Review
Environmental Sciences
Xueting Zhang, Wen Qi, Qi Xu, Xu Li, Liting Zhou, Lin Ye
Summary: DEHP, a ubiquitous environmental endocrine disruptor, can be absorbed into the human body through air, food, water, and skin. Once in the body, it is rapidly converted to the more toxic MEHP. Research suggests that DEHP or MEHP may damage thyroid tissue and disrupt function, but the specific mechanisms remain unclear.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
David Hala, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber, Guo-Fang Zhang
Summary: DEHP, a common plasticizer, is a metabolic disrupter that affects the production and sequestration of CoA, an essential cofactor for oxidative and biosynthetic reactions. Exposure to DEHP led to significantly increased hepatic levels of free CoA and various CoA esters, particularly the physiological CoA ester of malonyl-CoA and the DEHP-derived CoA ester of 3-keto-2-ethylhexanoyl-CoA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Shuang Ding, Wen Qi, Qi Xu, Tianyang Zhao, Xu Li, Jianli Yin, Ruxuan Zhang, Chuanyi Huo, Liting Zhou, Lin Ye
Summary: The study revealed that DEHP exposure may affect lipid metabolism in adolescents by regulating the expression of lipid metabolism-related genes, particularly showing significant associations with compounds like MECPP, MCMHP, and n-ary DEHP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Xiuzhen Liu, Ana M. Adamo, Patricia I. Oteiza
Summary: The study found that gestational exposure to DEHP could cause secondary zinc deficiency and impaired neurogenesis, which may have long-term consequences on the brain structure and function of adult offspring.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Environmental Sciences
Qi Xu, Tianyang Zhao, Hyonju Ri, Jiaming Ye, Weisen Zhao, Yuezhu Zhang, Lin Ye
Summary: In this study, the mechanism of Di(2-ethylhexyl) phthalate (DEHP) induced thyroid injury was clarified through in vivo and in vitro experiments. The results showed that DEHP could induce thyroid toxicity by activating endoplasmic reticulum stress.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shivani Popli Goyal, Tripti Agarwal, Vijendra Mishra, Ankur Kumar, Chakkaravarthi Saravanan
Summary: This study identified two strains of Lactobacillus (Lactobacillus rhamnosus GG and Lactobacillus plantarum MTCC 25,433) that can rapidly adsorb over 85% of DEHP. The adsorption of DEHP was affected by cell wall polysaccharides, proteins, lipids, and peptidoglycan. These findings suggest that these Lactobacillus strains could be potential strategies for detoxification of DEHP-contaminated foods.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Construction & Building Technology
Yatai Li, Di Xie, Longkun He, Anqi Zhao, Lixin Wang, Nathan M. Kreisberg, John Jayne, Yingjun Liu
Summary: The dynamics of semivolatile organic compounds (SVOCs) in indoor air is not well understood due to limitations in measurement techniques. This study used semivolatile thermal desorption aerosol gas chromatography (SV-TAG) to measure the airborne concentration of di-2-ethylhexyl phthalate (DEHP) in an office. The results showed that the indoor DEHP concentration varied significantly with possible influences from indoor temperature, particle mass concentration, and outdoor DEHP concentrations. Further analysis revealed that the dynamics of DEHP were primarily driven by variations in indoor temperature during the warmer period, and variations in particle mass concentration during the cooler period. The study also found a strong dependence of DEHP's particle fraction on particle concentration, fitted using a gas-particle equilibrium partitioning model.
BUILDING AND ENVIRONMENT
(2022)
Article
Chemistry, Applied
Yuting Liang, Zhi Jiang, Wenfeng Shangguan
Summary: This study investigated the photocatalytic reaction behavior of DEHP over surface platinized TiO2, with the oxidation state of platinum found to be crucial in determining the photocatalytic activity. Platinized titania with oxidized Pt species showed higher photocatalytic activity compared to metallic Pt. Photocatalysis coupled with thermal catalysis can enhance the degradation of DEHP, and Pt oxide, particularly PtO, can improve the photocatalytic oxidation efficiency by promoting the separation efficiency of photo generated carriers.
Article
Environmental Sciences
Ming-Hao Li, Jun-Jie Wang, Yan-Qin Feng, Xuan Liu, Zi-Hui Yan, Xiao-Jun Zhang, Ya-Xin Wen, Hao-Wei Luo, Lan Li, Massimo De Felici, Ai-Hong Zhao, Wei Shen
Summary: This study shows that Di(2-ethylhexyl) phthalate (DEHP) as a widely used plastics additive may negatively affect reproductive processes, especially during maternal exposure. Single-cell RNA sequencing analysis reveals that DEHP disrupts chromatin transcription, leading to impaired early follicle development. Overexpression of Smyd3 can alleviate the effects of DEHP, suggesting that Smyd3-H3K4me3 is a novel target for DEHP-induced follicle formation dysfunction.
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
XueXia Liu, YaNan Liu, Zi Teng, YuSheng Zhang, ZeLin Wang, Peng Zhu, MeiNa Xie, FuJun Liu
Summary: This study found that DEHP exposure reduces testis weight, serum testosterone levels, and sperm quality and function in male mice. DEHP exposure leads to decreased sperm count, motility, acrosome reaction rate, sperm-egg binding capacity, and blastocyte formation. DEHP also affects antioxidant indicators, protein expressions, cell proliferation, and apoptosis pathways in the testis.
Article
Environmental Sciences
Yue Tao, Chong Feng, Jiaming Xu, Lu Shen, Jianhua Qu, Hanxun Ju, Lilong Yan, Weichang Chen, Ying Zhang
Summary: This study investigated the impact of DEHP and DBP on nitrification microbial communities, related genes, and key enzyme activities in black soil. The results showed that DEHP and DBP inhibited urease activity during ammonia oxidation, reduced the copy number of amoA gene, and led microorganisms to use inorganic nitrogen as a nitrogen source. During nitrite oxidation, DEHP and DBP decreased the copy number of nxrA gene and the abundance of chemoautotrophic nitrifying bacteria. Path analysis results indicated that DEHP and DBP mainly affected AOB and NOB through direct or indirect pathways.
Article
Environmental Sciences
Yuezhu Zhang, Honghao Qian, Jia Wang, Ying Zhu, Xiaohan Miao, Xu Li, Jianli Yin, Ruxuan Zhang, Jiaming Ye, Chuanyi Huo, Weisen Zhao, Lin Ye
Summary: This study aimed to explore the molecular mechanism of DEHP/MEHP-induced hepatic lipid metabolism disorders. The results showed that DEHP/MEHP promoted the expression of Notch pathway molecules and led to lipid accumulation. Inhibiting the Notch pathway reversed the inflammation and lipid accumulation caused by MEHP. This study revealed that DEHP/MEHP induced lipid accumulation by up-regulating the Notch pathway, with inflammation playing a key role in the process.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuxuan Lin, Wenqi Xu, Zhengguo Chen, Jianan Zhai, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang, Guang Yang
Summary: Di-ethylhexyl phthalate (DEHP) is widely used as a plasticizer in various products. It has been found to have toxic effects on the testicles, causing testicular damage through oxidative stress, ferroptosis, interference with the hypothalamic-pituitary-gonadal axis, and testosterone level. Recent studies have identified protective agents that can repair this type of testicular damage, suggesting new directions for future research on the health effects and molecular mechanisms of DEHP.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Redouane Rouas, Makram Merimi, Mehdi Najar, Nabil El Zein, Mohammad Fayyad-Kazan, Mimoune Berehab, I. Douaa Agha, Dominique Bron, Arsene Burny, Walid Rachidi, Bassam Badran, Philippe Lewalle, Hussein Fayyad-Kazan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dermatology
Walid Mahfouf, Mohsen Hosseini, Elodie Muzotte, Martin Serrano-Sanchez, Lea Dousset, Francois Moisan, Walid Rachidi, Alain Taieb, Jana Rudolf, Hamid Reza Rezvani
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Elodie Clain, Juliano G. Haddad, Andrea C. Koishi, Laura Sinigaglia, Walid Rachidi, Philippe Despres, Claudia N. Duarte dos Santos, Pascale Guiraud, Nolwenn Jouvenet, Chaker El Kalamouni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Meeting Abstract
Dermatology
L. Jobeili, P. Rousselle, D. Beal, E. Blouin, O. Damour, W. Rachidi
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Reproductive Biology
Birce Sunman, Kadriye Yurdakok, Belma Kocer-Gumusel, Ozgur Ozyuncu, Filiz Akbiyik, Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Murat Yurdakok
REPRODUCTIVE TOXICOLOGY
(2019)
Article
Toxicology
Ozge Kose, Walid Rachidi, David Beal, Pinar Erkekoglu, Hussein Fayyad-Kazan, Belma Kocer Gumusel
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Saliha Kanik Yuksek, Hasan Tezer, Belgin Gulhan, Aslinur Ozkaya Parlakay, Dilek Guldemir, F. Filiz Coskun-Ari, Tugba Bedir Demirdag, Aysun Kara Uzun, Murat Kizilgun, Sinem Solmaz, Selcuk Kilic, Meltem Yalinay Cirak, Fatma Nur Baran Aksakal
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Naciye Dilara Zeybek, Unzile Sur, Ofcan Oflaz, Pinar Erkekoglu, Aylin Balci, Gizem Ozkemahli, Ali Asci, Murat Kizilgun, Oguz Han Edebal, Belma Kocer-Gumusel
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2020)
Article
Environmental Sciences
Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study evaluated the effects of single and combined exposures to BPA and/or DEHP during the prenatal and lactational period on the male reproductive system of rats in later stages of life. The results suggest that prenatal and lactational exposure to BPA and DEHP may have adverse effects on the male reproductive system in later stages of life, especially after combined exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Gamze Tilbe Sen, Gizem Ozkemahli, Reza Shahbazi, Pinar Erkekoglu, Kezban Ulubayram, Belma Kocer-Gumusel
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2020)
Article
Environmental Sciences
Anil Yirun, Gizem Ozkemahli, Aylin Balci, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study aimed to investigate the toxicity of BPA and/or DEHP on the central nervous system and neuroendocrine system in Sprague-Dawley rats during prenatal and lactational periods. The results showed that early-life exposure to these chemicals caused significant changes in lipid peroxidation, neurotransmitter levels, and apoptosis in the hippocampus. This suggests that alterations in oxidant/antioxidant status and neurotransmitters may be the underlying mechanisms of neurotoxicity induced by BPA and DEHP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Busra Ozyurt, Gizem Ozkemahli, Anil Yirun, Aylin Balci Ozyurt, Merve Bacanli, Nursen Basaran, Belma Kocer-Gumusel, Pinar Erkekoglu
Summary: The potential toxic effects of BPA, BPS, and BPF were comparatively evaluated in HepG2 cells. These bisphenol derivatives showed similar toxicities, with BPS > BPF > BPA in terms of cytotoxicity, increased intracellular ROS production, imbalance in oxidant/antioxidant parameters, and significant DNA damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Toxicology
Gulru Gurdemir, Pinar Erkekoglu, Aylin Balci, Unzile Sur, Gizem Ozkemahli, Engin Tutkun, Hinc Yilmaz, Ali Asci, Belma Kocer-Gumusel
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2019)
Meeting Abstract
Psychology, Developmental
Sinem Akgul, Unzile Sur, Yasemin Duzceker, Aylin Balci, Melis P. Kizilkan, Nuray Kanbur, Gurkan Bozdag, Pinar Erkekoglu, Ersin Gumus, Belma Kocer Gumusel, Orhan Derman
JOURNAL OF ADOLESCENT HEALTH
(2019)