Review
Cell Biology
Sonja I. Buschow, Diahann T. S. L. Jansen
Summary: Research on the impaired T cell responses in chronic hepatitis B patients has mainly focused on CD8(+) T cells, while CD4(+) T cells are crucial in the development of long-lasting effector CD8(+) T cells. This review discusses the importance of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
Article
Immunology
Jia Li, Thekla Kemper, Ruth Broering, Jieliang Chen, Zhenghong Yuan, Xueyu Wang, Mengji Lu
Summary: The study found that IFN alpha-2a treatment can interfere with multiple intracellular signaling pathways, promote autophagy initiation, but may also slightly increase HBV replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Chen-Shiou Wu, Yi-Chung Chien, Chia-Jui Yen, Jia-Yan Wu, Li-Yuan Bai, Yung-Luen Yu
Summary: This study reveals that HBx, an antigen encoded by the hepatitis B virus, promotes the development of hepatocellular carcinoma through complex mechanisms. The findings suggest that EZH2 epigenetically represses let-7c, leading to HCC migration induced by HBx. Thus, let-7c and HMGA2 may serve as important diagnostic markers and potential therapeutic targets for HBV-related HCC.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Claudia Hawkins, Minhee Kang, Debika Bhattacharya, Gavin Cloherty, Mary Kuhns, Roy Matining, Chloe Thio, Wadzanai Samaneka, Lameck Chinula, Nyirenda Mulinda, Sharlaa Badal-Faesen, Patcharaphan Sugandhavesa, Javier Lama, Simani Gaseitsiwe, Vera Holzmayer, Mark Anderson, Robert Murphy, Marion Peters
Summary: This study aims to identify serum biomarkers that assess the HBV cccDNA reservoir and predict functional cure in HIV/HBV co-infection. The results support the use of TDF-based DUAL-HBV active ART as the initial treatment option for HIV/HBV co-infection and suggest that HBV RNA could be a useful marker for evaluating treatment response in these patients.
Article
Microbiology
Maria Guadalupe Martinez, Emmanuel Combe, Aurore Inchauspe, Philippe Emmanuel Mangeot, Elodie Delberghe, Fleur Chapus, Gregory Neveu, Antoine Alam, Kara Carter, Barbara Testoni, Fabien Zoulim
Summary: CRISPR-Cas9 targeting of HBV DNA leads to effective disruption of viral replication and the appearance of episomal HBV DNA variants. Sustainable effects induced by Cas9 post RNP degradation suggest permanent changes in the HBV genome. This study provides insights into the potential of CRISPR-Cas9 as a therapeutic approach for chronic hepatitis B by targeting the viral minichromosome.
Article
Biochemistry & Molecular Biology
Laure Perrin-Cocon, Cindy Kundlacz, Clemence Jacquemin, Xavier Hanoulle, Anne Aublin-Gex, Marianne Figl, Jeremy Manteca, Patrice Andre, Pierre-Olivier Vidalain, Vincent Lotteau, Olivier Diaz
Summary: The HCV protein NS5A activates the glucokinase isoenzyme to redirect central carbon metabolism towards lipogenesis, contributing to the replication needs of the virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexey A. Komissarov, Maria A. Karaseva, Marina P. Roschina, Andrey Shubin, Nataliya A. Lunina, Sergey Kostrov, Ilya Demidyuk
Summary: Regulated cell death (RCD) is a fundamental process common to all living beings, and recent research has shown that picornaviral 3C proteases and human hepatitis A virus 3C protease can induce different types of cell death with distinct cellular changes. Specifically, it has been demonstrated for the first time that 3Cpro can induce ferroptosis when expressed individually in human cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yuanyue Guan, Bin Sun, Shijie Zhang, Yuan Zhuang, Yanxiang Huang, Minghua Lin, Rongling Zheng, Dexi Chen, Ying Shi, Yanjun Wang
Summary: The study reveals that hepatitis B virus can manipulate microtubule-associated protein 1S (MAP1S) to facilitate its transport and release. Furthermore, HBV X protein induces the formation of stable microtubules to promote the release of the virus.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Immunology
Kana Shiraishi, Osamu Yoshida, Yusuke Imai, Sheikh Mohammad Fazle Akbar, Takahiro Sanada, Michinori Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Julio Cesar Aguilar Rubido, Gerardo Guillen Nieto, Yoichi Hiasa
Summary: This study found that CVP-NASVAC has prophylactic capacity for HB vaccine non-responders. After administration of CVP-NASVAC, patients were able to produce antibodies, and the neutralizing activity in sera was also confirmed. In addition, CVP-NASVAC also induced the generation of specific cytotoxic T lymphocytes.
