Article
Oncology
Tzu-Chen Lan, Po-Han Tsou, Ka-Wai Tam, Tsai-Wei Huang
Summary: In this meta-analysis, it was found that the use of urea cream can effectively prevent and treat severe hand-foot syndrome (HFS).
Article
Medicine, Research & Experimental
Akhil Santhosh, Akash Kumar, Raja Pramanik, Ajay Gogia, Chandra Prakash Prasad, Ishaan Gupta, Nishkarsh Gupta, Winson Y. Cheung, Ravindra Mohan Pandey, Atul Sharma, Atul Batra
Summary: This study aims to compare the efficacy of 1% topical diclofenac gel with placebo in preventing capecitabine-induced hand-foot syndrome. If the trial meets the primary endpoint, 1% topical diclofenac will become the new standard of care for HFS prevention.
Review
Gastroenterology & Hepatology
Jingjuan Huang, Sihua Ye, Shaolan Feng, Minqi Zheng, Meihua Zhong
Summary: The study aimed to evaluate the prevalence of hand-foot syndrome (HFS) in patients with colorectal cancer undergoing chemotherapy. A total of 20 studies involving 4773 cases were included in the meta-analysis. The overall prevalence of HFS in patients with colorectal cancer undergoing chemotherapy was found to be 49.1%, with grades 1 and 2 being the most frequent. Various factors such as research type, country, drug type, and publication year did not contribute to heterogeneity.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Dermatology
Yung-Shuo Kao, Chen-Hsu Lo, Yu-Kang Tu, Cheng-Hsien Hung
Summary: This study conducted a network meta-analysis to investigate the best preventive regimen for capecitabine-induced hand-foot syndrome (HFS). Among all the regimens, topical silymarin was found to be the most effective in preventing HFS, followed by pyridoxine (400 mg) and celecoxib.
DERMATOLOGIC THERAPY
(2022)
Article
Oncology
Xiaozhe Li, Meilan Chen, Beihui Huang, Junru Liu, Jingli Gu, Lifen Kuang, Juan Li
Summary: This prospective randomized trial found that prophylactic pyridoxine may help reduce the incidence of hand-foot syndrome (HFS) induced by pegylated liposomal doxorubicin (PLD) in multiple myeloma (MM) patients. Further placebo-controlled research is recommended.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Pharmacology & Pharmacy
Delaram Shayeganmehr, Fatemeh Ramezannia, Behrooz Gharib, Azin Rezaeilaal, Farhad Shahi, Zahra Jafariazar, Minoo Afshar
Summary: This study formulated and optimized a topical hydrogel of celecoxib and investigated its efficacy in managing chemotherapy-induced Hand-foot syndrome (HFS). The optimized hydrogel showed suitable drug release and skin retention properties. Clinical trial results demonstrated significant improvement in HFS grades in patients treated with celecoxib hydrogel.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Mirjam de With, Leni van Doorn, Demi C. Maasland, Tessa A. M. Mulder, Esther Oomen-de Hoop, Bianca Mostert, Marjolein Y. V. Homs, Samira El Bouazzaoui, Ron H. J. Mathijssen, Ron H. N. van Schaik, Sander Bins
Summary: This study investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism other than DPYD are associated with an increased risk for capecitabine-induced hand-foot syndrome (HFS). The results showed that carriers of the CES1 1165-33 C>A (rs2244613) and CDA 266 + 242 A>G (rs10916825) variant alleles have a higher risk of HFS grade 2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Bo Chen, Ying Yang, Xufeng Xu, Haixia Zhao, Yi Li, Shi Yin, Yong-Quan Chen
Summary: This study examined the epidemic features of hand-foot-mouth disease in mainland China through systematic review and meta-analysis, revealing variations in region, time, population, and etiology. Key strategies and measures should be implemented by health departments to prevent and control the spread of hand-foot-mouth disease, and improvement in pathogen detection and typing in laboratories is recommended.
Review
Immunology
Yaqi Xie, Quanman Hu, Wenjie Jiang, Wangquan Ji, Shuaiyin Chen, Yuefei Jin, Guangcai Duan
Summary: This study identifies laboratory indicators associated with an increased risk of hand, foot, and mouth disease (HFMD) severity, including white blood cells, blood glucose, lymphocytes, creatinine, interleukins, interferon-gamma, tumor necrosis factor-alpha, and creatine kinase MB isoenzyme. The sensitivity analysis of these indicators shows stable results without publication bias. These findings provide useful evidence for predicting prognosis and guiding clinical management.
Review
Dermatology
S. Lian, X. Zhang, Y. Zhang, Q. Zhao
Summary: Currently, there is not enough evidence to support the use of pyridoxine in preventing chemotherapy-induced HFS, but the preventive use of pyridoxine may have a tendency to reduce the incidence of HFS.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Review
Medicine, General & Internal
Liangyu Li, Yingrui Zhang, Lizheng Qin
Summary: This study conducted a systematic review and meta-analysis to assess the impact of celecoxib, a nonsteroidal anti-inflammatory drug, combined with standard chemotherapy on the prognosis of cancer patients. The results showed that celecoxib adjuvant therapy did not significantly improve overall survival (OS) and progression-free survival (PFS) rates at 1 year, 3 years, or 5 years. However, it was associated with an increased risk of hematologic toxicity. Further randomized controlled trials are needed to clarify the effects and applications of celecoxib in cancer treatment.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pediatrics
Peiqing Li, Yuge Huang, Danping Zhu, Sida Yang, Dandan Hu
Summary: EV71, lifestyle habits, frequent hospital visits, and symptoms are risk factors for severe HFMD in children in China, while early diagnosis and admission to higher-level hospitals are protective factors.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Mingyi Jing, Qianying Yu, Baohua Zhu, Fan Yuan, Jie Zhang, Li Peng, Wenxia Lin, Mingling Chen
Summary: This study aims to assess the effectiveness and safety of topical 0.05% clobetasol cream in patients with Chronic Hand Eczema (CHE), providing evidence-based recommendations for clinicians.
Article
Oncology
Si-Qi Dong, Tong-Min Wang, Jiang-Bo Zhang, Yong-Qiao He, Wen-Qiong Xue, Zi-Yi Wu, Da-Wei Yang, Lian-Jing Cao, Jing-Wen Huang, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Wei-Hua Jia
Summary: This study aimed to identify genetic predictors of Capecitabine-induced HFS in Chinese colorectal cancer patients. New polymorphisms in the TYMS gene were significantly associated with CAP-HFS, providing potential genetic predictors and insights into the underlying mechanism of HFS.
CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
Maria Chiara Malevolti, Caterina Maci, Alessandra Lugo, Irene Possenti, Silvano Gallus, Giuseppe Gorini, Giulia Carreras
Summary: This study aimed to provide an accurate and updated estimate of the association between second-hand smoke (SHS) exposure and cervical cancer (CC) risk through a systematic review and meta-analysis. The results showed a significant association between SHS exposure and an increased risk of cervical intraepithelial neoplasia (CIN) and invasive CC. The intensity and duration of SHS exposure were found to be linearly associated with the risk of CC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Jessa Gilda P. Pandy, Paula Isabel G. Franco, Rubi K. Li
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
Paula Isabel G. Franco, Agnes E. Gorospe, Jose Mari Jardinero
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Paula Isabel G. Franco, Anna Pascual-Panganiban
Summary: We present a case of stage IV sigmoid colon adenocarcinoma with metastases to the left parotid. Despite appropriate treatment planning and control of the disease, the patient succumbed to respiratory failure due to COVID-19 pneumonia.
ECANCERMEDICALSCIENCE
(2023)