Article
Biochemistry & Molecular Biology
Gergely Pallag, Sara Nazarian, Dora Ravasz, David Bui, Timea Komlodi, Carolina Doerrier, Erich Gnaiger, Thomas N. Seyfried, Christos Chinopoulos
Summary: This study demonstrates that ProDH-directed proline catabolism can generate sufficient CIII and CIV proton pumping to support ATP production by the F1FO-ATPase even under CI inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Patricia Gonzalez-Rodriguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, Jose Lopez-Barneo, Paul T. Schumacker, D. James Surmeier
Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.
Article
Multidisciplinary Sciences
Injae Chung, John J. Wright, Hannah R. Bridges, Bozhidar S. Ivanov, Olivier Biner, Caroline S. Pereira, Guilherme M. Arantes, Judy Hirst
Summary: In this study, the authors reconstitute mammalian complex I and use cryo-EM and molecular dynamics simulations to investigate the binding and structural changes of Q(10) in the complex. The findings provide insights into the mechanism of Q(10) reduction and substrate binding in complex I.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Kotoko Makino, Yuhei Kumagai, Tatsuhiko Yoshino, Masahiro Kojima, Shigeki Matsunaga
Summary: A chiral paddle-wheel dinuclear ruthenium catalyst demonstrates superior substrate scope compared to analogous chiral paddle-wheel rhodium catalysts in catalytic asymmetric nitrene-transfer reactions with enol silyl ethers. Up to 97% ee of alpha-amino ketones can be obtained from aliphatic substrates using the ruthenium catalyst, while similar rhodium catalysts yield only moderate enantioselectivity.
Article
Multidisciplinary Sciences
Michael Ropke, Daniel Riepl, Patricia Saura, Andrea Di Luca, Max E. Muehlbauer, Alexander Jussupow, Ana P. Gamiz-Hernandez, Ville R. Kaila
Summary: Cellular respiration is powered by redox enzymes that convert chemical energy into an electrochemical proton gradient, driving energy metabolism. Studying conformational changes in mammalian complex I reveals details of proton pumping mechanism. Deactivation of complex I blocks proton transfer, while a potential gating region between membrane domain subunits regulates proton transfer through conformational changes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Aida Rodriguez-Nuevo, Ariadna Torres-Sanchez, Juan M. Duran, Cristian De Guirior, Maria Angeles Martinez-Zamora, Elvan Boke
Summary: Oocytes evade the negative effects of reactive oxygen species (ROS) by eliminating complex I in the mitochondrial electron transport chain. Early oocytes have low levels of complex I and an active mitochondrial unfolded protein response. This suppression of complex I represents a strategy for maintaining biological activity while achieving longevity.
Article
Food Science & Technology
Jun Wang, Xue Tang, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi, Peng Zhou
Summary: The study demonstrates that lycopene can alleviate myocardial dysfunction and energy metabolism issues induced by Dityrosine, by improving mitochondrial performance and reducing oxidative stress to enhance heart health.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
Tao Wang, Honghe Liu, Kie Itoh, Sungtaek Oh, Liang Zhao, Daisuke Murata, Hiromi Sesaki, Thomas Hartung, Chan Hyun Na, Jiou Wang
Summary: Haploinsufficiency of C9orf72 is linked to ALS and FTD, with C9orf72 playing a role in regulating cellular energy balance by stabilizing TIMMDC1, a crucial component of OXPHOS complex I in mitochondria.
