Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Roberta Troia, Francesco Dondi, Cristiana Maurella, Paola Gianella, Ilaria Lippi, Alberto Tarducci, Antonio Borrelli
Summary: This study evaluated the effects of constant rate infusion of HES 130/0.4 on renal biomarkers in dogs. The results indicated that in hypoalbuminemic dogs, the dose and rate of HES infusion did not lead to significant changes in the investigated biomarkers of kidney injury. Further prospective studies are needed to assess the renal safety profile of low-molecular-weight HES administration in more severely affected dogs.
Article
Veterinary Sciences
Antonio Borrelli, Massimo Giunti, Stefano Calipa, Angelica Botto, Giulio Mengozzi, Grassato Lisa, Cristiana Maurella, Barbara Bruno
Summary: In dogs with GDV, both HES and HS infusion caused similar hypocoagulability, with some differences between the two groups.
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2021)
Article
Medicine, General & Internal
Erika Yaguchi, Tomoaki Ujita, Shinsuke Hamaguchi
Summary: This study aimed to evaluate the utility of 6% hydroxyethyl starch (HES) 130/0.4 in oral cancer surgeries with durations over 6 hours. The results showed that administration of 6% HES130/0.4 at a dose lower than 25 mL/kg was effective for circulation maintenance but did not increase intraoperative blood loss or transfusion volume. This treatment did not cause any dilutional metabolic acidosis or renal dysfunction.
Review
Anesthesiology
Yi Xu, Siying Wang, Leilei He, Hong Yu, Hai Yu
Summary: This meta-analysis investigated the clinical effects of perioperative use of HES 130/0.4 in surgical patients. The results showed no significant differences in postoperative mortality or kidney dysfunction between HES 130/0.4 and other fluids, but further large-scale studies are needed to confirm these findings.
PERIOPERATIVE MEDICINE
(2021)
Article
Veterinary Sciences
Katja-Nicole Adamik, Michael H. Stoffel, Simone Tangermann, Bettina de Breuyn Dietler, Nadine Stokar-Regenscheit
Summary: This study investigated the severity of intracellular storage of HES in renal tissue samples from critically ill dogs receiving 6% HES 130/0.4. The results showed that a high percentage of dogs had renal tubular HES storage and one-third of dogs showed HES-induced osmotic nephrosis. Short-term HES administration caused vacuolization and accumulation, regardless of the dose or duration of administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Neurosciences
Ayaka Fujita, Masashi Matsuzaka, Norifumi Metoki, Joji Hagii, Hiroshi Shiroto, Manabu Iwata, Rina Tanaka, Eiichi Tsuda
Summary: Hydration therapy with HES 130/0.4 significantly decreased the total costs and hospitalisation duration of patients with SI in the posterior LSA territory.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Agriculture, Dairy & Animal Science
Corrin J. Boyd, Anthea L. Raisis, Claire R. Sharp, Melissa A. Claus, Giselle Hosgood, Lisa Smart
Summary: This study compared the effect of hydroxyethyl starch (HES) and crystalloids on blood clotting in critically ill dogs. The results did not show significant impairment of clotting with HES compared to crystalloids. However, larger studies are needed for further evaluation.
Review
Surgery
Christian J. Wiedermann
Summary: The meta-analysis compared the use of human albumin and 6% hydroxyethyl starches 130/0.4 in pediatric and adult cardiac surgery patients. The study found that ICU length of stay was significantly shorter for patients in the human albumin group, which may offset the economic advantage of using hydroxyethyl starches 130/0.4. The renal safety of hydroxyethyl starches 130/0.4 is also under review.
Article
Public, Environmental & Occupational Health
Benedict Morath, Andreas D. Meid, Johannes Rickmann, Jasmin Soethoff, Markus Verch, Matthias Karck, Marcin Zaradzki
Summary: This study found that postoperative administration of HES may reduce the occurrence of acute kidney injury in patients after cardiac surgery, and there was no association between HES and 90-day mortality. The study suggests that HES may be safely administered to cardiac surgery patients for better renal outcomes, especially if administered early and dosed appropriately.
Article
Anesthesiology
Mee Jee Lee, Charles Tannenbaum, Guangmei Mao, Yuan Jia, Steve Leung, Huseyin Oguz Yilmaz, Ilker Ince, Edward Soltesz, Andra E. Duncan
Summary: There was no significant difference in inflammatory markers and pulmonary function between cardiac surgical patients who received 6% HES 130/0.4 versus 5% albumin.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medicine, General & Internal
Simon Finfer, Sharon Micallef, Naomi Hammond, Leanlove Navarra, Rinaldo Bellomo, Laurent Billot, Anthony Delaney, Martin Gallagher, David Gattas, Qiang Li, M. Biostat, Diane Mackie, Jayanthi Mysore, Manoj Saxena, Colman Taylor, Paul Young, John Myburgh
Summary: There is no evidence that the use of balanced multielectrolyte solution (BMES) reduces the risk of death or acute kidney injury in critically ill patients compared to saline, according to a double-blind, randomized, controlled trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Kei Nagaya, Akiko Yoshida, Yosuke Ito, Suguru Watanabe, Tadanori Minagawa, Yoshifumi Saijo
Summary: This study aimed to investigate the impact of HES 130/0.4 on postoperative renal function in patients undergoing cardiac surgery using cardiopulmonary bypass. The results showed that there was no significant difference in the occurrences or stages of acute kidney injury within 30 days following surgery between patients administered with HES 130/0.4 or Ringer's bicarbonate.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Anesthesiology
Lohith H. N. Kumar, Swagata Tripathy, Prasanta Kumar Das
Summary: The study found that goal-directed therapy guided by DCO2 did not improve organ function, but it did reduce ICU stay. More evidence is needed to determine the routine use of DCO2 in sicker patients.
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, General & Internal
Kei Nagaya, Akiko Yoshida, Yosuke Ito, Suguru Watanabe, Tadanori Minagawa, Yoshifumi Saijo
Summary: There was no significant difference in the occurrences or stages of AKI during the 30 days following cardiac surgery with cardiopulmonary bypass between patients administered with HES 130/0.4 or Ringer's bicarbonate.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Pharmacology & Pharmacy
Lei Guo, Xiangsheng Xiong, Rui Qin, Zhenzhou Li, Yongqiang Shi, Wei Xue, Ling He, Shuqin Ma, Yi Chen
Summary: The study found that a prophylactic norepinephrine dosage of 0.05 μg/kg/min combined with a co-load infusion of 500 mL 6% hydroxyethyl starch (130/0.4) was optimal for preventing postspinal anesthesia hypotension during cesarean section.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)