Article
Biochemistry & Molecular Biology
Toshikazu Kakizaki, Tomokazu Ohshiro, Makoto Itakura, Kohtarou Konno, Masahiko Watanabe, Hajime Mushiake, Yuchio Yanagawa
Summary: GAD65 deficiency causes different phenotypes between rats and mice, with Gad2(-/-) rats being more severely affected and exhibiting more severe symptoms such as epilepsy and premature death. Considering the similarity of GAD65/GAD67 ratio in human brains to that in rat brains, Gad2(-/-) rats would be useful for further investigating the roles of GAD65 in vivo.
Article
Cell Biology
Carla Cristina Miranda Castro, Sayonara Pereira Silva, Livia Nascimento Rabelo, Jose Pablo Goncalves Queiroz, Laura Damasceno Campos, Larissa Camila Silva, Felipe Porto Fiuza
Summary: The study found that there are regional alterations of specific cellular subpopulations in the aging human hippocampus, which are influenced by factors such as age, sex, education years, and the concentration of neuropathological and inflammatory proteins. These findings provide insights into the distinct physiological changes that occur in hippocampal sub-regions and neurotransmitter systems during normal aging.
Article
Food Science & Technology
Yucui Zhang, Ming Zhang, Ting Li, Xinxia Zhang, Li Wang
Summary: Quinoa, when subjected to cold stress treatment, showed a significant increase in GABA content, making it a promising functional food with enhanced bioactive ingredients.
Article
Biochemistry & Molecular Biology
Chunmei Zeng, Danqing Lei, Yuling Lu, Qi Huang, Ying Wu, Shengyu Yang, Yuan Wu
Summary: The aim of this study was to modify the parvalbumin gene expression in PC12 cells and investigate its influence on the metabolic pathway involving glutamate and GABA. The expression of parvalbumin was found to be associated with GAD65 and GAD67. Overexpression of parvalbumin up-regulated GAD65 and GAD67, increased GABA levels, and decreased glutamate levels, while silencing parvalbumin had the opposite effects.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Microbiology
Nize Otaru, Kun Ye, Denisa Mujezinovic, Laura Berchtold, Florentin Constancias, Fabian A. Cornejo, Adam Krzystek, Tomas de Wouters, Christian Braegger, Christophe Lacroix, Benoit Pugin
Summary: Research investigated GABA production of Bacteroides and its protective role in acid stress, revealing the widespread presence of the GAD system in Bacteroides and its potential as the only amino acid-dependent acid tolerance system in the genus.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chigusa Shimizu-Okabe, Shiori Kobayashi, Jeongtae Kim, Yoshinori Kosaka, Masanobu Sunagawa, Akihito Okabe, Chitoshi Takayama
Summary: This study describes the transmission of GABAergic and glycinergic neurotransmitters and inhibitory networks in the mature mouse spinal cord. The research also provides insights into the developmental formation of these networks, including neuronal differentiation, synapse formation, maturation of removal systems, and changes in their function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Dana Marafi, Jawid M. Fatih, Rauan Kaiyrzhanov, Matteo P. Ferla, Charul Gijavanekar, Aljazi Al-Maraghi, Ning Liu, Emily Sites, Hessa S. Alsaif, Mohammad Al-Owain, Mohamed Zakkariah, Ehab El-Anany, Ulviyya Guliyeva, Sughra Guliyeva, Colette Gaba, Ateeq Haseeb, Amal M. Alhashem, Enam Danish, Vasiliki Karageorgou, Christian Beetz, Alaa A. Subhi, Sureni Mullegama, Erin Torti, Monisha Sebastin, Margo Sheck Breilyn, Susan Duberstein, Mohamed S. Abdel-Hamid, Tadahiro Mitani, Haowei Du, Jill A. Rosenfeld, Shalini N. Jhangiani, Zeynep Coban Akdemir, Richard A. Gibbs, Jenny C. Taylor, Khalid A. Fakhro, Jill Hunter, Davut Pehlivan, Maha S. Zaki, Joseph G. Gleeson, Reza Maroofian, Henry Houlden, Jennifer E. Posey, V. Reid Sutton, Fowzan S. Alkuraya, Sarah H. Elsea, James R. Lupski
Summary: SLC38A3 is a novel disease gene for developmental and epileptic encephalopathy, and the likely pathophysiology of the disease is perturbations in glutamine homeostasis.
