Article
Multidisciplinary Sciences
Ke Mo, Yu Zhang, Zheng Dong, Yuhang Yang, Xiaoqiang Ma, Ben L. Feringa, Depeng Zhao
Summary: Scientists have designed synthetic molecular motors that can be driven by chemical energy and have intrinsic control over the direction of rotation, simple autonomous motion, and near-perfect unidirectionality. This study demonstrates the potential for future generations of multicomponent machines to perform mechanical functions.
Article
Engineering, Biomedical
Ruslan Garifullin, Mustafa O. Guler
Summary: This review discusses the use of self-assembling peptide molecules and electroactive units in supramolecular functional electronic and optical materials, with potential biomedical and bioelectronics applications.
MATERIALS TODAY BIO
(2021)
Review
Biochemistry & Molecular Biology
Traian Constantin, Mihai Pavalean, Stefana Bucur, Maria Magdalena Constantin, Alin Codrut Nicolescu, Irina Pacu, Victor Madan
Summary: Bladder cancer animal models can be categorized as either autochthonous or non-autochthonous, with the non-autochthonous models further classified into syngeneic and xenograft models. These models have different characteristics and applications based on the type of tumor implantation.
Article
Oncology
Qiang Sun, Xiangying Qi, Wenyan Zhang, Xiaoyu Li
Summary: The study showed that circ_0007534 plays a crucial role in promoting cervical cancer progression by regulating the miR-206/GREM1 axis. Knockdown of circ_0007534 resulted in reduced cell growth and invasion, while promoting apoptosis in CC cells. The inhibitory effect on CC progression was mediated through the downregulation of GREM1 by upregulating miR-206 levels.
CANCER CELL INTERNATIONAL
(2021)
Article
Engineering, Multidisciplinary
Mariusz Ksiazek
Summary: The author explores the potential use of polymerized sulfur waste as a biocompatible material in biomaterial production, particularly in surgical applications. Experimental studies have demonstrated that polymerized sulfur waste shows promise as a biocomposite, opening up new possibilities for the industry.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Alana N. Vagnozzi, Jian-Guo Li, Jin Chiu, Roshanak Razmpour, Rebecca Warfield, Servio H. Ramirez, Domenico Pratico
Summary: VPS35 plays a crucial role in tau metabolism and neuropathology, with its overexpression reducing pathological tau in neuronal cells while genetic silencing leads to accumulation. The availability of active cathepsin D mediates the effect of VPS35 on pathological tau accumulation, making it a potential therapeutic target for human tauopathies.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
Etedal Ahmed A. Ibrahim, Ghada A. Mutaal Badri, Khabab Abbasher Hussien Mohamed Ahmed, Mohammed Eltahier Abdalla Omer
Summary: The study found that environmental conditions were the most common triggers of migraine headache among Sudanese patients, while Acetaminophen was the most commonly used drug for relieving migraine in this population. The majority of patients were female (80%), aged 26-35 years (56.9%), and a significant proportion were housewives (40%).
BRAIN AND BEHAVIOR
(2021)
Review
Humanities, Multidisciplinary
Ahmad Fekry Moussa, Ibrahim Suleiman Al Qatawneh, Moustafa Elmetwaly Kandeel
Summary: This study focuses on the procedural necessity of primary investigations in the Arab countries, particularly in Egypt. It analyzes the position of the Arab procedural legislation and judiciary systems regarding procedural necessity and argues against expanding discretionary powers that may lead to abuse of officials and restrict individual rights and freedoms.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Environmental Sciences
Yin Lu, Qin Ma, Xiaolu Xu, Zhefu Yu, Tianjiao Guo, Yangkai Wu
Summary: The study showed that exposure to poly styrene microplastics (PS-MPs) can lead to increased apoptosis and cell death, higher micronucleus rate, and reduced mitotic index in V. faba root cells. Additionally, it causes significant oxidative stress by altering the expression of antioxidant enzymes and genes related to cell cycle and DNA repair.
ENVIRONMENTAL POLLUTION
(2021)
Article
Physics, Multidisciplinary
Gabriel Koch Ocker
Summary: This study presents a statistical field theory for networks of integrate-and-fire neurons with stochastic spike emission, revealing the impact of spike-driven reset of the membrane voltage on population activity. The study uncovers bistability and fluctuation effects in the mean-field dynamics, as well as the roles of spike resets and recurrent inhibition in stabilizing network activity. It also calculates the phase diagram for inhibitory stabilization and finds that wide regions of parameter space exhibit inhibition-stabilized regime.
