Article
Plant Sciences
Ana Paula Martin, Maria Florencia Martinez, Maria Amalia Chiesa, Lucila Garcia, Nadia Gerhardt, Facundo Uviedo, Pablo S. Torres, Maria Rosa Marano
Summary: Plant bioactive compounds, such as rosemary-derived extracts, show potential in controlling plant diseases due to their antimicrobial and antioxidant activities. However, the effects of these extracts on plant diseases are not well understood, restricting their application in agriculture.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Applied
Engy M. Saad, Nesrine Abdelrehim El Gohary, Mohammad Abdel-Halim, Heba Handoussa, Rasha Mohamed El Nashar, Boris Mizaikoff
Summary: This study demonstrates a robust and reproducible approach for selectively extracting rosmarinic acid using molecularly imprinted polymers. By optimizing the molecularly imprinted solid phase extraction protocol, a remarkably selective extraction of RA from real-world Rosmarinus officinalis L. extract was achieved, with a recovery rate and purity of 81.96 +/- 6.33% and 80.59 +/- 0.30%, respectively.
Article
Agricultural Engineering
Ke Jin, Xun Shi, Jiaheng Liu, Wenwen Yu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu
Summary: Ursolic acid (UA) and oleanolic acid (OA) were synthesized with titers of 7.4 and 3.0 mg/L, respectively, through the heterologous expression and optimization of CrAS, CrAO, and AtCPR1. By redirecting metabolic flux and enhancing the NADPH regeneration system, the titers of UA and OA were increased to 692.3 and 253.4 mg/L in a shake flask, and to 1132.9 and 433.9 mg/L in a 3-L fermenter, respectively, which are the highest reported to date. This study provides a reference for constructing microbial cell factories for efficient terpenoid synthesis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Infectious Diseases
Sandrine Verstraeten, Lucy Catteau, Laila Boukricha, Joelle Quetin-Leclercq, Marie-Paule Mingeot-Leclercq
Summary: The study showed the synergy between pentacyclic triterpenes and ampicillin towards Methicillin-Resistant S. aureus by binding to LTA, inducing membrane permeabilization and depolarization. This effect was not accompanied by significant changes in cellular concentration, suggesting a mediated effect through lipid membranes.
Article
Plant Sciences
Majid Rasool Kamli, Abeer Abdullah M. Sharaf, Jamal S. M. Sabir, Irfan A. Rather
Summary: The ethyl-acetate extract showed the strongest inhibitory effect against AChE and had the highest antioxidant potential. It also contained the highest total phenolic content, suggesting it may serve as a potential pharmacological lead for treating cognitive disorders.
Article
Biochemistry & Molecular Biology
Anuj Kumar, Gourav Choudhir, Sanjeev Kumar Shukla, Mansi Sharma, Pankaj Tyagi, Arvind Bhushan, Madhu Rathore
Summary: The study identifies three natural metabolites, namely ursolic acid, carvacrol, and oleanolic acid, as potential inhibitors of the main protease (M-pro) of COVID-19. These molecules have stable and favorable energies, passing absorption and metabolism criteria, suggesting they could regulate M-protein function and control viral replication.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Applied
Atsumi Shimada, Hiroshi Ueno, Masanori Inagaki
Summary: Glutaminase is an important target in neurodegenerative and lifestyle related diseases, and three pentacyclic triterpene acids isolated from Thymus vulgaris L., including betulinic acid, have shown inhibitory effects against glutaminase activity. Compound 2, betulinic acid, significantly inhibited glutaminase activity and could potentially be used for the prevention and treatment of such diseases.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Sajjad Jabbari, Zainul Amiruddin Zakaria, Davoud Ahmadimoghaddam, Saeed Mohammadi
Summary: Lotus corniculatus leaves essential oil (LCEO) has antinociceptive effects and can alleviate both acute and chronic pain. It may act through modulation of opioid, TRPV, dopamine, cannabinoid mechanisms, as well as NO-cGMP-K+ channel, and also inhibit inflammatory processes.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Irina Ielciu, Mihaela Niculae, Emoke Pall, Cristina Barbalata, Ioan Tomuta, Neli-Kinga Olah, Ramona Flavia Burtescu, Daniela Benedec, Ilioara Oniga, Daniela Hanganu
Summary: This study evaluated the effects of R. officinalis-loaded liposomes on cell proliferation and antimicrobial activity. The liposomes showed high encapsulation efficiency, stability, and selective toxicity towards cancer cells, as well as effective antimicrobial activity against Gram-positive bacteria. These findings confirm the biological activities of R. officinalis and propose novel delivery systems for enhanced polyphenol activity.
Article
Chemistry, Medicinal
Barbara Bednarczyk-Cwynar, Anna Leskow, Izabela Szczuka, Lucjusz Zaprutko, Dorota Diakowska
Summary: This study aimed to synthesize new derivatives of oleanolic acid (OA) and investigate their anti-cancer potential against melanoma cells. Two OA derivatives (3a and 3b) showed significant anti-proliferative and cytotoxic effects on A375 and MeWo melanoma cells at certain concentrations and incubation times. Further studies are needed to explore the proapoptotic and anti-cancer activities of 3a and 3b on other cancer cells. The bromoacetoxyimine derivative (3b) of OA morpholide exhibited the highest effectiveness against the tested cancer cells.
