Article
Food Science & Technology
Fang Wu, Dan-Dan Wang, Hao-Hao Shi, Cheng-Cheng Wang, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: Early dietary n-3 PUFA deficiency exacerbates the development of Parkinson's disease in old age, while supplementation with DHA/EPA-PLs can restore brain DHA levels and exert neuroprotective effects in long-term n-3 PUFA-deficient mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Sarah B. Scheinman, Dhavamani Sugasini, Monay Zayed, Poorna C. R. Yalagala, Felecia M. Marottoli, Papasani V. Subbaiah, Leon M. Tai
Summary: Research suggests that LPC-DHA/EPA-enriched krill oil can increase brain DHA and improve memory-related behavior in mice with the APOE4 gene. Therefore, long-term use of LT-krill oil supplements may provide some level of protection against age-related neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Esmail Lutfi, Gerd M. Berge, Grete Baeverfjord, Trygve Sigholt, Marta Bou, Thomas Larsson, Turid Morkore, Oystein Evensen, Nini H. Sissener, Grethe Rosenlund, Lene Sveen, Tone-Kari Ostbye, Bente Ruyter
Summary: This study evaluated the effects of increasing dietary levels of EPA and DHA on growth performance, welfare, robustness, and overall quality of Atlantic salmon reared in sea cages. The results showed that a diet containing 3.5% EPA and DHA had significant beneficial effects on growth performance, fillet quality, and EPA and DHA content in tissues.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Medicinal
Yi-Wen Wang, Qian Li, Xiao-Yue Li, Ying-Cai Zhao, Cheng-Cheng Wang, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: This study evaluated the neuroprotective effects of DHA-PS and EPA-PS against oxidative damage in primary hippocampal neurons. The results showed that DHA-PS and EPA-PS could significantly improve cell morphology, promote neural network structure restoration, and alleviate oxidative stress-induced mitochondrial dysfunction. EPA-PS played an anti-apoptotic role by inhibiting ERK phosphorylation and had a neuroprotective effect by increasing the expression of p-TrkB and p-CREB. Furthermore, EPA-PS enhanced synaptic plasticity by increasing SYN expression, while both DHA-PS and EPA-PS reduced the expression levels of p-GSK3β and p-Tau.
Article
Agriculture, Multidisciplinary
Xiao-Yu Cui, Shan Jiang, Cheng-Cheng Wang, Jin-Yue Yang, Ying-Cai Zhao, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study demonstrated that EPA-PC, EPA-LPC, and DHA-LPC have different effects on DHA or EPA recovery and supplementation efficiency in different tissues, providing important references for understanding the time course of DHA or EPA recovery in phospholipid molecular species in different tissues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Fisheries
Xuexi Wang, Min Jin, Xin Cheng, Xiaoying Hu, Mingming Zhao, Ye Yuan, Peng Sun, Lefei Jiao, Monica B. Betancor, Douglas R. Tocher, Qicun Zhou
Summary: The optimal dietary DHA/EPA ratios for mud crab S. paramamosa were estimated to be 2.2 and 1.2 when supplied with optimal n-3 LC-PUFA at 7% and 12% lipid, respectively. The DHA/EPA ratio affected weight gain, growth rate, lipid content, fatty acid composition, and gene expression levels in the mud crabs. Differences in dietary lipid levels also influenced the crabs' response to the DHA/EPA ratio.
Article
Nutrition & Dietetics
Helena L. Fisk, Grete M. Kindberg, Svein O. Hustvedt, Philip C. Calder
Summary: The study compared the effect of glyceride and ethyl ester formulations on the concentrations of EPA and DHA in plasma, showing that glyceride-EPA and DHA had higher and faster concentrations. This mixture can enhance the absorption speed of EPA and DHA, potentially leading to better efficacy of n-3 FA in individuals on low-fat diets or with digestive impairments.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Shuai-Shuai Fu, Min Wen, Ying-Cai Zhao, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Zi-Hao Wei, Tian-Tian Zhang
Summary: A study found that dietary supplementation with EPA-pPE can significantly change the fatty acid composition in the brain and liver, especially in increasing the content of DHA. EPA-pPE has a more significant effect on increasing DHA compared to EPA-PC, making it a good nutritional supplement to increase DHA levels in n-3 PUFA-deficient offspring's brains.
