Article
Chemistry, Multidisciplinary
Dapeng Chen, Hanming Dai, Weili Wang, Yu Cai, Xiaozhou Mou, Jianhua Zou, Jinjun Shao, Zhengwei Mao, Liping Zhong, Xiaochen Dong, Yongxiang Zhao
Summary: In this study, a proton-driven transformable O-1(2)-nanotrap was developed to overcome tumor hypoxia and endosomal entrapment, leading to sustained antitumor performance.
Article
Biochemistry & Molecular Biology
Jaydeepsinh Chavda, Anjali Rajwar, Dhiraj Bhatia, Iti Gupta
Summary: Novel zinc porphyrins containing pharmacophoric groups derived from Sorafenib were found to have excellent PDT based autophagy inhibition of cancer cells. Molecular docking studies showed strong binding with mTOR protein kinase. These findings suggest that these zinc porphyrins have potential as theranostic agents for anti-cancer applications.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Engineering, Chemical
Fan Wu, Xueyu Nie, Yulun Nie, Chu Dai, Xike Tian
Summary: In this study, the degradation of sulfamethoxazole was regulated using layered double hydrotalcite and different reactive oxygen species. It was found that 1O2 and 'OH groups could enhance the removal efficiency and mineralization efficiency of sulfamethoxazole. The coupling of 1O2 and 'OH radicals achieved complete removal and mineralization of sulfamethoxazole, with removal efficiency reaching 100% and mineralization efficiency reaching 24.8%. The degradation behavior and kinetics of sulfamethoxazole could be controlled through sequential direct oxidation, 1O2, and 'OH treatment, improving the utilization efficiency of PMS. The interfacial PMS activation process was responsible for regulating the non-radical and radical processes.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Environmental
Wenxiao Zheng, Yingkai Chen, Hengyi Fu, Zhang Yan, Zhenchao Lei, Weijian Duan, Chunhua Feng
Summary: This study proposes a concept of converting reactive species into O-1(2) through the addition of H2O2 to reduce the formation of chlorinated organic compounds. The results show that the H2O2-involving EO system has higher reaction rates and lower accumulation of chlorinated organic products compared to the H2O2-absent system. Through electron paramagnetic resonance and computational kinetic simulation, the generation pathways of O-1(2) are revealed.
Article
Chemistry, Applied
Kunshan Huang, Han Zhang, Meiqi Yan, Jinping Xue, Juanjuan Chen
Summary: Introducing indomethacin to conjugate with zinc phthalocyanines successfully addresses the issues of photosensitizer aggregation, poor tumor targeting, and limited action radius of reactive oxygen species. The designed photosensitizer IMC-Pc shows improved efficiency in intracellular reactive oxygen species generation and anticancer efficacy through cyclooxygenase-2-driven dual targeting and aggregation inhibition.
Article
Chemistry, Organic
Ying Fu, Fei Duan, Zhengyin Du
Summary: A photosensitizer-free, visible light driven coupling of P(O)-H/P-OR compounds and amines was developed, using air as the terminal oxidant to generate phosphinamides, phosphonamides and phosphoramidates in good to excellent yields.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Oncology
Fahad Alkhudhairy, Abdullah S. Aljamhan
Summary: The aim of this study was to evaluate the antimicrobial effectiveness of different cavity disinfectants (CHX, ECL, CP) against Lactobacillus and the shear bond strength (SBS) of restorative materials (BA, BFC) bonded to carious affected dentin (CAD). The results showed that ECL had the highest survival rate of Lactobacillus, while CP activated by PDT had the lowest survival rate. ECL+BA group exhibited the highest SBS value, while CP+BA group had the lowest bond strength. The study concluded that disinfection with ECL, CP, and CHX can improve the bond scores of restorative materials. Evaluation: 8 points.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jaclyn M. Einstein, Mark Perelis, Isaac A. Chaim, Jitendra K. Meena, Julia K. Nussbacher, Alexandra T. Tankka, Brian A. Yee, Heyuan Li, Assael A. Madrigal, Nicholas J. Neill, Archana Shankar, Siddhartha Tyagi, Thomas F. Westbrook, Gene W. Yeo
Summary: RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene expression regulation, and disrupting YTHDF2-dependent mRNA degradation can induce apoptosis in triple-negative breast cancer (TNBC) cells and tumors. Our study identified 57 RBP candidates with distinct functions in supporting MYC-driven oncogenic pathways, highlighting the therapeutic potential of RBPs, especially YTHDF2, in counteracting global mRNA synthesis in MYC-driven breast cancers.