Review
Biochemistry & Molecular Biology
Gabriela Nistor, Cristina Trandafirescu, Alexandra Prodea, Andreea Milan, Andreea Cristea, Roxana Ghiulai, Roxana Racoviceanu, Alexandra Mioc, Marius Mioc, Viviana Ivan, Codruta Soica
Summary: This review summarizes the literature published in the last 10 years regarding derivatives of pentacyclic triterpenes bearing heterocyclic moieties and focuses on their biological activities and structure-activity relationships. The studies suggest that triterpenoid conjugates with heterocyclic moieties may be promising candidates for future clinical trials.
Article
Food Science & Technology
Kartini Kartini, Nina Wati, Rabbindra Gustav, Risa Wahyuni, Yosua Fernaldi Anggada, Risna Hidayani, Antoni Raharjo, Ridho Islamie, Sulistyo Emantoko Dwi Putra
Summary: This study investigated the wound healing effects of P. major leaf extracts, ursolic acid, and oleanolic acid in hyperglycemic rats. The results showed that these substances can improve wound closure and accelerate healing time without causing acute dermal irritation. It was also found that UA and OA may have different mechanisms of action in promoting wound healing in diabetic conditions.
Article
Biochemistry & Molecular Biology
Natalia Wronska, Michal Szlaur, Katarzyna Zawadzka, Katarzyna Lisowska
Summary: Currently, there is a need for new antimicrobial drugs due to the excessive use of antibiotics and emerging resistance amongst bacteria. This study found that two triterpenoids and one flavonoid displayed antimicrobial activity and showed potential synergistic effects, enhancing the antimicrobial potential.
Review
Biochemistry & Molecular Biology
Marius Mioc, Andreea Milan, Daniel Malita, Alexandra Mioc, Alexandra Prodea, Roxana Racoviceanu, Roxana Ghiulai, Andreea Cristea, Florina Caruntu, Codruta Soica
Summary: This review summarizes recent literature on the mechanism of action of three triterpenic acids and their biological activities. The compounds share similar mechanisms in anticancer, anti-inflammatory, and antidiabetic activities, while also highlighting specific mechanisms for individual triterpenic acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cristina Cedeno-Pinos, Magdalena Martinez-Tome, Dario Mercatante, Maria Teresa Rodriguez-Estrada, Sancho Banon
Summary: Using natural plant extracts with standardized antioxidant properties is a growing strategy for stabilizing food products. Rosemary diterpenes can resist pasteurization and demonstrate antioxidant activity during the shelf-life of pasteurized salmon pate.
Article
Plant Sciences
Ana Laura Martinez, Abraham Madariaga-Mazon, Isabel Rivero-Cruz, Robert Bye, Rachel Mata
Article
Medicine, Research & Experimental
Maria Eva Gonzalez-Trujano, Gerardo Uribe-Figueroa, Sergio Hidalgo-Figueroa, Ana Laura Martinez, Myrna Deciga-Campos, Gabriel Navarrete-Vazquez
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Plant Sciences
G. Perez-Ortega, P. Guevara-Fefer, M. Chavez, J. Herrera, A. Martinez, A. L. Martinez, M. E. Gonzalez-Trujano
JOURNAL OF ETHNOPHARMACOLOGY
(2008)
Article
Plant Sciences
Eva Aguirre-Hernandez, Ma Eva Gonzalez-Trujano, Ana Laura Martinez, Julia Moreno, Geoffrey Kite, Teresa Terrazas, Marcos Soto-Hernandez
JOURNAL OF ETHNOPHARMACOLOGY
(2010)
Article
Neurosciences
Ana Laura Martinez, Ma. Eva Gonzalez-Trujano, Eva Aguirre-Hernandez, Julia Moreno, Marco Soto-Hernandez, Francisco J. Lopez-Munoz
Article
Behavioral Sciences
Azucena I. Carballo, Ana Laura Martinez, Ma. Eva Gonzalez-Trujano, Francisco Pellicer, Rosa Ventura-Martinez, M. Irene Diaz-Reval, Francisco J. Lopez-Munoz
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2010)
Article
Behavioral Sciences
Ana Laura Martinez, Ma Eva Gonzalez-Trujano, Marco Chavez, Francisco Pellicer, Julia Moreno, Francisco J. Lopez-Munoz
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2011)
Article
Plant Sciences
Ana L. Martinez, Maria Eva Gonzalez-Trujano, Francisco Pellicer, Francisco J. Lopez-Munoz, Andres Navarrete
Article
Medicine, Research & Experimental
Claudia Lizbeth Martinez-Gonzalez, Laura Martinez, Efrain J. Martinez-Ortiz, Maria Eva Gonzalez-Trujano, Myrna Deciga-Campos, Rosa Ventura-Martinez, Irene Diaz-Reval
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Plant Sciences
M. E. Gonzalez-Trujano, E. I. Pena, A. L. Martinez, J. Moreno, P. Guevara-Fefer, M. Deciga-Campos, F. J. Lopez-Munoz
JOURNAL OF ETHNOPHARMACOLOGY
(2007)
Article
Plant Sciences
E. Aguirre-Hernandez, A. L. Martinez, M. E. Gonzalez-Trujano, J. Moreno, H. Vibrans, M. Soto-Hernandez
JOURNAL OF ETHNOPHARMACOLOGY
(2007)
Article
Plant Sciences
A. L. Martinez, F. Dominguez, S. Orozco, M. Chavez, H. Salgado, M. Gonzalez, M. E. Gonzalez-Trujano
JOURNAL OF ETHNOPHARMACOLOGY
(2006)
Article
Plant Sciences
Eva Gonzalez-Trujano, Ana Laura Martinez, Adelfo Reyes-Ramirez, Benito Reyes-Trejo, Andres Navarrete
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)