Review
Gastroenterology & Hepatology
Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh
Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Neurosciences
Na-Na Yang, Chun-Xia Tan, Lu-Lu Lin, Xin-Tong Su, Yue-Jie Li, Ling-Yu Qi, Yu Wang, Jing-Wen Yang, Cun-Zhi Liu
Summary: This article summarizes the potential mechanisms of acupuncture in the treatment of functional dyspepsia and provides guidance for future laboratory and clinical studies. Acupuncture has been proven to be a promising treatment for alleviating symptoms in patients with functional dyspepsia, and its mechanisms include controlling intestinal inflammation and acid secretion through autonomic reflex pathways, regulating the brain-gut axis through the intestinal microbiota, and potentially improving FD symptoms.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Obstetrics & Gynecology
Justin S. Brandt, Cande V. Ananth
Summary: Placental abruption is the premature separation of the placenta from the uterus before delivery, often causing vaginal bleeding and abdominal pain. This condition can be challenging when there is severe bleeding, necessitating urgent delivery due to concerns for maternal and fetal compromise. Abruption occurs in a small percentage of pregnancies, with a higher occurrence at term gestations. This review explores the pathophysiology, epidemiology, diagnosis, and management of abruption, providing guidance for optimal care during this critical period of gestation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Nutrition & Dietetics
Kerith Duncanson, Grace Burns, Jennifer Pryor, Simon Keely, Nicholas J. Talley
Summary: Functional dyspepsia is a common disorder characterized by upper gastrointestinal symptoms. Diet plays a role in symptom induction, and managing specific macronutrients or trigger foods can help alleviate symptoms. Emerging research suggests a focus on gastrointestinal microbiota may lead to more effective dietetic management strategies.
Review
Cardiac & Cardiovascular Systems
Serdar Farhan, Jeffrey J. Silbiger, Jonathan L. Halperin, Lily Zhang, Srinivas R. Dukkipati, Birgit Vogel, Annapoorna Kini, Samin Sharma, Stamatios Lerakis
Summary: The conventional view suggests that functional mitral regurgitation (MR) is caused by displacement of the papillary muscle-bearing segments of the left ventricle, but recent evidence shows that left atrial enlargement can also be a cause of functional MR.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Oncology
Meinolf Suttorp, Frederic Millot, Stephanie Sembill, Helene Deutsch, Markus Metzler
Summary: This article aims to provide a unified approach for the differential diagnosis, pathological features, and treatment methods of pediatric chronic myeloid leukemia. By detailing the biological characteristics and complications of patients, a clear understanding is crucial for accurate diagnosis and management of this rare disease.
Review
Endocrinology & Metabolism
Jin Joo Park
Summary: Diabetes increases the risk of cardiovascular disease by affecting vascular homeostasis and myocardial function. Prognosis is worse in heart failure patients with diabetes compared to those without diabetes.
DIABETES & METABOLISM JOURNAL
(2021)
Review
Hematology
Benjamin Garmezy, Jordan K. Schaefer, Jessica Mercer, Moshe Talpaz
Summary: Treatment options for primary myelofibrosis are limited, but diagnosis can often be established through appropriate clinical history, examination, laboratory evaluation, and bone marrow biopsy. Recent studies have characterized prognostic factors and driver mutations better, leading to the development of treatment strategies based on risk factors and clinical phenotype.
Review
Microbiology
Georgios Tziatzios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J. J. Giamarellos-Bourboulis, Konstantinos Triantafyllou
Summary: Functional dyspepsia (FD) is a common disorder with no definitive, universal treatment. Probiotics have been suggested as a potential therapeutic option for FD due to their effects on gastrointestinal symptoms in patients with Irritable Bowel Syndrome (IBS). However, the evidence for the efficacy of probiotics in FD remains unclear. This review aims to summarize the available evidence for the use of probiotics in FD.
