Article
Chemistry, Applied
Zarina Bano, Sabira Begum, Syed Saqib Ali, Zareena Kiran, Bina S. Siddiqui, Ayaz Ahmed, Shariqa Khawaja, Fatima Fatima, Almas Jabeen
Summary: Six natural products were isolated from the fresh leaves of Carissa carandas, with compounds 3-5 showing potential as anti-cancer drug leads due to their potent activity against lung cancer cell lines and anti-inflammatory properties.
NATURAL PRODUCT RESEARCH
(2022)
Article
Food Science & Technology
Muhammad Muneeb Ahmad, Shahzad Ali Shahid Chatha, Abdullah Ijaz Hussain, Ikramullah Khan
Summary: In this study, pectic polysaccharides were extracted from Carissa carandas fruit and their antioxidant activities were compared before and after modification. The modified polysaccharides showed significantly improved antioxidant activities, indicating their potential use as preservatives in various food, pharmaceutical, and functional commodities.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Immunology
Manjari Shukla, Vineeta Singh, Hamza Habeeballah, Mustfa F. Alkhanani, Manjul Lata, Yusuf Hussain, Madhuparna Mukherjee, Mukesh Pasupuleti, Abha Meena, Bhartendu Nath Mishra, Shafiul Haque
Summary: The inhibitory and degradation potential of Carissa carandas proteinaceous leaf extract against mixed bacterial biofilm responsible for nosocomial infections was evaluated. The extract showed significant inhibition and degradation of the biofilm, with the best degradation observed against Staphylococcus aureus biofilm. The presence of flavonoids, phenols, and tannins in the extract suggests their contribution to the antibiofilm property.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Manaschanok Lailerd, Thiri Wai Linn, Narissara Lailerd, Duangporn Amornlerdpison, Arisa Imsumran
Summary: This study investigated the effects of Carissa carandas fruit extract on inflammation and insulin resistance in vitro and in vivo. The results showed that the extract reduced inflammation and improved insulin resistance in cellular and animal models. It also significantly improved glycemic control and protected against pancreatic damage in diabetic rats.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Waranya Neimkhum, Songyot Anuchapreeda, Wei-Chao Lin, Shang-Chian Lue, Kuan-Han Lee, Wantida Chaiyana
Summary: This study revealed the potential of Carissa carandas as a natural anti-aging, antioxidant, and skin whitening agent. The leaf extract had the highest content of ursolic acid and showed the most significant inhibitory effects on MMP-1, NF-kappa B, and tyrosinase activity. Ursolic acid was suggested to be a key component in these biological activities, with the potential for use in cosmetics and cosmeceuticals.
Article
Biochemistry & Molecular Biology
Sudarshan Singh, Ozioma Forstinus Nwabor, Dwi Marlina Syukri, Supayang Piyawan Voravuthikunchai
Summary: Biodegradable chitosan-poly(vinyl alcohol) films containing natural anthocyanin-rich extracts were prepared and employed as intelligent indicators for monitoring beverages freshness. The films showed compact structure, enhanced radical scavenging efficacy, and color changes at different pH levels. Additionally, the films demonstrated good cell compatibility and pH sensing properties, indicating their potential for beverage freshness monitoring.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Reetika Singh, Christophe Hano, Gopal Nath, Bechan Sharma
Summary: The traditional medicinal plant Carissa carandas L. was used to green synthesize silver nanoparticles (AgNPs) with potential antioxidant and antibacterial activities, demonstrated through UV-Vis, FT-IR, XRD analysis, and DPPH assay.
Article
Multidisciplinary Sciences
Haajira Beevi Habeeb Rahuman, Ranjithkumar Dhandapani, Velmurugan Palanivel, Sathiamoorthi Thangavelu, Ragul Paramasivam, Saravanan Muthupandian
Summary: The surface modification of urinary catheters with environmentally friendly synthesized phytomolecules-capped silver nanoparticles effectively prevents urinary tract infections and has potential antibiofilm activity. Further research shows that the synergistic effects of synthesized AgNPs enhance antibacterial and antibiofilm activities, indicating a promising new approach to control clinical pathogens.