Article
Engineering, Chemical
James Dufty, Jeffrey Wrighton, Kai Luo
Summary: This article considers definitions for local pressure in an inhomogeneous fluid, covering both equilibrium and local equilibrium states, and reconciles thermodynamic and mechanical (hydrodynamic) contexts. Remaining problems and uncertainties in the topic are also discussed.
Article
Multidisciplinary Sciences
Peter C. Chu
Summary: In ocean dynamics, two different treatments are found for horizontal pressure gradient force and gravity, with vertical component being much larger than horizontal in both cases. Horizontal pressure gradient force is considered dominant, while horizontal gravity is completely omitted in oceanography. The importance of horizontal gravity is identified using a non-dimensional C number, with global data showing an unexpectedly large C number around 24.
SCIENTIFIC REPORTS
(2021)
Article
Education & Educational Research
Olga Garanina, Nidal Al Said, Valery Stepenko, Marija Troyanskaya
Summary: The study developed and tested an original model illustrating personality development in the information society, finding that its implementation increased students' use of resources for personal growth. The model's practical value lies in its applicability to higher education systems in various countries, especially in the context of distance learning and social isolation caused by the COVID-19 pandemic.
EDUCATION AND INFORMATION TECHNOLOGIES
(2021)
Article
Agricultural Engineering
Jiangkuan Xing, Ryoichi Kurose, Kun Luo, Jianren Fan
Summary: Researchers have developed a new tool for establishing solid fuel conversion kinetics from thermogravimetric analysis (TGA) measurements using chemistry-informed machine learning approaches. The derived pyrolysis kinetics accurately reproduce the pyrolysis process for different biomass types and demonstrate advantages in predicting volatiles yield.
BIORESOURCE TECHNOLOGY
(2022)
Article
Clinical Neurology
Julian Klingbeil, Max-Lennart Brandt, Max Wawrzyniak, Anika Stockert, Hans R. Schneider, Petra Baum, Karl-Titus Hoffmann, Dorothee Saur
Summary: Lesions in the left ventrolateral prefrontal cortex increase the risk of depressive symptoms 6 months poststroke, while lesions within the right hemisphere are unrelated to depressive symptoms. Early prediction factors for poststroke depression include depressive symptoms within the first 4 weeks poststroke.
Article
Immunology
Evan Der, Hemant Suryawanshi, Pavel Morozov, Manjunath Kustagi, Beatrice Goilav, Saritha Ranabathou, Peter Izmirly, Robert Clancy, H. Michael Belmont, Mordecai Koenigsberg, Michele Mokrzycki, Helen Rominieki, Jay A. Graham, Juan P. Rocca, Nicole Bornkamp, Nicole Jordan, Emma Schulte, Ming Wu, James Pullman, Kamil Slowikowski, Soumya Raychaudhuri, Joel Guthridge, Judith James, Jill Buyon, Thomas Tuschl, Chaim Putterman, Jennifer Anolik, William Apruzzese, Arnon Arazi, Celine Berthier, Michael Brenner, Sean Connery, Melissa Cunningham, Maria Dall'Era, Anne Davidson, Andrea Fava, Chamith Fonseka, Richard Furie, Dan Goldman, Rohit Gupta, Joel Guthridge, Nir Hacohen, David Hildeman, Paul Hoover, Raymond Hsu, Ruba Kado, Kenneth Kalunian, Diane Kamen, Mattias Kretzler, Holden Maecker, Elena Massarotti, William McCune, Maureen McMahon, Meyeon Park, Fernanda Payan-Schober, William Pendergraft, Michelle Petri, Mina Pichavant, Deepak Rao, Paul Utz, Dia Waguespack, David Wofsy, Fan Zhang
Article
Surgery
Simon Tremblay, James J. Driscoll, Adele Rike-Shields, David A. Hildeman, Rita R. Alloway, Alin L. Girnita, Paul A. Brailey, Ervin S. Woodle
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Biochemistry & Molecular Biology
Kun-Po Li, Brian H. Ladle, Sema Kurtulus, Allyson Sholl, Sharmila Shanmuganad, David A. Hildeman
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Immunology
Cyd M. Castro-Rojas, Alzbeta Godarova, Tiffany Shi, Sarah A. Hummel, Adele Shields, Simon Tremblay, Rita R. Alloway, Michael B. Jordan, E. Steve Woodle, David A. Hildeman
Article
Immunology
Jana Raynor, Adora Lin, Sarah A. Hummel, Kristin Lampe, Michael Jordan, Kasper Hoebe, David A. Hildeman
FRONTIERS IN IMMUNOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Hannah Newton, Ameet Chimote, Vaibhavkumar Gawali, Sarah Palackdharry, David Hildeman, Edith Janssen, Trisha Wise-Draper, Laura Conforti
Article
Multidisciplinary Sciences
Maha Almanan, Jana Raynor, Ireti Ogunsulire, Anna Malyshkina, Shibabrata Mukherjee, Sarah A. Hummel, Jennifer T. Ingram, Ankur Saini, Markus M. Xie, Theresa Alenghat, Sing Sing Way, George S. Deepe, Senad Divanovic, Harinder Singh, Emily Miraldi, Allan J. Zajac, Alexander L. Dent, Christoph Holscher, Claire Chougnet, David A. Hildeman
Article
Surgery
Allan D. Kirk, Andrew B. Adams, Antoine Durrbach, Mandy L. Ford, David A. Hildeman, Christian P. Larsen, Flavio Vincenti, David Wojciechowski, E. Steve Woodle
Summary: Kidney transplant recipients administered belatacept-based maintenance immunosuppression show a more favorable metabolic profile, but have higher rates of early cellular rejection. Further clinical trials are needed to determine the optimal alternative belatacept-based regimen.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Immunology
Amy P. Rossi, Rita R. Alloway, David Hildeman, E. Steve Woodle
Summary: Solid organ transplantation is a life-saving procedure that has made significant progress in the past 70 years, particularly in T-cell-targeted immunosuppression and organ allocation systems. However, humoral alloimmune responses remain a major challenge, especially for patients with preexisting anti-HLA antibodies. Therapies to target plasma cells, the source of antibody production, have had limited effectiveness in reducing antibody levels.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Greg Davis, Allen J. York, Willis Clark Bacon, Suh-Chin Lin, Monica Malone McNeal, Alexander E. Yarawsky, Joseph J. Maciag, Jeanette L. C. Miller, Kathryn C. S. Locker, Michelle Bailey, Rebecca Stone, Michael Hall, Judith Gonzalez, Alyssa Sproles, E. Steve Woodle, Kristen Safier, Kristine A. Justus, Paul Spearman, Russell E. Ware, Jose A. Cancelas, Michael B. Jordan, Andrew B. Herr, David A. Hildeman, Jeffery D. Molkentin
Summary: This study investigated the SARS-CoV-2 infection rates in Greater Cincinnati area from August to December 2020. Different rates of infection were observed among different age groups, genders, and ethnicities. Geographic analysis revealed higher infection rates on the West side of Cincinnati and the lowest rates in the adjoining region of Kentucky.
Article
Endocrinology & Metabolism
Maria E. Moreno-Fernandez, Vishakha Sharma, Traci E. Stankiewicz, Jarren R. Oates, Jessica R. Doll, Michelle S. M. A. Damen, Maha A. T. A. Almanan, Claire A. Chougnet, David A. Hildeman, Senad Divanovic
Summary: The study investigated the effects of gender, aging, diet, and housing conditions on obesity-driven metabolic derangements and immune responsiveness in mice, finding that aging attenuated the severity of metabolic derangements in obese mice and altered the immunological profile.
NUTRITION & DIABETES
(2021)
Article
Immunology
Sharmila Shanmuganad, Sarah A. Hummel, Vivian Varghese, David A. Hildeman
Summary: This study reveals the interaction between Bcl-2 and Bim proteins during the development of TCR alpha beta(+)CD8 alpha alpha(+) intraepithelial lymphocytes (IEL) and emphasizes the importance of Bcl-2 in promoting the survival of IEL precursors (IELp). The study also highlights the crucial role of Bcl-2 in both the survival of IELp in the gut and peripheral IEL.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Tiffany Shi, Krishna Roskin, Brian M. Baker, E. Steve Woodle, David Hildeman
Summary: Solid organ transplant recipients require long-term immunosuppression to prevent rejection. Limited knowledge exists on the effects of immunosuppressive regimens, such as CNI-based therapies, on immune cell populations in grafts. Novel genomics tools, including single cell sequencing techniques, offer insights into rejection processes at a single cell level.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Alyssa L. Thomas, Maria A. Lehn, Edith M. Janssen, David A. Hildeman, Claire A. Chougnet
Summary: Age-associated dysfunction in microglia contributes to the accumulation of Aβ plaques in Alzheimer's disease. Naturally aged microglia phagocytose less Aβ over time and show broad changes in gene expression, which may underlie the progression of neurological diseases.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Immunology
Hannah Newton, Vaibhavkumar S. Gawali, Ameet A. Chimote, Maria Lehn, Sarah Palackdharry, David Hildeman, Edith Janssen, Trisha Wise-Draper, Laura Conforti
JOURNAL OF IMMUNOLOGY
(2020)