Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Paul Geertsema, Hanneke C. Rijkmans, Michiel D. Voskuil, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Behrooz Z. Alizadeh, Gerard Dijkstra
Summary: This study identified 16 environmental factors associated with biological use and surgery in established IBD patients, providing important insights for further research on biological pathways, risk stratification, personalized interventions, and preventive strategies in IBD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sophie Vieujean, Benedicte Caron, Vincent Haghnejad, Jean-Yves Jouzeau, Patrick Netter, Anne-Charlotte Heba, Ndeye Coumba Ndiaye, David Moulin, Guillermo Barreto, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, influenced by both genetic predisposition and environmental factors. Epigenetics, including DNA methylation, histone modifications, and non-coding RNAs, can explain how the exposome affects gene expression to contribute to intestinal inflammation. This study identified various environmental factors, such as maternal lifestyle, breastfeeding, microbiota, diet, smoking habits, vitamin D, and drugs, that epigenetically influence the occurrence of IBD. However, the role of exposome-induced epigenetic modifications in IBD is still understudied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hannah Gordon, William Blad, Frederik Trier Moller, Timothy Orchard, Alan Steel, Gareth Trevelyan, Siew Ng, Marcus Harbord
Summary: The study explores the heritability of IBD using twin pairs and identifies associations with environmental factors such as smoking, breastfeeding, and occurrence of gastroenteritis. While smoking is predictive of CD, breastfeeding is protective against UC, and less occurrences of gastroenteritis are protective against future UC onset. Delivery method, parental hygiene attitudes, and diet recall do not impact future IBD concordance.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Pediatrics
Mohammed Hasosah, Wafaa Alhashmi, Renad Abualsaud, Anas Alamoudi, Afnan Aljawad, Mariam Tunkar, Nooran Felemban, Ahmed Basalim, Muhammad Khan, Aziz Alanazi, Ali Almehaidib
Summary: This study investigates environmental risk factors for inflammatory bowel disease (IBD) in the Saudi population. The results suggest that vaginal delivery, age above 10 years, deficient fruit intake, low physical activity, exposure to antibiotics, appendectomy, and frequent gastroenteritis admissions are associated with an increased risk of IBD.
Review
Public, Environmental & Occupational Health
Xuejie Chen, Sidan Wang, Xueyi Mao, Xin Xiang, Shuyu Ye, Jie Chen, Angran Zhu, Yifei Meng, Xiya Yang, Shuyu Peng, Minzi Deng, Xiaoyan Wang
Summary: In recent years, the prevalence of inflammatory bowel disease (IBD) has increased, especially in urban areas, due to improved living standards. The concept of emerging environmental contaminants, which refers to synthetic chemicals that were previously unnoticed or researched, is closely related to the development of industrialization and modernization, and is known to contribute to chronic diseases including IBD. These emerging contaminants include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, and persisting organic pollutants. This review summarizes the adverse health effects of these contaminants on humans and their association with IBD, aiming to enhance understanding of their impact, reduce exposure, and lower the future incidence of IBD.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Giulia Caioni, Angelo Viscido, Michele d'Angelo, Gloria Panella, Vanessa Castelli, Carmine Merola, Giuseppe Frieri, Giovanni Latella, Annamaria Cimini, Elisabetta Benedetti
Summary: The pathophysiological processes of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, are not fully understood, but dysregulation of the gut immune system leading to overproduction of pro-inflammatory cytokines is a key factor. Both environmental and genetic factors are involved, with the microbiota playing a crucial role. PPARγ modulates interactions with environmental factors, and its impaired expression may represent a critical step in IBD pathogenesis, particularly in ulcerative colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mielle Michaux, Justin M. Chan, Luke Bergmann, Luis F. Chaves, Brian Klinkenberg, Kevan Jacobson
Summary: Geographical clusters of pediatric inflammatory bowel disease (PIBD) were identified in British Columbia, Canada. The study found associations between PIBD incidence and ethnicity and environmental factors. The study also identified novel risk factors, such as fine particulate matter pollution and agricultural petroleum oil.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Konrad Lewandowski, Magdalena Kaniewska, Martyna Wiecek, Paulina Szwarc, Paulina Panufnik, Edyta Tulewicz-Marti, Magdalena Walicka, Edward Franek, Grazyna Rydzewska
Summary: This study assessed the frequency and risk factors of osteoporosis (OST) among patients with inflammatory bowel disease (IBD) compared to a group without IBD. It found that 7.3% of IBD patients suffered from OST. Factors such as male gender, ulcerative colitis, rare physical activity, past fractures, and abnormal levels of certain biomarkers were identified as risk factors for OST in IBD patients. The study highlights the importance of regular physical activity and the use of biomarkers in diagnosing and managing OST in IBD patients.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Dziabowska-Grabias, Malgorzata Sztanke, Przemyslaw Zajac, Michal Celejewski, Katarzyna Kurek, Stanislaw Szkutnicki, Patryk Korga, Wlodzimierz Bulikowski, Krzysztof Sztanke
Summary: Inflammatory bowel diseases (IBD) are chronic, incurable diseases of the digestive tract with unclear etiology, resulting in significant impact on patients' quality of life. The incidence and prevalence of IBD are continuously increasing worldwide, becoming a significant public health burden. Current pharmaceutical management options often have side effects and may not provide sufficient disease control, leading to research on antioxidant and anti-inflammatory substances as potential treatment options.
Article
Nutrition & Dietetics
Anna Maria Rychter, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Michal Michalak, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: The study found that reduced physical activity, smoking, and coffee and alcohol consumption are risk factors for osteoporosis in patients with inflammatory bowel disease. Patients with Crohn's disease who were diagnosed with osteopenia and osteoporosis had significantly lower physical activity levels compared to those with normal bone mineral density. Women with inflammatory bowel disease who had normal bone mineral density exercised more frequently than those with osteopenia and osteoporosis. However, no significant differences were observed in bone mineral density with regards to coffee use, alcohol consumption, or smoking.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Environmental Sciences
Paulina Jedynak, Lea Maitre, Monica Guxens, Kristine B. Gutzkow, Jordi Julvez, Monica Lopez-Vicente, Jordi Sunyer, Maribel Casas, Leda Chatzi, Regina Grazuleviciene, Mariza Kampouri, Rosie McEachan, Mark Mon-Williams, Ibon Tamayo, Cathrine Thomsen, Jose Urquiza, Marina Vafeiadi, John Wright, Xavier Basagana, Martine Vrijheid, Claire Philippat
Summary: This study found deleterious effects of prenatal exposure to bisphenol A (BPA) and mono-n-butyl phthalate (MnBP) on child behavior. Other associations should be interpreted cautiously as they were not consistent with previous studies or have not been extensively studied.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Plant Sciences
Min Li, Fang Wang, Ce Zhang, Min-An Li, Tian Wang, Yu-Chen Li, Feng-Hua Fu
Summary: This study aimed to explore the effects of Semen aesculi (SA) on the intestinal barrier in inflammatory bowel diseases (IBD) and elucidate its underlying mechanisms. The results showed that the main bioactive component of SA, escin, improved IBD by repairing the intestinal barrier and promoting intestinal motility. Additionally, the mechanism of action of SA was found to be related to inhibiting the Akt/NF-kappa B signaling pathway in intestinal tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jochen K. Lennerz, Kimberley W. J. van der Sloot, Long Phi Le, Julie M. Batten, Jae Young Han, Kenneth C. Fan, Corey A. Siegel, Amitabh Srivastava, Do Youn Park, Jey-Hsin Chen, Bruce E. Sands, Joshua R. Korzenik, Robert D. Odze, Dora Dias-Santagata, Darrell R. Borger, Hamed Khalili, A. John Iafrate, Gregory Y. Lauwers
