Article
Urology & Nephrology
Sidharth Kumar Sethi, Rajesh Sharma, Aditi Gupta, Abhishek Tibrewal, Romel Akole, Rohan Dhir, Kritika Soni, Shyam Bihari Bansal, Pranaw Kumar Jha, Anil Bhan, Vijay Kher, Rupesh Raina
Summary: This study aimed to establish long-term renal outcomes for pediatric patients after cardiac surgery, focusing on urinary biomarker abnormalities that persist years after surgery and may contribute to a low glomerular filtration rate during follow-up. The presence of AKI, AKI stage, and younger age were not associated with low GFR at follow-up, while children with a higher surgical complexity score tended to have lower GFR.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Antoine Beurton, Antoine Fajardie, Sebastien Rubin, Pierre Belnou, Clement Aguerreche, Mathieu Pernot, Stefano Mion, Julien Imbault, Alexandre Ouattara
Summary: Renal transplant recipients have a higher risk of acute kidney injury and a lower renal allograft survival rate after cardiac surgery with cardiopulmonary bypass. They are also at significant risk of AKI and acute kidney disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Anesthesiology
N. Boyer, K. Horne, N. M. Selby, L. G. Forni
Summary: Kidney disease is common in intensive care units and can greatly impact prescribing and therapeutic management due to the kidneys' role in maintaining whole body homeostasis. This review explores the pathophysiology of acute kidney injury and chronic kidney disease in critically ill patients. It covers various aspects of renal dysfunction management, including kidney replacement therapy, acute kidney injury management, and the use of novel biomarkers for identifying and stratifying patients. Early involvement of nephrology specialists can improve outcomes and provide valuable guidance for patients with end stage kidney disease or already known to nephrology services. Ongoing research questions within this field are also discussed.
Article
Anesthesiology
Yi Shun Wang, Dong Xu Chen, Min Yan, Zhong Wu, Ying Qiang Guo, Qian Li, Lei Du
Summary: This study developed and validated a model to predict the severity of acute kidney injury (AKI) after on-pump cardiac surgery using 10 predictors. The model showed good accuracy in predicting AKI severity and may be useful in clinical practice.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Multidisciplinary Sciences
Yichuan Wang, Xuliang Huang, Shanshan Xia, Qingqing Huang, Jue Wang, Maochao Ding, Yunchang Mo, Jianping Yang
Summary: There is no gender gap in AKI frequency for cardiac surgery patients below and above 60 years old. However, women exhibit increased AKI severity and extended intubation duration.
Review
Anesthesiology
Yu-qin Long, Xiao-mei Feng, Xi-sheng Shan, Qing-cal Chen, Zhengyuan Xia, Fu-hai Ji, Hong Liu, Ke Peng
Summary: This meta-analysis demonstrates that RIPC reduces the incidence of AKI after cardiac surgery. This renoprotective effect of RIPC is mainly evident during volatile only anesthesia, in non-high-risk patients, and when AKIN or KDIGO criteria used for AKI diagnosis.
ANESTHESIA AND ANALGESIA
(2022)
Article
Critical Care Medicine
Christina Massoth, Alexander Zarbock, Melanie Meersch
Summary: The incidence of acute kidney injury (AKI) after cardiac surgery is high, with about 3% of patients requiring renal replacement therapy. According to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, AKI is defined as a sudden deterioration of renal function, developing within a period of hours to days.
CRITICAL CARE CLINICS
(2021)
Article
Cardiac & Cardiovascular Systems
Sachin D. Tadphale, Karthik Ramakrishnan, Thomas Spentzas, T. K. Susheel Kumar, Jerry Allen, Steven J. Staffa, David Zurakowski, William A. Bigelow, Srirupa Hari Gopal, Umar S. Boston, Richard A. Jonas, Christopher J. Knott-Craig
Summary: This study aimed to compare the incidence and severity of acute kidney injury after open heart surgery in neonates and infants for two different cardiopulmonary bypass strategies. The results showed that higher flow rates and higher hematocrit during cardiopulmonary bypass were associated with better preservation of renal function.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Shouqiang Zhu, Peng Lu, Zhenran Liu, Shaoyang Li, Peitong Li, Bingdi Wei, Jiayi Li, Yupei Wang
Summary: This study aimed to describe the longitudinal dynamic hemoglobin trajectories in patients undergoing cardiac surgery and explore their predictive value for AKI compared to traditional threshold values. The interaction of red blood cell transfusion was also investigated. The results showed three distinct hemoglobin trajectories, and patients in the highest and medium trajectory groups had significantly lower AKI risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Hsun-Yi Fu, Nai-Kuan Chou, Yih-Sharng Chen, Hsi-Yu Yu
Summary: This study found a high incidence of postoperative AKI in patients with pre-existing impaired renal function, which was associated with high preoperative serum creatinine levels and decreased CPB target temperature. AKI patients had higher hospital mortality and a worse two-year renal function evolution compared to non-AKI patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Sairah Sharif, Bohan Chen, Pamela Brewster, Tian Chen, Lance Dworkin, Rujun Gong
Summary: This study aims to investigate the efficacy of short term low dose lithium on CSA-AKI in human patients through renal function evaluation using creatinine and AKI biomarkers. The study compares the effects of lithium treatment and placebo treatment on kidney injury and renal function.