Article
Engineering, Environmental
Peng Yang, Ke Wen, Kevin A. Beyer, Wenqian Xu, Qian Wang, Dong Ma, Juan Wu, Mengqiang Zhu
Summary: The presence of phosphate or silicate significantly decreases the rate and extent of reductive transformation of layered manganese oxides, likely due to the interference of oxyanions with electron transfer and structural rearrangements. Oxyanions also reduce the crystallinity and particle sizes of the transformation products, preventing further particle growth. This study enhances our understanding of how solution chemistry controls the redox-driven transformation of Mn oxides.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Debra Dorotea, Songling Jiang, Eun Seon Pak, Jung Beom Son, Hwan Geun Choi, Sung-Min Ahn, Hunjoo Ha
Summary: This study reveals the significant role of Fyn kinase, a member of the Src family kinases (SFKs), in the progression of diabetic kidney disease. Inhibiting Fyn can mitigate renal injury, and treatment with a pan-SFK kinase inhibitor (KF-1607) improves kidney function and reduces ER stress, inflammation, and fibrosis in diabetic rats.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Agricultural Engineering
Yunmeng Pang, Jianlong Wang
Summary: The presence of Fe2+ significantly affects the performance of sulfur-driven autotrophic denitrification, with higher concentrations leading to inhibition of denitrification and accumulation of nitrite and nitrous oxide. The abundance of Thiobacillus is positively correlated with nitrate removal rate, but negatively correlated with Fe2+ concentration. Fe2+ also influences the abundance of bacterial 16S rRNA, denitrifying genes, and sulfur-oxidizing genes, particularly nosZ and soxB, which have the most sensitivity to Fe2+.
BIORESOURCE TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Akshay Kashyap, Elamparuthi Ramasamy, Vijayakumar Ramalingam, Mahesh Pattabiraman
Summary: This passage discusses the historical background, applications, and research progress of singlet oxygen generation through photosensitized excitation of molecular oxygen. It highlights the impact of molecular structure control through supramolecular photochemistry on this reaction.
Article
Pharmacology & Pharmacy
Jun Chen, Li Li, Xueyang Bai, Lili Xiao, Jiahong Shangguan, Wenjing Zhang, Xiangqin Zhang, Shen Wang, Gangqiong Liu
Summary: Panax notoginseng saponins (PNS) protects against thapsigargin-induced ER stress and associated apoptosis in cardiac myocytes by regulating mitochondrial injury and ROS overproduction through modulation of autophagy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Liang-Cui Chu, Pedro Arede, Wei Li, Erika C. Urdaneta, Ivayla Ivanova, Stuart W. McKellar, Jimi C. Wills, Theresa Frohlich, Alexander von Kriegsheim, Benedikt M. Beckmann, Sander Granneman
Summary: RNA-binding proteins play a crucial role in controlling gene expression. This study identifies hundreds of RNA-binding proteins in methicillin-resistant Staphylococcus aureus (MRSA) and demonstrates that a major transcription factor binds RNAs near intrinsic transcription terminators using its helix-turn-helix domain.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Lewis Macdonald, Gillian C. Taylor, Jennifer Margaret Brisbane, Ersi Christodoulou, Lucy Scott, Alex von Kriegsheim, Janet Rossant, Bin Gu, Andrew J. Wood
Summary: Researchers have developed a genetic engineering method using CRISPR technology to efficiently degrade endogenous proteins in vivo, and found that degradation kinetics depend on the dosage of the protein, ligand, and substrate receptor. Applying this method to the study of key regulators of cell division, they discovered that these regulators are essential for cell division in precursor lymphocytes.
Article
Biochemistry & Molecular Biology
Anais Pannequin, Joelle Quetin-Leclercq, Jean Costa, Aura Tintaru, Alain Muselli
Summary: Chromatographic and spectroscopic methods were used to investigate the volatile metabolites of the liverwort Plagiochila porelloides harvested in Corsica. Three new compounds were isolated and their structures were determined. The essential oil and extract of P. porelloides showed moderate antiprotozoal and anticancer activities.
Article
Biochemistry & Molecular Biology
Allison Ledoux, Carla Hamann, Olivier Bonnet, Kateline Jullien, Joelle Quetin-Leclercq, Alembert Tchinda, Jacqueline Smadja, Anne Gauvin-Bialecki, Erik Maquoi, Michel Frederich
Summary: Casearia coriacea Vent., a plant endemic to the Mascarene Islands, exhibited potent antiplasmodial activity through the presence of three identified compounds, caseamembrin T (1), corybulosin I (2), and isocaseamembrin E (3), with IC50 values ranging from 0.25 to 0.51 μg/mL. While these compounds also showed antileishmanial and antitrypanosomal properties, they exhibited selectivity towards the malaria parasite with selectivity indices ranging from 6 to 12 and 25 to 100, respectively. Additionally, compounds 1-3 demonstrated promising activity against pancreatic carcinoma cells (IC50 < 1 μg/mL). However, the main compound, caseamembrin T (1), displayed significant toxicity when evaluated on zebrafish embryos.
Article
Biochemistry & Molecular Biology
Esaie Tchetan, Sergio Ortiz, Pascal Abiodoun Olounlade, Kristelle Hughes, Patrick Laurent, Erick Virgile Bertrand Azando, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: By performing LC-MS/MS analysis and molecular networking, the main compounds in Terminalia leiocarpa were identified as ellagic acid and derivatives, gallic acid, astragalin, rutin, quinic acid, and fructose. Among them, ellagic acid and gallic acid showed good anthelmintic activity against C. elegans. Other unidentified compounds may also contribute to the observed activity.
Article
Chemistry, Organic
Michela Maria Marchese, Sebastian Strahler, Lucian Ghiba, Olivier Riant
Summary: In this study, we developed a one-pot, copper-catalyzed aminodifluoroalkylation of enylaniline derivatives. This approach enables the catalytic construction of a wide range of pyrrolidines and piperidines substituted with a gem-difluoro moiety.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Applied
Mourad Boukachabia, Hacene Bendjeffal, Mounia Merabet Khelassi, Olivier Riant
Summary: A statistical approach was used to optimize the acylation of l-menthol using natural kaolin as a catalyst. The main operational parameters, such as solvent volume, acyl donor amount, temperature, and catalytic rate of kaolin, were studied. The results showed that temperature, acyl donor/acceptor ratio, kaolin mass, and solvent volume were significant factors affecting the acylation process. Optimal reaction conditions were determined and validated experimentally, achieving complete conversion after 30 minutes. The environmentally friendly process was also applied to other monoterpenic alcohols, yielding acetates with 45%-90% yield.
FLAVOUR AND FRAGRANCE JOURNAL
(2023)
Article
Chemistry, Physical
Nathalie Body, Corentin Lefebvre, Pierre Eloy, Tommy Haynes, Sophie Hermans, Olivier Riant
Summary: The impact of silica nanoparticles morphology on the photooxidation of citronellol was investigated. It was found that the core-shell structure of silica nanoparticles exhibited the best activity, recyclability, and dye immobilization rate.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joelle Quetin-Leclercq
Summary: Leishmaniasis, a neglected tropical disease, still infects thousands of people per year worldwide. Resistance to major treatments has become a healthcare burden, especially in low-income countries. Eugenol, a phenylpropanoid, has shown antileishmanial activity against Leishmania mexicana mexicana (Lmm), but its mechanism of action is still unclear.
Article
Multidisciplinary Sciences
Ana Martin-Vega, Laura Ruiz-Peinado, Rocio Garcia-Gomez, Ana Herrero, Dalia de la Fuente-Vivas, Swetha Parvathaneni, Ruben Caloto, Marta Morante, Alex von Kriegsheim, Xose R. Bustelo, David B. Sacks, Berta Casar, Piero Crespo
Summary: RAS-ERK pathway signals are regulated by scaffold proteins, and it is revealed that scaffold proteins can interact with each other and undergo phosphorylation reactions. The trans-phosphorylation process participates in KSR1-regulated adipogenesis and the cytotoxicity exhibited by KSR-directed inhibitors. This finding has implications in signaling and the design of scaffold protein-aimed therapeutics.
