Article
Chemistry, Medicinal
Lei Guo, Xiangzhao Xu, Rui Qin, Yongqiang Shi, Wei Xue, Ling He, Shuqin Ma, Yi Chen
Summary: By administering a prophylactic bolus of 8 μg norepinephrine and 90 μg phenylephrine, postspinal anesthesia hypotension during cesarean section can be effectively prevented.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Anesthesiology
Kamlesh Kumari, Kriti Chaudhary, Priyanka Sethi, Darshana Rathod, Tanvi Meshram, Nikhil Kothari, Ankur Sharma, Pradeep Bhatia, Surjit Singh
Summary: Norepinephrine and phenylephrine showed comparable efficacy in managing postspinal hypotension, but norepinephrine had a lower incidence of maternal bradycardia.
MINERVA ANESTESIOLOGICA
(2022)
Article
Pharmacology & Pharmacy
Yi Chen, Lili Zou, Zhenzhou Li, Lei Guo, Wei Xue, Ling He, Shuqin Ma, Xinli Ni
Summary: The study aimed to investigate the optimal prophylactic dose of norepinephrine to prevent postspinal anesthesia hypotension in cesarean section patients, with findings indicating that a prophylactic dose of 0.05 or 0.075 micrograms/kg/min effectively prevents postspinal anesthesia hypotension.
Article
Medicine, General & Internal
Qian-Qian Fan, Yong-Hui Wang, Jing-Wen Fu, Hai-Long Dong, Man-Ping Yang, Duo-Duo Liu, Xiao-Fan Jiang, Zhi-Xin Wu, Li-Ze Xiong, Zhi-Hong Lu
Summary: Norepinephrine infusion in parturients undergoing elective cesarean section with spinal anesthesia resulted in fewer cases of hypotension and tachycardia compared to ephedrine bolus, and showed potential benefits for neonates.
CHINESE MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Wenping Xu, Dan Michael Drzymalski, Ling Ai, Hanqing Yao, Lin Liu, Fei Xiao
Summary: The initial infusion dose of 0.1 µg/kg/min of norepinephrine was effective in preventing spinal anesthesia-induced hypotension.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuan Li, Bingxing Shuai, Han Huang
Summary: This study evaluated the dose-response relationship between prophylactic norepinephrine infusion rates and the risks of hypotension during cesarean section following spinal anesthesia. The results showed that an increased norepinephrine infusion rate was associated with a decreased incidence of post-spinal hypotension but an increased incidence of hypertension.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Kassiani Theodoraki, Sofia Hadzilia, Dimitrios Valsamidis, Konstantina Kalopita, Emmanouil Stamatakis
Summary: This study aimed to compare the incidence of maternal hypotension in parturients receiving either colloid preload or crystalloid co-load during prophylactic norepinephrine infusion. The results showed that the incidence of hypotension was low and comparable in both groups, indicating that both fluid-loading techniques are appropriate in women undergoing cesarean delivery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Roberta Troia, Francesco Dondi, Cristiana Maurella, Paola Gianella, Ilaria Lippi, Alberto Tarducci, Antonio Borrelli
Summary: This study evaluated the effects of constant rate infusion of HES 130/0.4 on renal biomarkers in dogs. The results indicated that in hypoalbuminemic dogs, the dose and rate of HES infusion did not lead to significant changes in the investigated biomarkers of kidney injury. Further prospective studies are needed to assess the renal safety profile of low-molecular-weight HES administration in more severely affected dogs.
Article
Anesthesiology
Zhi-min Sheng, Yan-ping Shen, Zheng-bin Pan, Miao Zhu, Hao-tian Sun, Jin-ping Liu, Xiao-wei Qian
Summary: This study compares the efficacy of variable-rate infusion and fixed-rate infusion of norepinephrine for preventing maternal hypotension during spinal anesthesia for cesarean delivery. The results show that the incidence of maternal hypotension was significantly lower in the variable-rate infusion group compared to the fixed-rate infusion group. However, the variable-rate infusion group required more physician interventions.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Pharmacology & Pharmacy
Peng Liu, Hong He, Shan-Shan Zhang, Yun Liang, Zi-Jun Gao, Hui Yuan, Bu-Huai Dong
Summary: This systematic review found that prophylactic use of norepinephrine is more effective than phenylephrine in maintaining blood pressure during cesarean delivery, without causing adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Qiang Huang, Gengzhi Wen, Chao Hai, Zihao Zheng, Yali Li, Zengping Huang, Bowan Huang
Summary: This study found that a height-based dosing algorithm of bupivacaine can provide adequate anesthesia and reduce maternal hypotension in spinal anesthesia without prophylactic fluid preloading and vasopressors.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Yi Chen, Xiangzhao Xu, Rui Qin, Lei Guo, Xinli Ni
Summary: This study compared the effect of crystalloid and hydroxyethyl starch co-load on the prophylactic norepinephrine infusion for preventing post-spinal anesthesia hypotension. The results showed that 6% hydroxyethyl starch did not have additional benefits compared to crystalloid co-load in reducing the ED90 of prophylactic norepinephrine infusion.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fei Xiao, Wen-Ping Xu, Han-Qing Yao, Jia-Ming Fan, Xin-Zhong Chen
Summary: The study aimed to determine the median effective dose (ED50) and 90% effective dose (ED90) of weight-based fixed-rate metaraminol infusions for preventing spinal-anesthesia-induced hypotension in Cesarean delivery. The results showed that as the infusion rate of metaraminol increased, the incidence of hypotension decreased, but the risk of reactive hypertension increased.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Kuo-Chuan Hung, Chien-Cheng Liu, Yen-Ta Huang, Jheng-Yan Wu, Jen-Yin Chen, Ching-Chung Ko, Chien-Ming Lin, Chung-Hsi Hsing, Ming Yew, I-Wen Chen
Summary: This meta-analysis assessed the predictive efficacy of perfusion index for hypotension following spinal anesthesia in parturients undergoing elective cesarean section. The results showed that the perfusion index exhibited an acceptable level of accuracy in predicting perioperative hypotension after spinal anesthesia in parturients undergoing elective CS, highlighting its potential value as a useful tool for clinicians.
Article
Anesthesiology
Rajesh Deshar, Asish Subedi, Krishna Pokharel, Birendra Prasad Sah, Jagat Narayan Prasad
Summary: This study found that prophylactic use of glycopyrrolate did not decrease the vasopressor requirements to prevent hypotension during non-elective cesarean section under spinal anesthesia. There were some differences in maternal hypotension and tachycardia between the glycopyrrolate group and the placebo group, but no significant differences were observed in other outcomes and neonatal outcomes.
BMC ANESTHESIOLOGY
(2022)