Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells

(2014) Annika Kötter et al.   Molecular Oncology

Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis

(2013) I. Eke et al.   CANCER RESEARCH

The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

(2013) Wael Y. Mansour et al.   DNA REPAIR

EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells

(2012) I. Eke et al.   CANCER RESEARCH

Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro

(2012) Iris Eke et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting FAK Radiosensitizes 3-Dimensional Grown Human HNSCC Cells Through Reduced Akt1 and MEK1/2 Signaling

(2012) Stephanie Hehlgans et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability

(2012) R. Kumareswaran et al.   JOURNAL OF CELL SCIENCE

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

(2012) Iris Eke et al.   JOURNAL OF CLINICAL INVESTIGATION

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

(2012) M Krajewska et al.   ONCOGENE

Modulation of radiation-induced oral mucositis (mouse) by selective inhibition of β1 integrin

(2012) Maria Albert et al.   RADIOTHERAPY AND ONCOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

(2011) Alan Serrels et al.   INTERNATIONAL JOURNAL OF CANCER

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks

(2011) Qiao Cheng et al.   NUCLEIC ACIDS RESEARCH

Influence of stress on extracellular matrix and integrin biology

(2011) C Jean et al.   ONCOGENE

A formal model for analyzing drug combination effects and its application in TNF-α-induced NFκB pathway

(2010) Han Yan et al.   BMC Systems Biology

Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification

(2010) K. Storch et al.   CANCER RESEARCH

Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

(2010) N. Chan et al.   CANCER RESEARCH

"Contextual" Synthetic Lethality and/or Loss of Heterozygosity: Tumor Hypoxia and Modification of DNA Repair

(2010) N. Chan et al.   CLINICAL CANCER RESEARCH

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth

(2010) Dalit Barkan et al.   EUROPEAN JOURNAL OF CANCER

Early Increase of Radiation-induced γH2AX Foci in a Human Ku70/80 Knockdown Cell Line Characterized by an Enhanced Radiosensitivity

(2010) Veerle VANDERSICKEL et al.   JOURNAL OF RADIATION RESEARCH

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

The Tumor Microenvironment and DNA Repair

(2010) Thomas J. Klein et al.   SEMINARS IN RADIATION ONCOLOGY

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

(2009) Alok Tomar et al.   CURRENT OPINION IN CELL BIOLOGY

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226

(2009) Stephanie Hehlgans et al.   RADIOTHERAPY AND ONCOLOGY

 1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts

(2008) C. C. Park et al.   CANCER RESEARCH

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics