Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Microbiology
Isabelle A. M. van Thiel, Shafaque Rahman, Theodorus B. M. Hakvoort, Mark Davids, Caroline Verseijden, Patricia H. P. van Hamersveld, Melanie Benard, Maarten H. Lodders, Teun Boekhout, Rene M. van den Wijngaard, Sigrid E. M. Heinsbroek, Cyriel Y. Ponsioen, Wouter J. de Jonge
Summary: This study reveals that the presence of Filobasidium spp. in the feces of donors is associated with a positive response to FMT for patients with UC, suggesting it may serve as a predictive fungal biomarker for successful FMT.
Article
Microbiology
Lingyun Xu, Yingchao Li, Yingli He
Summary: Anxiety and depression still exist in UC patients even in the remission period. This study found that the composition of intestinal microbiota differs between UC patients with anxiety and depression and those without, with a decrease in probiotics and an increase in pathogens in the former group. These findings may provide new insights into the recurrence of UC caused by impaired psychological function and offer potential treatment strategies for UC patients with psychological issues.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Sergii Tkach, Andrii Dorofeyev, Iurii Kuzenko, Tetyana Falalyeyeva, Olena Tsyryuk, Oleksandr Kovalchuk, Nazarii Kobyliak, Ludovico Abenavoli, Luigi Boccuto
Summary: This study aimed to evaluate the clinical and microbiological efficacy, tolerability, and safety of fecal microbiota transplantation (FMT) in patients with mild-to-moderate ulcerative colitis (UC). The results showed that FMT as an add-on therapy performed better in improving symptoms and disease activity levels compared to standard-care treatment. Additionally, FMT was found to significantly improve gut microbiota composition.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Severine Vermeire, Joao Sabino, Catherine Verfaillie, Marc Ferrante
Summary: Microbial dysbiosis is a known phenomenon in patients with inflammatory bowel disease, but the exact mechanism behind host-microbial interactions remains unclear. This study found that the transcriptional response of epithelial cells was not different between patients with ulcerative colitis (UC) and non-IBD controls following exposure to microbiota. However, UC microbiota exposure led to a significant decrease in epithelial barrier integrity, regardless of the origin of the epithelial cells. Furthermore, UC microbiota induced stress responses in all epithelial cells, while responses to healthy volunteer (HV) microbiota were milder.
Article
Microbiology
Ran Zhu, Junrui Tang, Chengfeng Xing, Qiong Nan, Guili Liang, Juan Luo, Jiao Zhou, Yinglei Miao, Yu Cao, Shaoxing Dai, Danfeng Lan
Summary: Ulcerative colitis (UC) is a serious chronic inflammatory bowel disease. This study analyzed paired fecal samples from 42 UC patients at the active and remission stages to study the changes in the intestinal microbiota. The study identified 13 species of microbes that can effectively distinguish the active and remission stages of UC. Functional analysis revealed downregulation of sporulation and biosynthesis, and upregulation of the hydrogen peroxide catabolic process in the remission of UC.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Review
Medicine, General & Internal
Dianbo Yao, Wanlin Dai, Ming Dong, Chaoliu Dai, Shuodong Wu
Summary: The MUC2 mucus barrier plays a crucial role in ulcerative colitis (UC). Interventions such as dietary adjustment, repair of the mucus barrier, microbiota transplantation, and targeted elimination of pathogenic bacteria can reduce the occurrence and recurrence of UC, maintaining a long-term remission period.
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Stefania De Santis, Marina Liso, Mirco Vacca, Giulio Verna, Elisabetta Cavalcanti, Sergio Coletta, Francesco Maria Calabrese, Rajaraman Eri, Antonio Lippolis, Raffaele Armentano, Mauro Mastronardi, Maria De Angelis, Marcello Chieppa
Summary: Colorectal cancer is a non-communicable disease caused by a combination of genetic predisposition and environmental triggers, including microbiota composition. The relationship between microbiota modulation and CRC risk factors is debated, but preventive strategies targeting dysbiosis may reduce the risk. Implementing these strategies during pregnancy and lactation could be particularly effective in reducing CRC risk in offspring.
Article
Plant Sciences
Wei Yu, Zizheng Jiang, Zhiqiang Zhang, Lu Jiang, Chen Liu, Chang Lu, Zhenghao Liang, Guoliang Wang, Jing Yan
Summary: This study used network pharmacology and gene co-expression network analysis to predict the mechanisms of the WSC formula in treating ulcerative colitis. The results showed that the formula can suppress inflammation, regulate gut microbiota balance, and improve the progression of colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Tao Wang, Caihong Shi, Shuxuan Wang, Yu Zhang, Shuang Wang, Mohamedelfaieh Ismael, Jing Zhang, Xin Wang, Xin Lu
Summary: This study used fecal microbiota transplantation (FMT) to verify the potential of Companilactobacillus crustorum MN047 (CCMN) in regulating gut microbiota and alleviating inflammation in ulcerative colitis (UC).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Svetlana F. Lima, Lasha Gogokhia, Monica Viladomiu, Lance Chou, Gregory Putzel, Wen-Bing Jin, Silvia Pires, Chun-Jun Guo, Ylaine Gerardin, Carl Crawford, Vinita Jacob, Ellen Scherl, Su-Ellen Brown, John Hambor, Randy S. Longman
Summary: This study identified transferable, donor-derived bacterial strains that correlate with clinical response to FMT in UC, with Odoribacter splanchnicus revealed as a key component promoting metabolic and immune cell protection from colitis. These mechanistic features will help enhance the efficacy of microbial therapy for UC.