Article
Medicine, General & Internal
Nan Hu, Kun Wang, Li Zhang, Zuo-Jing Liu, Zhu Jin, Rong-Li Cui, He-Jun Zhang, Zhong-Hu He, Yang Ke, Li-Ping Duan
Summary: This study investigated the epidemiological and clinical features of functional dyspepsia (FD) and organic dyspepsia (OD) in a population with a high prevalence of esophageal squamous cell carcinoma (ESCC). The prevalence of FD was found to be 5.11%, with FD cases mainly presenting as postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS), while OD cases were associated with reflux esophagitis, ESCC, and duodenal ulcer.
CHINESE MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Marta Cano-Castellote, Diego Fernando Afanador-Restrepo, Jhonatan Gonzalez-Santamaria, Carlos Rodriguez-Lopez, Yolanda Castellote-Caballero, Fidel Hita-Contreras, Maria Del Carmen Carcelen-Fraile, Agustin Aibar-Almazan
Summary: Spontaneous coronary artery dissection (SCAD) is a rare cause of nonobstructive ischemic heart disease in previously healthy young women, with a clear gender and age bias. Diagnosis methods include detailed medical history, electrocardiogram, and coronary angiography. Treatment options should be individualized and can involve conservative medical treatment or invasive procedures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ilpo T. Huhtaniemi, Frederick C. W. Wu
Summary: This narrative review provides an overview of the pathogenesis and diagnosis of the decline in testosterone levels in men associated with aging. The condition, commonly referred to as late-onset hypogonadism (LOH), is more appropriately termed functional hypogonadism (FH) as it is often caused by factors other than chronological aging, such as obesity and other comorbidities. Unlike classical organic hypogonadism, FH does not involve anatomical or genetic abnormalities and the suppression of testosterone is milder. Furthermore, FH can be reversible if the underlying cause, such as obesity or chronic disease, is treated. The diagnosis of FH is based on low serum total testosterone levels and specific hypogonadism-associated symptoms, primarily sexual symptoms. When testosterone concentrations are borderline, the accuracy of diagnosis can be improved by assessing free or calculated free testosterone, especially when sex hormone-binding globulin levels are likely suppressed due to obesity. Current data indicate that FH, characterized by low testosterone levels and sexual symptoms, is not a common condition and is present in approximately 2% of community-dwelling men aged 40 to 80 years.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Sung Ill Jang, Tae Hoon Lee, Seok Jeong, Chang-Il Kwon, Dong Hee Koh, Yoon Jae Kim, Hye Sun Lee, Min-Young Do, Jae Hee Cho, Dong Ki Lee
Summary: This study investigated the treatment effects of litholytic agents on refractory functional dyspepsia (RFD) patients. It was found that chenodeoxycholic and ursodeoxycholic acids improved the symptoms of RFD patients. This is a good treatment option for RFD patients with biliary dyspepsia secondary to biliary microlithiasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Christopher J. Black, Peter A. Paine, Anurag Agrawal, Imran Aziz, Maria P. Eugenicos, Lesley A. Houghton, Pali Hungin, Ross Overshott, Dipesh H. Vasant, Sheryl Rudd, Richard C. Winning, Maura Corsetti, Alexander C. Ford
Summary: This research aims to review and summarize the current evidence on functional dyspepsia, provide a practical framework for evidence-based diagnosis and treatment of patients, and provide specific recommendations based on the GRADE system. The study also considers the development of novel treatment methods and highlights areas of unmet need and priorities for future research.
