Article
Chemistry, Multidisciplinary
Nirmalya Pradhan, Nasim Akhtar, Barnali Nath, Jorge Pena-Garcia, Anjali Gupta, Horacio Perez-Sanchez, Sachin Kumar, Debasis Manna
Summary: Quinine derivatives effectively inhibit the activity of IDO1 by competing with heme, providing a potential avenue for immunotherapy-based drug discovery strategies.
CHEMICAL COMMUNICATIONS
(2021)
Review
Oncology
Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang
Summary: IDO1, a heme-containing enzyme, plays a crucial role in the kynurenine pathway of tryptophan metabolism, with implications in immunity and neuronal function. Despite potential applications in cancer and neurodegenerative diseases, cautionary notes from clinical trials indicate a need for better understanding of IDO1 inhibition mechanisms.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ruta Zulpaite, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Solid organ transplantation faces challenges such as organ shortage, extended criteria donor organs, and immune regulation issues with a lack of accurate biomarkers for predicting dysfunction and rejection. Tryptophan and its metabolites are of interest in this field, offering therapeutic and prognostic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Review
Chemistry, Medicinal
Rahul Singh, Deepak B. Salunke
Summary: IDO1 enzyme catalyzes the initial step of kynurenine pathway and is implicated in immune modulation, antioxidation, and cancer progression. Overexpression of IDO1 plays a pivotal role in immune evasion and cancer development. Research and development of IDO1 inhibitors holds significant potential in immunotherapy and disease treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Ana Dolsak, Stanislav Gobec, Matej Sova
Summary: This review discusses the key step of tryptophan metabolism and the importance of relevant enzymes in pathological conditions. In recent years, many inhibitors targeting these enzymes have been developed, and these inhibitors have entered clinical trials.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Engineering, Biomedical
Yixuan Guo, Yu Liu, Wei Wu, Daishun Ling, Qiao Zhang, Peng Zhao, Xi Hu
Summary: This article will discuss different types of IDO inhibitors and relevant clinical trials, especially feasible combined therapeutic modalities. In addition, it will also review cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities to effectively enhance the effectiveness of cancer therapy. Finally, the prospects of IDO inhibitors in clinical application and potential breakthroughs will be briefly discussed.
Article
Oncology
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphael Frederick, Etienne De Plaen, Christine Sers, Christiane A. Opitz, Benoit J. van den Eynde, Jingjing Zhu
Summary: This study aimed to clarify the link between IDO1/TDO expression, AHR pathway activation, and immune suppression. The results showed that tryptophan deprivation sensitizes the AHR pathway, leading to increased Treg differentiation and immune suppression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Microbiology
Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jessica Araujo da Paixao de Oliveira, Larissa Cristina Teixeira Tome, Victor Edgar Fiestas-Solorzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sanchez-Arcila, Iury Amancio Paiva, Luis Jose de Souza, Paulo Vieira Damasco, Valber da Silva Frutuoso, Manoela Heringer, Luzia Maria De Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo
Summary: This study evaluated the activity of IDO-1 and the patterns of cytokines/chemokines in CHIKV patients. It was found that IDO-1 activity increased during the early acute phase of infection and decreased in the chronic phase. In the acute phase, concentrations of TNF-alpha, IL-6, IFN-gamma, CCL2/MCP-1, and CXCL10/IP-10 were increased. In the chronic phase, concentrations of CCL4/MIP-1 beta were increased, especially in patients with arthritis.
