Article
Mechanics
Zhigang Gao, Dawen Zheng, Junhua Bai, Xiaolong Shang, Peng Li
Summary: The maneuverability of flight vehicles and their high working power lead to high non-uniform heat flux in their electrical components. The conventional heat sink is not suitable for the hostile heat dissipation environment, thus the microchannel heat sink (MCHS) has been proposed. However, the influence of semi-opening secondary branches on flow and heat transfer performance and temperature uniformity has not been studied.
Article
Thermodynamics
Zhigang Gao, Xiaolong Shang, Junhua Bai, Yuxin Yang, Peng Li
Summary: In this study, a 3D numerical model was established to examine the heat transfer and thermal performance of a microchannel heat sink for a power module with non-uniform heat flux. The effects of the inlet location and injection angle on flow distribution and heat dissipation were investigated. The results showed that the Z30 configuration provided the best inlet location and injection angle to match the non-uniform heat flux of the power module.
APPLIED THERMAL ENGINEERING
(2023)
Article
Thermodynamics
Yusi Tian, Yonggang Jiao, Fei Han, Zuo Cheng, Jian Li
Summary: In this paper, the structure of the interrupted microchannel is improved by numerical simulation, and the two-phase characteristics of the new microchannel are quantified using gas-liquid flow ratios, relative standard deviations, and pressure drop fluctuations. The simulation results show that the widening design of the two side branches offsets the effect of inertia force and balances the flow resistance in the downstream branches. The gas flow relative standard deviation of the interrupted microchannel is significantly lower than that of the traditional microchannel at high void fraction.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pearanat Chuchard, Nattakarn Numpanviwat
Summary: This study presents a mathematical model for pressure-driven and electroosmotic flow through elliptic microchannels under the slip-fluid condition, and investigates the effect of channel cross-section eccentricity on the volumetric flow rate.
Article
Chemistry, Multidisciplinary
Yanpeng Dong, Xingyu Xiang, Zhongdong Wang, Chunying Zhu, Youguang Ma, Taotao Fu
Summary: In this study, the distribution of fluid flow, as well as the uniformity and stability of droplets, in asymmetrical parallelized microchannels were explored using a high-speed camera. The effects of pressure difference fluctuation at the T-junction, hydrodynamic resistance in microchannels, and shear-thinning property of fluids on flow distribution and droplet formation were revealed. The uniformity and stability of droplets in microdevices with different cavity settings were compared, and an optimal configuration was proposed. Prediction models for the flow distribution of shear-thinning fluids in asymmetrical parallelized microchannels were also established.
Article
Mathematics, Interdisciplinary Applications
A. A. Avramenko, I. Shevchuk, A. Tyrinov
Summary: This article presents an analysis of the convective instability of a nanofluid in a vertical porous cylindrical microchannel with slip boundary conditions. It was found that an increase in the porosity of the medium promotes stabilization, while the conditions for the onset of convection are decisively influenced by the thermal conductivity of nanoparticles.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Mechanics
Maryam Maghazeh, Hossein Pishbin, Mahdi Navidbakhsh, Esmail Pishbin
Summary: This study presents a novel approach for generating stratified flow and slug flow for biochemical applications using centrifugal microfluidics. The technique involves stratifying liquid using centrifugal force and trapping bubbles between liquid plugs to form a slug flow. The fluidic behavior of the system is comprehensively characterized using a multiphase numerical model, and the results show that slug flow can significantly enhance the mixing efficiency compared to single-phase or stratified flow.
Article
Thermodynamics
Ali H. Al-Zaidi, Mohamed M. Mahmoud, Tassos G. Karayiannis
Summary: This paper presents an experimental study on flow boiling patterns, heat transfer rates, and pressure drop in multi-microchannels evaporators made of copper and aluminium. The results showed that aluminium heat sinks have comparable thermal performance to that of copper heat sinks.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Mechanics
Fang Chen, Kun Liu, Ping Li, Lucheng Ji
Summary: This study investigates the non-equilibrium gas flow around a circular cylinder within a range of Knudsen number (Kn) and free-stream Mach number (Ma), using the unstructured grid unified gas kinetic scheme. The impact of Kn and Ma on flow patterns is examined and illustrated through flow pattern diagrams. The results provide insight into the relationship between Reynolds number (Re), Kn, and Ma, and highlight the critical values associated with flow separation, vortex shedding, and shock-wave formation in different flow regimes.
Article
Energy & Fuels
Meng Lu, Regina Sander
Summary: This paper presents a comprehensive study on wetting and non-wetting liquid flow in nanopores, including the development of a new nanoflow model and its demonstration using published findings from molecular dynamics simulations and laboratory tests. The study provides new insights into wetting and non-wetting liquid flow behavior in nanopores.