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2016)
Article
Gastroenterology & Hepatology
Kimberley W. J. Van Der Sloot, Amit D. Joshi, Danielle R. Bellavance, Katherine K. Gilpin, Kathleen O. Stewart, Paul Lochhead, John J. Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N. Ananthakrishnan, Behrooz Z. Alizadeh, Ramnik J. Xavier, Hamed Khalili
INFLAMMATORY BOWEL DISEASES
(2017)
Review
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Marzyeh Amini, Vera Peters, Gerard Dijkstra, Behrooz Z. Alizadeh
INFLAMMATORY BOWEL DISEASES
(2017)
Article
Pathology
Namrata Setia, Lindsay Alpert, Kimberley W. J. van der Stoot, Dora Colussi, Kathleen O. Stewart, Joseph Misdraji, Hamed Khalili, Gregory Y. Lauwers
Article
Gastroenterology & Hepatology
Tracey G. Simon, Kimberley W. J. Van der Sloot, Samantha B. Chin, Amit D. Joshi, Paul Lochhead, Ashwin N. Ananthakrishnan, Ramnik Xavier, Raymond T. Chung, Hamed Khalili
INFLAMMATORY BOWEL DISEASES
(2018)
Article
Gastroenterology & Hepatology
Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra, R. K. Weersma
BMC GASTROENTEROLOGY
(2019)
Correction
Gastroenterology & Hepatology
Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra, R. K. Weersma
BMC GASTROENTEROLOGY
(2019)
Review
Food Science & Technology
Sara Moazzen, Kimberley J. W. van der Sloot, Geertruida H. de Bock, Behrooz Z. Alizadeh
Summary: The study found that high diet quality is associated with reduced risk of colorectal cancer, particularly with low Diet Inflammatory Index score and high Mediterranean Diet Score. However, concerns over inconsistency and imprecision led to the pooled results of all dietary indices being rated as low quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Rinse K. Weersma, Behrooz Z. Alizadeh, Gerard Dijkstra
JOURNAL OF CROHNS & COLITIS
(2020)
Review
Nutrition & Dietetics
Sara Moazzen, Kimberley W. J. van der Sloot, Roel J. Vonk, Geertruida H. de Bock, Behrooz Z. Alizadeh
Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Paul Geertsema, Hanneke C. Rijkmans, Michiel D. Voskuil, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Behrooz Z. Alizadeh, Gerard Dijkstra
Summary: This study identified 16 environmental factors associated with biological use and surgery in established IBD patients, providing important insights for further research on biological pathways, risk stratification, personalized interventions, and preventive strategies in IBD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Johan L. Tiems, Marijn C. Visschedijk, Eleonora A. M. Festen, Hendrik M. van Dullemen, Rinse K. Weersma, Gursah Kats-Ugurlu, Gerard Dijkstra
Summary: This study highlights the significant role of cigarette smoke in the development of colorectal neoplasia in patients with inflammatory bowel disease (IBD). Adding smoking as a risk factor improves the accuracy of current surveillance strategies for colorectal neoplasia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Michiel D. Voskuil, Tjasso Blokzijl, Annemieke Dinkla, Lars Ravesloot, Marijn C. Visschedijk, Hendrik M. van Dullemen, Eleonora A. M. Festen, Behrooz Z. Alizadeh, Coretta Van Leer-Buter, Rinse K. Weersma, Harry van Goor, Ad P. Koets, Gerard Dijkstra
Summary: This study evaluated extensive assays for serological response to MAP using stringent criteria for reliability. Increased IgA and IgM response to MAP antigens was found to be associated with higher usage of biologic therapy in patients with Crohn's disease and ulcerative colitis, but no genetic determinants underlying this humoral response were identified.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
M. D. Voskuil, L. M. Spekhorst, K. W. J. van der Sloot, B. H. Jansen, G. Dijkstra, C. J. van der Woude, F. Hoentjen, M. J. Pierik, A. E. van der Meulen, N. K. H. de Boer, M. Lowenberg, B. Oldenburg, E. A. M. Festen, R. K. Weersma
Summary: IBD phenotypes show significant heterogeneity between patients, and genetic risk scores [GRS] can help unravel the genetic contributions to these phenotypes. The study findings indicate that different CD and UC GRS are associated with specific IBD phenotypes, driven mainly by genetic variation.
JOURNAL OF CROHNS & COLITIS
(2021)