Article
Chemistry, Multidisciplinary
Kui Wang, Forrest M. Kievit, Peter A. Chiarelli, Zachary R. Stephen, Guanyou Lin, John R. Silber, Richard G. Ellenbogen, Miqin Zhang
Summary: The study introduces the development of iron oxide nanoparticles for targeted delivery of small interfering RNAs to suppress the TMZ-resistance gene in treating GBMs. This approach leads to increased apoptosis of GBM stem-like cells, reduced tumor growth, and significantly prolonged survival compared to conventional treatment with TMZ alone, offering promising outcomes for GBM patients.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Tao-Chieh Yang, Shih-Jung Liu, Wei-Lun Lo, Shu-Mei Chen, Ya-Ling Tang, Yuan-Yun Tseng
Summary: Embedding SN-38 into biodegradable microparticles enables efficient delivery and sustained release, combining this with TMZ reduces tumor growth and extends survival in mice, showing promising potential for GBM treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaolin Ai, Zengpanpan Ye, Chaoxin Xiao, Jian Zhong, Joseph J. Lancman, Xuelan Chen, Xiangyu Pan, Yu Yang, Lin Zhou, Xiang Wang, Huashan Shi, Dongmei Zhang, Yuqin Yao, Dan Cao, Chengjian Zhao
Summary: Accurate prediction of intracranial infiltration tendency and drug response of individual GBM cells is crucial for personalized prognosis and treatment. The zebrafish PDOX model provides a novel avenue for precision medicine of GBM, allowing for prediction of long-term outcomes within a short period of time.
DISEASE MODELS & MECHANISMS
(2022)
Article
Oncology
Gloria Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B. Redwood, Yan Jiang, Aaron McCoy, Amanda L. Rinkenbaugh, Rosanna Lau, Alexander J. Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E. Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E. Adrada, Deanna L. Lane, Gaiane M. Rauch, Wei T. Yang, Jason B. White, Jeffrey T. Chang, Stacy L. Moulder, W. Fraser Symmans, Susan G. Hilsenbeck, Helen Piwnica-Worms
Summary: This study established 369 orthotopic PDX models of breast cancer and found that treatment-resistant cancers were more likely to be successfully engrafted. The molecular subtype of breast cancer was not associated with engraftment rate. A statistical model predictive of engraftment was developed based on clinical indicators. These breast cancer models are valuable for clinical treatment and biomarker research.
Article
Oncology
Jacqueline P. P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. L. White, Molly K. K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. J. Girard, Maria Tsoli, David S. S. Ziegler, Jason M. M. Dyke, Sharon Lee, Paul G. G. Ekert, Mark J. J. Cowley, Nicholas G. G. Gottardo, Raelene Endersby
Summary: Ependymomas (EPN) are the third most common malignant brain cancer in children. Current treatment strategies for pediatric EPN have shown limited improvement in survival rates and often result in long-term neurological side effects. In order to develop safer and more effective treatments, it is crucial to establish laboratory models representative of the diverse molecular subtypes of EPN.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Environmental
Meijuan He, Tingting Xiao, Yihui Wang, Hongwei Yu, Zilin Wang, Xiangyang Shi, Han Wang
Summary: In this study, we developed an immunostimulated nanoplatform for MRI-guided radiotherapy against GBM. The platform effectively enhances the immune response and shows promising therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Shuhua Zheng, Wensi Tao
Summary: The study identified a simple three-gene transcriptome signature that can connect GBM's overall prognosis with gene expression, while also correlating perfusion imaging features with SOCS3 expression levels. SOCS3 expression levels are considered a potential selection marker for patients who may benefit from early initiation of angiogenesis inhibitors.
Article
Oncology
Henry S. Friedman, Michael D. Prados, Patrick Y. Wen, Tom Mikkelsen, David Schiff, Lauren E. Abrey, W. K. Alfred Yung, Nina Paleologos, Martin K. Nicholas, Randy Jensen, James Vredenburgh, Jane Huang, Maoxia Zheng, Timothy Cloughesy
Summary: This study evaluated the efficacy of bevacizumab, alone or in combination with irinotecan, in recurrent glioblastoma patients. The results showed that bevacizumab, either alone or in combination, was well tolerated and active in treating recurrent glioblastoma.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Engineering, Biomedical
Luiza C. S. Erthal, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez
Summary: The treatment for GBM has remained unchanged for over 20 years, with surgery, radiotherapy, and chemotherapy being the standard of care. Research is now focused on improving treatment outcomes and patient quality of life, with a particular emphasis on biomaterials such as hydrogels for new treatment options. Various formulations, including biocompatible polymers for injectable and localized therapies, are being developed and tested to enhance the localized treatment of GBM. Biomaterial formulations offer potential for better treatment outcomes for glioblastoma patients in the future.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Yi-Ping Huang, Yi-Shih Ma, Chao-Lin Kuo, Ching-Lung Liao, Po-Yuan Chen, Shu-Fen Peng, Fei-Ting Hsu, Kuang-Chi Lai
Summary: In a mouse model experiment, DMC was found to significantly suppress human glioblastoma multiforme cells, with a better effect at a higher dose, while not affecting body weight. Additionally, DMC treatment had an impact on the expression of tumor-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hui Yao, Jiangang Liu, Chi Zhang, Yunxiang Shao, Xuetao Li, Zhengquan Yu, Yulun Huang
Summary: Our study revealed that apatinib inhibits the malignancy of glioma cells by targeting THBS1, potentially through MYH9. This could provide novel targets for glioma therapy.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Ke Shen, Dandan Shen, Dongdong Jin, Yichao Zheng, Yuanhang Zhu, Xinyue Zhao, Zhenan Zhang, Nannan Wang, Huanhuan Chen, Li Yang
Summary: This study established a unique PDOX nude mouse model for studying influencing factors in ER positive endometrial cancer. The findings demonstrate that a high-fat diet can significantly promote tumor growth and increase the protein expression level of ER alpha in tumor tissues. This model has the potential for preclinical studies of cancer promoting factors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, Antonio Fioravanti, Mauro Comes Franchini, Mario Chiariello
Summary: This study aimed to design a new negative temperature-responsive gel formulation for the local release of TMZ beyond the blood-brain barrier. The newly designed gel-based local therapy showed promising potential for the treatment of GBM.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Mateusz Pinkiewicz, Milosz Pinkiewicz, Jerzy Walecki, Michal Zawadzki
Summary: Intra-arterial cerebral infusions of chemotherapeutics have been shown to be safe and effective in delivering high drug concentrations to targeted areas while limiting systemic toxicity. However, the lack of phase III trials prevents definitive conclusions on its therapeutic benefits. Therefore, further development of precise pharmacokinetic models, deeper understanding of glioblastoma biology, and effective strategies to reduce treatment-related neurotoxicity are crucial for this treatment approach to become a mainstay for glioblastoma multiforme.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, Antonio Fioravanti, Mauro Comes Franchini, Mario Chiariello
Summary: The study aimed to design new negative temperature-responsive gel formulations to locally release TMZ for the treatment of GBM. The biocompatibility of the gel formulations containing nanoparticles or microparticles was confirmed in vitro and in vivo, and the therapeutic potential of these formulations was tested in a glioblastoma resection and recurrence mouse model. The gel formulations showed promising results in inducing cell death in vitro and significantly reducing tumor recurrence in vivo.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
J. P. Dyke, D. Sondhi, H. U. Voss, D. C. Shungu, X. Mao, K. Yohay, S. Worgall, N. R. Hackett, C. Hollmann, M. E. Yeotsas, A. L. Jeong, B. Van de Graaf, I. Cao, S. M. Kaminsky, L. A. Heier, K. D. Rudser, M. M. Souweidane, M. G. Kaplitt, B. Kosofsky, R. G. Crystal, D. Ballon
AMERICAN JOURNAL OF NEURORADIOLOGY
(2013)
Article
Clinical Neurology
Jonathan C. Bardin, Joseph J. Fins, Douglas I. Katz, Jennifer Hersh, Linda A. Heier, Karsten Tabelow, Jonathan P. Dyke, Douglas J. Ballon, Nicholas D. Schiff, Henning U. Voss
Article
Biotechnology & Applied Microbiology
M. J. Hicks, K. Funato, L. Wang, E. Aronowitz, J. P. Dyke, D. J. Ballon, D. F. Havlicek, E. Z. Frenk, B. P. De, M. J. Chiuchiolo, D. Sondhi, N. R. Hackett, S. M. Kaminsky, V. Tabar, R. G. Crystal
CANCER GENE THERAPY
(2015)
Letter
Urology & Nephrology
Matthieu Durand, Brian D. Robinson, Eric Aronowitz, Ashutosh K. Tewari, Douglas J. Ballon
Article
Chemistry, Multidisciplinary
Conor P. Foley, David G. Rubin, Alejandro Santillan, Dolan Sondhi, Jonathan P. Dyke, Y. Pierre Gobin, Ronald G. Crystal, Douglas J. Ballon
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Neurosciences
Rebecca M. Jones, Leah H. Somerville, Jian Li, Erika J. Ruberry, Victoria Libby, Gary Glover, Henning U. Voss, Douglas J. Ballon, B. J. Casey
JOURNAL OF NEUROSCIENCE
(2011)
Article
Biochemical Research Methods
Alejandro Santillan, David G. Rubin, Conor P. Foley, Dolan Sondhi, Ronald G. Crystal, Y. Pierre Gobin, Douglas J. Ballon
JOURNAL OF NEUROSCIENCE METHODS
(2014)
Article
Clinical Neurology
Peter Grunert, Harry H. Gebhard, Robby D. Bowles, Andrew R. James, Hollis G. Potter, Michael Macielak, Katherine D. Hudson, Marjan Alimi, Douglas J. Ballon, Eric Aronowitz, Apostolos John Tsiouris, Lawrence J. Bonassar, Roger Haertl
JOURNAL OF NEUROSURGERY-SPINE
(2014)
Article
Orthopedics
Jonathan P. Dyke, Michael Synan, Paula Ezell, Douglas Ballon, Jennifer Racine, Roy K. Aaron
JOURNAL OF ORTHOPAEDIC RESEARCH
(2015)
Article
Neurosciences
Anat Maoz, Martin J. Hicks, Shankar Vallabhjosula, Michael Synan, Paresh J. Kothari, Jonathan P. Dyke, Douglas J. Ballon, Stephen M. Kaminsky, Bishnu P. De, Jonathan B. Rosenberg, Diana Martinez, George F. Koob, Kim D. Janda, Ronald G. Crystal
NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Biophysics
Robby D. Bowles, Harry H. Gebhard, Jonathan P. Dyke, Douglas J. Ballon, Andre Tomasino, Matthew E. Cunningham, Roger Haertl, Lawrence J. Bonassar
NMR IN BIOMEDICINE
(2012)
Article
Clinical Neurology
Peter Grunert, Katherine D. Hudson, Michael R. Macielak, Eric Aronowitz, Brandon H. Borde, Marjan Alimi, Innocent Njoku, Douglas Ballon, Apostolos John Tsiouris, Lawrence J. Bonassar, Roger Haertl
Article
Cell Biology
Jianmin Yang, Lauren C. Harte-Hargrove, Chia-Jen Siao, Tina Marinic, Roshelle Clarke, Qian Ma, Deqiang Jing, John J. LaFrancois, Kevin G. Bath, Willie Mark, Douglas Ballon, Francis S. Lee, Helen E. Scharfman, Barbara L. Hempstead
Article
Biotechnology & Applied Microbiology
Dolan Sondhi, Linda Johnson, Keith Purpura, Sebastien Monette, Mark M. Souweidane, Michael G. Kaplitt, Barry Kosofsky, Kaleb Yohay, Douglas Ballon, Jonathan Dyke, Stephen M. Kaminksy, Neil R. Hackett, Ronald G. Crystal
HUMAN GENE THERAPY METHODS
(2012)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)