Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Futaba Matsui, Sho T. T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou, Hiroaki Norimoto
Summary: Microglia, the macrophages in the brain, are not involved in the generation and light entrainment of circadian rhythms of behavior, as their depletion does not alter behavioral circadian rhythms. This suggests that the circadian rhythms of locomotor activity is unlikely to be produced by microglia.
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Ryan Hamnett, Johanna E. Chesham, Elizabeth S. Maywood, Michael H. Hastings
Summary: Circadian rhythms in mammals are generated by cell-autonomous transcriptional/translational feedback loops, coordinated by the hypothalamic suprachiasmatic nucleus (SCN). Cells expressing VIP mediate retinal entrainment of the SCN, while deletion of Bmal1 severely disrupts circadian behavioral rhythms.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Daisuke Ono, Ken-ichi Honma, Sato Honma
Summary: The central circadian clock in the mammalian suprachiasmatic nucleus (SCN) is regulated by the inhibitory neurotransmitter gamma-amino butyric acid (GABA), which influences circadian rhythms through intracellular Cl- concentration. The excitatory and inhibitory effects of GABA in the SCN are influenced by factors such as day-length, time, and region within the SCN. GABA mediates oscillatory coupling of circadian rhythms and refines circadian output rhythms, suggesting a downstream role in regulating the physiological and behavioral temporal order.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Genetics & Heredity
Xiaoxiao Lu, Minjie Zhou, Nannan Liu, Chengshun Zhang, Zhengyu Zhao, Dingjun Cai
Summary: This study found that EA treatment can partially restore the circadian rhythmicity of mice exposed to constant darkness for a long time. By using mass spectrometry-based phosphoproteomics, the molecular characteristics of phosphorylation modifications in the suprachiasmatic nucleus were explored, revealing the significant role of structural proteins in this process.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Deepak Kumar, Ashish Sharma, Rajeev Taliyan, Maiko T. Urmera, Oscar Herrera-Calderon, Thomas Heinbockel, Shafiqur Rahman, Rohit Goyal
Summary: Circadian rhythms are regulated by the master clock in the suprachiasmatic nucleus, entrained to the light-dark cycle by the retino-hypothalamic tract. Disruption of circadian rhythms due to unhealthy lifestyle and chronic photic disturbances has been linked to Alzheimer's disease. The presence of endocannabinoids in CRd-induced Alzheimer's disease has been identified as a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Yukie Shirakawa, Sachi N. N. Ohno, Kanae A. A. Yamagata, Eriko Kuramoto, Yoshiaki Oda, Takahiro J. J. Nakamura, Wataru Nakamura, Mitsutaka Sugimura
Summary: This study aimed to elucidate the rhythm of expression of clock gene in the trigeminal ganglion of mice to understand the mechanism of circadian regulation in the same area. The results showed distinct circadian oscillations of clock gene expression in the trigeminal ganglion. The conclusion is that the trigeminal ganglion is responsible for relay of sensory inputs and temporal gating through autonomous circadian oscillations.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Peripheral Vascular Disease
Hannah M. Costello, Michelle L. Gumz
Summary: The molecular circadian clock is crucial in blood pressure control, with central and peripheral clocks playing a key role. Dysregulation of the circadian rhythm of blood pressure is associated with adverse cardiorenal outcomes and increased risk of cardiovascular mortality. Understanding peripheral clock function in regulating the circadian rhythm of blood pressure will pave the way for targeted therapeutics in circadian blood pressure dysregulation and hypertension.
Article
Cell Biology
Waleed Hassan Almalki, Mohammed M. Ghoneim, Sultan Alshehri, Syed Sarim Imam, Imran Kazmi, Gaurav Gupta
Summary: Sleep and circadian rhythm disturbance are common in individuals with sepsis-related neurodegenerative illness, which may be caused by alteration in genomic expression linked with the immune-directed oxidative stress-inflammatory axis. Rare ailments often have connections with aberrant sleep and disturbance in the sleep-wake cycle.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Neurosciences
Atsuko Fujioka, Mamoru Nagano, Keisuke Ikegami, Koh-hei Masumoto, Tomoko Yoshikawa, Satoshi Koinuma, Ken-ichi Nakahama, Yasufumi Shigeyoshi
Summary: This study investigated the localization and function of synaptotagmin 17 in the suprachiasmatic nucleus, and found that it is involved in regulating circadian rhythms.
Review
Cell Biology
Victoria M. Alvord, Elizabeth J. Kantra, Julie S. Pendergast
Summary: Circadian rhythms are 24-hour cycles of behavior and physiology generated by molecular clocks in various tissues. The suprachiasmatic nucleus (SCN) serves as the main circadian clock in mammals, receiving light information and coordinating tissue clocks. Estrogens play a role in regulating biological processes and behavior by interacting with circadian genes. This review focuses on the interplay between estrogens and the circadian system in female rodents, summarizing current understanding of their effects.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashish Sharma, Ashu Mohammad, Adesh K. Saini, Rohit Goyal
Summary: This study suggests that chronic exposure to constant light disrupts circadian rhythms and brain function in rats, potentially contributing to the progression of Alzheimer's disease. However, treatment with fluoxetine can protect against these effects by preventing oxidative damage and gene dysregulation associated with AD.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biology
Nayara AC. Horta, Paola Fernandes, Thais SR. Cardoso, Frederico SM. Machado, Lucas R. Drummond, Candido C. Coimbra, Samuel P. Wanner, Ana Maria L. Castrucci, Maristela O. Poletini
Summary: This study aimed to evaluate the effects of TRPV1 desensitization or blockade on body temperature, locomotor activity, blood corticosterone, and clock genes expression in the liver and adrenal glands. The results showed that TRPV1 desensitization or blockade altered the expression of clock genes and corticosterone levels in the liver and adrenal glands, but had minimal effects on body temperature and locomotor activity.
JOURNAL OF THERMAL BIOLOGY
(2023)
Review
Neurosciences
Nikolas Bergum, Casey-Tyler Berezin, Jozsef Vigh
Summary: Chronic opioid use is associated with sleep disturbances, but the mechanism is unclear. Animal studies suggest that opioids disrupt the circadian rhythms by affecting retinal cells responsible for light detection. Therefore, ipRGCs may be a potential therapeutic target for opioid-related sleep problems.
FRONTIERS IN NEUROSCIENCE
(2022)
Letter
Biochemistry & Molecular Biology
Paul J. Lucassen, Nicolas Toni, Gerd Kempermann, Jonas Frisen, Fred H. Gage, Dick F. Swaab
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
M. Schouten, P. Bielefeld, L. Garcia-Corzo, E. M. J. Passchier, S. Gradari, T. Jungenitz, M. Pons-Espinal, E. Gebara, S. Martin-Suarez, P. J. Lucassen, H. E. De Vries, J. L. Trejo, S. W. Schwarzacher, D. De Pietri Tonelli, N. Toni, H. Mira, J. M. Encinas, C. P. Fitzsimons
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Sylvie L. Lesuis, Paul J. Lucassen, Harm J. Krugers
Summary: This study investigates the effects of early life stress (ELS) on fear learning and hippocampal synaptic potentiation in AD mice. The results indicate that ELS increases fear memory in both familiar and novel contexts, accompanied by aberrant hippocampal synaptic potentiation.
Review
Behavioral Sciences
Paul J. Lucassen, Carlos P. Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Endocrinology & Metabolism
Sylvie L. Lesuis, Wendy Timmermans, Paul J. Lucassen, Casper C. Hoogenraad, Harm J. Krugers
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Pu Hu, Ji Liu, Isabella Maita, Christopher Kwok, Edward Gu, Mark M. Gergues, Frederric Kelada, Mimi Phan, Jiang-Ning Zhou, Dick F. Swaab, Zhiping P. Pang, Paul J. Lucassen, Troy A. Roepke, Benjamin A. Samuels
JOURNAL OF NEUROSCIENCE
(2020)
Article
Psychiatry
Lin Zhang, Ronald W. H. Verwer, Paul J. Lucassen, Inge Huitinga, Dick F. Swaab
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Review
Behavioral Sciences
Pu Hu, Anne-Marie van Dam, Yu Wang, Paul J. Lucassen, Jiang-Ning Zhou
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Nutrition & Dietetics
Maralinde R. Abbink, Lidewij Schipper, Eva E. G. Naninck, Cato M. H. de Vos, Romy Meier, Eline M. van der Beek, Paul J. Lucassen, Aniko Korosi
Article
Psychiatry
Michelle M. Solleveld, Anouk Schrantee, Hee Kyung Baek, Marco A. Bottelier, Hyke G. H. Tamminga, Cheima Bouziane, Reino Stoffelsen, Paul J. Lucassen, Eus J. W. Van Someren, Roselyne M. Rijsman, Liesbeth Reneman
FRONTIERS IN PSYCHIATRY
(2020)
Article
Immunology
Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen, Aniko Korosi
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Luciana D'Alessio, Lucia Mesarosova, Jasper J. Anink, Silvia Kochen, Patricia Solis, Silvia Oddo, Hector Konopka, Anand M. Iyer, Angelika Muhlebner, Paul J. Lucassen, Eleonora Aronica, Erwin A. van Vliet
Article
Psychiatry
Lin Zhang, Ronald W. H. Verwer, Paul J. Lucassen, Inge Huitinga, Dick F. Swaab
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Clinical Neurology
Michelle M. Solleveld, Anouk Schrantee, Judith R. Homberg, Paul J. Lucassen, Liesbeth Reneman
PSYCHIATRY RESEARCH-NEUROIMAGING
(2020)
Meeting Abstract
Neurosciences
Harmen Krugers, Sylvie Lesuis, Hui Xiong, Rolinka van der Loo, Steven Kushner, Paul Lucassen, Michel Van den Oever
BIOLOGICAL PSYCHIATRY
(2020)