Review
Pharmacology & Pharmacy
Lei Zhang, Yayu Liang, Guohui Liang, Zhili Tian, Yue Zhang, Zhihui Liu, Xinying Ji
Summary: This article introduces RNA interference technology and its application in genetic therapy, focusing on the advantages and limitations of GalNAc-siRNA conjugates and lipid nanoparticles as delivery systems, and looking forward to the development of oligonucleotide drugs in genetic therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beinuo Wang, Ruijie Zhang, Yao Wang, Hang Qian, Di Wu, Binfeng He, Hu Liao
Summary: Overcoming cisplatin-based drug resistance in lung cancer remains a challenge globally. Recent studies have shown that Rab GTPases play a role in multiple aspects of tumor progression, including drug resistance. In this study, a nanosystem was developed using Rab26 siRNA-loaded nanoparticles, which effectively transfected cisplatin-resistant lung cancer cells and induced apoptosis while inhibiting autophagy disruption. The combination therapy of siRab26 knockdown with cisplatin improved antitumor therapy in vitro and in vivo. These findings suggest that siRNP is an effective platform for lung cancer therapy in cases of drug resistance.
Article
Medicine, Research & Experimental
Jing Miao, Xiqin Yang, Xuwei Shang, Zhe Gao, Qian Li, Yun Hong, Jiaying Wu, Tingting Meng, Hong Yuan, Fuqiang Hu
Summary: This study developed a Gal-CSSO system for targeted HB therapy by exploiting the difference in glutathione concentration between hepatocytes (HCs) and Kupffer cells (KCs). The system showed low cytotoxicity, endosomal escape, and glutathione responsiveness in vitro, leading to significant reduction in HBeAg and HBsAg secretion in HepG2.2.15 cells. In vivo, the Gal-CSSO system targeted HCs, effectively reducing HBeAg and HBsAg titers in HBV-infected mice without noticeable hepatotoxicity or systemic toxicity, showing promise for efficient and safe gene therapy of HB.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Medicine, Research & Experimental
Mehrdad Hashemi, Rezvaneh Aparviz, Marzie Beickzade, Mahshid Deldar Abad Paskeh, Simin Khorsand Kheirabad, Zeinab Khazaei Koohpar, Amir Moravej, Hossein Dehghani, Hamidreza Saebfar, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Maliheh Entezari, Saeed Samarghandian
Summary: This review explores the potential applications of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in the treatment of gastric cancer. It highlights the ability of siRNA to reduce the proliferation and invasion of gastric cancer cells and induce chemosensitivity. However, the unmodified siRNA faces challenges in translational potential. The role of nanostructures in facilitating siRNA delivery to gastric cancer cells and suppressing tumor progression is emphasized. The translation of these findings into clinical trials holds promise for advancing the treatment of gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Na Peng, Yijing Du, Guang Yu, Chenglan Zhang, Qun Cai, Hu Tang, Yi Liu
Summary: This study explores the combination of polymeric nanoplatforms with reactive oxygen species (ROS) responsiveness and mitochondria targeting for enhanced photodynamic therapy (PDT). The results show that Ce6-loaded BioPEGDMA@RM, which contains TK linkers, exhibits higher cytotoxicity and ROS production compared to nanoparticles without TK linkages. Additionally, Ce6-loaded BioPEGDMA@RM shows stronger in vitro cytotoxicity and immunologic reactions, suggesting its potential for ROS-responsive drug delivery systems in advanced PDT efficiency.
Review
Multidisciplinary Sciences
Dong-Dong Wu, Yasmine Ahmed Salah, Ebenezeri Erasto Ngowi, Yan-Xia Zhang, Saadullah Khattak, Nazeer Hussain Khan, Yan Wang, Tao Li, Zi-Hua Guo, Yan-Mei Wang, Xin-Ying Ji
Summary: Neurological diseases are a global issue that requires urgent attention. Nanotechnology shows promise in delivering therapeutics to the brain and treating CNS disorders. The combination of nanotechnology and gene-altering molecules may provide a cure for diseases like Alzheimer's and brain tumors.
Article
Chemistry, Physical
Marketa Paloncyova, Petra Cechova, Martin Srejber, Petra Kuhrova, Michal Otyepka
Summary: Recent advances in RNA-based medicine have opened up new opportunities for addressing the current global challenge of the COVID-19 pandemic. The lipid mixtures and ILs used in mRNA vaccines play a crucial role in vaccine stability and can impact RNA flexibility and base pairing, ultimately affecting RNA delivery efficiency through rational tailoring of LNP composition.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Dan Li, Xin Li, Jie Bai, Ying Liu, Renko de Vries, Yuan Li
Summary: Rod-shaped nanoparticles made of C-S-B triblock polypeptides show efficient delivery of siRNA into cells, leading to gene knockdown and apoptosis. However, their lower effectiveness in inducing cell death compared to cationic lipid-based formulations is attributed to high lysosome co-localization, which requires future optimization. Overall, non-toxic C-S-B nanoparticles warrant further development as a new siRNA delivery system for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Yuan Zhang, Juhura G. G. Almazi, Hui Xin Ong, Matt D. D. Johansen, Scott Ledger, Daniela Traini, Philip M. M. Hansbro, Anthony D. D. Kelleher, Chantelle L. L. Ahlenstiel
Summary: This review article introduces the potential and application of RNA-interference-based gene therapy in antiviral treatment of COVID-19 disease, with a focus on the role and challenges of nanoparticles as carriers in siRNA delivery, as well as the application of inhalation devices and animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Manon Berger, Francois Toussaint, Sanaa Ben Djemaa, Erik Maquoi, Helene Pendeville, Brigitte Evrard, Christine Jerome, Jeanne Leblond Chain, Anna Lechanteur, Denis Mottet, Antoine Debuigne, Geraldine Piel
Summary: Lipid-based nanocarriers have shown great potential in delivering genetic material, but PEGylation can have adverse effects on cellular uptake and endosomal escape. This study proposes amphiphilic poly(N-methyl-N-vinylacetamide) (PNMVA) derivatives as alternatives to lipid-PEG for siRNA delivery. DSPE-PNMVA(24) demonstrates comparable stealth properties to DSPE-PEG, but without adverse impact on cellular uptake and endosomal escape. In vivo studies with mice show that DSPE-PNMVA(24) lipoplexes have good stealth properties, extended circulation time, reduced immunological reaction, and no systemic pro-inflammatory response.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Xing Huang, Meng Chen, Zhan Huang, Yanfei Zhang, Taorong Shen, Yakun Shi, Yanli Tong, Xiaoyong Zou, Si-Yang Liu, Jianhe Guo, Zong Dai
Summary: In this study, a novel DNA nanodevice was proposed for dual-biomarker sensing, enabling highly specific imaging of cancer cells. By performing transmembrane logic operations from the cell membrane to the cytoplasm, the nanodevice achieved reliable analysis of intracellular biomarkers such as nucleolin protein and microRNAs.
ANALYTICAL CHEMISTRY
(2023)
Article
Polymer Science
Shiou-Fen Hung, Yu-Han Wen, Lu-Yi Yu, Hsin-Cheng Chiu, Yi-Ting Chiang, Chun-Liang Lo
Summary: In this study, two copolymers were synthesized and characterized for assembling siRNA to form polyplex-mixed micelles for the treatment of human colon cancer cells. The cationic pyridoxal molecules and pH-sensitive properties of the copolymers played key roles in attracting and protecting the siRNA, leading to reduced FAK expression and demonstrated cytotoxicity towards cancer cells within 24 hours. The results suggest the promising potential of pH-sensitive polyplex-mixed micellar system in siRNA delivery for cancer treatment.
Review
Engineering, Biomedical
Zheng-Rong Lu, Victoria E. A. Laney, Ryan Hall, Nadia Ayat
Summary: Environment-responsive lipids are a novel type of siRNA delivery system that can respond to environmental changes during the delivery process. Lipid/siRNA nanoparticles have been developed for efficient delivery of therapeutic siRNA into cancer cells.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ye Cao, Yang Fei Tan, Yee Shan Wong, Muhammad Aminuddin, Bhuthalingam Ramya, Melvin Wen Jie Liew, Jiaxin Liu, Subbu S. Venkatraman
Summary: Despite the challenges, this study presents a new nanogel system that can encapsulate and sustainably release siRNA, enhancing its efficiency and prolonging the gene silencing effect. This system shows promise for both fundamental biological studies and clinical applications in siRNA-based therapies.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Anna Clua, Santiago Grijalvo, Namrata Erande, Swati Gupta, Kristina Yucius, Raimundo Gargallo, Stefania Mazzini, Muthiah Manoharan, Ramon Eritja
Summary: The development of oligonucleotide conjugates for in vivo targeting, particularly GalNAc-oligonucleotides, is an exciting area in oligonucleotide therapeutics. In this study, the authors explore the use of G-rich sequences functionalized with GalNAc to form tetrameric nanostructures that can bind to ASGPR. The study demonstrates the feasibility and potential benefits of using parallel G-quadruplexes for targeting hepatocytes.
