TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1

Myeloid-Derived Tissue-Type Plasminogen Activator Promotes Macrophage Motility through FAK, Rac1, and NF-κB Pathways

(2014) Ling Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic translation in acute kidney injury: the epithelial/endothelial axis

(2014) Bruce A. Molitoris   JOURNAL OF CLINICAL INVESTIGATION

The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury

(2013) Barbara A. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis

(2013) Claudie M. Hecquet et al.   CIRCULATION RESEARCH

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia/Reperfusion

(2013) Ramazan Altintas et al.   JOURNAL OF ENDOUROLOGY

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

(2013) Simone M. Blattner et al.   KIDNEY INTERNATIONAL

Rac1 Activation in Podocytes Induces Rapid Foot Process Effacement and Proteinuria

(2013) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease

(2013) Andrea Babelova et al.   PLoS One

Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels

(2012) Gui-Lan Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury

(2012) Toshihito Hiroi et al.   CARDIOVASCULAR RESEARCH

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

(2011) Adriana Sumoza-Toledo et al.   FASEB JOURNAL

Myocardial Ischemia Activates an Injurious Innate Immune Signaling via Cardiac Heat Shock Protein 60 and Toll-like Receptor 4

(2011) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke

(2011) Jia Jia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain

(2010) Limei Shan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endogenous IL-10 Attenuates Cisplatin Nephrotoxicity: Role of Dendritic Cells

(2010) R. K. Tadagavadi et al.   JOURNAL OF IMMUNOLOGY

Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes

(2010) Janine Wehrhahn et al.   JOURNAL OF IMMUNOLOGY

TRPM2: a multifunctional ion channel for calcium signalling

(2010) Adriana Sumoza-Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Renal TRPathies

(2010) A. Dietrich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Rac1 GTPase in NADPH Oxidase Activation and Cognitive Impairment Following Cerebral Ischemia in the Rat

(2010) Limor Raz et al.   PLoS One

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

Netrin-1 Overexpression Protects Kidney from Ischemia Reperfusion Injury by Suppressing Apoptosis

(2009) Weiwei Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia

(2009) Quan-Guang Zhang et al.   BRAIN RESEARCH

Renal Dendritic Cells Ameliorate Nephrotoxic Acute Kidney Injury

(2009) R. K. Tadagavadi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bcl-2 Protects Tubular Epithelial Cells from Ischemia Reperfusion Injury by Inhibiting Apoptosis

(2008) Chigure Suzuki et al.   CELL TRANSPLANTATION

TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity

(2008) B. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ischemia/Reperfusion Injury in Kidney Transplantation: Mechanisms and Prevention

(2008) M. Kosieradzki et al.   TRANSPLANTATION PROCEEDINGS

Role of TRPM2 Channel in Mediating H 2 O 2 -Induced Ca 2+ Entry and Endothelial Hyperpermeability

(2007) Claudie M. Hecquet et al.   CIRCULATION RESEARCH