Article
Chemistry, Applied
Shaghayegh Ahmadi, Mohammad Hasanzadeh, Zahra Ghasempour
Summary: An electrochemical sensor was developed for detecting food colorants in juices, which showed high selectivity and sensitivity. By fabricating a nanocomposite and decorating it with gold nanoparticles on a gold electrode, the modification of the electrode was successfully achieved. Experimental results demonstrated that the sensor has a wide linear range and low detection limit.
Article
Chemistry, Analytical
Nianzu Liu, Shuju Zhao, Yanxin Li, Mingxuan Li, Yingshu Guo, Xiliang Luo
Summary: Researchers have developed a reliable and concise ultralow fouling electrochemical sensing system for monitoring targets in complex biological media. The system, based on gold nanoparticles-peptide hydrogel-modified screen-printed electrode, showed satisfactory antifouling capability in complex biological media and displayed highly sensitive sensing properties for dopamine determination.
Article
Chemistry, Analytical
Yifei Zhang, Danlei Li, Richard G. Compton
Summary: We have developed a new and sensitive stripping voltammetric method for the detection of As(III) in aqueous solution using gold macroelectrode or gold nanoparticle-modified glassy carbon electrode (GCE). The method is based on underpotential deposition (UPD) of As ad-atoms and provides linear responses within the range of 0.01 μM to 0.1 μM or 0.005 μM to 0.1 μM for gold macroelectrodes and gold nanoparticle-modified electrodes, respectively. The method shows practical value with clear and discernable signals even at low concentrations of As(III), meeting the WHO limit for drinking water.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Giles G. Gerent, Edson R. Santana, Eduardo C. Martins, Almir Spinelli
Summary: In this study, a modified electrode with Co-Ag bimetallic nanoparticles stabilized in poly(vinylpyrrolidone) was developed for the quantification of butralin, providing a non-mercury alternative. The electrode was characterized using spectroscopic and microscopic techniques, and optimized experimental parameters led to linear calibration plots for butralin in honey and apple jam samples. The results obtained were validated by UV-vis spectrometry and statistical tests.
Article
Engineering, Electrical & Electronic
Nirgaman Bage, Pradip Kar
Summary: The study investigated the influence of silver nanoparticles labeled with biomolecules on electrochemical sensing, showing that AgNP labeled layers can serve as ultrasensitive detectors for detecting biotin-avidin couple and sensing concentration changes even at higher concentrations.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Nastaran Aletaha, Kambiz Ghaseminasab, Mohammad Hasanzadeh, Fereshteh Kohansal, Yuqian Liu, Farzad Seidi
Summary: In this study, a new sandwich-type electrochemical immune device was used to detect 2-AG in human plasma. The use of poly-beta-cyclodextrin functionalized with AuNPs-DDT and toluidine blue improved the activity and stability of the immobilized 2-AG antibody. The developed immunosensor showed high sensitivity and accuracy, making it suitable for the diagnosis of 2-AG.
Article
Chemistry, Analytical
Zhongxin Zhuang, Jiawei Xu, Yan Chen, Zheng Guo, Zhonggang Liu, Xingjiu Huang
Summary: In this study, a nanoporous gold microelectrode was developed for the precise detection of arsenite in a lung cancer cellular environment. The electrode exhibited excellent electrochemical performance and successfully investigated the impact of exposure time on arsenite in the cellular environment.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Xuhua Zhan, Shiyu Hu, Jiaqi Wang, Hong Chen, Ximing Chen, Jianbo Yang, Hai Yang, Zhaohong Su
Summary: A sensitive electroanalysis method for bisphenol A (BPA) based on a novel metal organic frameworks (MOFs) composite was developed, using gold nanoparticles (AuNPs) and electroreduced carbon dots (ErCDs) to enhance the conductivity of the composite. The electrochemical sensor showed a wide linear range and a low detection limit for BPA, with satisfactory recovery when applied to test BPA in plastic products.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Pankaj Gupta, Vandna K. Gupta, Artur Huseinov, Connor E. Rahm, Kiera Gazica, Noe T. Alvarez
Summary: The study developed a nonenzymatic glucose sensor using copper nanoparticles and carbon nanotubes microelectrode set, demonstrating excellent sensitivity, low detection limit, and resistance to external interference. The sensor was successfully applied for quantifying glucose in physiological samples, showing great potential for commercial nonenzymatic glucose sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shiyu Hu, Hong Chen, Xuhua Zhan, Xiaoli Qin, Yiwen Kuang, Mengxue Li, Zhanning Liang, Jianbo Yang, Zhaohong Su
Summary: This study reported a composite material consisting of metal organic frameworks (MOFs), electro-reduced graphene oxide (ErGO), and gold nanoparticles (AuNPs) for sensitive electroanalysis of rutin. The composite showed a good detection limit, acceptable stability, and reproducibility.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Enrico Benassi, Haiyan Fan, Qinglei Sun, Kanat Dukenbayev, Qian Wang, Ainur Shaimoldina, Aigerim Tassanbiyeva, Lazzat Nurtay, Ayan Nurkesh, Aidana Kutzhanova, Chenglin Mu, Adilet Dautov, Madina Razbekova, Anar Kabylda, Qing Yang, Ziye Li, Amr Amin, Xugang Li, Yingqiu Xie
Summary: Processed herbs exhibit phosphatase-like activity, which can effectively inhibit cancer cell growth via phosphatase signaling and potentially interact with kinase signaling or directly bind/unwind DNA. The study introduces a new term "herbzyme" to describe the enzymatic/co-enzymatic activity attributed to the nanosized assemblies in herbs and herbal food beyond their known pharmacological properties.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Bekir Asilcan Unlu, Serife Akkoyun, Ahmet Karatay, Aytunc Ates, Ayhan Elmali
Summary: This study investigated the effect of aluminum (Al) concentration on the surface plasmon resonance (SPR) band position of aluminum/polyvinylpyrrolidone (Al/PVP) composite nanofibers and found that increasing Al content can enhance nonlinear absorption (NLA) effects. Experimental and theoretical analysis showed that the first model provided more accurate results. It was observed that the NLA performance of Al/PVP nanofibers significantly improved with increasing Al content, accompanied by aggregation effects and broadening and red shifting of the SPR band, indicating a decreasing interparticle distance in Al particles.
Article
Genetics & Heredity
Renfei Ma, Shangfu Li, Wenshuo Li, Lantian Yao, Hsien-Da Huang, Tzong-Yi Lee
Summary: The purpose of this work is to enhance the KinasePhos tool, which predicts kinase-specific phosphorylation sites using machine learning. Through collecting experimentally verified data, a total of 41,421 phosphorylation sites were identified, which cover 1380 unique kinases. Based on kinase classification, 771 predictive models were built, showing higher accuracy than other tools. The web interface of KinasePhos 3.0 has been redesigned to provide comprehensive annotations, and a downloadable prediction tool is available for large-scale phosphoproteomic data.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Chemistry, Analytical
Yan Tan, Jianxing Zhou, Xiaotong Xing, Junren Wang, Jinkun Huang, Huiyu Liu, Jiajie Chen, Mingjie Dong, Qin Xiang, Haifeng Dong, Xueji Zhang
Summary: In this study, the controllable self-assembly of DNA-linked gold nanoparticles (AuNPs) for in vivo biomedical applications was achieved by using programmable DNA tetrahedral structures. Three different sizes of AuNPs (20nm, 10nm, and 5nm) were organized and positioned using this method. The density and arrangement of the satellite AuNPs around the core AuNPs were controlled by tuning the size and amount of DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement. With the conjugation of Raman molecules, strong surface-enhanced Raman scattering photoacoustic imaging signals were generated, allowing for the imaging of microRNA-21 and tumor tissues in vivo. This study provides an efficient strategy for building precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yasaman-Sadat Borghei, Hamid Reza Samadikhah, Saman Hosseinkhani
Summary: A label-free and RNA extraction-free method for detecting SARS-CoV-2 has been developed, which uses DNA as a template to form anisotropic gold nanoparticles without any chemical modification. The plasmonic biosensor based on this method can detect low concentrations of SARS-CoV-2 and has the potential for point-of-care testing.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Meiwen Wang, Yingying Tang, Yaoyao Chen, Ya Cao, Guifang Chen
ANALYTICA CHIMICA ACTA
(2019)
Article
Biochemical Research Methods
Xiangyang Miao, Yang Wang, Zhun Gu, Dongsheng Mao, Limin Ning, Ya Cao
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Danhong Yan, Xiangyang Miao, Ronghua Ma, Huashan Yao, Jinlong Li, Ya Cao
SUPRAMOLECULAR CHEMISTRY
(2019)
Article
Electrochemistry
Jingwen Li, Yifei Li, Xingwei Zhai, Ya Cao, Jing Zhao, Yuguo Tang, Kun Han
ELECTROCHEMISTRY COMMUNICATIONS
(2020)
Review
Chemistry, Analytical
Xiaomeng Yu, Lingjun Sha, Langjian Dong, Ya Cao, Jing Zhao
Summary: Exosomes play a crucial role in intercellular transport and communication, and have the potential to serve as biomarkers for early detection and real-time monitoring of tumors. This review provides a summary of the recent advances in tumor exosome detection and their potential applications.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Bing Han, Cheng Fang, Lingjun Sha, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: A new fluorescent aptasensor using cascade strand displacement reaction was proposed for the detection of ochratoxin A, achieving an improved detection limit and short assay time. The method showed potential for use in food quality control in the future.
Article
Biophysics
Ya Cao, Ying Wang, Xiaomeng Yu, Xihui Jiang, Gang Li, Jing Zhao
BIOSENSORS & BIOELECTRONICS
(2020)
Review
Chemistry, Analytical
Yuhao Dai, Bing Han, Langjian Dong, Jing Zhao, Ya Cao
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Bing Han, Langjian Dong, Lingling Li, Lingjun Sha, Ya Cao, Jing Zhao
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Biophysics
Bing Han, Lingjun Sha, Xiaomeng Yu, Mei Yang, Ya Cao, Jing Zhao
Summary: The study introduced a novel method for simultaneous identification of dual therapeutic targets in breast cancer using in situ automatous DNA assembly reaction and electrochemical techniques. The method demonstrated high sensitivity and specificity in identifying co-existed therapeutic targets, even in serum samples, and could potentially provide valuable information for enhancing the efficiency of combined therapy in clinic. The use of quantum dots as electrochemical labeling allowed for the creation of increased electrochemical signaling to reveal the co-expression of the two targets.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Ying Wang, Langjian Dong, Jing Zhao, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: The developed dual-functional probe sensing method can specifically identify CD44 even in serum samples and breast cancer cells with broad detection range and high sensitivity. The method can monitor changes in CD44 expression, providing a new approach to study stem-like properties in breast cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yuxin Lin, Beibei Nie, Xinyu Qu, Minghui Wang, Jie Yang, Genxi Li
Summary: Covalent organic frameworks (COFs) have attracted much attention for their unique physical-chemical characteristics and potential applications in biosensing. In this study, spherical COFs with regular shape and good dispersion were synthesized, and a novel nanoprobe was developed by modifying Histostar on the COFs surface. The nanoprobe was then applied to fabricate an electrochemical biosensor for exosomes detection, achieving a low detection limit and wide linear detection range. This work offers a promising platform for ultrasensitive detection of exosomes.
Article
Nanoscience & Nanotechnology
Yingyan Zhao, Qi Liu, Yujia Qin, Yue Cao, Jing Zhao, Kai Zhang, Ya Cao
Summary: In this work, an electrochemical aptasensor was designed for the high-accuracy assay of AFP-L3 ratio. The aptasensor demonstrated the ability to accurately measure the AFP-L3 ratio in a linear range of 0.0008-40 ng mL-1, with satisfactory specificity and good recoveries in complex serum samples. This aptasensor may serve as a valuable tool for the measurement of AFP-L3 ratio and have great potential for early warning of hepatocellular carcinoma in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Xiaomeng Yu, Ya Cao, Yingyan Zhao, Jianan Xia, Jie Yang, Yuanyuan Xu, Jing Zhao
Summary: This study presents a universal method for accurate and sensitive analysis of tumor-associated glycoprotein biomarkers. The method utilizes dual recognition of carbohydrates and proteins to achieve amplified electrochemical responses for glycoprotein analysis. The results show high accuracy, specificity, and versatility in complex serum samples, making this method a valuable tool for the analysis of glycoprotein biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xu Chen, Xianyong Wu, Ziyu He, Juan Zhang, Ya Cao, Dongsheng Mao, Chang Feng, Bo Tian, Guifang Chen
NEW JOURNAL OF CHEMISTRY
(2020)