Article
Multidisciplinary Sciences
Xue Wang, Yuetong Wang, Zhaoyuan Fang, Hua Wang, Jian Zhang, Longfu Zhang, Hsinyi Huang, Zhonglin Jiang, Yujuan Jin, Xiangkun Han, Shenda Hou, Bin Zhou, Feilong Meng, Luonan Chen, Kwok-Kin Wong, Jinfeng Liu, Zhiqi Zhang, Xin Zhang, Haiquan Chen, Yihua Sun, Liang Hu, Hongbin Ji
Summary: Somatic mutations of the chromatin remodeling gene ARID2 are found in around 7% of human lung adenocarcinomas, and its decreased expression is associated with lung cancer malignant progression. Knockout of ARID2 significantly promotes lung cancer progression, while knockdown of Hspa1a specifically inhibits malignant progression of ARID2-deficient lung cancers. Treatment with an HSPA1A inhibitor could significantly inhibit the malignant progression of lung cancer with ARID2 deficiency.
NATIONAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Abhilash Venugopalan, Matthew Lynberg, Constance M. Cultraro, Khoa Dang P. Nguyen, Xu Zhang, Maryam Waris, Noelle Dayal, Asebot Abebe, Tapan K. Maity, Udayan Guha
Summary: Mutant EGFRs in lung adenocarcinoma target SCAMP3, which functions as a tumor suppressor by promoting EGFR degradation and attenuating MAP kinase signaling pathways. Phosphorylation of SCAMP3 at Y86 is critical for its function, affecting cytokinesis in cells.
Review
Biochemistry & Molecular Biology
Yongan Song, Leonardo Kelava, Istvan Kiss
Summary: Lung cancer, particularly lung adenocarcinoma (LUAD), is a major public health challenge and the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) have crucial roles in gene regulation and their involvement in cancer is extensively studied. However, there is a gap in the literature regarding the specific role of miRNAs in LUAD. This review provides an inclusive overview of the research conducted on miRNAs in the context of LUAD, highlighting their potential diagnostic, prognostic, and therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Albano Toska, Nikita Modi, Lin-Feng Chen
Summary: RUNX3 is a transcription factor involved in cell proliferation and development. It can act both as a tumor suppressor and an oncogene in different cancers. The tumor suppressor function of RUNX3 is mainly attributed to its ability to suppress cancer cell proliferation through ubiquitination and proteasomal degradation, while it can also be inactivated through the same mechanism.
Article
Oncology
Ningning Zhu, Yueyang Yang, Haitong Wang, Peng Tang, Hongdian Zhang, Haiyan Sun, Lei Gong, Zhentao Yu
Summary: CSF2RB has been found to play an important role in the tumor microenvironment of LUAD. It is expressed at a lower level in tumor tissues compared to normal tissues. Low expression of CSF2RB is associated with poor survival and is an independent risk factor for prognosis in LUAD patients, regardless of chemotherapy or radiotherapy. High expression of CSF2RB is associated with early T, N, and clinical stages. CSF2RB is involved in various immune-related pathways and correlates positively with infiltrating CD4+ T cells, macrophages, NK cells, and monocytes in LUAD. The study suggests that CSF2RB could be a potential target for cancer treatment and has prognostic value in LUAD patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sun Hee Lee, Do Young Hyeon, Soo-Hyun Yoon, Ji-Hak Jeong, Saeng-Myung Han, Ju-Won Jang, Minh Phuong Nguyen, Xin-Zi Chi, Sojin An, Kyung-gi Hyun, Hee-Jung Jung, Ji-Joon Song, Suk-Chul Bae, Woo-Ho Kim, Daehee Hwang, You Mie Lee
Summary: Under hypoxic conditions, G9a-mediated methylation regulates the inactivation of RUNX3, promoting cancer cell proliferation and suppressing immune response and apoptosis, thereby facilitating tumor growth during early tumorigenesis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Lecai Xiong, Yanhong Wei, Xiao Zhou, Peng Dai, Yi Cai, Xuefeng Zhou, Ming Xu, Jinping Zhao, Hexiao Tang
Summary: The AGTR1 gene is expressed less in most tumors but is associated with a better prognosis in lung adenocarcinoma. It is related to lymph node metastasis and MET mutation, as well as the anti-tumor immune microenvironment. Additionally, AGTR1 may play a role in LUAD through the PI3K/AKT3 pathway.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Feng Zhang, Tao Su, Meifang Xiao
Summary: This study investigated the function of circMETTL3/miR-107/PER3 in colorectal cancer (CRC). The findings suggest that circMETTL3, transcriptionally activated by RUNX3, acts as a sponge for miR-107 to regulate PER3 signaling, thereby inhibiting CRC cell proliferation and invasion and restraining tumor growth and metastasis.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Takahito Suzuki, Satoshi Sakai, Kosuke Ota, Mika Yoshida, Chiharu Uchida, Hiroyuki Niida, Takafumi Suda, Masatoshi Kitagawa, Tatsuya Ohhata
Summary: A novel mechanism for regulation in lung adenocarcinoma, the LINC00173-SNAIL-FHIT axis, is uncovered in this study. LINC00173 positively regulates FHIT gene expression by binding to SNAIL and inhibiting its function, which may be a key mechanism for carcinogenesis and progression in lung adenocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Shuhei Kajikawa, Keisuke Omori, Ichiro Taniuchi, Masahiro Umeda, Toshihisa Komori, Junya Toguchida, Kosei Ito
Summary: This study found that the deficiency of p53 promotes osteosarcomagenesis in both human and mouse by allowing Runx3 to induce oncogenic Myc expression. Reduction of Myc levels by disrupting mR1 or knocking down Runx3 can decrease tumorigenicity in p53-deficient OS cells and effectively suppress OS development in OS mice. Furthermore, Runx inhibitors have therapeutic effects on OS mice.
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Daniele Tavernari, Elena Battistello, Elie Dheilly, Aaron S. Petruzzella, Marco Mina, Jessica Sordet-Dessimoz, Solange Peters, Thorsten Krueger, David Gfeller, Nicolo Riggi, Elisa Oricchio, Igor Letovanec, Giovanni Ciriello
Summary: This study provides a detailed molecular map of intratumor spatial heterogeneity in lung adenocarcinoma, revealing non-genetic routes of cancer evolution. The transition from indolent to aggressive patterns in tumors is driven by epigenetic and transcriptional reprogramming reshaping cancer cell identity rather than genetic alterations. Highly multiplexed protein spatial profiling shows the coexistence of immune desert, inflamed, and excluded regions within individual tumors, matching histologic pattern composition.
Article
Cell Biology
Yuan Wang, Zhenchang Jia, Chenxi Liang, Yunfei He, Min Cong, Qiuyao Wu, Pu Tian, Dasa He, Xiang Miao, Beibei Sun, Yue Yin, Chao Peng, Feng Yao, Da Fu, Yajun Liang, Peiyuan Zhang, Hua Xiong, Guohong Hu
Summary: The downregulation of MTSS1 leads to upregulation of PD-L1 in lung adenocarcinoma, impairing CD8(+) lymphocyte function and promoting tumor progression. MTSS1 downregulation correlates with improved efficacy of ICB treatment. Mechanistically, MTSS1 interacts with the E3 ligase AIP4 to monoubiquitinate PD-L1 at Lysine 263, resulting in PD-L1 endocytic sorting and lysosomal degradation. Additionally, EGFR-KRAS signaling suppresses MTSS1 and upregulates PD-L1 in lung adenocarcinoma. Furthermore, combining AIP4-targeting with the clinical antidepressant drug clomipramine and ICB treatment improves therapy response and effectively suppresses the growth of ICB-resistant tumors in both immunocompetent and humanized mouse models.
Article
Oncology
Koichi Tomoshige, William D. Stuart, Iris M. Fink-Baldauf, Masaoki Ito, Tomoshi Tsuchiya, Takeshi Nagayasu, Tomoki Yamatsuji, Morihito Okada, Takuya Fukazawa, Minzhe Guo, Yutaka Maeda
Summary: The transcription factor FOXA2 has different effects on lung tumorigenesis depending on the oncogenes present. It inhibits tumor development driven by EGFRL858R but promotes tumor growth driven by KRASG12D. Additionally, FOXA2 induces the expression of MUC5AC, leading to the development of invasive mucinous adenocarcinoma (IMA), a subtype of lung cancer.