Article
Thermodynamics
Yuanzheng Lv, Guodong Xia, Lixin Cheng, Dandan Ma
Summary: Experiments were conducted in two parallel rectangular multi-microchannels using HFE-7100 for flow boiling, revealing significant differences in heat flux and pressure drop under different aspect ratios, with the minimum heat flux decreasing as the aspect ratio decreases. The physical mechanisms of unstable vapor liquid two phase phenomena were analyzed based on a simplified mathematical model, suggesting that a wide flat regime in the hydrodynamic curves may decrease such phenomena.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2021)
Article
Engineering, Environmental
Wei Zhang, Junfeng Wang, Bin Li, Kai Yu, Dongbao Wang, Piyaphong Yongphet, Haojie Xu, Jiang Yao
Summary: This study investigated the characteristics of bubble interactions in ethanol under a direct current electric field using high-speed photography. Different regimes of bubble coalescence were identified, and it was observed that bubble dynamics in the electric field were different from those reported in literature. The increase in Weber number and electrical Bond number influenced the frequency of bubble coalescence.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Thermodynamics
Ali H. Al-Zaidi, Mohamed M. Mahmoud, Tassos G. Karayiannis
Summary: The study experimentally investigated the influence of channel aspect ratio on flow boiling characteristics of HFE-7100 in copper multi-microchannel heat sinks. It found that increasing channel aspect ratio led to higher heat transfer coefficient and lower flow boiling pressure drop, but the heat transfer rate was higher in the heat sink with the smallest aspect ratio due to its larger surface area.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Mechanics
Zheng Zhang, Guanmin Zhang, Min Wei, Yi Zhang, Maocheng Tian
Summary: This study investigates two-phase flow and heat transfer in vertical upward rectangular microchannels using the volume of fluid method and the Lee phase-change mass transfer model. The results reveal the sequential occurrence of different flow patterns with increasing heat flux and establish a phase diagram to predict flow pattern transitions. A new correlation for two-phase flow boiling heat transfer in microchannels is proposed.
Article
Thermodynamics
Yun Li, Yuanpeng Yao, Huiying Wu
Summary: In this study, a novel bidirectional counter-flow microchannels (CFMC) with regulated mass flux distribution were proposed for efficient heat dissipation in high-power electronics. Experimental results showed that CFMC outperforms traditional parallel-flow microchannels (PFMC) in heat transfer enhancement. Precise regulation of wall temperature distributions, heat transfer characteristics, and two-phase pressure drops can be achieved in CFMC. This study has essential value for optimizing the flow boiling process in microchannels and has great potential in practical applications.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Materials Science, Multidisciplinary
Seyed Shahaboddin Ayati, Mehdi Karevan, Evan Stefanek, Mohammed Bhia, Mohsen Akbari
Summary: This study presents a new method for fabricating nanofibers using centrifugal spinning and solution blowing. The process involves a rotating reservoir and high velocity expanding gas to extrude fibers. The morphology of the fibers depends on various factors.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Review
Chemistry, Analytical
Mostafa Azimzadeh, Patricia Khashayar, Meitham Amereh, Nishat Tasnim, Mina Hoorfar, Mohsen Akbari
Summary: Quantification of oxygen (O-2) is crucial for assessing cell metabolism and viability. Recent advances in microfluidics have made O-2 sensing a crucial feature in organ-on-chip devices. This review provides an overview of on-chip O-2 sensors integrated with organ-on-chip devices and evaluates their advantages and disadvantages.
Article
Multidisciplinary Sciences
Brent Godau, Evan Stefanek, Sadaf Samimi Gharaie, Meitham Amereh, Erik Pagan, Zohreh Marvdashti, Eryn Libert-Scott, Samad Mohsen, Mohsen Akbari
Summary: This study uses a non-destructive method to analyze the viscoelastic properties of hydrogel tissue scaffolds and demonstrates the influence of bioprinting strategy. Structure-function relationships are developed for common 3D bioprinting parameters, and further studies include mechanical characterization during degradation and monitoring of cell growth effects.
Article
Mathematics
Meitham Amereh, Yakine Bahri, Roderick Edwards, Mohsen Akbari, Ben Nadler
Summary: In this study, the stability of radially symmetric growth in tumor spheroids was investigated using a reaction-diffusion model. The results showed that under symmetric growth conditions, small asymmetric perturbations could change the shape of the tumor, indicating that the spherical configuration of tumor spheroids is naturally unstable.
Article
Chemistry, Multidisciplinary
Amir Seyfoori, Seyyed Ali Seyyed Ebrahimi, Mohamadmahdi Samandari, Ehsan Samiei, Evan Stefanek, Cathie Garnis, Mohsen Akbari
Summary: Capturing rare disease-associated biomarkers from body fluids can provide early-stage diagnosis of different cancers. This paper introduces a novel method for making soft micromagnet patterns with optimized geometry and magnetic material, integrated into a bilayer microfluidic chip to enhance the capture efficiency of cancer cells. The proposed design enables high capture efficiency and purity of target cells, as well as real-time monitoring of their behavior. This strategy offers a simple, low-cost, and robust opportunity for early-stage diagnosis and monitoring of cancer-associated biomarkers.
Review
Engineering, Biomedical
Mahsa Janmohammadi, Zahra Nazemi, Amin Orash Mahmoud Salehi, Amir Seyfoori, Johnson John, Mohammad Sadegh Nourbakhsh, Mohsen Akbari
Summary: Cellulose-based scaffolds have great potential in bone tissue engineering due to their non-toxicity, biocompatibility, renewable nature, and low cost. They can deliver growth factors and antibiotics directly to the site of impaired bone tissue to promote tissue repair. This review focuses on the various types of cellulose-based composite scaffolds used for bone drug delivery systems and bone regeneration, highlighting their physicochemical, mechanical, and biological properties.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Dana Hellmold, Pietro Arnaldi, Michael Synowitz, Janka Held-Feindt, Mohsen Akbari
Summary: Current treatment strategies for GBM have limited effectiveness, so there is a need for more effective treatments. A localized drug delivery system called AT101-GlioMesh, which releases the drug AT101 at the tumor site, has shown promising results in inhibiting tumor recurrence and inducing cytotoxic effects on GBM cell lines.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Bahram Mirani, Zhina Hadisi, Erik Pagan, Seyed Mohammad Hossein Dabiri, Antonia van Rijt, Lama Almutairi, Iman Noshadi, David G. Armstrong, Mohsen Akbari
Summary: Managing slow-healing wounds and associated complications is challenging. Systematic collection, analysis, and dissemination of correct wound status data are critical for enhancing healing outcomes and reducing complications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Mahmood Razzaghi, Amir Seyfoori, Erik Pagan, Esfandyar Askari, Alireza Hassani Najafabadi, Mohsen Akbari
Summary: To address the need for continuous monitoring and treatment adjustments in chronic diseases, a microneedle array technique is proposed to extract interstitial skin fluid (ISF) painlessly and bloodlessly. The molecular composition of ISF resembles blood plasma, making it a good choice for biomarker identification. The integration of a multiplexed sensor in the microneedle array enables rapid biomarker detection, allowing for practical and self-administrable monitoring and management of metabolic diseases.
Article
Chemistry, Analytical
Mahmood Razzaghi, Mohsen Akbari
Summary: Microneedle arrays (MNAs) are emerging devices used for drug delivery and diagnostics through the skin. 3D printing-based fabrication methods offer advantages such as faster and more precise fabrication, but the penetration capability into the skin needs improvement.
Review
Engineering, Biomedical
Esfandyar Askari, Mahdieh Shokrollahi Barough, Mehdi Rahmanian, Nazanin Mojtabavi, Ramin Sarrami Forooshani, Amir Seyfoori, Mohsen Akbari
Summary: This article summarizes the applications of micro/nanostructured hydrogels in cancer immunotherapy, focusing on their local and systemic effects and potential clinical translation. Hydrogels as carriers can stimulate immune cells by releasing tumor lysate, drugs, or nanovaccines, activating systemic antitumor immune responses and inhibiting tumor metastasis and recurrence.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Brent Godau, Sadaf Samimi, Amir Seyfoori, Ehsan Samiei, Tahereh Khani, Parvaneh Naserzadeh, Alireza Hassani Najafabadi, Emal Lesha, Keivan Majidzadeh-A, Behnaz Ashtari, Gabriel Charest, Christophe Morin, David Fortin, Mohsen Akbari
Summary: Injectable shear-thinning hydrogel (STH) acts as a non-invasive local delivery vehicle for slow-releasing anticancer drugs, reducing systemic toxicity and improving treatment effectiveness. Experimental results show that STH injected into tumor tissue significantly increases overall survival in animal models of breast cancer and glioblastoma, demonstrating potential for localized treatment.
Review
Polymer Science
Amirhossein Sadeghi, Shadi Poureskandar, Esfandyar Askari, Mohsen Akbari
Summary: Polymeric nanomaterials, nanogels, and solid nanoparticles can be made using single or double emulsion methods. These materials show promise for biomedical applications due to their biocompatibility, biodegradability, and ability to interact with body fluids and cells. However, the understanding of the biological behavior of polymeric nanoparticles is incomplete.
Article
Engineering, Multidisciplinary
Meitham Amereh, Amir Seyfoori, Briana Dallinger, Mostafa Azimzadeh, Evan Stefanek, Mohsen Akbari
Summary: This study investigated the effect of matrix stiffness on the invasion pattern of human glioblastoma tumoroids. A tumor-on-a-chip platform was used to culture the tumoroids and evaluate the effect of stiffness on tumor progression. Results showed that tumoroids exhibited two distinct invasion patterns, ring-type and finger-type, in response to collagenase concentration. Higher concentrations of collagenase resulted in greater invasion lengths, highlighting the dependence of tumor behavior on the stiffness of the surrounding matrix. The use of a mathematical model provided insights into the mechanisms involved in GBM invasion in an inhomogeneous environment.
Review
Materials Science, Biomaterials
Ali Mousavi, Maedeh Rahimnejad, Mostafa Azimzadeh, Mohsen Akbari, Houman Savoji
Summary: Electronic skins have revolutionized the lives of patients with skin and muscle dysfunction. This review highlights the recent advancements in sensory function of electronic skins and categorizes them based on tactile sensors, temperature sensors, and multi-sensors. The role of material selection and structure in sensory function is also discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
