Article
Medicine, Research & Experimental
Akhil Santhosh, Akash Kumar, Raja Pramanik, Ajay Gogia, Chandra Prakash Prasad, Ishaan Gupta, Nishkarsh Gupta, Winson Y. Cheung, Ravindra Mohan Pandey, Atul Sharma, Atul Batra
Summary: This study aims to compare the efficacy of 1% topical diclofenac gel with placebo in preventing capecitabine-induced hand-foot syndrome. If the trial meets the primary endpoint, 1% topical diclofenac will become the new standard of care for HFS prevention.
Article
Behavioral Sciences
Hamed Cheraghmakani, Maryam Rezapour, Faezeh Asghari, Reza Alizadeh-Navaei, Monireh Ghazaeian, Nasim Tabrizi
Summary: This study investigated the effect of pyridoxine on the behavioral side effects of levetiracetam in adult patients with epilepsy. The results showed no significant differences between the pyridoxine-treated group and the placebo group. Further placebo-controlled trials with larger sample sizes and higher doses are needed to determine the effectiveness of pyridoxine.
EPILEPSY & BEHAVIOR
(2022)
Article
Anesthesiology
Jonathan Vela, Lene Dreyer, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Kirsten Skjaerbaek Duch, Salome Kristensen
Summary: This study aimed to investigate the use of CBD as an adjuvant analgesic therapy in patients with hand osteoarthritis or psoriatic arthritis. The results showed no significant effects of CBD on pain intensity, sleep quality, depression, anxiety, or pain catastrophizing scores compared to placebo.
Article
Oncology
Xiaozhe Li, Meilan Chen, Beihui Huang, Junru Liu, Jingli Gu, Lifen Kuang, Juan Li
Summary: This prospective randomized trial found that prophylactic pyridoxine may help reduce the incidence of hand-foot syndrome (HFS) induced by pegylated liposomal doxorubicin (PLD) in multiple myeloma (MM) patients. Further placebo-controlled research is recommended.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Medicine, Research & Experimental
Mirjam de With, Leni van Doorn, Demi C. Maasland, Tessa A. M. Mulder, Esther Oomen-de Hoop, Bianca Mostert, Marjolein Y. V. Homs, Samira El Bouazzaoui, Ron H. J. Mathijssen, Ron H. N. van Schaik, Sander Bins
Summary: This study investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism other than DPYD are associated with an increased risk for capecitabine-induced hand-foot syndrome (HFS). The results showed that carriers of the CES1 1165-33 C>A (rs2244613) and CDA 266 + 242 A>G (rs10916825) variant alleles have a higher risk of HFS grade 2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Clinical Neurology
Adel Mahmoud, Sadia Tabassum, Shoaa Al Enazi, Nahed Lubbad, Ali Al Wadei, Ali Al Otaibi, Lamya Jad, Ruba Benini
Summary: The study indicates that supplementation of therapeutic doses of pyridoxine can significantly improve neuropsychiatric symptoms in children experiencing side effects from taking levetiracetam, compared to a placebo. Therefore, clinicians may consider a trial of pyridoxine in these patients to avoid unnecessary medication changes.
PEDIATRIC NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Review
Oncology
Jessa Gilda P. Pandy, Paula Isabel G. Franco, Rubi K. Li
Summary: This meta-analysis evaluated the efficacy of preventive strategies for hand-foot syndrome and hand-foot skin reaction, and found that urea cream and celecoxib are effective in preventing these side effects. Urea cream is more effective in preventing moderate to severe hand-foot skin reaction, while celecoxib is more effective in preventing hand-foot syndrome induced by capecitabine.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Muhammed Majeed, Kalyanam Nagabhushanam, T. V. Devarajan, Santhosh Saklecha, S. Venkata Krishna Reddy, Lakshmi Mundkur
Summary: Metabolic syndrome is a disease characterized by at least three interrelated risk factors. Calebin A, a minor phytochemical from Curcuma longa, has shown potential in managing symptoms related to metabolic syndrome in obese adults.
Article
Biochemistry & Molecular Biology
Maja Di Rocco, Eduardo Forleo-Neto, Robert J. Pignolo, Richard Keen, Philippe Orcel, Thomas Funck-Brentano, Christian Roux, Sami Kolta, Annalisa Madeo, Judith S. Bubbear, Jacek Tabarkiewicz, Malgorzata Szczepanek, Javier Bachiller-Corral, Angela M. Cheung, Kathryn M. Dahir, Esmee Botman, Pieter G. Raijmakers, Mona Al Mukaddam, Lianne Tile, Cynthia Portal-Celhay, Neena Sarkar, Peijie Hou, Bret J. Musser, Anita Boyapati, Kusha Mohammadi, Scott J. Mellis, Andrew J. Rankin, Aris N. Economides, Dinko Gonzalez Trotter, Gary A. Herman, Sarah J. O'Meara, Richard Delgizzi, David M. Weinreich, George D. Yancopoulos, E. Marelise W. Eekhoff, Frederick S. Kaplan
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by abnormal bone formation in connective tissues and painful flare-ups. Garetosmab, an activin A-blocking antibody, can prevent the formation of new lesions but does not significantly impact the activity of pre-existing lesions.
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Peter J. Ruane, Bradley L. Freilich, Guy Neff, Rashmee Patil, Cynthia A. Behling, Chen Hu, Erica Fong, Brittany de Temple, Erik J. Tillman, Timothy P. Rolph, Andrew Cheng, Kitty Yale
Summary: The study demonstrated the efficacy of efruxifermin in treating NASH by significantly reducing HFF levels in patients, with an acceptable safety profile.
Article
Allergy
Melody C. Carter, Irina Maric, Erica H. Brittain, Yun Bai, Keith Lumbard, Hyejeong Bolan, Daly Cantave, Linda M. Scott, Dean D. Metcalfe
Summary: The study aimed to determine the efficacy of omalizumab in managing patients with frequent episodes of IA, showing a trend of efficacy in the treatment group but no statistically significant differences. Overall, omalizumab was safely administered to a difficult-to-treat patient population with IA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Anesthesiology
Anthony Lembo, John M. Kelley, Judy Nee, Sarah Ballou, Johanna Iturrino, Vivian Cheng, Vikram Rangan, Jesse Katon, William Hirsch, Irving Kirsch, Kathryn Hall, Roger B. Davis, Ted J. Kaptchuk
Summary: In the study on irritable bowel syndrome, open-label placebo (OLP) treatment was found to be superior to no-pill control (NPC) and had similar efficacy to double-blind placebo (DBP).
Article
Medicine, General & Internal
Zhirajr Mokini, Valentina Genocchio, Patrice Forget, Flavia Petrini
Summary: In women undergoing cesarean section with subarachnoid anesthesia, the combination of propofol and metoclopramide can reduce intra-operative nausea and vomiting.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Young Ju Cheon, Kyong Nam Ye, Kyong ha Park, Jung Bo Kim, Ji Eun Yoon, Min Kyung Lee, Jung Tae Kim, Sook Hee An
Summary: This study analyzed the implementation of a pre-issue monitoring program for intravenous compatibility in a pharmacy at a general hospital in South Korea. The results showed that despite pharmacist shortages, intravenous compatibility can be effectively monitored before issuing injectable products in all wards. The study emphasizes the importance of tailoring pharmacists' tasks based on the prescribing patterns in different wards and generating more evidence to improve the completeness of information.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Article
Education, Scientific Disciplines
Jung Tae Kim, Jeong Yun Park, Hyun Jung Lee, Young Ju Cheon
JOURNAL OF EDUCATIONAL EVALUATION FOR HEALTH PROFESSIONS
(2020)