Review
Biotechnology & Applied Microbiology
Neha Kaushik, Shweta B. Borkar, Sondavid K. Nandanwar, Pritam Kumar Panda, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: Nanocarriers (NCs) have attracted significant attention for their structural ability, good biocompatibility, and biodegradability. The development of NCs with stimuli-responsive properties has become a hot topic among scientists. These NCs can deliver drugs to tumors by regulating their pH, temperature, and enzyme responsiveness, thereby improving the accuracy of drug delivery and minimizing side effects. Material carriers for chemotherapeutic medicines are discussed in this review, with a focus on their structural properties and targeting methods that enhance therapeutic efficacy and trigger metabolic pathways. Overall, the development of NCs that respond to endogenous and exogenous stimuli in tumor regions and the understanding of their mechanisms have great potential for advancing tumor therapy and precision diagnosis in the future.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Dalei Wang, Xiaoxia Han, Bin Dong, Feng Shi
Summary: In the past decade, there have been significant advances in the field of micromotors, especially in the development of stimuli-responsive polymer based micromotors. These micromotors show unprecedented properties and have potential applications in various fields.
APPLIED MATERIALS TODAY
(2021)
Review
Oncology
Fakhara Sabir, Mahira Zeeshan, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Magali Cucchiarini, Sadanand Pandey
Summary: DNA-based smart nano-carriers can deliver drugs to tumor cells efficiently, enhancing treatment efficacy and minimizing damage to healthy cells. However, before clinical translation, challenges such as understanding in vivo parameters and drug delivery mechanisms must be addressed.
Article
Pharmacology & Pharmacy
Riddhi Trivedi, Pravin Shende
Summary: This study aimed to develop a novel nanoparticulate theranostic nanocarrier for the combined diagnosis and treatment of epilepsy. The nanocarrier can detect epileptic conditions through changes in pH and provide therapeutic alleviation of seizures using a glutaminase inhibitor. In animal experiments, the nanocarrier effectively suppressed epileptic seizures, prolonged latency duration, and reduced the duration of convulsions and recovery period, while also lowering glutaminase levels in the brain.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Zhiqin Xia, Chang-Gen Lin, Yang Yang, Yongkang Wang, Zhanpeng Wu, Yu-Fei Song, Thomas P. Russell, Shaowei Shi
Summary: Integrating different types of supramolecular interactions allows the generation of nanoparticle surfactants that are responsive to multiple stimuli. A covalently modified polyoxometalate/beta-cyclodextrin organic-inorganic hybrid is developed, which can interact with ligands in an oil phase at a liquid-liquid interface, producing surfactants with pH, redox, and guest-competitive responsiveness.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Tianshuai Wang, Chen Wu, Yanggen Hu, Yan Zhang, Junkai Ma
Summary: Platinum-based anticancer drugs are important in cancer treatment, but their toxicity and drug resistance limit their application. Stimuli-responsive nanocarrier drug delivery systems provide a promising strategy to overcome these limitations. Significant progress has been made in stimuli-responsive delivery systems for platinum-based drugs.
Review
Polymer Science
Louise Van Gheluwe, Igor Chourpa, Coline Gaigne, Emilie Munnier
Summary: Progress in stimuli-responsive polymers has led to advancements in smart drug delivery systems (SDDS) which can address targeted drug delivery and personalized medicine challenges. SDDS, mainly explored in oncology, are now extending to dermatology and cosmetics fields. pH and temperature are the most commonly used stimuli for controlled release of active ingredients.
Article
Chemistry, Applied
Eunhye Yang, Ho-Sup Jung, Pahn-Shick Chang
Summary: In this study, a stimulus-responsive polymer complex called capsosomes containing trilaurin-based solid lipid nanoparticles (SLNs) known as CSLNs was prepared for the oral delivery of hydrophilic molecules. The capsosomes showed improved stability and prolonged retention time under small intestinal conditions and bypassed the gastrointestinal tract. These findings demonstrate the potential application of pH-sensitive capsosomes for the oral delivery of food nutraceuticals.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Mingming Song, Chang Liu, Siyu Chen, Wenxiang Zhang
Summary: Nanotechnologies show promise as an effective oncology treatment strategy by delivering drugs to targeted tissues with low toxicity, improving the clinical efficacy of cancer therapy. The application of nanoparticles in melanoma treatment has a broad potential, including chemotherapy, immunotherapy, mRNA vaccines, and photothermal therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jian Chen, Lujie Song, Youping Wu, Biao Zhao, Jianping Deng
Summary: Fluorescent silicone elastomers with stable and highly efficient properties have been successfully fabricated, showing multiple stimulus responsiveness. The fluorescence properties of the silicone elastomers can be modulated by changing the molecular weight or aggregation state.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Jitender Bariwal, Hairong Ma, Guillermo A. Altenberg, Hongjun Liang
Summary: Cancer therapy faces challenges in drug delivery to cancer cells and non-selective killing of healthy cells. Nano-formulations show promising potential for targeted drug delivery. The shape and size of nanocarriers significantly impact their transport and internalization. Nanodiscs are desirable nano-formulations with enhanced anisotropic character and versatile functionalization potential.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Immunology
Liucan Wang, Min Yu, Hua Yang
Summary: Effective colon drug delivery using nanocarrier-based nanomedicine is an international frontier research in IBD therapy, offering new opportunities for treatment and diagnoses. Functional nanocarriers with varying characteristics can improve target therapy and bioavailability, enhancing therapeutic efficacy in the treatment of IBD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jelena Dini, Mathew R. Schnorenberg, Matthew V. Tirrell
Summary: This comprehensive study focuses on the influence of sequence charge pattern on the secondary structure preferences of annealed polyampholytes and their responsiveness to external stimuli. The study shows that the sequence charge pattern significantly affects the secondary structure preferences of polyampholytes at physiological pH and that external stimuli such as pH, ionic strength, and solvent dielectric constant can be used to modulate the secondary structure of the studied sequences.