Article
Chemistry, Medicinal
Kai Tang, Bo Wang, Bin Yu, Hong-Min Liu
Summary: Indoleamine 2,3-dioxygenase 1 (IDO1) is an important immunosuppressive enzyme in cancer therapy. Multiple IDO1 inhibitors have entered clinical trials, and PROTAC-based degraders also show promise for cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Daojing Yan, Jiakun Xu, Xiang Wang, Jiaxing Zhang, Gang Zhao, Yingwu Lin, Xiangshi Tan
Summary: This study systematically investigated the SAR405838 analogs as potential IDO inhibitors for cancer immunotherapy. The results showed that inhibitor 3 exhibited the highest IDO1 inhibitory activity among all inhibitors and demonstrated effective inhibition in MCF-7 cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Arina Kozlova, Leopold Thabault, Maxime Liberelle, Simon Klaessens, Julien R. C. Prevost, Caroline Mathieu, Luc Pilotte, Vincent Stroobant, Benoit Van den Eynde, Raphael Frederick
Summary: In this study, a new scaffold of TDO2 inhibitors, 6-(1H-indol-3-yl)-benzotriazole, was developed through rational design, leading to the synthesis of stable compounds with nanomolar cellular potency. The rigidification of the initial scaffold provided a better understanding of the structural modulations inside the active site of hTDO2.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Carolina Manganeli Polonio, Carla Longo de Freitas, Marilia Garcia de Oliveira, Cristiano Rossato, Wesley Nogueira Brandao, Nagela Ghabdan Zanluqui, Lilian Gomes de Oliveira, Luiza Ayumi Nishiyama Mimura, Maysa Braga Barros Silva, Vera Lucia Garcia Calich, Marcelo Gil Nisenbaum, Silvio Halpern, Lucila Evangelista, Mariangela Maluf, Paulo Perin, Carlos Eduardo Czeresnia, Jean Pierre Schatzmann Peron
Summary: The research demonstrates the suppressive activity of murine endometrial-derived MSCs on EAE by modulating Th1, Th17 lymphocytes, and IL-10-secreting T CD4(+) cells. The mechanism relies on the IDO-kynurenines-Aryl hydrocarbon receptor (AhR) axis.
Review
Physiology
Corina Bello, Paul Philipp Heinisch, Maks Mihalj, Thierry Carrel, Markus M. Luedi
Summary: IDO is a rate-limiting enzyme in the tryptophan catabolism pathway, playing a crucial role in immune modulation and the pathogenesis of various diseases. Its involvement has been extensively studied in autoimmune processes and highly malignant cancers, with potential as a predictive biomarker and therapeutic target in immune-mediated diseases. Additionally, IDO shows promise as a biomarker in the pre-operative setting for decision-making and treatment of surgical patients experiencing trauma-induced stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Medicinal
Ke Wang, Long-Hao Song, Qiao-Ling Liang, Ye Zhang, Xian-Li Ma, Qi Wang, Hui-Yong Zhang, Cai-Na Jiang, Jian-Hua Wei, Ri-Zhen Huang
Summary: A series of chromone-oxime derivatives containing piperazine sulfonamide moieties were synthesized and evaluated as IDO1 inhibitors. Compound 10m exhibited good inhibitory activity against IDO1. It was found that 10m directly interacted with IDO1 and formed key interactions. These chromone-oxime derivatives containing sulfonamide moieties might be potential IDO1 inhibitors for the development of new antitumor agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Xiaoyu He, Qiaohong Lai, Cai Chen, Na Li, Fei Sun, Wenting Huang, Shu Zhang, Qilin Yu, Ping Yang, Fei Xiong, Zhishui Chen, Quan Gong, Boxu Ren, Jianping Weng, Decio L. Eizirik, Zhiguang Zhou, Cong-Yi Wang
Review
Biochemistry & Molecular Biology
Jing Zhang, Longmin Chen, Fei Xiong, Shu Zhang, Kun Huang, Ziyun Zhang, Cong-Yi Wang
MOLECULAR IMMUNOLOGY
(2019)
Review
Cell Biology
Na Li, Furong Liu, Ping Yang, Fei Xiong, Qilin Yu, Jinxiu Li, Zhiguang Zhou, Shu Zhang, Cong-Yi Wang
Article
Cell Biology
Faxi Wang, Fei Sun, Jiahui Luo, Tiantian Yue, Longmin Chen, Haifeng Zhou, Jing Zhang, Chunliang Yang, Xi Luo, Qing Zhou, He Zhu, Jinxiu Li, Ping Yang, Fei Xiong, Qilin Yu, Huilan Zhang, Wanguang Zhang, Aimin Xu, Zhiguang Zhou, Qianjin Lu, Decio L. Eizirik, Shu Zhang, Cong-Yi Wang
