Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

TLR Agonists Promote Marginal Zone B Cell Activation and Facilitate T-Dependent IgM Responses

(2014) A. V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

(2013) X. Sun et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Type I IFN Drives Emergency Myelopoiesis and Peripheral Myeloid Expansion during Chronic TLR7 Signaling

(2013) M. B. Buechler et al.   JOURNAL OF IMMUNOLOGY

Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation

(2012) HyeMee Joo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global analysis of B cell selection using an immunoglobulin light chain–mediated model of autoreactivity

(2012) Sarah F. Andrews et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8−dendritic cells require the intramembrane endopeptidase SPPL2A

(2012) Hannes Bergmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

(2012) Janna Schneppenheim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

(2012) Daniel R. Beisner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice

(2012) Emilie M. Fournier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extrafollicular B cell activation by marginal zone dendritic cells drives T cell–dependent antibody responses

(2012) Craig P. Chappell et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B-cell selection and the development of autoantibodies

(2012) Natalia V Giltiay et al.   ARTHRITIS RESEARCH & THERAPY

Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies

(2011) A. Vossenkämper et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

(2011) Ryutaro Fukui et al.   IMMUNITY

Increased Expression of B Cell Activation Factor Supports the Abnormal Expansion of Transitional B Cells in Systemic Lupus Erythematosus

(2011) C. LANDOLT-MARTICORENA et al.   JOURNAL OF RHEUMATOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Toll-like receptor driven B cell activation in the induction of systemic autoimmunity

(2011) Nathaniel M. Green et al.   SEMINARS IN IMMUNOLOGY

TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

(2011) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

(2010) H. Garcia-Ortiz et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation

(2010) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

TLR Ligation Triggers Somatic Hypermutation in Transitional B Cells Inducing the Generation of IgM Memory B Cells

(2010) A. Aranburu et al.   JOURNAL OF IMMUNOLOGY

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Epstein–Barr viral infection in systemic lupus erythematosus

(2009) Brian D. Poole et al.   AUTOIMMUNITY REVIEWS

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

(2009) Ryutaro Fukui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Marginal Zone Precursor B Cells as Cellular Agents for Type I IFN–Promoted Antigen Transport in Autoimmunity

(2009) John H. Wang et al.   JOURNAL OF IMMUNOLOGY

Murine B Cell Response to TLR7 Ligands Depends on an IFN-  Feedback Loop

(2009) N. M. Green et al.   JOURNAL OF IMMUNOLOGY

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

(2008) Donna L. Thibault et al.   JOURNAL OF CLINICAL INVESTIGATION