival of patients with Ewing sarcoma.
Review
Medicine, Research & Experimental
Elizaveta Belyaeva, Nina Loginova, Brett A. Schroeder, Ian S. Goldlust, Arbind Acharya, Sandeep Kumar, Peter Timashev, Ilya Ulasov
Summary: The balance between cell death and cell survival involves the breakdown and removal of unnecessary or harmful materials in a controlled manner. Autophagy, initiated by various stresses, is a well-regulated process with specific genes and proteins. Targeting autophagy shows promise as an anti-tumor therapy, but its effects on different tumor cells remain unclear. This review investigates autophagy as a potential therapeutic target for aggressive sarcomas.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Sergey Tsibulnikov, Daria Fayzullina, Irina Karlina, Brett A. A. Schroeder, Olga Karpova, Peter Timashev, Ilya Ulasov
Summary: Ewing sarcoma is an aggressive malignancy characterized by specific chromosomal translocations that result in fusion genes. These fusion genes and their protein products hold promise as targets for gene therapy. In this review, we discuss the active molecules and delivery methods utilized in gene therapy, both of which are essential for effective treatment.
CANCER GENE THERAPY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Kamilla Kantserova, Ilya Ulasov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Andrey L. L. Istranov, Ivan G. G. Makarov, Natalya V. V. Makarova, Inna Tulina, Ilya V. V. Ulasov, Yuliya I. I. Isakova
Summary: This paper demonstrates the efficacy of a combination of conservative and surgical methods in the treatment of giant lymphedema of the scrotum using a case of a patient with severe genital lymphedema. The patient's body weight decreased by 69.4 kg and the scrotum decreased by 63 cm after the combination of conservative and surgical treatment, leading to full recovery of sexual function.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Darya Fayzullina, Semyon Yakushov, Kamilla Kantserova, Elizaveta Belyaeva, Denis Aniskin, Sergey Tsibulnikov, Nafisa Fayzullina, Stanislav Kalinin, Olga Romantsova, Peter S. Timashev, Brett A. Schroeder, Ilya V. Ulasov
Summary: This study discovered that carbonic anhydrase II (CAII) inhibitors can inhibit the growth and invasion of Ewing sarcoma (ES) cells through multiple mechanisms, trigger cell death, and have potential therapeutic effects. The results suggest that cytosolic CAII may be a promising target for ES treatment, and CAII inhibitors can be considered as potential single-agent or combination antitumor agents in the treatment of ES.
Review
Biochemistry & Molecular Biology
Ilya Ulasov, Anton Borovjagin, Anastasia Laevskaya, Margarita Kamynina, Peter Timashev, Laura Cerchia, Elena A. Rozhkova
Summary: This article discusses the potential of nanoscale materials in the diagnosis and treatment of brain cancer, and summarizes the evidence for the use of IL-13R alpha 2 receptor in the early diagnosis and experimental therapy of glioblastoma.
Review
Medicine, Research & Experimental
Ilya Ulasov, Vaishali Singh, Anastasia Laevskaya, Peter Timashev, Rajesh Kumar Kharwar
Summary: Glioblastoma multiforme is a highly inflammatory brain tumor, and its tumor microenvironment consists of various tumor cells, immune cells, and extracellular matrix. Cytokines, as important communicators in the tumor microenvironment, have both pro-inflammatory and anti-inflammatory effects, playing crucial roles in glioblastoma communication with the microenvironment.
DISCOVERY MEDICINE
(2023)
Meeting Abstract
Oncology
Semyon Yakushov, Irina Karlina, Maxim Menyailo, Viktoria Zainullina, Evgeny Denisov, Ilya Ulasov
PEDIATRIC BLOOD & CANCER
(2022)