FRONTIERS IN MEDICINE
(2021)
Review
Medical Laboratory Technology
Giuseppe Lapergola, Alessandro Graziosi, Ebe D'Adamo, Patrizia Brindisino, Mariangela Ferrari, Anna Romanelli, Mariachiara Strozzi, Roberta Libener, Danilo A. W. Gavilanes, Antonio Maconi, Angela Satriano, Alessandro Varrica, Diego Gazzolo
Summary: Recent advances in perioperative management have significantly reduced mortality rate in open heart surgery and cardiopulmonary bypass for heart disease repair. However, the morbidity rate remains unchanged. The measurement of neuro-biomarkers, particularly S100B protein, can be useful in detecting early stage brain damage during the perioperative period. This review provides an updated overview of the pros and cons of using S100B protein for perioperative monitoring in both adult and pediatric patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medicine, General & Internal
Jakub Udzik, Jerzy Pacholewicz, Andrzej Biskupski, Pawel Walerowicz, Kornelia Januszkiewicz, Ewa Kwiatkowska
Summary: This review summarizes current knowledge on renal physiology during cardiac surgery and discusses nephroprotective strategies. Adequate kidney perfusion and fluid balance are crucial for maintaining postoperative kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer P. Ngo, Khin M. Noe, Michael Z. L. Zhu, Andrew Martin, Meg Ollason, Andrew D. Cochrane, Julian A. Smith, Amanda G. Thrift, Roger G. Evans
Summary: Intraoperative change in pEPO does not predict AKI, but UPO2 shows promise, particularly in patients with higher risk of operative mortality. The disparity between these two markers of renal hypoxia may indicate that UPO2 reflects medullary oxygenation whereas pEPO reflects cortical oxygenation.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Medicine, General & Internal
Melissa Spoden, Christiane S. Hartog, Peter Schlattmann, Antje Freytag, Marlies Ostermann, Lisa Wedekind, Josephine Storch, Konrad Reinhart, Christian Guenster, Carolin Fleischmann-Struzek
Summary: This study investigates the occurrence and risk factors of long-term adverse events in survivors of sepsis, and finds that pre-existing comorbidities, age, hospital-acquired infections, multi-resistant infections, and organ dysfunction are important factors leading to adverse outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Marlies Ostermann, Sean M. Bagshaw, Nuttha Lumlertgul, Ron Wald
Summary: KRT is considered for patients with severe AKI and associated complications. The exact indications for initiating KRT have been debated for decades. In this review, the latest evidence and strategies for decision making regarding KRT are summarized.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Critical Care Medicine
Marlies Ostermann, Andrew D. Shaw, Michael Joannidis
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Lui G. Forni, Michael Joannidis, Antonio Artigas, Max Bell, Eric Hoste, Olivier Joannes-Boyau, Kianoush Kashani, Jay Koyner, Thomas Rimmele, Jing Shi, Marlies Ostermann, Lakhmir S. Chawla, John A. Kellum, Sapphire Investigators
Summary: This study aimed to evaluate the predictive role of biomarkers associated with renal stress and markers of glomerular function in acute kidney injury (AKI). The results showed that biomarkers of renal stress performed better than those associated with glomerular function. Combining renal stress biomarkers with serum creatinine improved the accuracy of predicting AKI.
JOURNAL OF CRITICAL CARE
(2022)
Editorial Material
Critical Care Medicine
Marlies Ostermann, Rajit K. Basu, Ravindra L. Mehta
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
James C. Doidge, Doug W. Gould, Zia Sadique, Mark Borthwick, Robert A. Hatch, Fergus J. Caskey, Lui Forni, Robert F. Lawrence, Clare MacEwan, Marlies Ostermann, Paul R. Mouncey, David A. Harrison, Kathryn M. Rowan, J. Duncan Young, Peter J. Watkinson
Summary: This study evaluated the clinical and health economic impacts of transitioning from systemic heparin anticoagulation (SHA) to regional citrate anticoagulation (RCA) for continuous kidney replacement therapy (CKRT) in intensive care units (ICUs). The results showed that transition to RCA was not associated with changes in mortality, but was associated with increases in kidney support duration, advanced cardiovascular support duration, and ICU length of stay.
