Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2

IL-2/Anti-IL-2 Antibody Complex Enhances Vaccine-Mediated Antigen-Specific CD8+ T Cell Responses and Increases the Ratio of Effector/Memory CD8+ T Cells to Regulatory T Cells

(2014) S. Mostbock et al.   JOURNAL OF IMMUNOLOGY

IL-2–dependent adaptive control of NK cell homeostasis

(2013) Georg Gasteiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

(2013) Georg Gasteiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?

(2012) E. Bonifacio   DIABETES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

Cutting Edge: In the Absence of TGF-  Signaling in T Cells, Fewer CD103+ Regulatory T Cells Develop, but Exuberant IFN-  Production Renders Mice More Susceptible to Helminth Infection

(2012) L. A. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A Novel Mechanism Bridging Innate and Adaptive Immunity: IL-12 Induction of CD25 To Form High-Affinity IL-2 Receptors on NK Cells

(2012) S.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Anti-CD25 Immunotherapy: Regulating the Regulators

(2012) J. W. Rose   Science Translational Medicine

Application of IL-2 therapy to target T regulatory cell function

(2012) Ethan M. Shevach   TRENDS IN IMMUNOLOGY

Central Role for Interleukin-2 in Type 1 Diabetes

(2011) M. A. Hulme et al.   DIABETES

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

(2010) M. Feuerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

(2009) Markus Feuerer et al.   IMMUNITY

Cytokine-induced memory-like natural killer cells

(2009) Megan A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of KIR2DL2 polymorphism rs2756923 with type 1 diabetes and preliminary evidence for lack of inhibition through HLA-C1 ligand binding

(2009) E. Ramos-Lopez et al.   TISSUE ANTIGENS

Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells

(2008) M. Marzec et al.   CANCER RESEARCH

Regulating Treg Cells at Sites of Inflammation

(2008) Christopher A. Lazarski et al.   IMMUNITY

Response: Regulating Treg Cells at Sites of Inflammation

(2008) Qizhi Tang et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY

Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation

(2008) G.-H. Jin et al.   INTERNATIONAL IMMUNOLOGY

T Regulatory Cells in Autoimmune Diabetes: Past Challenges, Future Prospects

(2008) Jeffrey A. Bluestone et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology