Article
Multidisciplinary Sciences
Yutao Huang, Shuyu Cai, Xiaoli Ruan, Jun Xu, Dongdong Cao
Summary: The study found that compound sodium nitrophenolate (CSN) significantly increased the germination rate and seedling emergence rate of aged sunflower seeds. Biochemical analysis showed that CSN treatment significantly enhanced the sucrose and fructose contents in aged sunflower seeds during early germination period. Enzyme activity analysis revealed that CSN treatment remarkably up-regulated the activities of several critical enzymes related to triacylglycerol hydrolysis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Food Science & Technology
Lichun Chen, Songwen Xue, Binhao Dai, Huimin Zhao
Summary: This study evaluated the effects of various dietary oils on obese mice and found that coix seed oil (CSO) has anti-obesity properties and can improve lipid metabolism. CSO contains a high content of medium-chain fatty acids, which can modify hepatic fatty acid metabolism and lipid levels.
Article
Biochemistry & Molecular Biology
Yan Liang, Fan Kong, Xiaofeng Ma, Qingyan Shu
Summary: Acer truncatum seed coat (ESA) has been found to inhibit fatty acid synthase (FAS) activity, with quinic acid, malic acid, gentisic acid, procyanidin dimer, procyanidin trimer, catechin, and quercetin identified as the main compounds. This study provides new insights for the development of obesity treatments and the industrial production of vegetable oil.
Article
Food Science & Technology
Yingling Sui, Deping Xu, Xiulan Sun
Summary: This study isolated and screened active compounds with uric acid-lowering effect from Coix seed, and their structures were identified using NMR and mass spectrometry. The results showed that Coix seed effectively reduced serum uric acid and creatinine levels, suppressed liver xanthine oxidase activity, and improved kidney damage in hyperuricemic mice. Two major anti-hyperuricemic compounds, including a new compound, were identified from the seed. These compounds exhibited potent inhibitory activity against xanthine oxidase in vitro and interacted with residues within the active pocket of the enzyme. This study provides a new alternative for the development of uric acid-lowering medications.
Article
Plant Sciences
Yutao Huang, Min Lu, Huaping Wu, Tiyuan Zhao, Pin Wu, Dongdong Cao
Summary: The drying temperature of sunflower seeds significantly affects seed vigor and deterioration during storage. A temperature of 40 degrees Celsius is safe for sunflower seeds, but higher drying temperatures reduce seed vigor by regulating metabolism and balance. High drying temperatures increase activities that lead to over-accumulation of harmful substances and inhibit crucial enzyme activities during germination.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Haichuan Wang, Yi Zhou, Hongwei Xu, Xue Wang, Yi Zhang, Runze Shang, Marie O'Farrell, Stephanie Roessler, Carsten Sticht, Andreas Stahl, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: This study evaluated the therapeutic efficacy of the FASN inhibitor TVB3664 for HCC treatment and found that it has limited effectiveness as monotherapy, but can be combined with other drugs for improved results. These combination therapies can be developed based on driver oncogenes, supporting precision medicine approaches for HCC treatment.