Article
Biochemistry & Molecular Biology
Aunji Pradhan, Shwetha Shivaprasad, Shuchismita Dey, Amit Goel, Rakesh Aggarwal, Saumitra Das
Summary: In this study, the role of exosome-associated miR-375 in HCV-induced liver disease progression was investigated. It was found that miR-375 is significantly upregulated in exosomes isolated from patients with cirrhosis and hepatocellular carcinoma. Depletion of miR-375 inhibited HCV-induced cell migration and proliferation, and exosomal transfer of miR-375 increased cell proliferation and migration in recipient cells. Additionally, miR-375 was found to target a gene involved in cell growth and malignancy. These findings demonstrate the critical involvement of exosome-associated miR-375 in HCV-induced disease progression.
MOLECULAR MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Zezheng Liu, Qian Ye, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Juan Huang, Qun Gao, Bin Tian, Mingshu Wang
Summary: The study found that the 2B protein of Duck hepatitis A virus 1 can induce autophagy in host cells, but the autophagic flow is incomplete. This suggests that the infection and pathogenic mechanism of DHAV-1 may be related to autophagy.
Article
Microbiology
Yuanzhi Liu, Anchun Cheng, Mingshu Wang, Sai Mao, Xumin Ou, Qiao Yang, Ying Wu, Qun Gao, Mafeng Liu, Shaqiu Zhang, Juan Huang, Renyong Jia, Dekang Zhu, Shun Chen, Xinxin Zhao, Yanling Yu, Yunya Liu, Ling Zhang, Bin Tian, Leichang Pan
Summary: DHAV-1 virus inhibits cellular translation in duck embryo fibroblasts by inducing eIF2 alpha phosphorylation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marzieh Jamalidoust, Maryam Shafaati, Mehdi Kalani, Maryam Zare, Mazyar Ziyeayan
Summary: The study demonstrates the inhibitory effect of let-7b on HCV replication by promoting apoptosis and reducing HCV-RNA load. Therefore, let-7b may serve as a potential antiviral therapy target.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Microbiology
Maria Bousali, Timokratis Karamitros
Summary: This study investigated the preferential integration of hepatitis B virus (HBV) into specific genes and evaluated their contribution to hepatocellular carcinoma (HCC) development. The results suggested that 15 genes are frequently affected by HBV integrations and significantly associated with HBV-HCC.