Article
Plant Sciences
Gauri Pathak, Shilpi Singh, Mohit Singhal, Jyoti Singh, Yusuf Hussain, Madhuri Gupta, Abha Meena, Pratima Gupta, Prasant Kumar Rout
Summary: Carissa carandas leaf extracts show potential anti-proliferative, antioxidant, and antimicrobial properties, with methanol and methanol-water extracts demonstrating strong activity and safety in in vivo toxicity assessment in mice.
Article
Chemistry, Applied
Tintu Jose Manicketh, Mannacheril Sebastian Francis, Geo Joseph
Summary: This study aimed to explore the potential of natural colorants from plants in textile dyeing. Different natural dyes extracted from plants were applied on cotton, silk, and polyester yarns with and without mordants, showing enhanced color strength values with the addition of mordants. The fastness properties of the dyed yarns were found to be good, indicating that the plants used could be a promising source of natural colorants.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Medicinal
Chanchal Kumar Mishra, Ashok Kumar Pattnaik, Pankaj Dagur, Dhiraj Kumar, Manik Ghosh
Summary: The study found that the ethanolic fruit extract of Carissa carandas has a significant effect on wound healing, with better results compared to the untreated and simple ointment groups. Through mechanical and pathological studies, it was also found that the extract promotes the production of collagen, mononuclear cells, and fibroblasts.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Plant Sciences
Monika Mahajan, Harsimrat K. Bons, Gurpreet Kaur Dhillon, Poonam Aggarwal Sachdeva
Summary: Karonda is an underutilized fruit shrub mainly grown in the Indian subcontinent. Its edible fruits are enriched in nutrients and can be a boon for those who cannot afford expensive fruits and vegetables. However, due to high perishability and improper post-harvest management, a large amount of Karonda fruits go to waste. Sun drying and low power microwave drying are the best methods for retaining maximum nutritional compounds in Karonda powder, and both methods show better color retention and anthocyanin content compared to oven drying.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Pharmacology & Pharmacy
N. Thitilertdecha, P. Pintathong
Summary: This study evaluated the efficacy of Carissa carandas pulp and seed extracts in cosmetic application. The seed extract exhibited higher phenolic content and better radical scavenging ability, while the emulgel containing the seed extract showed significant improvement in skin conditions. It was concluded that the phenolic compounds of Carissa carandas extract could be used as an anti-aging agent in cosmetics.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Plant Sciences
Shagufta Irshad, Asia Iqbal, Amna Zulqarnain, Sadia Nawaz, Saadat Anjum
Summary: The study explored the full potential of Carissa carandas fruits and found that ripe fruits exhibited the highest phytochemical content and antioxidant activity. The method of sequential solvent extraction was used to investigate maximum phytochemicals, with methanol and aqueous extracts showing the highest levels of phytochemicals. Antioxidant contents were highest in methanol extracts of ripe fruits, indicating the higher antioxidant potential of fully ripe reddish-purple fruits.
PAKISTAN JOURNAL OF BOTANY
(2021)
Article
Plant Sciences
Nguyen Phuoc Minh
Summary: The research found that under specific conditions, karanda wine produced has high ethanol content and total phenolic content, with good overall acceptability. Moderate consumption of wine made from this valuable fruit would be beneficial for health.
PLANT SCIENCE TODAY
(2021)
Article
Environmental Sciences
Muhammad Ejaz Ul Haq, Muhammad Sajid Hamid Akash, Shakila Sabir, Malik Hassan Mahmood, Kanwal Rehman
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Jamshed Arslan, Anwar-ul-Hassan Gilani, Humaira Jamshed, Sumaiya F. Khan, Mohammad A. Kamal
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Integrative & Complementary Medicine
Muhammad Nabeel Ghayur, Saeed Ahmad, Anwarul Hassan Gilani
Summary: The extract of Grewia asiatica fruit exhibits antispasmodic and vasorelaxant effects through the mechanism of opening K+ channels and releasing NO from vascular endothelium, in both gastrointestinal tract and blood vessels, respectively.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Amber Hanif Palla, Najeeb Ur Rehman, Hasan Salman Siddiqi, Anwar-Ul-Hassan Gilani, Bina Shaheen Siddiqui, Maimoona Ilyas, Sobiya Perwaiz
Summary: Flaxseed, traditionally used for managing hypertension, may exert its antihypertensive activity by acting as an alpha-1 receptor antagonist and Ca+2 channel blocker, according to a study showing its effects on arterial blood pressure and vasodilation.
Review
Pharmacology & Pharmacy
Amber Hanif Palla, Faridah Amin, Bilqees Fatima, Arooj Shafiq, Najeeb Ur Rehman, Ikram ul Haq, Anwar-ul-Hassan Gilani
Summary: Herbal combinations have shown potential efficacy in treating metabolic syndrome, providing a direction for future research in herbal combinations, drug development, and prevention and management of metabolic syndrome.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A. Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Haq
Summary: The study reveals that Sarcorucinine-D, a pregnane type steroidal alkaloid, is a potential lead molecule for the treatment of Alzheimer's disease due to its properties as a noncompetitive acetylcholinesterase inhibitor and a calcium channel blocker.
Article
Biotechnology & Applied Microbiology
Muhammad Nabeel Ghayur, Mohnad Abdalla, Asaad Khalid, Saeed Ahmad, Anwarul Hassan Gilani
Summary: This study found that Fenugreek extract did not have any stimulant or relaxant activity on isolated GI smooth muscles, and its constituent diosgenin could inhibit the activity of acetylcholinesterase. This suggests that Fenugreek extract may enhance memory.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Saara Ahmad, Saad Bilal Ahmed, Asra Khan, Muhammad Wasim, Saiqa Tabassum, Saida Haider, Fatima Ahmed, Zehra Batool, Saima Khaliq, Hamna Rafiq, Prashant Tikmani, Anwar-ul-Hassan Gilani
Summary: This review explores the role of natural alternatives in the treatment of Alzheimer's disease (AD). The analysis shows that herbal remedies, especially when combined with FDA-approved drugs, have positive effects on AD and are more effective than allopathic treatment alone.
METABOLIC BRAIN DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Malik Hassan Mehmood, Bushra Shaukat, Babar Murtaza, Farah Javaid, Muhammad Tariq Khan, Maryam Farrukh, Reemal Rana, Muhammad Shahzad
Summary: This study investigated the beneficial effects and mechanisms of A. bracteosa in L-NAME-induced hypertensive rats. The results showed that A. bracteosa has antihypertensive, antioxidant, and anti-inflammatory activities, possibly mediated through the regulation of eNOS, ACE, NF-kB, and COX-2 gene expressions.
Article
Biology
Reemal Rana, Malik Hassan Mehmood, Bushra Shaukat, Sidra Shahid, Abdul Malik, Babar Murtaza
Summary: This study found that coriander and lemon have significant antihypertensive activity, possibly mediated through endothelial protection and antioxidant effects. This provides a rationale for the medicinal use of coriander and lemon in treating hypertension and cardiovascular complications induced by arsenic.
Review
Immunology
Rida Siddique, Malik Hassan Mehmood, Liaqat Hussain, Abdul Malik, Ayesha Sethi, Maryam Farrukh, Shaneel Kousar
Summary: Burn management is a complex process involving multiple phases of wound healing. The use of medicinal plants and phytochemicals as alternative agents for burn wound management shows promise due to their biocompatibility, cost-effectiveness, and cultural acceptance. This review highlights the therapeutic potential of 35 medicinal herbs and 10 phytochemicals in burn wound healing, including their mechanisms of action such as modulation of inflammatory cytokines and oxidative stress. The review also emphasizes the need for efficacious alternative agents to combat the high cost of synthetic drugs and antibiotic resistance.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Malik Hassan Mehmood, Abdul Malik, Muhammad Shoaib Akhtar, Ghulam Haider, Anwarul Hassan Gilani
Article
Pharmacology & Pharmacy
Muhammad Zeeshan Ali, Malik Hassan Mehmood, Muhammad Haneef, Muhammad Saleem, Ghazala Ishrat, Hassan Salman Siddiqi, Anwar-ul-Hassan Gilani, Mansoor Ahmed
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Integrative & Complementary Medicine
Muhammad Zeeshan Ali, Malik Hassan Mehmood, Muhammad Saleem, Anwarul-Hassan Gilani
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)