JOURNAL OF CRITICAL CARE
(2023)
Editorial Material
Urology & Nephrology
Marlies Ostermann, Mitchell H. Rosner
Summary: Acute kidney injury (AKI) is a complex syndrome involving various inflammatory cells and mediators. Current research aims to identify important contributing pathways, identify high-risk groups, characterize AKI sub-phenotypes, and develop therapeutic interventions.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Thiago Reis, Federico Ronco, Marlies Ostermann
Summary: Fluid overload is a dangerous condition that can increase morbidity and mortality, especially in patients with heart disease. The available treatment options for decongestion, such as diuretics and mechanical fluid removal, have limitations. This paper provides a comprehensive overview of the challenges in managing fluid overload and discusses the risks and benefits of different pharmacological and extracorporeal techniques, aiming to provide guidance for clinical practice.
CARDIORENAL MEDICINE
(2023)
Article
Urology & Nephrology
Alexander Zarbock, Mitra K. Nadim, Peter Pickkers, Hernando Gomez, Samira Bell, Michael Joannidis, Kianoush Kashani, Jay L. Koyner, Neesh Pannu, Melanie Meersch, Thiago Reis, Thomas Rimmele, Sean M. Bagshaw, Rinaldo Bellomo, Vicenzo Cantaluppi, Akash Deep, Silvia De Rosa, Xose Perez-Fernandez, Faeq Husain-Syed, Sandra L. Kane-Gill, Yvelynne Kelly, Ravindra L. Mehta, Patrick T. Murray, Marlies Ostermann, John Prowle, Zaccaria Ricci, Emily J. See, Antoine Schneider, Danielle E. Soranno, Ashita Tolwani, Gianluca Villa, Claudio Ronco, Lui G. Forni
Summary: Sepsis-associated acute kidney injury (SA-AKI) is a common condition that is strongly associated with poor outcomes in critically ill patients. The exact cause of SA-AKI is still not fully understood, but dysfunction in microcirculation, cellular metabolism, and inflammatory responses are considered to be involved. Early identification of patients at risk and timely initiation of supportive measures are crucial for improving outcomes. Research on biomarkers for early diagnosis and clinical trials on potential therapeutic approaches are ongoing.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Biology
Onn Shaun Thein, Naeman Akbar Ali, Rahul Y. Mahida, Rachel C. A. Dancer, Marlies Ostermann, Karin Amrein, Gennaro Martucci, Aaron Scott, David R. Thickett, Dhruv Parekh
Summary: This study aims to investigate the relationship between Fibroblast Growth Factor 23 (FGF23) levels and mortality in critically ill patients. The results showed that patients with high FGF23 levels are more likely to die, regardless of chronic kidney disease. This suggests that FGF23 may affect our immune system in a previously unexplored way. Further research may help improve the survival rate of intensive care patients by targeting FGF23 levels.
Article
Nutrition & Dietetics
Lynda K. Cameron, Nuttha Lumlertgul, Danielle E. Bear, Enya Cooney, Catherine McKenzie, Marlies Ostermann
Summary: This survey aimed to understand the prescribing practice of micronutrients in UK critical care units. The results showed that micronutrient prescribing in UK ICUs is heterogeneous, with clinical scenarios often guiding decisions to use these products. Further research is needed to examine the potential benefits and harms on patient-oriented outcomes of micronutrient product administration.
CLINICAL NUTRITION ESPEN
(2023)
Review
Urology & Nephrology
Alexander Zarbock, Lui G. Forni, Marlies Ostermann, Claudio Ronco, Sean M. Bagshaw, Ravindra L. Mehta, Rinaldo Bellomo, John A. Kellum
Summary: Acute kidney injury (AKI) is a common clinical condition associated with increased mortality and the risk of developing chronic kidney disease and kidney failure. Currently, there is no specific therapy for AKI and novel interventions targeting the underlying pathophysiology are needed. Well-designed clinical trials with appropriate end points are crucial to evaluate the efficacy of these new interventions and improve outcomes.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Critical Care Medicine
Timothy Felton, Natalie Pattison, Simon Fletcher, Simon Finney, Tim Walsh, Paul Dark
Summary: This article discusses the development of guidelines for enrolling individuals in multiple critical care trials, known as co-enrolment. The emphasis is on ensuring patient safety and robust trial outcomes. The authors wish to revisit these guidelines in light of more experience with co-enrolment and increased awareness of different consent models.
JOURNAL OF THE INTENSIVE CARE SOCIETY
(2022)
Meeting Abstract
Anesthesiology
Benjamin Milne, Sinead Helyar, Thomas Gilbey, Daveena Meeks, Carol Pellowe, Eugenia D'Andrea, Marlies Ostermann, Gudrun Kunst
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Review
Urology & Nephrology
Marlies Ostermann, Emma Karsten, Nuttha Lumlertgul
Summary: New biomarkers for AKI have improved our understanding of the disease, playing a role in screening, diagnosis, prognosis, and monitoring. Despite offering opportunities for better management of AKI, concerns and limitations remain.
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)