Article
Chemistry, Multidisciplinary
Wei Jiang, Zhiqiang Shen, Zixuan Guo, Qin Wang, Quan Li, Jinming Hu, Yucai Wang
Summary: In this study, smart materials capable of adapting to the pathological oxygen levels in tumors were developed to enhance cancer immunotherapy. These materials generate immunogenic stimuli that induce immunogenic cell death, stimulate dendritic cell maturation, and increase the infiltration of cytotoxic T cells into tumors, thus overcoming the oxygen heterogeneity in tumors and boosting immunotherapy.
Article
Materials Science, Biomaterials
Xue Hu, Jie Li, Yuhao Zhang, Menghua Xiong, Houbing Zhang, Youyong Yuan
Summary: In this study, a cationic helical oncolytic polypeptide (OLPP) with potent membranolytic activity was synthesized using ring-opening polymerization and thiol-ene reaction. The OLPP showed resistance to protease, high cytotoxicity to cancer cells, and induced cancer cell necrosis by lysing the cancer cell membrane independent of intracellular pathways. Intra-tumoral injection of the OLPP effectively suppressed tumor growth in mice, suggesting its potential as an oncolytic chemotherapeutic for cancer therapy.
BIOMATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Chang Xie, Li Wang, Yajuan Liu, Muqing Chen, Pingwu Du, Yucai Wang, Xiaopeng Ma, Shangfeng Yang
Summary: Photothermal therapy (PTT) using near-infrared-II (NIR-II) light is an effective tumor therapy technique with deeper tissue penetration and higher laser power density. Black phosphorus (BP) has potential applications in PTT, but its low stability and limited photothermal conversion efficiency pose challenges. In this study, fullerene covalently modified few-layer BP nanosheets (BP-ester-C60) were developed to enhance stability and photothermal conversion efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Yuanyuan Geng, Yueling Yuan, Yan Bao, Songyin Huang, Xiaochuan Wang, Liangqi Huang, Chun She, Xiangjun Gong, Menghua Xiong
Summary: Antimicrobial polymers show potential for treating drug-resistant bacteria, but the challenge lies in designing polymers that selectively kill bacteria with low toxicity to normal tissues/cells. This study reports a pH window for ionizable polymers with high selectivity towards bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Pharmacology & Pharmacy
Qi-Jia Duan, Zhong-Yi Zhao, Yao-Jun Zhang, Liangbing Fu, You-Yong Yuan, Jin-Zhi Du, Jun Wang
Summary: Surgery and drug therapy are hindered by difficulties in accurate tumor location and timely monitoring of drug efficacy, but rapid development of imaging techniques, particularly fluorescence imaging, provides promising tools to address these challenges. Fluorescent probes, especially site-specifically activatable nanoprobes, have been developed and explored for tumor diagnosis and treatment monitoring. This review discusses recent advances in fluorescent probes and highlights the potential implementation of activatable nanoprobes in fluorescence imaging-guided surgery and imaging-guided drug therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Engineering, Biomedical
Yi Liu, Wang Dong, Yinchu Ma, Jiaxiang Dou, Wei Jiang, Li Wang, Qin Wang, Shuya Li, Yucai Wang, Min Li
Summary: Tumor hypoxia heterogeneity, a characteristic feature of the tumor microenvironment, leads to resistance to chemotherapy. To overcome this, a nanomedicine called NPHPaPN was developed, which utilizes hypoxia-responsive PEG shell deshielding and drug internalization through the HA-CD44 pathway to target cisplatin-resistant tumor cells. The release of cisplatin prodrug and a DNA damage repair inhibitor within the tumor cells enhances drug sensitivity and leads to significant tumor growth suppression with an inhibition rate of approximately 84.4%.