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Article
Multidisciplinary Sciences
Wataru Matsunaga, Toru Shinoe, Moritoshi Hirono
Summary: GAD65-KO mice are more sensitive to the effect of acute ethanol exposure on motor coordination and cerebellar Purkinje cell firing, which may be related to their low GABA concentration in the brain.
Article
Clinical Neurology
Sarah E. Heron, Brigid M. Regan, Rebekah V. Harris, Alison E. Gardner, Matthew J. Coleman, Mark F. Bennett, Bronwyn E. Grinton, Katherine L. Helbig, Michael R. Sperling, Sheryl Haut, Eric B. Geller, Peter Widdess-Walsh, James T. Pelekanos, Melanie Bahlo, Slave Petrovski, Erin L. Heinzen, Michael S. Hildebrand, Mark A. Corbett, Ingrid E. Scheffer, Jozef Gecz, Samuel F. Berkovic
Summary: Missense variants in SLC32A1 have been identified as causative for GEFS+ and IGE, leading to altered neuronal inhibition by affecting GABA transport. These findings have been validated by studying multiple families.
Article
Neurosciences
Haiyan Li, Maia Datunashvili, Reno C. C. Reyes, Susan M. M. Voglmaier
Summary: Inositol pyrophosphates play a crucial role in cellular signaling and membrane trafficking, particularly in synaptic vesicle recycling. Two isoforms of Inositol hexakisphosphate kinases (IP6Ks), IP6K1 and IP6K3, are expressed in axons and regulate vesicle recycling through different endocytic pathways. IP6Ks also affect synaptic facilitation and glutamate signaling.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Lidia Bravo, Patricia Mariscal, Meritxell Llorca-Torralba, Jose Maria Lopez-Cepero, Juan Nacher, Esther Berrocoso
Summary: This study examined the effects of neuropathic pain on noradrenergic neurons in the locus coeruleus (LC) and found that neuropathic pain leads to an increase in excitatory synapse markers and a decrease in mitochondrial and lysosomal densities. Long-term pain also activates apoptosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yuanyuan Wu, Yuerong Chen, Yunyun Xu, Wenqin Ni, Chalian Lin, Xiaomei Shao, Zui Shen, Xiaofen He, Chao Wang, Jianqiao Fang
Summary: Pain sufferers often dislike the environment associated with pain, known as pain aversion. The amygdala, a limbic structure in the brain, plays a critical role in emotion and pain. However, research on aversion caused by inflammatory pain is limited, and the underlying mechanisms are not well understood. This study used proteomics analysis to identify potential proteins involved in pain aversion in rats. Glutamate transporter-1 (GLT-1) was found to have correlation with pain aversion and may modulate the excitability of glutamatergic neurons. This study highlights the extensive biological changes in the amygdala induced by inflammatory pain.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lovely Mahawar, Aparna Pandey, Kesava Priyan Ramasamy, Sakshi Pandey, Sheo Mohan Prasad
Summary: This article provides an overview of the research progress on the synthesis and metabolic pathways of GABA in cyanobacteria, as well as the feasibility of enhancing GABA production and extraction methods by modifying external conditions and gene expression. In addition, it introduces the commercial applications of GABA in various industries.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Clinical Neurology
Andre Dik, Guido Widman, Andreas Schulte-Mecklenbeck, Juri-Alexander Witt, Julika Pitsch, Kristin S. Golombeck, Jan Wagner, Marco Gallus, Christine Strippel, Niels Hansen, Constanze Moenig, Saskia Raeuber, Heinz Wiendl, Christian E. Elger, Rainer Surges, Sven G. Meuth, Christoph Helmstaedter, Catharina C. Gross, Albert J. Becker, Nico Melzer
Summary: The study revealed a pathogenic effect of CD8(+) T cells and a regulatory effect of CD4(+) T cells in patients with long-standing GAD65-LE. Elevated levels of activated CD8(+) and CD4(+) T cells in peripheral blood and cerebrospinal fluid were found to be negatively correlated with hippocampal volume and memory function, indicating a potential link to disease progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angela Anderegg, Jean-Francois Poulin, Rajeshwar Awatramani
Article
Neurosciences
Navid Nouri, Meera J. Patel, Milan Joksimovic, Jean-Francois Poulin, Angela Anderegg, M. Mark Taketo, Yong-Chao Ma, Rajeshwar Awatramani
MOLECULAR AND CELLULAR NEUROSCIENCE
(2015)
Review
Neurosciences
Jean-Francois Poulin, Bosiljka Tasic, Jens Hjerling-Leffler, Jeffrey M. Trimarchi, Rajeshwar Awatramani
NATURE NEUROSCIENCE
(2016)
Article
Cell Biology
Qiaoling Cui, Jason E. Pitt, Arin Pamukcu, Jean-Francois Poulin, Omar S. Mabrouk, Michael P. Fiske, Isabel B. Fan, Elizabeth C. Augustine, Katherine A. Young, Robert T. Kennedy, Rajeshwar Awatramani, C. Savio Chan
Article
Neurosciences
Jean-Francois Poulin, Patrick Berube, Sylvie Laforest, Guy Drolet
EUROPEAN JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Jean-Francois Poulin, Giuliana Caronia, Caitlyn Hofer, Qiaoling Cui, Brandon Helm, Charu Ramakrishnan, C. Savio Chan, Daniel A. Dombeck, Karl Deisseroth, Rajeshwar Awatramani
NATURE NEUROSCIENCE
(2018)
Article
Neurosciences
Patrick Berube, Jean-Francois Poulin, Sylvie Laforest, Guy Drolet
NEUROPSYCHOPHARMACOLOGY
(2014)
Review
Clinical Neurology
Jean-Francois Poulin, Danielle Arbour, Sylvie Laforest, Guy Drolet
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2009)
Article
Behavioral Sciences
Jean-Francois Poulin, Sylvie Laforest, Guy Drolet
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2014)
Article
Cell Biology
Jean-Francois Poulin, Jian Zou, Janelle Drouin-Ouellet, Kwang-Youn A. Kim, Francesca Cicchetti, Rajeshwar B. Awatramani
Article
Biology
Nao Chuhma, Susana Mingote, Leora Yetnikoff, Abigail Kalmbach, Thong Ma, Samira Ztaou, Anna-Claire Sienna, Sophia Tepler, Jean-Francois Poulin, Mark Ansorge, Rajeshwar Awatramani, Un Jung Kang, Stephen Rayport
Article
Cell Biology
Jean-Francois Poulin, Milagros Pereira Luppi, Caitlyn Hofer, Giuliana Caronia, Pei-Ken Hsu, C. Savio Chan, Rajeshwar Awatramani
DEVELOPMENTAL CELL
(2020)
Article
Neurosciences
Willemieke M. Kouwenhoven, Guillaume Fortin, Anna-Maija Penttinen, Clelia Florence, Benoit Delignat-Lavaud, Marie-Josee Bourque, Thorsten Trimbuch, Milagros Pereira Luppi, Alix Salvail-Lacoste, Pascale Legault, Jean-Francois Poulin, Christian Rosenmund, Raj Awatramani, Louis-Eric Trudeau
JOURNAL OF NEUROSCIENCE
(2020)
Article
Cell Biology
Milagros Pereira Luppi, Maite Azcorra, Giuliana Caronia-Brown, Jean-Francois Poulin, Zachary Gaertner, Serafin Gatica, Oscar Andres Moreno-Ramos, Navid Nouri, Marilyn Dubois, Yongchao C. Ma, Charu Ramakrishnan, Lief Fenno, Yoon Seok Kim, Karl Deisseroth, Francesca Cicchetti, Daniel A. Dombeck, Rajeshwar Awatramani
Summary: The study found that Sox6 expression distinguishes ventrally and dorsally biased dopamine (DA) neuron populations in the substantia nigra pars compacta (SNc), showing distinct molecular profiles, projections, and functions. This adult division was encoded early in development.
Editorial Material
Neurosciences
Jean-Francois Poulin, Talia Newcombe Lerner, Mark W. Howe
FRONTIERS IN NEURAL CIRCUITS
(2022)