Article
Gastroenterology & Hepatology
Xin Shi, Hui Luo, Xiangping Wang, Gui Ren, Linhui Zhang, Qin Tao, Shuhui Liang, Na Liu, Xiaojun Huang, Xiaoyin Zhang, Hui Deng, Wei Qin, Xiaoyu Kang, Yanglin Pan, Daiming Fan
Summary: This study reveals the correlation between the newly developed Functional Dyspepsia Symptom Diary (FDSD) and other functional dyspepsia-related questionnaires. FDSD ≥ 20 and HAMD ≥ 13 are independently associated with severe functional dyspepsia reported by patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Liuying Chen, Huikuan Chu, Lilin Hu, Zhonglin Li, Ling Yang, Xiaohua Hou
Summary: This study reveals that alcohol consumption can lead to intestinal barrier injury. NOX1, a protein, plays a role in accumulating reactive oxygen species (ROS) and causing cell apoptosis in intestinal epithelial cells. Propionate, an endogenous inhibitor of HDAC2, can alleviate oxidative stress injury and reduce cell apoptosis in the intestines.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Da Hyun Jung, Ji Hyun Youn, Bo Mi Moon, Ji Hye Lee, Hyun-Seung Ryu, Joon Sung Kim, Hyuk Lee, Gwang Ha Kim, Jun Chul Park
Summary: This study explored the hemostatic effects and mechanisms of two hemostatic powders in a porcine upper gastrointestinal hemorrhage model, demonstrating their ability to improve initial hemostasis effectively, with additional ulcer-healing effects from EGF.
Article
Gastroenterology & Hepatology
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
Summary: Abdominal obesity is associated with an increased risk of developing Crohn's disease, but not ulcerative colitis, according to a population-based cohort study in Korea.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Microbiology
Bangzhou Zhang, Luxi Yang, Hanbing Ning, Man Cao, Zhangran Chen, Qiongyun Chen, Guanghui Lian, Hailing Tang, Qizhi Wang, Junping Wang, Zhihui Lin, Jianbo Wen, Yuedong Liu, Ji Xuan, Xuejun Li, Aiqiang Lin, Jianquan He, Lei Zhang, Xiaohua Hou, Qiang Zeng, Chuanxing Xiao
Summary: FMT, a treatment method for UC targeting gut microbiota, has shown varying effectiveness in clinical trials. Donor selection might be a contributing factor to this variability, as a patient's response to FMT could depend on the ability of the used donor's microbiota to restore the specific gut disturbances of the patient. This study developed a donor-recipient matching model to guide donor selection for UC in FMT, based on analysis of fecal bacterial diversity and composition.
MICROBIOLOGY SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
Da Hyun Jung, Chan Hyuk Park, Soo In Choi, Hye Rim Kim, Myeongjee Lee, Hee Seok Moon, Jun Chul Park
Summary: This study demonstrates that polysaccharide hemostatic powder (PHP) is an effective initial treatment for peptic ulcer bleeding (PUB) and is not inferior to conventional treatments. Further research is needed to confirm the re-bleeding rate of PHP.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
G. Pennisi, M. Enea, V. Falco, G. P. Aithal, N. Palaniyappan, Y. Yilmaz, J. Boursier, C. Cassinotto, V. De Ledinghen, W. K. Chan, S. Mahadeva, P. Eddowes, P. Newsome, T. Karlas, J. Wiegand, V. Wai-Sun Wong, J. M. Schattenberg, C. Labenz, W. Kim, M. S. Lee, M. Lupsor-Platon, J. F. L. Cobbold, J. Fan, F. Shen, K. Staufer, M. Trauner, R. Stauber, A. Nakajima, M. Yoneda, E. Bugianesi, R. Younes, S. Gaia, M. Zheng, C. Camma, Q. M. Anstee, F. E. Mozes, M. Pavlides, S. Petta
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Kee Huat Chuah, Wen Xuan Hian, Aik Tatt Teoh, Justin Kwan Yeu Ling, Sanjiv Mahadeva
Summary: This study investigated the outcome of routine treatment for disorders of gut-brain interaction (DGBI) in secondary care. It found that after 2 years of treatment, 66.1% of patients reported symptom improvement. Reassurance was associated with better symptom improvement, while patients with an overlap syndrome had a poorer outcome, leading to more healthcare consultations and work absenteeism.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Orthopedics
C. W. Jang, M. Bang, J. H. Park, H. E. Cho
Summary: This study aims to summarize changes in recommendations for injection treatments for knee osteoarthritis (OA) in clinical practice guidelines (CPGs) and assess their impact on public interest. The findings show that while CPGs have shifted their recommendations, public interest and YouTube videos have not responded accordingly.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Surgery
So Young Han, Hong Jin Yoon, Jie-Hyun Kim, Hye Sun Lee, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
Summary: By analyzing the characteristics of patients with early gastric cancer who underwent ESD, we developed a nomogram to predict the risk of non-CR. This nomogram includes endoscopic features, radiologic findings, and pathology results, and it showed good predictive performance in the external validation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Neurosciences
Hoo Young Lee, Suk-Young Song, Jihye Hwang, Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jung Hyun Park, Sungchul Choi, Soonil Pyo, Sung-Rae Cho
Summary: Appropriate early rehabilitation is important for stroke patients, but the best strategy is currently unclear. This study investigates the effects of early exposure to environmental enrichment on stroke rehabilitation and identifies the mechanisms by which it improves outcomes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Ferenc E. Mozes, Jenny A. Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E. Stauber, Adriaan G. Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jerome Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupsor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbold, Thomas Karlas, Johannes Wiegand, Giada Sebastiani, Emmanuel Tsochatzis, Antonio Liguori, Masato Yoneda, Atsushi Nakajima, Hannes Hagstrom, Camilla Akbari, Masashi Hirooka, Wah-Kheong Chan, Sanjiv Mahadeva, Ruveena Rajaram, Ming-Hua Zheng, Jacob George, Mohammed Eslam, Salvatore Petta, Grazia Pennisi, Mauro Vigano, Sofia Ridolfo, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Dae Ho Lee, Mattias Ekstedt, Patrik Nasr, Christophe Cassinotto, Victor de Ledinghen, Annalisa Berzigotti, Yuly P. Mendoza, Mazen Noureddin, Emily Truong, Celine Fournier-Poizat, Andreas Geier, Miljen Martic, Theresa Tuthill, Quentin M. Anstee, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Non-invasive tests show comparable prognostic performance to histologically assessed fibrosis in predicting clinical outcomes in NAFLD patients, suggesting they could be considered as alternatives to liver biopsy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Clinical Neurology
Ai Huey Tan, Kee Huat Chuah, Yuan Ye Beh, Jie Ping Schee, Sanjiv Mahadeva, Shen-Yang Lim
Summary: Patients with Parkinson's disease often experience gastrointestinal symptoms like nausea, bloating, reduced bowel movements, and difficulties with defecation. These symptoms are common but difficult to manage, and objective testing does not always match up with symptoms. Treatment options are limited and evidence is scarce. Upper GI dysfunction can also complicate the pharmacological treatment of motor symptoms in PD. This review discusses the recognition, diagnosis, and management of common GI problems in PD, as well as potential future research.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Editorial Material
Gastroenterology & Hepatology
Sanjiv Mahadeva
Article
Gastroenterology & Hepatology
Hai Tao Shang, Zhen Ouyang, Can Chen, Chao Fan Duan, Tao Bai, Xiao Hua Hou
Summary: The aim of this study was to determine the prevalence and risk factors, particularly lifestyle factors, of belching disorders among freshman college students in central China. The study found that coffee consumption and stress were independent risk factors for belching disorders, while intake of whole grains was a protective factor. Therefore, dietary intervention may be a potential management for belching disorders.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Ao Liu, Yongqiang Zheng, Pengcheng Yang, Huikuan Chu, Xiaohua Hou
Summary: The average age of first primary colorectal cancer (CRC) diagnosis in the USA has decreased significantly from 1992 to 2017, with a more pronounced decline after 2000. Proximal CRC cases have a higher age at diagnosis compared to distal CRC cases. Advanced stage CRC patients have a lower age at diagnosis than early stage patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)