Review
Nanoscience & Nanotechnology
Dong-Kun Zhao, Jie Liang, Xiao-Yi Huang, Song Shen, Jun Wang
Summary: The rapid development and widespread application of nanomedicines in cancer treatment over the past decades have not been effectively translated into clinical practice, as evidenced by the low commercialization rate. Inadequate understanding of nanomedicine-tumor interactions and inappropriate evaluation models are two major challenges limiting their clinical translation. The use of cell lines or mouse models to study nanomedicine-tumor interactions and therapeutic effects lack the complex tumor microenvironment found in human patients. Patient-derived tumor organoids, on the other hand, retain the key features of the parent tumor and can provide valuable insights for the rational design of nanomedicines. This review highlights the potential of combining organoids and nanotechnology to develop safe and effective cancer nanomedicines and accelerate their clinical application.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yue Wang, Shi-Kun Zhou, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu, Jun Wang
Summary: This study describes a tumor-specific expression strategy to promote the secretion of CXCL9 and an anti-PD-L1 scFv (alpha PD-L1) in the tumor microenvironment, enhancing T cell recruitment and anti-tumor immune response.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Aoxing Cheng, Tian Xu, Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo, Haiyan Zhang, Xin Pan, Yucai Wang, Liu Liu, Kaiguang Zhang, Jue Shi, Xuebiao Yao, Jing Guo, Zhenye Yang
Summary: Research has found that redox metabolites in cancer cells fluctuate during the cell cycle, but the functional impacts of these metabolic oscillations are still unknown. A mitosis-specific upsurge of nicotinamide adenine dinucleotide phosphate (NADPH) has been discovered, which is essential for tumor progression. This upsurge is produced by glucose 6-phosphate dehydrogenase (G6PD) upon mitotic entry and neutralizes elevated reactive oxygen species (ROS), preventing ROS-induced inactivation of mitotic kinases and chromosome missegregation. The study reveals that aneuploid cancer cells with high ROS levels depend on a G6PD-mediated NADPH upsurge during mitosis to protect against ROS-induced chromosome missegregation, making this upsurge a cell cycle-dependent metabolic vulnerability.
Article
Nanoscience & Nanotechnology
Wenxiu Duan, Lifeng Hang, Yinchu Ma, Qin Wang, Xinfeng Tang, Wei Jiang, Yi Wu, Weifu Lv, Yucai Wang
Summary: Nano-metal-organic frameworks (nMOFs) can load and protect bioactive macromolecules, and selectively release them at the target location after stimulation, showing promising applications in co-delivery of biomacromolecules.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kaige Chen, Zheng Zhang, Ziyuan Fang, Jiachen Zhang, Qian Liu, Wang Dong, Yang Liu, Yucai Wang, Jun Wang
Summary: This study reports a nano-mediated strategy to stimulate the precise clearance of activated neutrophils using an artificial aged signal, thus alleviating inflammation. The findings show that this strategy effectively targets and clears activated neutrophils, preventing inflammatory responses and tissue damage.
Article
Engineering, Biomedical
Dongdong Li, Ziyang Cao, Chaoran Chen, Hengyi Li, Shan He, Xurui Hou, Ming Liang, Xianzhu Yang, Jun Wang
Summary: This study developed a nanoassembly that efficiently reawakens T cell and macrophage-mediated anticancer activity. By downregulating CD47 expression, the nanoassembly can block antiphagocytic signals and enhance macrophage-mediated immunotherapy. Additionally, the conjugated chemotherapy drug can induce immunogenic cell death and promote T cell-mediated anticancer immune response.
Article
Chemistry, Multidisciplinary
Qian Liu, Li Wang, Yitan Su, Wang Dong, Huiru Wang, Yang Liu, Hang Liu, Lianxin Liu, Yucai Wang
Summary: Protein drugs are potential candidates for treating complex diseases like cancer. Metal-organic-framework (MOF) is considered a promising carrier for encapsulating protein drugs, but its limited loading efficiency and potential toxicity hinder its clinical application. In this study, a tumor targeted collagenase-encapsulating MOF (PMOCol) is developed for refining deep tissue pancreatic cancer photoimmunotherapy. PMOCol demonstrates high encapsulation efficiency (80.3 wt%) and can effectively regulate extracellular matrix, enhancing immunocyte infiltration for cancer immunotherapy. By integrating a hyperthermia agent, PMOCol induces acute immunogenicity and systemic immune memory to prevent tumor development and recurrence.
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yue Zhang, Gui Zhao, Yi-Fang Chen, Shi-Kun Zhou, Yue Wang, Yi-Qun Sun, Song Shen, Cong-Fei Xu, Jun Wang
Summary: By fusing ligands targeting TNFRs with a multivalent protein scaffold (MV), strong agonists for cross-linking TNFRs can be devised. This study provides a promising strategy for engineering multivalent antitumor protein drugs, which can promote T cell activation and directly induce tumor cell apoptosis.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