Article
Oncology
Tianxing Guo, Zhenlong Zhang, Lihuan Zhu, Wenshu Chen, Yun Ding, Wujin Li, Yangyun Huang, Jianyuan Huang, Xiaojie Pan
Summary: This study aimed to investigate the role of TRIM55 in patients with lung adenocarcinoma and identify potential therapeutic targets. The results showed that TRIM55 played a crucial role in inhibiting the migration, chemo-resistance, and cancer stem-cell like phenotype of lung cancer cells by promoting the degradation of Snail1 through the UPP pathway. This study provides evidence for TRIM55 as a potential tumor suppressor and offers insights into improving therapeutic effects for lung adenocarcinoma patients.
CANCER BIOLOGY & THERAPY
(2022)
Article
Cell Biology
Tingsheng Yu, Oscar Cazares, Alison D. Tang, Hyun-Yi Kim, Tomas Wald, Adya Verma, Qi Liu, Mary Helen Barcellos-Hoff, Stephen N. Floor, Han-Sung Jung, Angela N. Brooks, Ophir D. Klein
Summary: The study reveals that SRSF1 protein plays a crucial role in supporting adult tissue homeostasis and renewal by controlling specific alternative splicing events, particularly in dental proliferation and progenitor cell survival. This regulatory mechanism is also found to be conserved in other adult epithelial tissues, demonstrating the importance of SRSF1 in different organs.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Kamini Kaushal, Apoorvi Tyagi, Janardhan Keshav Karapurkar, Eun-Jung Kim, Parthasaradhireddy Tanguturi, Kye-Seong Kim, Han-Sung Jung, Suresh Ramakrishna
Summary: The study demonstrates that ubiquitin-specific protease 11 (USP11) is a key regulator of MSX1 protein in osteogenic differentiation. USP11 interacts with MSX1 and prevents its degradation through deubiquitinating activity, enhancing the differentiation potential of human mesenchymal stem cells. These findings suggest USP11 as a potential target for bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kamini Kaushal, Eun-Jung Kim, Apoorvi Tyagi, Janardhan Keshav Karapurkar, Saba Haq, Han-Sung Jung, Kye-Seong Kim, Suresh Ramakrishna
Summary: The deubiquitinating enzyme USP49 interacts with and stabilizes the protein levels of PAX9 and MSX1, promoting successful tooth development.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Anish Ashok Adpaikar, Sushan Zhang, Hyun-Yi Kim, Ki Woo Kim, Seok Jun Moon, Jong-Min Lee, Han-Sung Jung
Summary: In this study, a suspension-culture method was established to fine-tune taste bud organoids by altering their apicobasal polarity, enabling the accessible localization of taste receptor cells. These suspension-cultured organoids showed comparable differentiation and renewal rates to those of taste buds in vivo, and exhibited functional taste receptor cells and cycling progenitor cells. This method provides an efficient model for taste research, including taste bud development, regeneration, and transplantation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mi-Sun Hur, Seunggyu Lee, Han-Sung Jung, Richard A. Schneider
Summary: This study investigates the anatomical connections of the depressor supercilii (DS) with the levator labii superioris alaeque nasi (LLSAN) and inferior fibers of the orbicularis oculi (OOc INF) in the human midface. The findings reveal that the DS is connected to the LLSAN and OOc INF through muscle fibers or thin aponeuroses, influencing the movement of the eyebrows, nasal ala, and upper lip.
Article
Cell Biology
Seung-Jun Lee, Ka-Hwa Kim, Dong-Joon Lee, Pyunggang Kim, Jinah Park, Seong-Jin Kim, Han-Sung Jung
Summary: Spermatogonial stem cell (SSC) self-renewal is regulated by reciprocal interactions between Sertoli cells and SSCs in the testis. The study focused on the mechanism by which MAST4 in Sertoli cells transmits the signal and regulates SSCs, especially cell cycle regulation. The results demonstrate that MAST4 plays a pivotal role in maintaining the cell cycle of SSCs via the CDK2-PLZF interaction.
