期刊
BRAIN
卷 134, 期 -, 页码 769-782出版社
OXFORD UNIV PRESS
DOI: 10.1093/brain/awr005
关键词
blunt-head injury; brain stem; cognitive impairment; functional magnetic resonance imaging; minimally conscious state
资金
- National Institutes of Health NIH-NICHD
- James S. McDonnell Foundation
- Dana Foundation
- Robert Wood Johnson Foundation
- Lounsbery Foundation
- Jerold B. Katz Foundation
- Buster Foundation
- Deutsche Forschungsgemeinschaft DFG-Research Centre MATHEON
- Weill Cornell Center for Translational Science Activity
Functional neuroimaging methods hold promise for the identification of cognitive function and communication capacity in some severely brain-injured patients who may not retain sufficient motor function to demonstrate their abilities. We studied seven severely brain-injured patients and a control group of 14 subjects using a novel hierarchical functional magnetic resonance imaging assessment utilizing mental imagery responses. Whereas the control group showed consistent and accurate (for communication) blood-oxygen-level-dependent responses without exception, the brain-injured subjects showed a wide variation in the correlation of blood-oxygen-level-dependent responses and overt behavioural responses. Specifically, the brain-injured subjects dissociated bedside and functional magnetic resonance imaging-based command following and communication capabilities. These observations reveal significant challenges in developing validated functional magnetic resonance imaging-based methods for clinical use and raise interesting questions about underlying brain function assayed using these methods in brain-injured subjects.
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