Article
Biochemistry & Molecular Biology
Sebastien Dilly, Miguel Romero, Stephanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok
Summary: ROS in cancer cells play a crucial role in regulating cell death, stemness maintenance, and metabolic reprogramming, which are associated with resistance to chemo/immunotherapy. This paper introduces new inhibitors of NADPH oxidase (NOX), which is important in the tumor microenvironment. One of the inhibitors, called Nanoshutter-1 (NS1), decreases tumor-promoting M2 macrophages in human blood monocytes. NS1 disrupts the NOX2 complex in the macrophages' membrane and mitochondria, leading to vasodilation of blood vessels and potential reduction of hypoxia. By targeting specific cells, NOX2-specific inhibitors could provide precision therapies.
Article
Chemistry, Physical
Denis Chusov, Gary A. A. Molander, Virginie Ratovelomanana-Vidal, Olivier Riant, Emmanuelle Schulz
Summary: In this paper, we discuss the extensive scholarly contributions of Professor Henri B. Kagan, our mentor and colleague, and the significant impact of his research on various fields of chemistry, including asymmetric oxidation, asymmetric reduction, unique features in lanthanide chemistry, issues of nonlinear effects, and the question of the origin of chirality on earth.
Article
Oncology
Aoife Nolan, Cinzia Raso, Walter Kolch, Alex von Kriegsheim, Kieran Wynne, David Matallanas
Summary: RAS proteins play a crucial role in cell signalling, regulating cell functions such as proliferation, differentiation, and death. Mutations in genes of this family, particularly KRAS, are common and were believed to constitutively activate KRAS. However, recent findings show that some mutants can switch between active and inactive states. This, along with the development of covalent KRASG12C inhibitors, has led to the emergence of KRAS inhibitors in clinical use. Despite this, resistance to targeted therapies remains a challenge, and effective treatments for other KRAS mutants are lacking. To overcome these hurdles and accelerate RAS targeting therapies, a comprehensive understanding of the molecular mechanisms underlying KRAS signalling networks and the differences in downstream signalling of KRAS mutants is needed. This study employed affinity purification mass-spectrometry proteomics to analyze the interactome of KRAS wild-type and three KRAS mutants. Through bioinformatic analysis and experimental validation, the researchers mapped the signalling network mediated by different KRAS proteins. The study also revealed novel crosstalk between KRAS and effector pathways, including AKT and JAK-STAT signalling modules.
Article
Endocrinology & Metabolism
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sorensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
Summary: This study reveals the oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, and its connection to tumorigenesis in von Hippel-Lindau syndrome. The findings suggest that impaired mitochondrial biogenesis is linked to VHL tumorigenesis, and targeting mitochondria could sensitize therapy-resistant VHL tumors.
Article
Medicine, Research & Experimental
Angela M. Araujo, Andrea Abaurrea, Peio Azcoaga, Joanna Lopez-Velazco, Sara Manzano, Javier Rodriguez, Ricardo Rezola, Leire Egia-Mendikute, Fatima Valdes-Mora, Juana M. Flores, Liam Jenkins, Laura Pulido, Inaki Osorio-Querejeta, Patricia Fernandez-Nogueira, Nicola Ferrari, Cristina Viera, Natalia Martin-Martin, Alexandar Tzankov, Serenella Eppenberger-Castori, Isabel Alvarez-Lopez, Ander Urruticoechea, Paloma Bragado, Nicholas Coleman, Asis Palazon, Arkaitz Carracedo, David Gallego-Ortega, Fernando Calvo, Clare M. Isacke, Maria M. Caffarel, Charles H. Lawrie
Summary: This study reveals the pivotal role of the cytokine oncostatin M (OSM) in regulating interactions between immune and nonimmune stromal cells and epithelial cancer cells. It demonstrates that the stromal OSM/OSMR axis reprograms the tumor microenvironment and plays a key role in breast cancer progression.
JOURNAL OF CLINICAL INVESTIGATION
(2022)