Cellular origin and pathophysiology of chronic lymphocytic leukemia

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma

(2012) L. Xie et al.   BLOOD

JAB1 Is Essential for B Cell Development and Germinal Center Formation and Inversely Regulates Fas Ligand and Bcl6 Expression

(2012) S. Sitte et al.   JOURNAL OF IMMUNOLOGY

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

(2011) R. Nahar et al.   BLOOD

FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling

(2011) H. W. Sohn et al.   BLOOD

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

(2011) Yoshikane Kikushige et al.   CANCER CELL

Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts

(2011) Jennifer L. Marshall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70−

(2011) Daniel O. Griffin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia/small lymphocytic lymphoma in small B-cell lymphomas

(2011) Bevan Tandon et al.   MODERN PATHOLOGY

Activation-induced cytidine deaminase mediates central tolerance in B cells

(2011) M. Kuraoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

(2011) G. Meyers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

(2010) N. Chiorazzi et al.   BLOOD

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

(2010) A. Gutierrez et al.   BLOOD

Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin

(2010) C. C. Chu et al.   BLOOD

Human Marginal Zone B Cells

(2009) Jean-Claude Weill et al.   Annual Review of Immunology

Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells

(2009) G. Maarof et al.   BLOOD

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL

(2009) F. Forconi et al.   BLOOD

Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+B cells and the dynamics of memory B cell generation

(2009) Marc Seifert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence

(2009) N Darzentas et al.   LEUKEMIA

BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia

(2009) Eloisa Jantus Lewintre et al.   LEUKEMIA & LYMPHOMA

B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia

(2009) Ola Landgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

FOXP1 and BCL2 Show Similar Immunoenzymatic Pattern in Bone Marrow Trephines of Chronic Lymphocytic Leukemia Patients

(2009) Petra Korać et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA

(2008) C. C. Chu et al.   BLOOD

Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

(2008) M. Muzio et al.   BLOOD

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia

(2008) L. Z. Rassenti et al.   BLOOD

Genetic Variants in Apoptosis and Immunoregulation-Related Genes Are Associated with Risk of Chronic Lymphocytic Leukemia

(2008) A. Enjuanes et al.   CANCER RESEARCH

Transitional B cells in humans: Characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation

(2008) Aude Marie-Cardine et al.   CLINICAL IMMUNOLOGY

Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia

(2008) Tohid Kazemi et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of phenotypically distinct B-cell subsets and receptor-stimulated mitogen-activated protein kinase activation in human cord blood B cells

(2008) Yun Jung Ha et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2008) Rosa Catera et al.   MOLECULAR MEDICINE