Article
Gastroenterology & Hepatology
Jing Lin, Miao-Fang Su, Jiao-Long Zheng, Lei Gu, Hai-Cong Wu, Xia Wu, Hai-Yan Lin, Zhi-Xian Wu, Dong-Liang Li
Summary: This study investigated the clinicopathological features and pathogenic mechanisms of chronic active Epstein-Barr virus hepatitis (CAEBVH). The clinical features of CAEBVH patients included fever, hepatosplenomegaly, and lymphadenopathy. Histopathological changes revealed lymphocytic infiltration in the liver and positive Epstein-Barr virus-encoded small RNA in-situ hybridization. Fas/FasL and complement activation were found to be involved in the pathogenesis of CAEBVH.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Biochemical Research Methods
Sufang Wang, Michael Gribskov, Tony R. Hazbun, Pete E. Pascuzzi
Article
Biochemistry & Molecular Biology
H. Fan, Z. Cui, H. Zhang, S. K. Mani, A. Diab, L. Lefrancois, N. Fares, P. Merle, O. Andrisani
Article
Genetics & Heredity
Siwen Wang, Zheng Xing, Pete E. Pascuzzi, Elizabeth J. Tran
G3-GENES GENOMES GENETICS
(2017)
Article
Immunology
Shankar Thangamani, Matthew Maland, Haroon Mohammad, Pete E. Pascuzzi, Larisa Avramova, Carla M. Koehler, Tony R. Hazbun, Mohamed N. Seleem
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Oncology
Zhuangzhuang Zhang, Lijun Cheng, Jie Li, Elia Farah, Nadia M. Atallah, Pete E. Pascuzzi, Sanjay Gupta, Xiaoqi Liu
Article
Biochemistry & Molecular Biology
Benjamin Carter, Brett Bishop, Kwok Ki Ho, Ru Huang, Wei Jia, Heng Zhang, Pete E. Pascuzzi, Roger B. Deal, Joe Ogas
Article
Plant Sciences
Lorenzo Concia, Ashley M. Brooks, Emily Wheeler, Gregory J. Zynda, Emily E. Wear, Chantal LeBlanc, Jawon Song, Tae-Jin Lee, Pete E. Pascuzzi, Robert A. Martienssen, Matthew W. Vaughn, William F. Thompson, Linda Hanley-Bowdoin
Article
Biochemistry & Molecular Biology
Elia Farah, Chaohao Li, Lijun Cheng, Yifan Kong, Nadia A. Lanman, Pete Pascuzzi, Gabrielle Renee Lorenz, Yanquan Zhang, Nihal Ahmad, Lang Li, Tim Ratliff, Xiaoqi Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Plant Sciences
Jeong Im Kim, Xuebin Zhang, Pete E. Pascuzzi, Chang-Jun Liu, Clint Chapple
Article
Information Science & Library Science
Wei Zakharov, Haiyan Li, Michael Fosmire, Pete E. Pascuzzi, Jon Harbor
Summary: In the current dynamic information environment, promoting students' scientific news literacy and critical thinking skills is crucial for information professionals. However, instructors in large-scale online classes face challenges in assessing and providing constructive feedback. Online peer-assessment tools can help facilitate reliable self- and peer-assessment in scientific literacy education at scale.
COLLEGE & UNDERGRADUATE LIBRARIES
(2021)
Proceedings Paper
Computer Science, Theory & Methods
William S. Monroe, Ravi Tripathi, Dong San Choi, Yuting Chen, Zuofu Cheng, Ujjal Bhowmik, Gladys K. Andino, Pete E. Pascuzzi, Mark D. Ward, Michael Witt, Maria Pantoja, Chris Lupo, Anne C. Elster, Joel C. Adams, Mark C. Wissink, Hang Liu, Raphael B. Yehezkael, Brian Smith, Ben Glick, Jens Mache, Chunhua Liao, Trilce Estrada, Debzani Deb
PROCEEDINGS OF 2019 ACM/IEEE WORKSHOP ON EDUCATION FOR HIGH PERFORMANCE COMPUTING ( EDUHPC 2019)
(2019)
Article
Biochemistry & Molecular Biology
Shankar Thangamani, Hassan E. Eldesouky, Haroon Mohammad, Pete E. Pascuzzi, Larisa Avramova, Tony R. Hazbun, Mohamed N. Seleem
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Biochemistry & Molecular Biology
Kourtney M. Goode, Dino P. Petrov, Renee E. Vickman, Scott A. Crist, Pete E. Pascuzzi, Tim L. Ratliff, V. Jo Davisson, Tony R. Hazbun
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Ophthalmology
Prahatha Venkatraman, Ishara Mills-Henry, Karthik Ramaswamy Padmanabhan, Pete Pascuzzi, Menna Hassan, Jingyi Zhang, Xinlian Zhang, Ping Ma, Chi Pui Pang, John E. Dowling, Mingzhi Zhang, Yuk Fai Leung
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)