Review
Cardiac & Cardiovascular Systems
Junbin Yan, Yunmeng Nie, Jielu Cao, Minmin Luo, Maoxiang Yan, Zhiyun Chen, Beihui He
Summary: FGF21, as a crucial factor, plays a significant role in regulating metabolism and cellular aging, making it important for addressing aging-associated metabolic diseases. FGF21 affects cellular function by activating autophagy genes, improving inflammation, and regulating glucose and lipid metabolism.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marie O'Farrell, Greg Duke, Richard Crowley, Douglas Buckley, Eduardo B. Martins, Dipankar Bhattacharya, Scott L. Friedman, George Kemble
Summary: FASN inhibition can reduce the development of fatty liver and fibrosis, and alleviate the inflammatory and fibrotic drivers of NASH by inhibiting immune and stellate cell activity.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Chi Zhou, Weisong Pan, Qi Peng, Yanchao Chen, Ting Zhou, Chuan Wu, William Hartley, Juan Li, Minhui Xu, Chuwei Liu, Peng Li, Liqun Rao, Qiming Wang
Summary: In this study, widely targeted metabolomics was used to investigate the metabolites of normal-oleic-acid and high-oleic-acid rapeseed, revealing key differential metabolites. Lipid profile experiments further confirmed the impact of RNAi technology on FAD2 gene expression. Additionally, resequencing analysis of the transgenic B. napus plants was conducted, focusing on the insertion site and sequence integrity of FAD2 genes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Michael J. Haas, Emad Naem, Sultan Almdallaleh, Arshag D. Mooradian
Summary: Black seed extract stimulates the expression of apo A-I gene and elevates the levels of PPAR alpha and RXR alpha. In HepG2 cells, it reduces lipid content and affects the expression of key regulators of fatty acid metabolism. It also increases the expression of fatty acid oxidation enzymes and reduces lipogenic signaling. Therefore, black seed extract may have potential benefits in metabolic diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Nutrition & Dietetics
Wei Zhang, Xiuzhen Jia, Yuhan Xu, Qiaoling Xie, Meizhen Zhu, Hesong Zhang, Zifu Zhao, Jingyu Hao, Haoqiu Li, Jinrui Du, Yan Liu, Wei-Hsien Liu, Xia Ma, Weilian Hung, Haotian Feng, Hongwei Li
Summary: Research has shown that Coix seed extract (CSE) and probiotics can regulate glycolipid metabolism, control weight gain, reduce fat content, and regulate blood lipids and abnormal blood sugar. These effects may be due to the reduction of chronic inflammatory states, improvement in energy metabolism, exercise, relief of insulin sensitivity, and reduction in lipid synthesis.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Cuncun Lu, Shuilin Wu, Lixin Ke, Fumei Liu, Wenru Shang, Xiuxiu Deng, Yanli Huang, Qiang Zhang, Xin Cui, Alexios-Fotios A. Mentis, Yanming Xie, Zhifei Wang
Summary: This overview examines the evidence landscape based on published meta-analyses of Kanglaite (KLT) in cancer treatment. The results indicate that KLT can be effective and safe as an adjunctive therapy for non-small cell lung cancer, malignant pleural effusion, and digestive system malignancies. However, the methodological quality of these meta-analyses is questionable.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Xue Li, Juanjuan Yi, Jiaqing Zhu, Changcheng Zhao, Yan Cui, Yanling Shi, Limin Hao, Jike Lu
Summary: Coix seed seedling extract (CSS-E) exhibits a strong radioprotective effect, reducing oxidative damage caused by ionizing radiation (IR). By modulating the activities of key enzymes such as superoxide dismutase and glutathione peroxidase, CSS-E effectively protects the body from radiation-induced harm.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Lam Phuoc Thanh, Pham Truong Thoai Kha, Juan J. Loor, Tran Thi Thuy Hang
Summary: The study shows that PUFA in SBO combined with CT are effective in modulating ruminal BH and CH4 production, but high doses of added CT can reduce ruminal VFA concentration. A level of 0.4% GSTE added to diets containing 2.5% PUFA from plant origin may optimize ruminal fermentation and BH of C18:2 c9,c12 to fatty acid intermediates. Adding 0.4% grape seed tannin extract with 2.5% soybean oil is suitable for improving in vitro ruminal fermentation and BH.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Food Science & Technology
Qi Mei, Zhaona Xu, Quanye Wu, Likang Qin, Haiying Zeng, Yi Zhu
Summary: This study used LC-MS to investigate the differential metabolites of coix seed after fermentation by Monascus purpureus. The results showed that fermentation significantly increased the contents of amino acids, peptides, and steroids in coix seed metabolites. The findings suggest that Monascus purpureus fermentation can successfully transform coix seed, improving its functional activities.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)