Article
Health Care Sciences & Services
Karina Gonzalez-Becerra, Elisa Barron-Cabrera, Jose F. Munoz-Valle, Nathaly Torres-Castillo, Juan J. Rivera-Valdes, Roberto Rodriguez-Echevarria, Erika Martinez-Lopez
Summary: The study aimed to analyze the effects of n-3 PUFA supplementation on fatty acid profile, biochemical markers, and inflammatory markers in subjects with obesity. The results showed that both the supplementation and placebo groups increased PUFA intake and DHA in red blood cells, but the placebo group had reductions in IL-8 and MCP-1 levels. Regression analysis revealed that increased DHA levels were associated with decreased IL-8 levels in both groups, suggesting the beneficial anti-inflammatory effects of dietary DHA and n-3 supplementation.
Article
Cell Biology
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Summary: The study demonstrates that pretreating MM cells with DHA/EPA before bortezomib significantly enhances chemosensitivity by decreasing GSH levels and altering metabolism, highlighting the role of GSH degradation in overcoming drug resistance. RNA-seq results suggest the NRF2-ATF3/4-CHAC1 signaling pathway as central in GSH degradation and indicate potential connections to various pathways contributing to the tumor suppressive effect. The findings implicate GSH degradation as a promising therapeutic target in MM and provide new insights into combating bortezomib resistance.
Review
Cell Biology
Mariangela Rondanelli, Simone Perna, Antonella Riva, Giovanna Petrangolini, Enrica Di Paolo, Clara Gasparri
Summary: This systematic review and meta-analysis investigated the effect of n-3 EPA and DHA supplementation on fat free mass and physical performance indicators in the elderly. The findings suggest that daily n-3 EPA + DHA supplementation decreases the Time Up and Go (TUG) test time, with a trend of improvement in fat free mass but no statistically significant effects on other physical performance indicators. N-3 EPA + DHA supplementation may be a promising strategy to enhance muscle quality and prevent or treat frailty.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Nutrition & Dietetics
Leslie Couedelo, Benjamin Buaud, Helene Abrous, Ikram Chamekh-Coelho, Didier Majou, Carole Boue-Vaysse
Summary: The study showed that increasing dietary levels of alpha-linolenic acid (ALA) can enhance its bioavailability and conversion in rats without impacting oxidative stress markers. This was demonstrated by an increase in plasma and red blood cell levels of ALA and EPA during a 15-30 day period with a 10% ALA diet in rats.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Chemistry, Medicinal
Marine Remize, Yves Brunel, Joana L. Silva, Jean-Yves Berthon, Edith Filaire
Summary: n-3 polyunsaturated fatty acids, especially EPA and DHA, are essential for human health and mainly come from marine sources. However, due to overfishing and global warming, their supply is becoming scarce. Microalgae are considered a sustainable source of these healthy molecules.
Article
Food Science & Technology
Jiayu Liu, Qi Liu, Jiahui Han, Jiayu Feng, Tianmin Guo, Zhiman Li, Fenyi Min, Ruyi Jin, Xiaoli Peng
Summary: The study found that PAT can cause mitochondrial oxidative phosphorylation dysfunction and excessive ROS production in HEK293 cells, while NAC can improve cell survival by clearing excess ROS, modulating gene and protein expression of mitochondrial respiratory chain complexes.
Article
Chemistry, Applied
Robbe Demets, Lore Gheysen, Ann Van Loey, Imogen Foubert
Summary: This research investigates the role of carotenoids in the oxidative stability of mixtures of fish oil and lipid extracts of two different microalgae. It finds that the initial amount of carotenoids relative to n-3 LC-PUFA is a good indicator to differentiate between oxidatively stable and unstable mixtures. The degradation of fucoxanthin, diatoxanthin, and beta-carotene during storage illustrates their antioxidative role.