IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

(2014) M Ogrunc et al.   CELL DEATH AND DIFFERENTIATION

TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence

(2014) Miroslava Kretova et al.   CELLULAR SIGNALLING

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

Changing T-cell enigma: Cancer killing or cancer control?

(2013) Thomas Wieder et al.   CELL CYCLE

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

(2013) K Evangelou et al.   CELL DEATH AND DIFFERENTIATION

Reactive oxygen species generated in different compartments induce cell death, survival, or senescence

(2013) Emiliano Panieri et al.   FREE RADICAL BIOLOGY AND MEDICINE

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Post-translational regulation of TGF-β receptor and Smad signaling

(2012) Pinglong Xu et al.   FEBS LETTERS

Detection of reactive oxygen species derived from the family of NOX NADPH oxidases

(2012) Ghassan J. Maghzal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells

(2012) Howard E. Boudreau et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence

(2012) Ryo Kodama et al.   GENES TO CELLS

Interleukin 6 Signaling Regulates Promyelocytic Leukemia Protein Gene Expression in Human Normal and Cancer Cells

(2012) Sona Hubackova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4

(2012) G. Fazeli et al.   MUTAGENESIS

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

(2012) Maria V. Chiantore et al.   PLoS One

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β signals the formation of a unique NF1/Smad4-dependent transcription repressor-complex in human diploid fibroblasts

(2011) Katarina Luciakova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress

(2011) Hyun Soo Kim et al.   FREE RADICAL RESEARCH

Differential expression of extracellular matrix proteins in senescent and young human fibroblasts: A comparative proteomics and microarray study

(2011) Kyeong Eun Yang et al.   MOLECULES AND CELLS

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells

(2010) Charalambos Michaeloudes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hybridoma Growth Factor

(2010) LUCIEN A. AARDEN   Annals of the New York Academy of Sciences

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

A chemotherapy-associated senescence bystander effect in breast cancer cells

(2010) Xu Di et al.   CANCER BIOLOGY & THERAPY

The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells

(2010) Annalisa Lena et al.   FEBS Journal

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

(2010) Rodolphe Besancenot et al.   PLOS BIOLOGY

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

(2009) Adrian Manea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells

(2009) Barbara Lener et al.   BIOCHEMICAL JOURNAL

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

(2009) L. Caja et al.   CANCER RESEARCH

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cytokine expression and signaling in drug-induced cellular senescence

(2009) Z Novakova et al.   ONCOGENE

Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex

(2008) Katarina Luciakova et al.   BIOCHEMICAL JOURNAL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY

Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

(2008) Kwang Seok Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cytokine loops driving senescence

(2008) Jiri Bartek et al.   NATURE CELL BIOLOGY

Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6

(2008) Y Adachi et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Overexpression of human NOX1 complex induces genome instability in mammalian cells

(2007) Federica Chiera et al.   FREE RADICAL BIOLOGY AND MEDICINE