CELL DEATH & DISEASE
(2019)
Article
Cell Biology
Lei Zhang, Yi Wang, Guorao Wu, Lizong Rao, Yanqiu Wei, Huihui Yue, Ting Yuan, Ping Yang, Fei Xiong, Shu Zhang, Qing Zhou, Zhishui Chen, Jinxiu Li, Bi-Wen Mo, Huilan Zhang, Weining Xiong, Cong-Yi Wang
CELL PROLIFERATION
(2020)
Article
Endocrinology & Metabolism
Jing Zhang, Longmin Chen, Faxi Wang, Yuan Zou, Jingyi Li, Jiahui Luo, Faheem Khan, Fei Sun, Yang Li, Jing Liu, Zhishui Chen, Shu Zhang, Fei Xiong, Qilin Yu, Jinxiu Li, Kun Huang, Bao-Ling Adam, Zhiguang Zhou, Decio L. Eizirik, Ping Yang, Cong-Yi Wang
Letter
Medicine, General & Internal
Huilan Zhang, Peng Zhou, Yanqiu Wei, Huihui Yue, Yi Wang, Ming Hu, Shu Zhang, Tanze Cao, Chengqing Yang, Ming Li, Guangyun Guo, Xianxiang Chen, Ying Chen, Mei Lei, Huiguo Liu, Jianping Zhao, Peng Peng, Cong-Yi Wang, Ronghui Du
ANNALS OF INTERNAL MEDICINE
(2020)
Review
Immunology
Fei Sun, Jia-Hui Luo, Tian-Tian Yue, Fa-Xi Wang, Chun-Liang Yang, Shu Zhang, Xin-Qiang Wang, Cong-Yi Wang
Summary: Hydrogen sulphide (H2S) is a recently identified gaseous mediator with important roles in neuronal activity and immune regulation, affecting macrophage function through modulation of inflammatory pathways and promotion of mitochondrial biogenesis.
Article
Cell Biology
Chun-Liang Yang, Fei Sun, Fa-Xi Wang, Shan-Jie Rong, Tian-Tian Yue, Jia-Hui Luo, Qing Zhou, Cong-Yi Wang, Shi-Wei Liu
Summary: Type 1 diabetes is an autoimmune disease with viral infections playing a critical role in its initiation. Interferon regulatory factors have a significant impact on T1D pathogenesis.
CELLULAR IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Shan Jie Rong, Chun Liang Yang, Fa Xi Wang, Fei Sun, Jia Hui Luo, Tian Tian Yue, Ping Yang, Qilin Yu, Shu Zhang, Cong-Yi Wang
Summary: Macrophages play important roles in immune response, tissue homeostasis, and disease development. FoxO1, a member of the forkhead box transcription factor family, regulates macrophage functions including phagocytosis, migration, differentiation, and inflammatory activation. Macrophages also reciprocally modulate FoxO1 activity through post-translational modifications.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Fei Sun, Chun-Liang Yang, Fa-Xi Wang, Shan-Jie Rong, Jia-Hui Luo, Wan-Ying Lu, Tian-Tian Yue, Cong-Yi Wang, Shi-Wei Liu
Summary: Type 1 diabetes (T1D) is a chronic autoimmune disorder caused by a breakdown of self-tolerance and unrestrained immune response against beta cells. Pancreatic draining lymph nodes (PLNs) play a crucial role in amplifying the immune response and affecting T1D progression. Intervention strategies for T1D should focus on cutting off harmful signals, modulating immune activation in PLNs, and blocking the detrimental effects of PLNs on pancreatic islets.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Leike Zhang, Xuefang Peng, Qingxing Wang, Jin Li, Shouming Lv, Shuo Han, Lingyu Zhang, Heng Ding, Cong-Yi Wang, Gengfu Xiao, Xuguang Du, Ke Peng, Hao Li, Wei Liu
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne bunyavirus with a high fatality rate. C-C motif chemokine receptor 2 (CCR2) was identified as the host receptor for SFTSV, and its knockout reduced viral binding and infection. CCR2 enhanced SFTSV binding through direct binding to SFTSV glycoprotein N (Gn), and individuals with higher CCR2 surface expression showed stronger SFTSV binding and replication. CCR2 is a potential target for developing anti-SFTSV therapeutics.
Meeting Abstract
Immunology
C. -Y. Wang
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Lei Zhang, Yi Wang, Nuruliarizki Shinta Pandupuspitasari, Guorao Wu, Xudong Xiang, Quan Gong, Weining Xiong, Cong-Yi Wang, Ping Yang, Boxu Ren
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)
Review
Respiratory System
Lei Zhang, Yi Wang, Guorao Wu, Weining Xiong, Weikuan Gu, Cong-Yi Wang
RESPIRATORY RESEARCH
(2018)