Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

(2010) Hua-shan Shi et al.   CANCER SCIENCE

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

(2010) Wenhao Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells

(2010) M. S. Goldberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis

(2009) Y.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

New roles for pyruvate kinase M2: working out the Warburg effect

(2008) Emily C. Ferguson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

(2007) Jungwoon Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY