Article
Clinical Neurology
Lin Zhang, Ronald W. H. Verwer, Juan Zhao, Inge Huitinga, Paul J. Lucassen, Dick F. Swaab
Summary: This study found different glial alterations in the prefrontal cortex of patients with major depressive disorder, which were associated with suicide behaviors or psychotic features. Certain genes showed differences in expression levels between suicide and psychotic feature patients, providing insights into the pathophysiology of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevensek, Dick F. Swaab
Summary: This study identified expression changes in PACAP-related genes that are associated with schizophrenia, suicide, and gender. Upregulation of PACAP, PAC1, VPAC1, and VPAC2 was observed in the ACC of suicide completers with schizophrenia. Additionally, an increase in PAC1 expression was found in the DLPFC of schizophrenia patients who died naturally compared to suicide completers and controls.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Edison Leung, Ethan W. Lau, Andi Liang, Constanza de Dios, Robert Suchting, Linda Ostlundh, Joseph C. Masdeu, Masahiro Fujita, Marsal Sanches, Jair C. Soares, Sudhakar Selvaraj
Summary: This study systematically reviews the pathophysiological mechanisms of bipolar and major depressive disorders, focusing on synaptic proteins and RNA alterations. Meta-analysis results indicate specific changes in synaptic proteins and RNAs in both disorders, although conflicting results are observed due to small sample sizes and variations in data sources.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean
Summary: The study found alterations in RAPGEF1 expression in the BA 8 of subjects with schizophrenia, but no differences in BA 8 and 44. Suicide completers had higher RAPGEF1 levels compared to non-suicide schizophrenia subjects in BA 8. Further investigation into the function of RAPGEF1 may provide insights into the pathophysiology of schizophrenia.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Andrea Mountney, Jennifer Blaze, Zhaoyu Wang, Michelle Umali, William Jesse Flerlage, Jacqueline Dougherty, Yongchao Ge, Deborah Shear, Fatemeh Haghighi
Summary: Traumatic brain injury (TBI) can lead to sleep disturbance and molecular changes affecting immune-related and sleep-related genes, potentially causing neurodegeneration, sleep disturbances, and mood disorders. Rodent models of TBI showed significant differences in sleep architecture, with injured animals spending more time in slow wave sleep and less time in REM sleep. Transcriptome-wide gene expression profiling identified these differences and their potential impact on post-TBI pathology and symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vasiliy V. Reshetnikov, Polina E. Kisaretova, Natalia P. Bondar
Summary: Research on the molecular causes of stress-associated psychopathologies is crucial for understanding the development mechanisms of depression, generalized anxiety disorder, and posttraumatic stress disorders. This study conducted a meta-analysis of transcriptome changes in mice and human patients, finding the most reliable molecular alterations associated with different durations of stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ming-Fen Ho, Cheng Zhang, Irene Moon, Xiujuan Zhu, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Kristen Schmidt, Kate Gliske, Quyen Ngo, Cedric Skillon, Marvin D. Seppala, Hu Li, Richard M. Weinshilboum
Summary: This study used single-cell sequencing technology to investigate the response of OUD patients to oxycodone and buprenorphine. The results revealed that buprenorphine significantly influenced transcriptional regulation in glial cells, while oxycodone induced type I interferon signaling in multiple cell types. These findings provide novel mechanistic insights into the actions of drugs at the single-cell level.
MOLECULAR PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Paulina G. Eusebi, Natalia Sevane, Thomas O'Rourke, Manuel Pizarro, Cedric Boeckx, Susana Dunner
Summary: This study compared gene expression profiles of aggressive and non-aggressive cattle breeds, revealing up-regulated genes related to pathways like Alzheimer's disease, integrins, and ERK/MAPK signaling in aggressive cattle. Down-regulated genes may be associated with PFC activity and aggression. These findings provide insights into the molecular mechanisms underlying aggressive behavior.
Article
Clinical Neurology
Maria S. Garcia-Gutierrez, Daniela Navarro, Abraham B. Torregrosa, Adrian Viudez-Martinez, Salvador Giner, Jorge Manzanares
Summary: This study investigated the gene expression changes of mGluR5 and its associated proteins in the brains of suicide decedents and controls. The results revealed significant differences in gene expression levels between the two groups, providing insights into the biological basis of suicide and potential biomarkers for suicide prevention.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Tiziana Imbriglio, Marika Alborghetti, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Summary: The study found that TAAR1 mRNA levels were increased in the SCZ prefrontal cortex, with no correlation to various factors. Differences in TAAR1 protein levels were observed between neuropathological burden subgroups of CTRL, but not within the SCZ group. TAAR1 protein levels were lower in CTRL with low neuropathological burden compared to all SCZ samples or SCZ samples with low neuropathological burden. In the SCZ group, TAAR1 protein levels were inversely correlated with duration of antipsychotic treatment and higher in individuals treated with second-generation antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yin
Summary: Increased expression of Nrg1 in GABAergic interneurons can cause cortical disinhibition, leading to various neuropsychiatric disorders. The interaction between NRG1 and Na(v)1.1 inhibits Na-v currents critical for GABAergic interneuron excitability, and activating GABAergic interneurons or restoring NRG1 expression can rescue related symptoms.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
Summary: Dopamine in the prefrontal cortex has opposing effects on social behavior depending on the duration of its activation. Sustained dopamine activation suppresses social behavior while acute activation enhances it. The duration of social interactions is positively correlated with transient dopamine release and negatively correlated with sustained dopamine increase in the prefrontal cortex. Dopamine levels also modulate neural calcium signaling and c-Fos induction triggered by social stimuli in prefrontal neurons.
Review
Biochemistry & Molecular Biology
Yu-Ting Hu, Zhong-Lin Tan, Dusan Hirjak, Georg Northoff
Summary: The excitation-inhibition (E/I) imbalance is a significant molecular pathological feature of major depressive disorder (MDD), and altered GABA and glutamate levels have been observed in MDD patients. This systematic review of postmortem MDD brain studies found abnormal E/I balance topographies based on GABA- and glutamate-related signaling in various brain regions, providing important insight into the pathophysiology of MDD and potential therapeutic implications.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Tomoya Nakamachi, Seiji Shioda, Takashi Dan, Toshio Miyata, Yasumasa Nishito, Kazuhiro Suzuki, Mitsuhiro Miyashita, Toshifumi Tomoda, Takatoshi Hikida, Junjiro Horiuchi, Masanari Itokawa, Makoto Arai, Haruo Okado
Summary: Metabolic dysfunction is believed to exacerbate psychiatric disorders, and a high-sucrose diet during adolescence has been shown to induce psychosis-related behaviors in mice deficient for glyoxalase-1. This diet also caused microcapillary impairments and reduced brain glucose uptake, with aspirin offering protection against these vascular changes and abnormal behavioral phenotypes. The findings suggest that psychiatric disorders may be associated with brain angiopathy caused by metabolic stress.
Article
Neurosciences
Gijsje J. L. J. Snijders, Welmoed van Zuiden, Marjolein A. M. Sneeboer, Amber Berdenis van Berlekom, Astrid T. van der Geest, Tatiana Schnieder, Donald J. MacIntyre, Elly M. Hol, Rene S. Kahn, Lot D. de Witte
Summary: The density and morphology of microglial cells in schizophrenia patients were found to be unchanged, while the expression of several microglial-specific genes was decreased. This indicates a change in microglial phenotype rather than density, which could provide a crucial molecular hallmark for future research into the role of microglia in schizophrenia and other psychiatric disorders.
Letter
Biochemistry & Molecular Biology
Paul J. Lucassen, Nicolas Toni, Gerd Kempermann, Jonas Frisen, Fred H. Gage, Dick F. Swaab
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
M. Schouten, P. Bielefeld, L. Garcia-Corzo, E. M. J. Passchier, S. Gradari, T. Jungenitz, M. Pons-Espinal, E. Gebara, S. Martin-Suarez, P. J. Lucassen, H. E. De Vries, J. L. Trejo, S. W. Schwarzacher, D. De Pietri Tonelli, N. Toni, H. Mira, J. M. Encinas, C. P. Fitzsimons
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Sylvie L. Lesuis, Paul J. Lucassen, Harm J. Krugers
Summary: This study investigates the effects of early life stress (ELS) on fear learning and hippocampal synaptic potentiation in AD mice. The results indicate that ELS increases fear memory in both familiar and novel contexts, accompanied by aberrant hippocampal synaptic potentiation.
Review
Behavioral Sciences
Paul J. Lucassen, Carlos P. Fitzsimons, Evgenia Salta, Mirjana Maletic-Savatic
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Endocrinology & Metabolism
Sylvie L. Lesuis, Wendy Timmermans, Paul J. Lucassen, Casper C. Hoogenraad, Harm J. Krugers
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Review
Behavioral Sciences
Pu Hu, Anne-Marie van Dam, Yu Wang, Paul J. Lucassen, Jiang-Ning Zhou
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Nutrition & Dietetics
Maralinde R. Abbink, Lidewij Schipper, Eva E. G. Naninck, Cato M. H. de Vos, Romy Meier, Eline M. van der Beek, Paul J. Lucassen, Aniko Korosi
Article
Psychiatry
Michelle M. Solleveld, Anouk Schrantee, Hee Kyung Baek, Marco A. Bottelier, Hyke G. H. Tamminga, Cheima Bouziane, Reino Stoffelsen, Paul J. Lucassen, Eus J. W. Van Someren, Roselyne M. Rijsman, Liesbeth Reneman
FRONTIERS IN PSYCHIATRY
(2020)
Article
Immunology
Maralinde R. Abbink, Janssen M. Kotah, Lianne Hoeijmakers, Aline Mak, Genevieve Yvon-Durocher, Bram van der Gaag, Paul J. Lucassen, Aniko Korosi
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Luciana D'Alessio, Lucia Mesarosova, Jasper J. Anink, Silvia Kochen, Patricia Solis, Silvia Oddo, Hector Konopka, Anand M. Iyer, Angelika Muhlebner, Paul J. Lucassen, Eleonora Aronica, Erwin A. van Vliet
Article
Psychiatry
Lin Zhang, Ronald W. H. Verwer, Paul J. Lucassen, Inge Huitinga, Dick F. Swaab
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Clinical Neurology
Michelle M. Solleveld, Anouk Schrantee, Judith R. Homberg, Paul J. Lucassen, Liesbeth Reneman
PSYCHIATRY RESEARCH-NEUROIMAGING
(2020)
Meeting Abstract
Neurosciences
Harmen Krugers, Sylvie Lesuis, Hui Xiong, Rolinka van der Loo, Steven Kushner, Paul Lucassen, Michel Van den Oever
BIOLOGICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Mirjana Maletic-Savatic, Yao Li, Damian Young, Torbjorn Elvsashagen, Colleen Loo, Liesbeth Reneman, Paul J. Lucassen, Chadi Calarge, Michael Valenzuela
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)