Article
Chemistry, Multidisciplinary
Gabriele Giachin, Matthew Jessop, Romain Bouverot, Samira Acajjaoui, Melissa Saidi, Anais Chretien, Maria Bacia-Verloop, Luca Signor, Philippe J. Mas, Adrien Favier, Eve Borel Meneroud, Michael Hons, Darren J. Hart, Eaazhisai Kandiah, Elisabetta Boeri Erba, Alain Buisson, Gordon Leonard, Irina Gutsche, Montserrat Soler-Lopez
Summary: ECSIT functions as the bridging node of the MCIA core complex, inducing the transformation of ACAD9 from a FAO enzyme to an MCIA factor, providing a unique molecular mechanism for coordinating the regulation of the FAO and OXPHOS pathways.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Angela M. Barragan, Alexander Soudackov, Zaida Luthey-Schulten, Sharon Hammes-Schiffer, Klaus Schulten, Ilia A. Solov'yov
Summary: The cytochrome bc(1) complex is a transmembrane enzymatic protein complex that plays a central role in cellular energy production. Research suggests that its reaction mechanism may involve a concerted proton-coupled electron transfer (PCET) reaction with significant hydrogen tunneling and nonadiabatic effects. The theoretical framework used in this study provides a general strategy for describing PCET reactions in bioenergetic systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Pharmacology & Pharmacy
Eugenia Trushina, Sergey Trushin, Md Fayad Hasan
Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure. Emerging data suggest that mitochondria can initiate an integrated stress response that is beneficial for healthy aging and neuroprotection. Partial inhibition of mitochondrial complex I has been explored as a treatment strategy for various diseases, including Alzheimer's disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Chidozie N. Okoye, Shon A. Koren, Andrew P. Wojtovich
Summary: Mitochondria are a significant source of cellular energy, with complex I playing a crucial role in producing ROS that have diverse functions in cell metabolism, serving as important signaling molecules and indicating a mismatch in energy production and demand.
Article
Multidisciplinary Sciences
Enrique Balderas, David R. Eberhardt, Sandra Lee, John M. Pleinis, Salah Sommakia, Anthony M. Balynas, Xue Yin, Mitchell C. Parker, Colin T. Maguire, Scott Cho, Marta W. Szulik, Anna Bakhtina, Ryan D. Bia, Marisa W. Friederich, Timothy M. Locke, Johan L. K. Van Hove, Stavros G. Drakos, Yasemin Sancak, Martin Tristani-Firouzi, Sarah Franklin, Aylin R. Rodan, Dipayan Chaudhuri
Summary: Mitochondrial complex I deficiency is common in congenital, neurologic, and cardiovascular diseases. This study reveals that Complex I stimulates the turnover of a mitochondrial calcium channel, preserving energetic homeostasis during Complex I deficiency. Calcium influx into mitochondria enhances ATP synthesis and is increased in cardiomyopathies caused by mitochondrial dysfunction. The impairment of Complex I leads to increased activity of the mitochondrial calcium uniporter channel. The authors propose that calcium influx compensates for Complex I dysfunction via an impairment in Complex I-induced protein turnover and Uniporter stabilization.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Pharmacology & Pharmacy
Gabriela Reyes-Castellanos, Alice Carrier
Summary: This study reveals that inhibition of mitochondrial complex I promotes anticancer immune surveillance, which has significant implications for metabolic reprogramming in cancer therapy.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Biology
C. J. Kelly, Reid K. Couch, Vivian T. Ha, Camille M. Bodart, Judy Wu, Sydney Huff, Nicole T. Herrel, Hyunsung D. Kim, Azaad O. Zimmermann, Jessica Shattuck, Yu-Chen Pan, Matt Kaeberlein, Anthony S. Grillo
Summary: Mice lacking Complex I subunit NDUFS4 exhibit mitochondrial dysfunction and the abnormal iron homeostasis may contribute to the progression of Leigh Syndrome and other mitochondrial disorders.
Article
Ecology
Katja J. Geiger, Julio Arrontes, Antonella Rivera, Consolacion Fernandez, Jorge Alvarez, Jose Luis Acuna
Summary: A two-year experiment was conducted to investigate the impact of Pollicipes pollicipes harvest on intertidal community structure and ecological diversity. The study found that intensive exploitation resulted in a decrease in P. pollicipes and Mytilus spp. coverage, while Chthamalus spp. and Corallina spp. increased. The recovery of P. pollicipes aggregations was slow and variable, but their coverage increased under non-extracted conditions.
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
(2024)
Article
Ecology
Daniel Castro Martignago, Leandro Godoy, Amanda Pereira Amaral, Guendalina Turcato Oliveira
Summary: This study evaluates the effects of bleaching on the oocytes of the Mussismilia harttii coral and investigates the strategies employed by these cells to maintain antioxidant balance and cellular homeostasis. The research finds that bleached coral oocytes experience lipid damage, but are still able to maintain their quality and potentially elongate their lifespan and fertilization capability. This response may be linked to an intensification of heterotrophy in bleached corals.
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
(2024)