Review
Biochemical Research Methods
Amit Singh, Mansoor M. Amiji
Summary: Nanotechnology has greatly impacted the advancement in disease imaging, early detection, diagnosis, and prognosis. The unique properties of nanoparticles enable contrast enhancement for biomedical imaging and molecular level tissue-specific diagnosis. Small variations in nanoparticle size or composition can result in significant changes in their optical, magnetic, or electrical properties, allowing for unique possibilities of multiplexing.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Mathematics, Applied
Izzettin Demir
Summary: The paper discusses the lack of discussion on mappings in N-soft set theory, introduces a new definition of complement for N-soft sets, and investigates N-soft mappings and their properties.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Joel Bourquin, Ana Milosevic, Daniel Hauser, Roman Lehner, Fabian Blank, Alke Petri-Fink, Barbara Rothen-Rutishauser
ADVANCED MATERIALS
(2018)
Review
Polymer Science
Marc P. Wolf, Georgette B. Salieb-Beugelaar, Patrick Hunziker
PROGRESS IN POLYMER SCIENCE
(2018)
Article
Multidisciplinary Sciences
Peter Nirmalraj, Roman Lehner, Damien Thompson, Barbara Rothen-Rutishauser, Michael Mayer
SCIENTIFIC REPORTS
(2018)
Review
Engineering, Environmental
Roman Lehner, Christoph Weder, Alke Petri-Fink, Barbara Rothen-Rutishauser
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Marc P. Wolf, Kegang Liu, Thomas F. W. Horn, Patrick Hunziker
Review
Cardiac & Cardiovascular Systems
Marc P. Wolf, Patrick Hunziker
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2020)
Article
Toxicology
Roman Lehner, Wendel Wohlleben, Dedy Septiadi, Robert Landsiedel, Alke Petri-Fink, Barbara Rothen-Rutishauser
ARCHIVES OF TOXICOLOGY
(2020)
Article
Environmental Sciences
Jessica Caldwell, Livius F. Mu, Christopher K. Pham, Alke Petri-Fink, Barbara Rothen-Rutishauser, Roman Lehner
MARINE POLLUTION BULLETIN
(2020)
Review
Chemistry, Multidisciplinary
Aurora Bas, Nicole Burns, Andrew Gulotta, James Junker, Barbara Drasler, Roman Lehner, Lothar Aicher, Samuel Constant, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: Researchers are advocating for alternative in vitro test methods to replace or reduce animal experiments, but awareness of the standardization, validation, and approval process is a major obstacle; efforts are needed to demonstrate the reliability of in vitro methods for early screening testing; the development process of alternative methods focuses on validation to regulatory acceptance, with challenges in understanding the intricacies.
Review
Environmental Sciences
Jessica Caldwell, Patricia Taladriz-Blanco, Roman Lehner, Andriy Lubskyy, Roberto Diego Ortuso, Barbara Rothen-Rutishauser, Alke Petri-Fink
Summary: This review summarizes research on various aspects of plastic particle analysis, including definitions, detection and characterization techniques, and generation of reference particles. Based on these studies, recommendations are provided to help researchers study plastics in complex environments.
Article
Engineering, Environmental
Livius F. Muff, Sandor Balog, Jozef Adamcik, Christoph Weder, Roman Lehner
Summary: Research on polymer nanoparticles in the environment and their impact on animal and human health is growing. This study presents a method to prepare well-defined nanoparticles with tailored characteristics, allowing for their detection in complex environments and mimicking environmentally relevant morphologies.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jessica Caldwell, Roman Lehner, Sandor Balog, Christian Rheme, Xin Gao, Dedy Septiadi, Christoph Weder, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: With the increasing prevalence of plastic micro- and nanoparticles in the environment, the risk of human exposure and uptake is elevated, yet little is known about their potential adverse effects. This study successfully created fluorescently labeled plastic nanoparticles of heterogeneous shapes, and found differences in their uptake and compatibility within different cell types.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Nanoscience & Nanotechnology
Kegang Liu, Xueya Wang, Xiaochun Li-Blatter, Marc Wolf, Patrick Hunziker
ACS APPLIED BIO MATERIALS
(2020)
Proceedings Paper
Environmental Sciences
Roman Lehner, Alke Petri-Fink, Barbara Rothen-Rutishauser
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MICROPLASTIC POLLUTION IN THE MEDITERRANEAN SEA
(2018)
Article
Biochemistry & Molecular Biology
Roman Lehner, Kegang Liu, Xueya Wang, Patrick Hunziker
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)