Article
Nutrition & Dietetics
Yanquan Fei, Siying Li, Zaoyi Wang, Yong Ma, Jun Fang, Gang Liu
Summary: Our study found that the dietary oligopeptide Ile-Arg-Trp (IRW) can significantly alleviate colon barrier damage and promote intestinal health. Furthermore, we observed that different concentrations of IRW can modulate the abundance of Bacillota, Odoribacter, and Lactobacillus, which are important members of the gut microbiota.
Article
Biotechnology & Applied Microbiology
Haiming Fang, Lian Fu, Xuejun Li, Chunxia Lu, Yuan Su, Kangwei Xiong, Lijiu Zhang
Summary: The study demonstrates that monotherapy with a single fresh FMT is an effective and safe strategy for inducing long-term remission in patients with active UC, providing a potential alternative to drug therapy for recurrent or primary UC.
MICROBIAL CELL FACTORIES
(2021)
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Isabelle A. M. van Thiel, Shafaque Rahman, Theodorus B. M. Hakvoort, Mark Davids, Caroline Verseijden, Patricia H. P. van Hamersveld, Melanie Benard, Maarten H. Lodders, Teun Boekhout, Rene M. van den Wijngaard, Sigrid E. M. Heinsbroek, Cyriel Y. Ponsioen, Wouter J. de Jonge
Summary: This study reveals that the presence of Filobasidium spp. in the feces of donors is associated with a positive response to FMT for patients with UC, suggesting it may serve as a predictive fungal biomarker for successful FMT.
Article
Agriculture, Multidisciplinary
Tao Wang, Caihong Shi, Shuxuan Wang, Yu Zhang, Shuang Wang, Mohamedelfaieh Ismael, Jing Zhang, Xin Wang, Xin Lu
Summary: This study used fecal microbiota transplantation (FMT) to verify the potential of Companilactobacillus crustorum MN047 (CCMN) in regulating gut microbiota and alleviating inflammation in ulcerative colitis (UC).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Xiaoxia Liu, Yunhui Zhang, Wanhua Li, Bowei Zhang, Jia Yin, Sijing Liuqi, Jin Wang, Bo Peng, Shuo Wang
Summary: Gut dysbiosis and bile acid metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate the effect of fucoidan on BA metabolism and gut microbiota in dextran sulfate sodium-induced colitis mice. Our results showed that fucoidan effectively suppressed colonic inflammation and repaired the gut barrier. In addition, fucoidan increased the relative abundance of certain bacteria families and short-chain fatty acids, while modulating bile acid metabolism. These findings suggest that fucoidan may be a potential functional food for colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Gastroenterology & Hepatology
Essi K. Karjalainen, Laura Renkonen-Sinisalo, Reetta Satokari, Harri Mustonen, Ari Ristimaki, Perttu Arkkila, Anna H. Lepisto
Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Immunology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Zhangran Chen, Lin Wang, Yiqun Hu, Qingwen Huang, Jingling Su, Jianlin Ren, Hongzhi Xu
Summary: This study examined the association between gut fungal community and capsulized FMT outcomes in ulcerative colitis (UC) patients. The results showed that capsulized FMT improved fungal diversity and induced remission in UC patients. Specific fungal species were identified to be associated with the induction of remission. This study provides important insights into the mechanism of FMT treatment for UC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Fangyuan Zhu, Yifan Ke, Yiting Luo, Jiaqian Wu, Pei Wu, Fangxiao Ma, Yingchao Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and fecal microbiota transplantation (FMT) has been shown to improve UC symptoms. Results of the study indicate that frozen FMT has a better therapeutic effect in treating UC in rat models compared to fresh FMT.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Lingyun Xu, Yingchao Li, Yingli He
Summary: Anxiety and depression still exist in UC patients even in the remission period. This study found that the composition of intestinal microbiota differs between UC patients with anxiety and depression and those without, with a decrease in probiotics and an increase in pathogens in the former group. These findings may provide new insights into the recurrence of UC caused by impaired psychological function and offer potential treatment strategies for UC patients with psychological issues.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Haixia Liu, Jing Li, Jiaxin Yuan, Jinke Huang, Youqi Xu
Summary: This study aims to systematically gather, evaluate, and synthesize solid evidence for using fecal microbiota transplantation (FMT) to treat ulcerative colitis (UC) based on the current overview of published systematic reviews and meta-analyses.
Article
Microbiology
Hao-Ming Xu, Hong-Li Huang, Jing Xu, Jie He, Chong Zhao, Yao Peng, Hai-Lan Zhao, Wen-Qi Huang, Chuang-Yu Cao, Yong-Jian Zhou, You-Lian Zhou, Yu-Qiang Nie
Summary: FMT can increase fecal butyric acid levels in UC patients, and combination with butyrate-producing bacteria may prolong the therapeutic effect of FMT on UC.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cell Biology
Chunlan Huang, Qixiang Mei, Lihong Lou, Zehua Huang, Yang Fu, Junjie Fan, Jingjing Wang, Nuoming Yin, Yi Zheng, Yingying Lu, Yue Zeng
Summary: The colonization of Faecalibacterium after fecal microbiota transplantation plays a crucial role in the remission of ulcerative colitis by alleviating intestinal inflammation. This anti-inflammatory effect of Faecalibacterium may be achieved by regulating the imbalance of Th17/Treg levels in ulcerative colitis.
Article
Chemistry, Organic
Hai-Xue Pan, Zhang Chen, Tianfang Zeng, Wen-Bing Jin, Yujie Geng, Geng-Min Lin, Juan Zhao, Wei-Tao Li, Zijun Xiong, Sheng-Xiong Huang, Xin Zhai, Hung-wen Liu, Gong-Li Tang
Article
Biochemistry & Molecular Biology
Silvia Pires, Dane Parker
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2019)
Article
Microbiology
Tania Wong Fok Lung, Ian R. Monk, Karen P. Acker, Andre Mu, Nancy Wang, Sebastian A. Riquelme, Silvia Pires, Loreani P. Noguera, Felix Dach, Stanislaw J. Gabryszewski, Benjamin P. Howden, Alice Prince
NATURE MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Clarissa Campbell, Peter T. McKenney, Daniel Konstantinovsky, Olga I. Isaeva, Michail Schizas, Jacob Verter, Cheryl Mai, Wen-Bing Jin, Chun-Jun Guo, Sara Violante, Ruben J. Ramos, Justin R. Cross, Krishna Kadaveru, John Hambor, Alexander Y. Rudensky
Article
Infectious Diseases
Silvia D. S. Pires, Rute Oliveira, Pedro Moradas-Ferreira, Marta V. Mendes
Article
Multidisciplinary Sciences
Rute Oliveira, Matthew J. Bush, Silvia Pires, Govind Chandra, Delia Casas-Pastor, Georg Fritz, Marta V. Mendes
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Monica Viladomiu, Maeva L. Metz, Svetlana F. Lima, Wen-Bing Jin, Lance Chou, Jri Live Cell Bank, Chun-Jun Guo, Gretchen E. Diehl, Kenneth W. Simpson, Ellen J. Scherl, Randy S. Longman
Summary: This study revealed the association of AIEC encoding PduC with the microbiome of CD patients, driving AIEC-induced intestinal T cell inflammation. The inflammatory cascade requires the catalytic activity of PduC to generate propionate, synergizing with lipopolysaccharide to induce IL-1 beta by MNPs. Disrupting fucose availability can limit AIEC-induced propionate production and intestinal inflammation.
CELL HOST & MICROBE
(2021)
Article
Biochemistry & Molecular Biology
Wen-Bing Jin, Ting-Ting Li, Da Huo, Sophia Qu, Xin V. Li, Mohammad Arifuzzaman, Svetlana F. Lima, Hui-Qing Shi, Aolin Wang, Gregory G. Putzel, Randy S. Longman, Davi Artis, Chun-Jun Guo
Summary: Understanding the causal contribution of microbiota genes to host biology is challenging due to the lack of genetic targeting for nonmodel gut commensals. A newly developed pipeline enables the identification of gene transfer methods and the construction of genetic tools for nonmodel microbes, facilitating the study of microbiota-host interactions.
Article
Immunology
Lavoisier Akoolo, Silvia Pires, Jisun Kim, Dane Parker
Summary: The study reveals that type I interferon (IFN) response can be induced by A. baumannii infection, which is dependent on TLR4-TRIF-IRF3 signaling pathway and bacterial phagocytosis. Enhanced IFN induction was observed in phase variants of A. baumannii with reduced capsule and in capsule-deficient strains, accompanied by increased phagocytosis and host cell-mediated killing. The absence of the capsule also led to increased levels of several cytokines, including proinflammatory IL-6. However, the role of this pathway was not observed in vivo. This study highlights the importance of phase variation in modulating host immune responses and the protective role of A. baumannii capsule against host cell killing and activation of innate immunity.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Wen Zhang, Mengze Lyu, Nicholas J. Bessman, Zili Xie, Mohammad Arifuzzaman, Hiroshi Yano, Christopher N. Parkhurst, Coco Chu, Lei Zhou, Gregory G. Putzel, Ting-Ting Li, Wen-Bing Jin, Jordan Zhou, Hongzhen Hu, Amy M. Tsou, Chun-Jun Guo, David Artis
Summary: Research has found that nociceptive neurons have a significant impact on intestinal inflammation. Disrupted nociception leads to more severe inflammation and defective tissue repair processes. This disruption also causes changes in the intestinal microbiota and dysbiosis, while certain bacteria can promote tissue protection. Additionally, abnormal nociceptor gene expression was observed in intestinal biopsies from patients with inflammatory bowel diseases.
Article
Multidisciplinary Sciences
Mohammad Arifuzzaman, Tae Hyung Won, Ting-Ting Li, Hiroshi Yano, Sreehaas Digumarthi, Andrea F. Heras, Wen Zhang, Christopher N. Parkhurst, Sanchita Kashyap, Wen-Bing Jin, Gregory Garbes Putzel, Amy M. Tsou, Coco Chu, Qianru Wei, Alex Grier, Stefan Worgall, Chun-Jun Guo, Frank C. Schroeder, David Artis
Summary: Dietary fibre, particularly inulin, alters the composition of the microbiota and levels of microbiota-derived metabolites, such as bile acids, leading to type 2 inflammation in the intestine and lungs. This study provides insights into the pathophysiology of allergic inflammation, tissue protection, and host defense.
Article
Medicine, Research & Experimental
Silvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker
Review
Biochemistry & Molecular Biology
Wen-Bing Jin, Sheng Wu, Yi-Fan Xu, Hua Yuan, Gong-Li Tang
NATURAL PRODUCT REPORTS
(2020)