Article
Medicine, Research & Experimental
Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang
Summary: In this study, upregulated DCLK1 in macrophages in atherosclerotic lesions of ApoE(-/-) mice fed an HFD was identified, and it was determined that macrophage-specific DCLK1 deletion attenuates atherosclerosis by reducing inflammation in mice. RNA sequencing analysis indicated that DCLK1 mediates oxLDL-induced inflammation via NF-kappa B signaling pathway, and DCLK1 directly interacts with IKK beta and phosphorylates IKK beta at S177/181, thereby activating NF-kappa B and promoting inflammatory gene expression in macrophages.
EMBO MOLECULAR MEDICINE
(2023)
Review
Genetics & Heredity
Antero Salminen
Summary: The functional competence of the immune system declines with aging, leading to immunosenescence. Involving both adaptive and innate immunity, immunosenescence is associated with chronic inflammation and a state called inflammaging. This process also occurs in pathological conditions, where persistent inflammation triggers compensatory immunosuppression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Tomoaki Hirashima, Hideaki Karasawa, Takashi Aizawa, Takashi Suzuki, Akihiro Yamamura, Hideyuki Suzuki, Taiki Kajiwara, Hiroaki Musha, Ryo Funayama, Matsuyuki Shirota, Shinobu Ohnuma, Keiko Nakayama, Michiaki Unno
Summary: The study reveals that cancer-associated fibroblasts with increased expression of Wnt5a play a crucial role in the progression of colorectal cancer, and may serve as a target for anti-cancer therapies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Liyuan Mao, Fang Xin, Jie Ren, Shuai Xu, Haixia Huang, Xu Zha, Xinxin Wen, Guoqing Gu, Guang Yang, Yuan Cheng, Chen Zhang, Wei Wang, Xicheng Liu
Summary: This study demonstrates the dual functions of 5-HT/5-HT2B/TGF-beta signaling in the initiation and progression of colitis-associated cancer (CAC), with a critical role in tumor suppression but a promotion of cancer progression in the late-stage of CAC.
Article
Biochemistry & Molecular Biology
Fangzhen Chen, Wulei Hou, Xiangtian Yu, Jing Wu, Zhengda Li, Jietian Xu, Zimu Deng, Gaobin Chen, Bo Liu, Xiaoxing Yin, Wei Yu, Lei Zhang, Guoliang Xu, Hongbin Ji, Chunmin Liang, Zuoyun Wang
Summary: In this study, the researchers found that CBX4 deletion promotes the proliferation and progression of lung adenocarcinoma under Kras mutation background. CBX4 deletion causes genomic instability, leading to tumorigenesis. Low expression of CBX4 is associated with poor prognosis in lung adenocarcinoma patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Jinsen Zheng, Rongzhang Dou, Xinyao Zhang, Bo Zhong, Chenggang Fang, Qian Xu, Ziyang Di, Sihao Huang, Zaihuan Lin, Jialin Song, Shuyi Wang, Bin Xiong
Summary: The overexpression of LINC00543 in colorectal cancer tissues is associated with advanced TNM stage and poorer prognosis of CRC patients. LINC00543 promotes tumorigenesis and metastasis of CRC cells by enhancing EMT and remodeling the TME.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yuki Takakura, Naoto Hori, Natsumi Terada, Moeka Machida, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
Summary: Elevated VGLL3 expression is associated with NF-kappa B activation and IL-1 alpha secretion, potentially leading to an inflammatory response. TGF-beta signaling induces VGLL3 expression, which in turn promotes IL-1 alpha secretion and NF-kappa B activation, contributing to inflammation in diseases like highly malignant breast cancer.
Article
Medicine, Research & Experimental
So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Won-Jae Lee, Tae-Young Jang, So-El Jeon, Jae-Hyun Kim, Sang-Hee Cho, Ji-Shin Lee, Jeong-Seok Nam
Summary: This study reveals the role of Dysadherin in the progression of colorectal cancer (CRC) by regulating the mechanotransduction pathway, promoting cancer cell growth, migration, and invasion. It highlights Dysadherin as a potential therapeutic target for CRC.
Article
Multidisciplinary Sciences
Lei Yue, Xiaozhang Xu, Shipeng Dai, Fan Xu, Wenhu Zhao, Jian Gu, Xinzheng Dai, Xiaofeng Qian
Summary: In this study, ORM1 was identified as a biomarker for predicting liver metastasis in patients with colorectal cancer. ORM1 promoted tumor cell growth, epithelial-mesenchymal transition, and activated the PI3K/AKT signaling pathway. It also induced macrophage M2 polarization and elevated interleukin-10 (IL-10) expression, contributing to tumor immune tolerance.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jorge Morales-Valencia, Lena Lau, Teresa Marti-Nin, Ugur Ozerdem, Gregory David
Summary: Exposure to cytotoxic drugs can lead to the acquisition of aggressive and metastatic properties in cancer cells. The senescence-associated secretory phenotype (SASP) plays a role in this process, but the specific mechanisms involved are poorly understood. This study identifies Lipocalin-2 (LCN2) as a critical regulator of SASP-induced cellular plasticity in breast cancer cells, and suggests that targeting LCN2 may prevent the emergence of aggressive tumors following chemotherapy.
Article
Oncology
Bing Li, Zhi-Peng Qi, Dong-Li He, Zhang-Han Chen, Jing-Yi Liu, Meng-Wai Wong, Jia-Wei Zhang, En-Pan Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Li-Qing Yao, Ping-Hong Zhou, Yun-Shi Zhong
Summary: The study demonstrated that NLRP7 promotes colorectal cancer progression and induces the polarization of pro-tumor M2-like macrophages. NLRP7 interacts with ubiquitin-specific protease 10 to modulate its stability and protein levels in CRC cells. NLRP7 also promotes NF-kappa B nuclear translocation and activation of C-C motif chemokine ligand 2 transcription in CRC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Jian-Wei Zhang, Dan Zhang, Hai-Sen Yin, Han Zhang, Kun-Qiao Hong, Jing-Ping Yuan, Bao-Ping Yu
Summary: Chemotherapy induces senescence in cancer cells and senescent cells secrete SASP, which promotes cancer recurrence and chemoresistance. The gut microbiota is closely associated with cancer progression, but the relationship between the gut microbiota and therapy-induced senescent cells is not well understood. This study revealed that F. nucleatum promotes the secretion of chemotherapy-induced SASP in ESCC cells, driving ESCC progression and chemoresistance.
Article
Oncology
Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang, Hao Wang
Summary: This study explored the role of N6-methyladenosine (m6A) modification in glycolysis and revealed the significance of m6A methyltransferase METTL16 in the progression of Colorectal cancer (CRC). The findings showed that METTL16 regulates glycolytic metabolism in CRC by enhancing the expression and stability of Suppressor of glucose by autophagy (SOGA1), thereby promoting CRC progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Zienab Etwebi, Jason R. Goldsmith, Mayassa Bou-Dargham, Yuhua Tian, Ryan Hood, Nina Spitofsky, Mingyue Li, Honghong Sun, Yunwei Lou, Suxia Liu, Christopher Lengner, Youhai H. Chen
Summary: TIPE2 has dual effects in CAC, acting as a tumor suppressor in colonocytes and potentially promoting or inhibiting tumorigenesis through immune cells. Targeting TIPE2 for CRC therapy requires specific cell- and pathway-dependent approaches, cautioning against immunotherapy strategies in colon cancer due to the dual role of intestinal inflammation in cancer regulation.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Eirini Martinou, Carla Moller-Levet, Dimitrios Karamanis, Izhar Bagwan, Angeliki M. Angelidi
Summary: HOXB9 plays an important role in colorectal cancer, promoting disease progression and affecting overall survival. In vitro experiments showed that HOXB9 overexpression increased cell proliferation and upregulated the expression of genes related to epithelial-mesenchymal transition. In patients with colorectal liver metastases, high expression of HOXB9 was associated with worse overall survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lu Zhang, Sang Bum Kim, Gaoxiang Jia, Abdelbaset Buhmeida, Ashraf Dallol, Woodring E. Wright, Albert J. Fornace, Mohammed Al-Qahtani, Jerry W. Shay
Article
Immunology
So-Youn Min, Mei Yan, Sang Bum Kim, Sneha Ravikumar, Seong-Ryuel Kwon, Kamala Vanarsa, Ho-Youn Kim, Laurie S. Davis, Chandra Mohan
JOURNAL OF INFLAMMATION-LONDON
(2015)
Article
Cell Biology
Lu Zhang, Panayotis C. Theodoropoulos, Ugur Eskiocak, Wentian Wang, Young-Ah Moon, Bruce Posner, Noelle S. Williams, Woodring E. Wright, Sang Bum Kim, Deepak Nijhawan, Jef K. De Brabander, Jerry W. Shay
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Sang Bum Kim, Lu Zhang, Jimok Yoon, Jeon Lee, Jaewon Min, Wenlin Li, Nick V. Grishin, Young-Ah Moon, Woodring E. Wright, Jerry W. Shay
MOLECULAR AND CELLULAR BIOLOGY
(2018)
Article
Oncology
Lu Zhang, Sang Bum Kim, Krishna Luitel, Jerry W. Shay
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Cell Biology
Aadil Kaisani, Oliver Delgado, Gail Fasciani, Sang Bum Kim, Woodring E. Wright, John D. Minna, Jerry W. Shay
Article
Astronomy & Astrophysics
Krishna Luitel, Sang Bum Kim, Summer Barron, James A. Richardson, Jerry W. Shay
LIFE SCIENCES IN SPACE RESEARCH
(2020)
Article
Oncology
Yunji Lee, Chae Eun Lee, Sejin Oh, Hakhyun Kim, Jooyoung Lee, Sang Bum Kim, Hyun Seok Kim
Article
Biology
Youngkyung Cho, Sang Bum Kim, Jiyoon Kim, An Vuong Quynh Pham, Min Ji Yoon, Jeong Hwan Park, Ki-Tae Hwang, Dongeun Park, Yongcheol Cho, Moon Gyo Kim, Chungho Kim
Article
Oncology
Jang Hee Han, Yong Keon Kim, Hakhyun Kim, Jooyoung Lee, Myung Joon Oh, Sang Bum Kim, Minjee Kim, Kook Hwan Kim, Hyun Ju Yoon, Myung-Shik Lee, John D. Minna, Michael A. White, Hyun Seok Kim
Summary: This study reveals that autophagy promotes the acetylation of the EMT-inducing transcription factor Snail through increasing acetyl-coenzyme A (acetyl-CoA), thereby facilitating invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells. Inhibition of the autophagy/acetyl-CoA/acetyl-Snail axis could be a potential therapeutic strategy to suppress metastasis of KL lung cancer.
CANCER COMMUNICATIONS
(2022)
Article
Cell Biology
Peter C. Goughnour, Min Chul Park, Sang Bum Kim, Sangmi Jun, Won Suk Yang, Sehyun Chae, Seongmin Cho, Chihong Song, Ji-Hyun Lee, Jae Kyung Hyun, Byung Gyu Kim, Daehee Hwang, Hyun Suk Jung, Yong Song Gho, Sunghoon Kim
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Astronomy & Astrophysics
Krishna Luitel, Ronald Bozeman, Aadil Kaisani, Sang Bum Kim, Summer Barron, James A. Richardson, Jerry W. Shay
LIFE SCIENCES IN SPACE RESEARCH
(2018)
Article
Cell Biology
Jimok Yoon, Sang Bum Kim, Giasuddin Ahmed, Jerry W. Shay, Jonathan R. Terman
DEVELOPMENTAL CELL
(2017)
Article
Astronomy & Astrophysics
Sang Bum Kim, Lu Zhang, Summer Barron, Jerry W. Shay
LIFE SCIENCES IN SPACE RESEARCH
(2014)