CELL PROLIFERATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
E. -j. Kim, H. -y. Kim, L. Li, Q. Tang, K. -h. Kim, H. Ohshima, H. -s. Jung
Summary: The enamel knot (EK) is a cluster of nondividing epithelial cells that acts as a signaling center in tooth germs. This study analyzed the cellular mechanisms in the EK related to bone morphogenetic protein (Bmp) and compared two species with different cuspal patterning. The findings suggest that the cellular mechanisms in the EK, such as cell proliferation and apoptosis, are associated with Bmp4 and play a crucial role in tooth morphogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jong-Min Lee, Tae-Yang Lim, Sang-Bin Oh, Seung-Jun Lee, Yun Soo Bae, Han-Sung Jung
Summary: The localization of Ahnak gene is abnormal in the kidney and ureter, which is associated with the imbalance of calcium homeostasis, leading to nonobstructive hydronephrosis. Ahnak plays a crucial role in the development of the kidney and ureter, and in maintaining the function of the urinary system.
CELL AND BIOSCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ahmed Elhakim, Sunil Kim, Su-Jung Shin, Han-Sung Jung, Euiseong Kim
Summary: In this study, the authors investigated the effect of icariin on reducing root resorption and promoting functional healing of denuded roots in a rat model of tooth replantation. The results showed that icariin had a dose-dependent inhibitory effect on the differentiation of osteoclasts and enhanced osteogenic activity in stem cells. Micro-CT imaging and histological analysis confirmed the effectiveness of icariin in reducing root resorption and improving tooth retention and survival.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Cell Biology
Ka-Hwa Kim, Eun-Jung Kim, Hyun-Yi Kim, Shujin Li, Han-Sung Jung
Summary: Tooth development relies on the interactions between dental epithelium and dental mesenchyme. In this study, hiPSC-derived human ameloblast organoids (hAOs) were cultured using a 3D system. hAOs exhibited similar properties to ameloblasts and showed enamel formation in response to calcium and mineralization in interaction with dental mesenchyme. Additionally, hAOs showed osteogenic and odontogenic differentiation potential and demonstrated tooth regenerative potential in interaction with mouse dental mesenchyme. This research provides insights into hiPSC-derived dental source and highlights the potential of hAOs for tooth regeneration and study of dental diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anish Ashok Adpaikar, Jong-Min Lee, Dong-Joon Lee, Hye-Yeon Cho, Hayato Ohshima, Seok Jun Moon, Han-Sung Jung
Summary: Taste receptor cells can dedifferentiate and acquire stem/progenitor cell-like states after nerve injury, leading to enhanced taste bud regeneration. This finding suggests that differentiated taste receptor cells have the potential to enter the cell cycle and contribute to taste bud renewal. These dedifferentiated cells, along with resident stem/progenitor cells, play a crucial role in the regeneration of taste buds following nerve injury.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Shujin Li, Dong-Joon Lee, Hyun-Yi Kim, Hidemitsu Harada, Young-Soo Jung, Han-Sung Jung
Summary: Cancer initiation and progression are closely related to the interaction between cancer cells and the surrounding stroma. This study focuses on the role of collagen-rich extracellular matrix (ECM) in the invasion of ameloblastoma (AM), a representative odontogenic epithelial tumor. Transcriptomic analysis showed up-regulation of ECM- and epithelial-to-mesenchymal transition (EMT)-related genes in AM compared to the ameloblastoma cell line. Tumoroid forming analysis demonstrated the importance of collagen-rich ECM in AM progression, particularly in aggressive growth patterns and collective invasion.
INTERNATIONAL JOURNAL OF STEM CELLS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tomoaki Komada, Keisuke Mitomo, Takatoshi Ikarashi, Masaki Shimono, Han-Sung Jung, Takashi Muramatsu
Summary: This study used a mouse in situ model to investigate the histological healing process of regenerative endodontic cell-homing procedures. It was found that periodontal ligament cells and vascular endothelial cells grew into the root canals from the apex, replaced the blood clots, and participated in the formation of cementum-like tissues with angiogenesis.
FRONTIERS IN DENTAL MEDICINE
(2022)