Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

SAMHD1-dependent retroviral control and escape in mice

(2013) Jan Rehwinkel et al.   EMBO JOURNAL

Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase fromEnterococcus faecalis

(2013) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication

(2013) Eui Tae Kim et al.   JOURNAL OF VIROLOGY

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

(2013) Chunfeng Zhu et al.   Nature Communications

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

(2013) Rayk Behrendt et al.   Cell Reports

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

(2013) Joseph A. Hollenbaugh et al.   PLoS Pathogens

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

(2012) G. Pontarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein fromEnterococcus faecalisand Crystal Structure of the Activator-Substrate Complex

(2011) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

A Review Comparing Deoxyribonucleoside Triphosphate (dNTP) Concentrations in the Mitochondrial and Cytoplasmic Compartments of Normal and Transformed Cells

(2011) Vishal V. Gandhi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Two dNTP triphosphohydrolases fromPseudomonas aeruginosapossess diverse substrate specificities

(2009) Ryosuke Mega et al.   FEBS Journal

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS